AutismKB 2.0

Annotation Detail for ARFIP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ARFIP1 ( HSU52521,MGC117369 )
Gene Full Name: ADP-ribosylation factor interacting protein 1
Band: 4q31.3
Quick LinksEntrez ID:27236; OMIM: 605928; Uniprot ID:ARFP1_HUMAN; ENSEMBL ID: ENSG00000164144; HGNC ID: 21496
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ARFIP1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ARFIP1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of ARFIP1 mRNAincreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ARFIP1 mRNAdecreases expression 19150397
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ARFIP1 mRNAincreases expression 20360939
D005419 Flavonoids Flavonoids results in decreased expression of ARFIP1 mRNAdecreases expression 18035473
D008727 Methotrexate ARFIP1 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C006253 pirinixic acid pirinixic acid results in increased expression of ARFIP1 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.5812039119
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3311798837 19825857
MESH:D000236 Adenoma Diethylnitrosamine 2.9810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.2419052882 16434500 18056438 19061943 17162532 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2416434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1417286800
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.8216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.8219483382
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.4617474063
MESH:D001943 Breast Neoplasms Methotrexate 2.4616978400
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.723084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7215553829 16217749 15073043 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7216540662 17978847 17162532 17428255 20101231 17173139 16698587 16288022 16830150 3581430 19107877 19539802 19208518 19701751 18494052 17138121 18978308 3084413 20727157 19335982 16569478 19052882 19383236 19519916 16878318 18785209 16935385 18393292 18788625 19919837 16328049 16807293 16502159 19394651 20214788 18506893 20524982 20084675 18665156 10672840 19822196 20514400 20512989 17055752 19418558 17761372 21159647 20935162 20432363 18210153 16779866 19171122 11831363 18691550 16681979 18971187 18056438 20007298 10737359
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2120889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.2117174075 21159647 7505956 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.0410525206
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.049562676 12039119
MESH:D003550 Cystic Fibrosis Methotrexate 4.4719747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003882 Dermatomyositis Methotrexate 5.4120191521
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9410774834 14550746 16485898 10663392 16177239 12705907 12594235 11529661 19085960 17906064 12392966 12153990 16081117 12540782 2444490 10915739 15619225 11287661 16393943 17522070 15968718 11461765 19420014 18071297 18713872 16227642 19164858 19416960 11743745 11834606 19923254 14986274 11739529 16109766 19370779 19739265 17562736 16781746 12958197 14725611 11421492
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.9419107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6320426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6312903497
MESH:D005234 Fatty Liver arsenic trioxide 14.5715073043
MESH:D005234 Fatty Liver Diethylnitrosamine 14.5720387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 14.5719236843 20131406
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006086 Graft vs Host Disease Methotrexate 5.4516518429
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3019176532 18467677 16221962 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D007249 Inflammation Diethylnitrosamine 5.5618785209
MESH:D007249 Inflammation Flavonoids 5.5617296493
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007805 Language Development Disorders Methotrexate 5.369562676
MESH:D007938 Leukemia arsenic trioxide 2.9315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0412560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1716467208 16968895 20471514 17050201 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3615622746 12018890 19225113 15336539 17649720 15748426 11161223 17217047 17869043 17712046 16966277 16331271 16823087 12712474 19642359 12679006 19035177 16330433 15213294 9834237 16891316 17107899 19075265 16112521 11468182
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.3418522880 18665156 19638242 20032147 18407596
MESH:D008103 Liver Cirrhosis Methotrexate 7.3414986274
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.0811587558 16610002 19784758 16611625 12587719 12969438 19460945 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0817034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 7.8814682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.8818754104 18977376 12112319 19254457 20452335 21167192 19256749 20101389 20492335 15885732 21047994 19255062 19638242 18648771 19499222 15175105 19690152 20583210 21278145 19294768 20137499 19996281 19426721 19850985 19812893 19551842 19833225 2862719 12771043 19073162 20405173 2422723 9163691 19642983 10737359 19090486 18644402 19427195 21071580 20501860 18978307 16942905 20118626 20434301
MESH:D008113 Liver Neoplasms pirinixic acid 7.8816377806 15890375 20007298
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.4620377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.4617854601 18093689 2563599 18079962 9362446 18775883 3124819 17942915 19004024 18544905 18253720 19539802 18164116 18308698 17174075 18282651 19519916 16842330 19126423 16267830 19009564 21159647
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.4018516814
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5419825857 11798837
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.5421163286 20512841 6695378 20970405
MESH:D008223 Lymphoma Methotrexate 4.1217352296
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D052016 Mucositis Methotrexate 5.6217488658
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2711468182 19417148 15949261 14977855 19549372
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2616882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.653581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2610525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.8620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4719769630 16624393 12452020
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5215580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5216540662
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2319131511
MESH:D011565 Psoriasis Methotrexate 3.5017410198
MESH:D051437 Renal Insufficiency Methotrexate 5.0217352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4917007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4918456281
MESH:D013576 Syndactyly Methotrexate 5.329562676
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.8119014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.817505956
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5620435036 11780464 12845720 12973940
MESH:D014581 Urticaria Acetaminophen 3.2410982225
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved