AutismKB 2.0

Annotation Detail for TJP3


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Basic Information Top
Gene Symbol:TJP3 ( MGC119546,ZO-3,ZO3 )
Gene Full Name: tight junction protein 3 (zona occludens 3)
Band: 19p13.3
Quick LinksEntrez ID:27134; OMIM: 612689; Uniprot ID:ZO3_HUMAN; ENSEMBL ID: ENSG00000105289; HGNC ID: 11829
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of TJP3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TJP3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of TJP3 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in decreased expression of TJP3 mRNAdecreases expression 17991464
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TJP3 mRNAincreases expression 17557909
D005472 Fluorouracil Fluorouracil affects the expression of TJP3 mRNAaffects expression 16584549
C004925 methylmercuric chloride methylmercuric chloride results in decreased expression of TJP3 mRNAdecreases expression 19465457
D017239 Paclitaxel TJP3 protein results in decreased susceptibility to Paclitaxeldecreases response to substance 16734730
D010634 Phenobarbital Phenobarbital results in decreased expression of TJP3 mRNAdecreases expression 19270015
C006253 pirinixic acid pirinixic acid results in decreased expression of TJP3 mRNAdecreases expression 17426115
D011374 Progesterone NCOA2 protein affects the reaction [Progesterone results in decreased expression of TJP3 mRNA]affects reaction|decreases expression 17556502
D011374 Progesterone Progesterone results in decreased expression of TJP3 mRNAdecreases expression 17556502
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methylmercuric chloride 9.646734493
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.646195326
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4414692618
MESH:D000230 Adenocarcinoma Fluorouracil 4.4417638652
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.7817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7816434500
MESH:D000740 Anemia Fluorouracil 3.8415504547 16511603 17963324
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9318057881 18218290 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001281 Atrial Fibrillation Amiodarone 4.0118651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.5519483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5519483382
MESH:D001859 Bone Neoplasms Paclitaxel 4.7215867366
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5617868700
MESH:D001930 Brain Injuries Progesterone 4.4315665606 15380490 15845082
MESH:D001943 Breast Neoplasms Fluorouracil 2.0516110121 16595493 18357371 18608205 15136595 16557594 19217205
MESH:D001943 Breast Neoplasms Paclitaxel 2.0518323546 16244791 18234424 15136595 16115903 16273361 18223236 11325840
MESH:D001943 Breast Neoplasms Progesterone 2.0516175315 17614352 15562024
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8916051944
MESH:D002277 Carcinoma Fluorouracil 3.6817121937
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.6716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.6716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.673084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.6717971768 17045692 18930000 16799960 16332177 17088986
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 11.6716313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.6720007298 17173139 20935162 1701930 6705139
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0718695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5218986760 16757204 16280240 17066447
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9315710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2818974383
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.866135515
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.434080065
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0917333356 16105132 17110522 16919318 17681005 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 8.0919176532
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2517169374 15001691 18772588 16510598 17172411 17725105 17287894 17016597 17018589 16340194
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7914970324 17695437 18288408 15148649 15289873 18383874 17594712 16282729 16331619 18802399 18949393 17454858 17255274 18448328 17094418 16303861 17016601 18509181 16391804 16524972 20501625 17401013
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.7918802399
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.4918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.4918551238
MESH:D007644 Darier Disease Fluorouracil 4.9916733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003929 Diabetic Neuropathies Progesterone 4.6717187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.3021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.3018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3016177239 18713872 19164858 12153990 16393943 12540782 19085960 19420014 11287661 11739529 2444490 14725611 15968718 10774834 16109766 11461765 19739265 19416960 12958197 10663392 17522070 12392966 10915739 12705907 12594235 14550746 19370779 18071297 14986274 17906064 17562736 11743745 11421492 16781746 11834606 11529661 16081117 15619225 19923254 16227642 16485898
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.3018218290 15265979
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004421 Dystonia Phenobarbital 4.151851702
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.5812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.5817692515
MESH:D004715 Endometriosis Progesterone 3.9016134523
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.283659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.0911558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.676401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.437750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.213659116
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.9216337965 16481741 15173087 17638652 16785472
MESH:D004938 Esophageal Neoplasms Paclitaxel 4.9216481741
MESH:D005234 Fatty Liver Amiodarone 13.9214986274
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.9215345470
MESH:D005234 Fatty Liver pirinixic acid 13.9219236843 20131406
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005910 Glioma Fluorouracil 2.9216145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4815102660 18337622 15162350
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006529 Hepatomegaly Amiodarone 15.5615265979
MESH:D006529 Hepatomegaly Phenobarbital 15.5616109766
MESH:D006529 Hepatomegaly pirinixic acid 15.5616221962 19176532 19772884 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.018137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.6917991464 18020914
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5815869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Progesterone 2.6615869954
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.2715629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.1416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.1416705839
MESH:D007680 Kidney Neoplasms Fluorouracil 13.1416985049
MESH:D008064 Lipidoses Amiodarone 3.6115342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 4.9717353645
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9621047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 4.0419784758 12969438 12587719 16611625 11587558 19460945 19014921 16610002
MESH:D008107 Liver Diseases Phenobarbital 4.0419363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.117678174
MESH:D008113 Liver Neoplasms Fluorouracil 11.1116603448 15113037 18383874 17045692
MESH:D008113 Liver Neoplasms Phenobarbital 11.1121047994 19812893 15975961 8742319 19073162 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 11.1120007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.232876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.2317172636 6150874 18308698 1399818 2563599
MESH:D008133 Long QT Syndrome Amiodarone 3.6917391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 3.4612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.7018516814
MESH:D008175 Lung Neoplasms Fluorouracil 2.0015246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9915086387
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.2114749477
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.9517203775 11408345
MESH:D008545 Melanoma Paclitaxel 2.6016342250 12025231 12040289
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7416757204 18986760
MESH:D009101 Multiple Myeloma Paclitaxel 3.7814749477
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009181 Mycoses Amiodarone 5.1212754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6717484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.0018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.0018551238 7678174
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.3015867366
MESH:D009369 Neoplasms Fluorouracil 5.1918239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 5.1917405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5316436463
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.3312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3316049721
MESH:D010014 Osteolysis Paclitaxel 5.1715867366
MESH:D010018 Osteomalacia Phenobarbital 4.5617016548
MESH:D010051 Ovarian Neoplasms Paclitaxel 5.2811161223
MESH:D010051 Ovarian Neoplasms Progesterone 5.2817393432 16525653
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.5016929163 19003803 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.5016965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D011230 Precancerous Conditions Phenobarbital 3.752563599
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.5219082440 18626508
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.5217172428 16729912 17136230 16356831
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.7112752131
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9012490602 12832656 11597910
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1418722050 15538739 18286688 16160472
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9018045962
MESH:D012640 Seizures 2,4-dinitrotoluene 10.3618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.3618551238
MESH:D012640 Seizures Phenobarbital 10.363137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.026407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2818724381
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.4716503802 15862959
MESH:D013274 Stomach Neoplasms Fluorouracil 2.7718396642 15786421 17522103 19015929 16951190 17172411 18567086 17498489 16424979 19084572
MESH:D013274 Stomach Neoplasms Paclitaxel 2.7718506536 18396642
MESH:D013276 Stomach Ulcer Amiodarone 3.4518087811
MESH:D013610 Tachycardia Amiodarone 4.4511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3519225199
MESH:D024801 Tauopathies Paclitaxel 5.0116930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Amiodarone 4.9819731979
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.161399818
MESH:D013971 Thyrotoxicosis Amiodarone 5.0419584973 18020914
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1216280240
MESH:D016171 Torsades de Pointes Amiodarone 4.3811989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.1816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.6510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.6510091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0116803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
Pathway ID Pathway Name
KEGG:04530 Tight junction
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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