AutismKB 2.0

Annotation Detail for GPC3


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Basic Information Top
Gene Symbol:GPC3 ( DGSX,GTR2-2,MXR7,OCI-5,SDYS,SGB,SGBS,SGBS1 )
Gene Full Name: glypican 3
Band: Xq26.2
Quick LinksEntrez ID:2719; OMIM: 300037; Uniprot ID:GPC3_HUMAN; ENSEMBL ID: ENSG00000147257; HGNC ID: 4451
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200008Glypican pathway
200193Glypican 3 network
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
1940Ovarian disease
No data
No data
Desease Name
Wilms tumor, somatic
Simpson-Golabi-Behmel syndrome, type 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of GPC3 mRNA]affects expression|affects reaction 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of GPC3 mRNA]affects expression|affects reaction 19414516
D000082 Acetaminophen Acetaminophen affects the expression of GPC3 mRNAaffects expression 17562736
D000242 Cyclic AMP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of GPC3 mRNA]affects expression|affects reaction 19414516
D001104 Arbutin Arbutin results in decreased expression of GPC3 mRNAdecreases expression 17103032
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPC3 mRNAaffects cotreatment|increases expression 18164116
D002251 Carbon Tetrachloride AFR2 protein affects the reaction [Carbon Tetrachloride results in increased expression of GPC3 mRNA]affects reaction|increases expression 17668883
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of GPC3 mRNAincreases expression 17668883
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPC3 mRNAaffects cotreatment|increases expression 18164116
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of GPC3 mRNAdecreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of GPC3 mRNAdecreases expression 17351261
15576828
15834898
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of GPC3 mRNAincreases expression 17187413
C056507 gemcitabine gemcitabine results in increased expression of GPC3 mRNAincreases expression 17039268
D020849 Raloxifene Raloxifene results in increased expression of GPC3 mRNAincreases expression 15576828
C066340 tolcapone tolcapone binds to GPC3 proteinaffects binding 19783845
C025643 vinclozolin vinclozolin affects the expression of GPC3 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma 2-Acetylaminofluorene 11.6210737359
MESH:D000236 Adenoma beta-Naphthoflavone 11.6219389873
MESH:D000236 Adenoma Diethylnitrosamine 11.626695378 10737359
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.146705139
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0216434500 19052882 17162532 17620307 18056438 19061943
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.4311080934
MESH:D000419 Albuminuria Raloxifene 4.6917308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 4.7415800139
MESH:D000544 Alzheimer Disease tolcapone 4.7420150427
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7019015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001930 Brain Injuries Raloxifene 4.5816580743
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1117474063
MESH:D001943 Breast Neoplasms gemcitabine 2.1117039268 18382427
MESH:D001943 Breast Neoplasms Raloxifene 2.1116912660 17242785 17893378 17595753 15758505 17049068 17952589 15775269 17261762 16837676 15572757 17440819
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8810355542 15721981 3786805 15700767 16192424 15673190 16050911 16227642 16097048 16011737 18705752 16124888
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 16698587
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 6.703084413 3581430 17761372 6705139 10737359
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.703084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7018788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.7016698587 16878318 16540662 16569478 16328049 20514400 16830150 18393292 16502159 18210153 18494052 17055752 20101231 19208518 19383236 19919837 19107877 10672840 18978308 19052882 17162532 19171122 18971187 19701751 11831363 18788625 16779866 17978847 21159647 17761372 3581430 3084413 20935162 19539802 20512989 16288022 19335982 17138121 18785209 20214788 19394651 18506893 19418558 20727157 20084675 16935385 10737359 17173139 19822196 18665156 19519916 16681979 18691550 18056438 20524982 20007298 20432363 17428255 16807293
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1517572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5015775269
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.9117174075 21159647 7505956 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7619052882
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9311677210 17110522 16919318 15861022 17681005 17333356 16105132
MESH:D003072 Cognition Disorders Raloxifene 4.7215800139
MESH:D003456 Cryptorchidism vinclozolin 4.4414966744
MESH:D003866 Depressive Disorder tolcapone 4.367768276 11224284
MESH:D003865 Depressive Disorder, Major Raloxifene 10.4917474826
MESH:D003865 Depressive Disorder, Major tolcapone 10.4910440460
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D003928 Diabetic Nephropathies Raloxifene 4.0117451421 17308373 15920148
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2211287661 12540782 12705907 2444490 10663392 12153990 10915739 19420014 17906064 12392966 14986274 19085960 16109766 15619225 11834606 11743745 11461765 10774834 16081117 14550746 16227642 16177239 19416960 16485898 14725611 19923254 16781746 11529661 17522070 18713872 11421492 11739529 19739265 16393943 12958197 17562736 18071297 19164858 12594235 15968718 19370779
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.2221278145 6623471 10915739 11566570 7440962 7120509 15968718 10092053 9327722 15027814 4309450 15998439 2869522 19336974 17522070 3786805 3732212 7179309 16227642 6884620 16177239 19085960
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.2219107877
MESH:D056486 Drug-Induced Liver Injury tolcapone 9.2219783845 16604736
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.5311455177
MESH:D004487 Edema Raloxifene 3.4215860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.4315845917
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2516302075
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 6.0819578428
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.4912795759 61145 12631006 17595544 15959796 16239168 16045604 19224547
MESH:D005234 Fatty Liver Diethylnitrosamine 19.4920387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.4915345470
MESH:D005234 Fatty Liver Raloxifene 19.4917473493
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5618705752
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4316417039
MESH:D006331 Heart Diseases Raloxifene 3.5911110106
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.456705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.496705139
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919900420 19110552
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D006973 Hypertension Raloxifene 2.8917577099 15787275
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8417937319
MESH:D007248 Infertility, Male vinclozolin 6.8416467254
MESH:D007249 Inflammation Diethylnitrosamine 2.4118785209
MESH:D007674 Kidney Diseases Acetaminophen 2.2415629191 12587719
MESH:D007889 Leiomyoma Raloxifene 4.5816973256
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8516417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.7521278145 11408273 11903743 16943688 16239168 17334410 17174718 17157831 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.7518665156 19638242 20032147 18522880 18407596
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7518339082 12389079 18205269 15893842 12741479 12632514 15362042 17708605 17721639 17557913 10355542 18006644 18279442 18251166 15818738 14748882 15123356 12898905 15996030 18395914 17761835 15650968 12586293 15370692 15052691 17698563 18429990 15931870 18156304 18376398 14716833 17869086 18263696 15925388 15959796 12546737 12958196 17823541 12632512 14512876 11481614 15673190 16027843 18472094 17944888 18277467 15876570 16136751 18420326 16638106 16192424 12666154 12609069 18472332 18395095 12649538 17976157 16015684 17766677 15338365 17631135 14716496 17640975 18210741 16011737 15730626 12445421 16248980 17525996 17481882 12667390 12445418 18705752 18412020 20821823 17922224 18418968 17805973 13678700 14724832 18166357 17714472 16033810 14620537 16097048 18054572 16116963 18481824 17900296 18317297 17565644 15057751 18187930
MESH:D008107 Liver Diseases Acetaminophen 6.5916611625 19014921 11587558 12969438 12587719 19460945 16610002 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.5915830285 16246199 16964402 17285989 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 6.5917034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.6716871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.6716899240 14706259
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 11.0310672840 14678523 16273603 11376686 18001218 10737359
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 11.0321295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.0319294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.0320492335 12771043 19090486 20137499 19073162 18977376 2422723 19833225 19642983 19690152 10737359 15175105 21071580 19254457 19551842 19812893 20118626 21278145 18978307 19638242 19850985 12112319 20434301 19426721 20501860 19294768 2862719 18754104 9163691 19499222 21047994 18644402 16942905 20452335 19256749 19255062 20405173 21167192 19427195 20583210 18648771 19996281 20101389 15885732
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 14.626150874 534488 1399818
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 14.6218164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.6212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.6218253720 18079962 17942915 19009564 2563599 18775883 9362446 16267830 17174075 18544905 3124819 19539802 17854601 18093689 19126423 16842330 19004024 21159647 19519916 18282651 18164116 18308698
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 2.8011376686
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.8020970405 21163286 6695378 20512841
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma marker/mechanism 10656689
MESH:D020326 Migraine without Aura Cyclic AMP 5.2511304026
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.6915863610
MESH:D009101 Multiple Myeloma Raloxifene 3.4916497877
MESH:D009232 Myxoma Raloxifene 5.6916343187
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.593581430 9029167
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.4120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2520387270
MESH:D010024 Osteoporosis Raloxifene 3.4419059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3117823083 15758505 17893378 15579764
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.7316540662
MESH:D010190 Pancreatic Neoplasms gemcitabine 5.7311504793 17440100 18383843 16929163 18992248
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010300 Parkinson Disease tolcapone 3.6218328768 20216409 11432539 9305320 8739811 9591521 11586115 16758261 20334432 1977408 9333106 8635184 11746615 11793426 19783845 9708959 9754991 17089403 10651109 19578428 7566641
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.622563599
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.0118042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.0518220299
MESH:D011471 Prostatic Neoplasms Raloxifene 3.5915731164 16220300 16536755
MESH:D011472 Prostatitis vinclozolin 5.0518629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D011693 Purpura Raloxifene 5.6915770314
OMIM:312870 SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 1 marker/mechanism
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Raloxifene 3.8916837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.047505956
MESH:D013978 Tibial Fractures Raloxifene 5.3419048282
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 6.0819578428
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 5.6615289314 1399818 15867355
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.6617572228
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D054556 Venous Thromboembolism Raloxifene 5.3416837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D014820 Vitiligo tolcapone 5.2910573327
MESH:D014846 Vulvar Neoplasms Raloxifene 5.6916343187
MESH:D009396 Wilms Tumor marker/mechanism
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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