AutismKB 2.0

Annotation Detail for GLS2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GLS2 ( GA,GLS,LGA,MGC71567,hLGA )
Gene Full Name: glutaminase 2 (liver, mitochondrial)
Band: 12q13.3
Quick LinksEntrez ID:27165; OMIM: 606365; Uniprot ID:GLSL_HUMAN; ENSEMBL ID: ENSG00000135423; HGNC ID: 29570
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
CITRULBIO-PWYcitrulline biosynthesis
PWY-5004superpathway of citrulline metabolism
Pathway IDPathway Name
hsa00250Alanine, aspartate and glutamate metabolism
hsa00910Nitrogen metabolism
hsa00330Arginine and proline metabolism
hsa04964Proximal tubule bicarbonate reclamation
hsa01100Metabolic pathways
hsa00471D-Glutamine and D-glutamate metabolism
Pathway IDPathway Name
Synaptic Transmission
Metabolism of amino acids and derivatives
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2035Brain disease
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014024 2,4,5,2',4',5'-hexachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of GLS2 mRNAaffects cotreatment|decreases expression 16984957
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GLS2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GLS2 mRNAaffects expression 21346803
C019499 2-nitrofluorene 2-nitrofluorene results in decreased expression of GLS2 mRNAdecreases expression 14600272
C023035 3,4,5,3',4'-pentachlorobiphenyl [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of GLS2 mRNAaffects cotreatment|decreases expression 16984957
C023035 3,4,5,3',4'-pentachlorobiphenyl 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GLS2 mRNAdecreases expression 16984957
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of GLS2 mRNAdecreases expression 14600272
D000082 Acetaminophen Acetaminophen affects the expression of GLS2 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GLS2 proteinaffects expression 20106945
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GLS2 mRNAaffects cotreatment|decreases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of GLS2 mRNAincreases expression 20106945
D002101 Cacodylic Acid Cacodylic Acid results in increased expression of GLS2 mRNAincreases expression 17720352
D002995 Clofibric Acid Clofibric Acid affects the expression of GLS2 mRNAaffects expression 17602206
D016572 Cyclosporine Cyclosporine results in decreased expression of GLS2 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GLS2 mRNAaffects cotreatment|decreases expression 18164116
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of GLS2 mRNAdecreases expression 14600272
D004958 Estradiol Estradiol results in decreased expression of GLS2 mRNAdecreases expression 20106945
D005419 Flavonoids Flavonoids results in decreased expression of GLS2 mRNAdecreases expression 18035473
C023036 perfluorooctanoic acid perfluorooctanoic acid affects the expression of GLS2 mRNAaffects expression 18281256
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GLS2 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of GLS2 mRNAdecreases expression 17164430
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GLS2 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GLS2 mRNAdecreases expression 18796159
16054898
16984957
C024746 tobacco tar tobacco tar results in decreased expression of GLS2 mRNAdecreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7411752688 15322242 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.0118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9820127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 6.9816033868
MESH:D000230 Adenocarcinoma Estradiol 6.9811473722
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 20.3816176798
MESH:D000236 Adenoma Benzo(a)pyrene 20.386695378
MESH:D000236 Adenoma beta-Naphthoflavone 20.3819389873
MESH:D000236 Adenoma Diethylnitrosamine 20.3810737359 6695378
MESH:D000236 Adenoma Dimethylnitrosamine 20.3819555203
MESH:D018248 Adenoma, Liver Cell 3,4,5,3',4'-pentachlorobiphenyl 24.0316628245
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 24.0317620307 17162532 19052882 16434500 19061943 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 24.0316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 24.0316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9619183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.4319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.4312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6915746008
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 2.9220146248
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9220146248 17474063
MESH:D001943 Breast Neoplasms Cacodylic Acid 2.9217474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9217474063
MESH:D001943 Breast Neoplasms Estradiol 2.9212948864 17018787 17289903 16675129 18497071 19861407 17261762 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3516111702
MESH:D002277 Carcinoma Dimethylnitrosamine 8.0619555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.0616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.1616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 11.1616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.163084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.1621507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.1618691550 20727157 19335982 20214788 21159647 16935385 10672840 18210153 19418558 16878318 20512989 18393292 17428255 19052882 18971187 17055752 19822196 19919837 16681979 16569478 18494052 16328049 19383236 16502159 20514400 19539802 16807293 19701751 3581430 19208518 20084675 18788625 19519916 3084413 18665156 17138121 16779866 16288022 10737359 17761372 19107877 17978847 18056438 19171122 16830150 18506893 11831363 20524982 20101231 20007298 20935162 17173139 17162532 18785209 16540662 20432363 19394651 16698587 18978308
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.1616924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7020419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 4.7016033868
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3118670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.5210977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 20.306135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.3012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 20.3017174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 20.3018566989
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 20.3019559774
MESH:D018281 Cholangiocarcinoma 3,4,5,3',4'-pentachlorobiphenyl 15.6716628245
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 15.6719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 15.6716835633
MESH:D002779 Cholestasis Cyclosporine 7.4919486331
MESH:D002779 Cholestasis pirinixic acid 7.4919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0612621046 15340226 16354765 8697196 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9614669216 17141729
MESH:D019465 Craniofacial Abnormalities 3,4,5,3',4'-pentachlorobiphenyl 2.8917686920
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8920055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.5318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.5318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1317107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.8421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 14.8421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.8411529661 18713872 12540782 12958197 2444490 16781746 12153990 11834606 10774834 16177239 16485898 15968718 14550746 16109766 17562736 19085960 19370779 10915739 12594235 16081117 19923254 14986274 16393943 17906064 10663392 14725611 19164858 11739529 12392966 11461765 11421492 11743745 15619225 16227642 19420014 11287661 17522070 19739265 12705907 18071297 19416960
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 14.8419107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 14.848172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.8420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D004487 Edema perfluorooctanoic acid 10.8712083418 17259670
MESH:D004487 Edema pirinixic acid 10.8712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.8711000095 12711302
MESH:D004489 Edema, Cardiac 3,4,5,3',4'-pentachlorobiphenyl 12.0717686920
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.0715322242 18230668 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 2.9118566989 19148513 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9210568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0116302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5616530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 4.5617016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005234 Fatty Liver Cyclosporine 12.4619224547
MESH:D005234 Fatty Liver Diethylnitrosamine 12.4621071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 12.4619236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005355 Fibrosis Cyclosporine 8.1212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.1220067830
MESH:D005756 Gastritis Acetaminophen 3.5716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.118708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006330 Heart Defects, Congenital 3,4,5,3',4'-pentachlorobiphenyl 10.9317686920 20471113
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.9320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.9310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006529 Hepatomegaly perfluorooctanoic acid 13.833609246
MESH:D006529 Hepatomegaly pirinixic acid 13.8319176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.8316120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.9315709030
MESH:D019584 Hot Flashes Estradiol 3.6517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9415340226 16354765 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.5716870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.5712083418
MESH:D006943 Hyperglycemia pirinixic acid 3.0820558911
MESH:D006973 Hypertension Cyclosporine 4.8110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8118670907 18850075
MESH:D007249 Inflammation Diethylnitrosamine 11.5218785209
MESH:D007249 Inflammation Flavonoids 11.5217296493
MESH:D007249 Inflammation perfluorooctanoic acid 11.5212083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.5212200463 12878042
MESH:D007333 Insulin Resistance Estradiol 6.9616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.9616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3415604871
MESH:D007674 Kidney Diseases Acetaminophen 9.6112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.6118776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 9.6115618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.9916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.9916705839
MESH:D007680 Kidney Neoplasms Cyclosporine 16.9912371664
MESH:D007680 Kidney Neoplasms Estradiol 16.9915610895
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.128812269
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7620032147 19638242 18522880 18407596 18665156
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 4.8415161499 16169303 15842777 15504291 12925901 16627068 15366600 18567088 15298665 17724770 15339415 15383259 16270385 18239293 15798949 16009107 15733078 15793283 17640959 14643895 18371158 14568256 12918455 17534399 14709902 15723089 18210741 15081153 15479170 15591649 17196135 17198567 17465448 18364076 17036385 15571005 15099470 16603200 15942678 15744066 16042886 15577212 18095165 14726149 15763062 16570917 15492853 17201889 17719030 18637143 17666798 18629640 15138612 17203207 17881167 15369754 15864749 14659978 15086199 17432682 15067225 18672772 17348192 18237412 16544323
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.8414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8412878042
MESH:D008107 Liver Diseases Acetaminophen 3.8112969438 11587558 19784758 12587719 19460945 16611625 16610002 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 3.8117034775
MESH:D017114 Liver Failure, Acute Acetaminophen 9.3516871587 17185352
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 9.3517457977
MESH:D008113 Liver Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 47.2116835634 18644402
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 47.217678174
MESH:D008113 Liver Neoplasms 2-nitrofluorene 47.2115890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 47.2115890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 47.2115890375 9163691 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 47.2120195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 47.2119389873 21295105
MESH:D008113 Liver Neoplasms Clofibric Acid 47.2117602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 47.2115175105 20583210 19294768 19255062 18644402 21047994 19426721 19427195 18977376 19551842 18754104 9163691 19690152 20492335 18648771 20405173 20101389 2862719 19254457 19833225 19812893 2422723 20137499 10737359 21278145 20501860 16942905 19642983 12112319 18978307 20452335 20434301 19499222 19850985 19638242 15885732 12771043 19996281 21167192 19256749 19073162 20118626 21071580 19090486
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 47.2115890375 3113478
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 47.2114757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 47.2115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 47.2116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 22.492876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 22.498603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 22.4918164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 22.4918093689 18775883 17942915 16267830 17854601 19539802 19519916 19009564 9362446 18079962 2563599 19126423 18308698 18544905 19004024 17174075 3124819 18164116 18253720 18282651 21159647 16842330
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 22.496150874 1848544 15603536
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.4912151625
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 8.3916061637 12438228 9255578 19931552 17139156 18508827 15172992 15893417 16401635 14755239 18813816
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.3914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.3918816296 20869020 20464547 20064080 18569708 18520028 20135361 17053015 6695378
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.3920970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 8.3916061637 11884234 19555203
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.3911884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.4911807958 16891317 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.3819453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.4016239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.9716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9716411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.9818551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.9818551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.529029167 3581430
MESH:D009369 Neoplasms 2,4,5,2',4',5'-hexachlorobiphenyl 8.058820588
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0511141357
MESH:D009369 Neoplasms pirinixic acid 8.0517405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1918481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 9.1116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.1114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.8820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0120387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.849802331
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.5616049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.5616049721
MESH:D010051 Ovarian Neoplasms Estradiol 2.1919401270
MESH:D010146 Pain Acetaminophen 2.3016870215
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 5.4812384795
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4816540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.6312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.632563599
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.3117132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.3111118676 11896295 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1417292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.1416740699
MESH:D011565 Psoriasis Cyclosporine 2.1916882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012640 Seizures 2,4-dinitrotoluene 5.6218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.6218551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.3019755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3016192470
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.1612587719
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3620155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3618456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 3.3616033868
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.907505956
MESH:D013978 Tibial Fractures Estradiol 4.5819048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.6216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.6216049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.6217053015
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 11.6215537745
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.6310091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.6310091137
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D014605 Uveitis Cyclosporine 3.881336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D014985 Xerophthalmia Cyclosporine 4.3417120751
Pathway ID Pathway Name
KEGG:00250 Alanine, aspartate and glutamate metabolism
KEGG:00330 Arginine and proline metabolism
KEGG:00471 D-Glutamine and D-glutamate metabolism
KEGG:04724 Glutamatergic synapse
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00910 Nitrogen metabolism
KEGG:04964 Proximal tubule bicarbonate reclamation
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134933506
    • No data
    Releated disease ID Related disease Name
    PA447199Bipolar Disorder
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA10090l-glutamine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00130 - L-Glutamine Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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