AutismKB 2.0

Annotation Detail for ARHGEF16


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Basic Information Top
Gene Symbol:ARHGEF16 ( GEF16,NBR )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 16
Band: 1p36.32
Quick LinksEntrez ID:27237; OMIM: NA; Uniprot ID:ARHGG_HUMAN; ENSEMBL ID: ENSG00000130762; HGNC ID: 15515
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Signaling by Rho GTPases
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ARHGEF16 mRNAaffects expression 17562736
C014347 decitabine [[decitabine co-treated with trichostatin A] affects the methylation of ARHGEF16 promoter] which affects the expression of ARHGEF16 mRNAaffects cotreatment|affects expression|affects methylation 18803327
D002117 Calcitriol Calcitriol results in increased expression of ARHGEF16 mRNAincreases expression 16002434
C011890 kojic acid kojic acid results in decreased expression of ARHGEF16 mRNAdecreases expression 16595896
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARHGEF16 mRNAaffects binding|decreases expression|increases activity 19710929
C012589 trichostatin A [[decitabine co-treated with trichostatin A] affects the methylation of ARHGEF16 promoter] which affects the expression of ARHGEF16 mRNAaffects cotreatment|affects expression|affects methylation 18803327
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001943 Breast Neoplasms Calcitriol 2.4011237771
MESH:D001943 Breast Neoplasms decitabine 2.4018320071 19208741
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.1411237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.1419215824
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6516485898 12705907 16109766 18071297 12958197 16227642 16081117 17906064 16177239 11529661 15968718 12540782 17522070 12153990 19923254 14550746 19085960 11287661 11421492 14986274 16393943 16781746 2444490 19416960 17562736 11461765 19370779 10915739 10774834 19739265 19164858 11834606 12392966 14725611 18713872 10663392 19420014 11743745 11739529 15619225 12594235
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.3115138306
MESH:D004701 Endocrine Gland Neoplasms decitabine 15.8319294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 15.8319294695
MESH:D005234 Fatty Liver pirinixic acid 3.0920131406 19236843
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005909 Glioblastoma trichostatin A 4.0218801729
MESH:D006258 Head and Neck Neoplasms decitabine 3.6919215824
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4116221962 18467677 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007248 Infertility, Male decitabine 3.4017581917
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D007938 Leukemia decitabine 3.2119235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.3319117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.4319387464 18704418 19010910 18460780 17679729 18206229
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.4318206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9818055864
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6916610002 16611625 12587719 12969438 11587558 19014921 19460945 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.9115890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental kojic acid 3.5118544905
MESH:D008223 Lymphoma decitabine 3.6419470736
MESH:D008545 Melanoma decitabine 3.8616505122 17785578
MESH:D008545 Melanoma trichostatin A 3.8616505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009101 Multiple Myeloma decitabine 8.3918172295
MESH:D009101 Multiple Myeloma trichostatin A 8.3918172295
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5419010910 16882708 18608210 19157545
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009369 Neoplasms decitabine 5.4817925555 19470736 19116145
MESH:D009369 Neoplasms pirinixic acid 5.4817405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010051 Ovarian Neoplasms decitabine 5.5419259094 19331143
MESH:D010051 Ovarian Neoplasms trichostatin A 5.5419331143
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.9919294695
MESH:D010190 Pancreatic Neoplasms trichostatin A 5.9919294695
MESH:D055728 Primary Myelofibrosis decitabine 13.8617616702
MESH:D055728 Primary Myelofibrosis trichostatin A 13.8617616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.2415572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.6012479363 16289102 16644109 15754350 18247401
MESH:D011471 Prostatic Neoplasms trichostatin A 3.6018798265 19789329
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012208 Rhabdomyosarcoma decitabine 4.7519155313
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013964 Thyroid Neoplasms decitabine 3.5717967635
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.8219087683 17616700
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014604 Uveal Neoplasms decitabine 5.4317785578
Pathway ID Pathway Name
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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