AutismKB 2.0

Annotation Detail for DISC1


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Basic Information Top
Gene Symbol:DISC1 ( C1orf136,FLJ13381,FLJ21640,FLJ25311,FLJ41105,KIAA0457,SCZD9 )
Gene Full Name: disrupted in schizophrenia 1
Band: 1q42.2
Quick LinksEntrez ID:27185; OMIM: 605210; Uniprot ID:DISC1_HUMAN; ENSEMBL ID: ENSG00000162946; HGNC ID: 2888
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1907Depression
2045Bipolar disorder
2124Autistic disorder
2198Psychotic disorder
2221Behavior disease
Desease Name
bipolar disorder
cognitive function
Alzheimer's disease
PSYCH
schizoaffective disorder
Amyotrophic Lateral Sclerosis
NEUROLOGICAL
schizophrenia
Asperger syndrome
Desease Name
Alzheimer's disease
Response to statin therapy
Amyotrophic lateral sclerosis
Desease Name
Schizoaffective disorder, susceptibility to
Schizophrenia, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DISC1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DISC1 mRNAdecreases expression 20064835
C055494 caffeic acid phenethyl ester caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of DISC1 mRNA]decreases reaction|increases expression 20360939
D003024 Clozapine DISC1 gene mutant form results in decreased susceptibility to Clozapinedecreases response to substance 20531374
D003024 Clozapine DISC1 protein affects the susceptibility to Clozapineaffects response to substance 20531374
D004052 Diethylnitrosamine caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of DISC1 mRNA]decreases reaction|increases expression 20360939
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of DISC1 mRNAincreases expression 20360939
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 7.256695378
MESH:D000236 Adenoma Diethylnitrosamine 7.2510737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.4419061943 19052882 17620307 17162532 16434500 18056438
MESH:D000380 Agranulocytosis Clozapine 5.5414617031 16160616 12649775
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D020817 Asperger Syndrome marker/mechanism 17579608
MESH:D001321 Autistic Disorder marker/mechanism 17579608
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0520146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.0517474063
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8720514400 16698587 10737359 17428255 17162532 20524982 20512989 17173139 16328049 19335982 16878318 21159647 20101231 19171122 18056438 16807293 18665156 20007298 18691550 19418558 19107877 20935162 18788625 19822196 20432363 19394651 16502159 18971187 18494052 16779866 19383236 11831363 16681979 17138121 18393292 3581430 19052882 20084675 17055752 18978308 18210153 19539802 19919837 16540662 20214788 16288022 18506893 17978847 19208518 18785209 17761372 19519916 10672840 16830150 3084413 19701751 16935385 16569478 20727157
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.0921159647 2727394 17174075 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 4.0119052882
MESH:D003072 Cognition Disorders Clozapine 5.4517123785
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.9316402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.9320387270
MESH:D006970 Disorders of Excessive Somnolence Clozapine 6.1715331141
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.1319107877
MESH:D050171 Dyslipidemias Clozapine 4.4316402076
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.7316302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver Diethylnitrosamine 3.5621071580 20387270
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006948 Hyperkinesis Clozapine 5.4516046005
MESH:D007249 Inflammation Diethylnitrosamine 2.5318785209
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.9310783313
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.7315369732
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.2116766008
MESH:D008064 Lipidoses Clozapine 4.2117567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9918665156 19638242 20032147 18407596 18522880
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1617034775
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8920195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.8920452335 20405173 18977376 2422723 18754104 10737359 21278145 20492335 19499222 19996281 18644402 19073162 19294768 20583210 19426721 9163691 15175105 19833225 19254457 19642983 19638242 12112319 20101389 19255062 19812893 19090486 18648771 21167192 20501860 21071580 20118626 12771043 19551842 20137499 20434301 19256749 19850985 16942905 15885732 2862719 18978307 19427195 19690152 21047994
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.8319009564 18093689 16267830 18308698 19004024 16842330 17174075 19126423 2563599 18282651 21159647 17942915 17854601 18253720 19539802 3124819 18079962 18164116 18775883 19519916 18544905 9362446
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4620135361 18520028 6695378 18569708 17053015 20464547 20869020 18816296 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.4620970405 6695378 20512841 21163286
MESH:D001523 Mental Disorders Clozapine 4.4816856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.7219142101
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.689029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6520387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.7320387270
MESH:D009765 Obesity Clozapine 3.0818515891 19142110
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5216540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.882563599
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D011618 Psychotic Disorders Clozapine 4.4315331141
MESH:D012559 Schizophrenia marker/mechanism 20531374
MESH:D012559 Schizophrenia Clozapine 2.7720580759 20521320 18855531 20168265 20107430 17667964 20521326 17123785 17726453 19369910 20452607 11151749 11763009 18806925 16141801
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5110029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4020155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4018456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.257505956
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2917053015
MESH:D015430 Weight Gain Clozapine 4.7920564506 16141801 16402076 20521320 17502770 20107430
MESH:D015431 Weight Loss Clozapine 5.6217933447
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27342
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    PA443319Alzheimer Disease
    PA447198Autistic Disorder
    PA447199Bipolar Disorder
    PA447278Depression
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA153906323rolipram
    PA449061clozapine
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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