AutismKB 2.0

Annotation Detail for TNFRSF21


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Basic Information Top
Gene Symbol:TNFRSF21 ( BM-018,DR6,MGC31965 )
Gene Full Name: tumor necrosis factor receptor superfamily, member 21
Band: 6p12.3
Quick LinksEntrez ID:27242; OMIM: 605732; Uniprot ID:TNR21_HUMAN; ENSEMBL ID: ENSG00000146072; HGNC ID: 13469
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04060Cytokine-cytokine receptor interaction
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
PSYCH
panic disorder
Desease Name
Panic disorder
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of TNFRSF21 mRNAdecreases expression 19933214
C006632 arsenic trioxide arsenic trioxide affects the expression of TNFRSF21 mRNAaffects expression 17530438
C006632 arsenic trioxide arsenic trioxide results in increased expression of TNFRSF21 mRNAincreases expression 19730151
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNFRSF21 mRNAdecreases expression 19150397
C004541 biochanin A biochanin A results in decreased expression of TNFRSF21 mRNAdecreases expression 12111696
D002117 Calcitriol Calcitriol results in increased expression of TNFRSF21 mRNAincreases expression 16002434
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TNFRSF21 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of TNFRSF21 mRNAincreases expression 19619570
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of TNFRSF21 mRNAaffects cotreatment|decreases expression 17404688
D007052 Ibuprofen Ibuprofen inhibits the reaction [TNF protein results in increased expression of TNFRSF21 protein]decreases reaction|increases expression 11753679
D007052 Ibuprofen Ibuprofen results in decreased expression of TNFRSF21 mRNAdecreases expression 11753679
D007052 Ibuprofen Ibuprofen results in decreased expression of TNFRSF21 proteindecreases expression 11753679
D007213 Indomethacin Indomethacin inhibits the reaction [TNF protein results in increased expression of TNFRSF21 protein]decreases reaction|increases expression 11753679
D007213 Indomethacin Indomethacin results in decreased expression of TNFRSF21 proteindecreases expression 11753679
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of TNFRSF21 mRNAdecreases expression 20713471
D019800 Phenol Phenol results in increased expression of TNFRSF21 mRNAincreases expression 17547211
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TNFRSF21 mRNAaffects binding|increases activity|increases expression 19710929
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of TNFRSF21 mRNAaffects cotreatment|decreases expression 17404688
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of TNFRSF21 mRNAaffects cotreatment|increases expression 19059307
C118258 SN50 peptide SN50 peptide inhibits the reaction [TNF protein results in increased expression of TNFRSF21 mRNA]decreases reaction|increases expression 11753679
C118258 SN50 peptide SN50 peptide inhibits the reaction [TNF protein results in increased expression of TNFRSF21 protein]decreases reaction|increases expression 11753679
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of TNFRSF21 mRNAaffects cotreatment|increases expression 19059307
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TNFRSF21 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TNFRSF21 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TNFRSF21 mRNAdecreases expression 19933214
C088658 zoledronic acid zoledronic acid results in increased expression of TNFRSF21 mRNAincreases expression 19036117
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8411752688 15322242 14514962
MESH:D058186 Acute Kidney Injury Ibuprofen 9.236375363
MESH:D058186 Acute Kidney Injury zoledronic acid 9.2319715164
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.4720200999
MESH:D000230 Adenocarcinoma arsenic trioxide 10.2319825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 10.2311473722
MESH:D000230 Adenocarcinoma Ibuprofen 10.2310697514
MESH:D000230 Adenocarcinoma Indomethacin 10.2316537180
MESH:D000236 Adenoma Indomethacin 7.1211497255
MESH:D000236 Adenoma Methylcholanthrene 7.126695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.8716835633
MESH:D000419 Albuminuria Raloxifene 4.5817308373 17451421
MESH:D016301 Alveolar Bone Loss Indomethacin 5.3717225004
MESH:D000544 Alzheimer Disease Ibuprofen 6.8218351690
MESH:D000544 Alzheimer Disease Indomethacin 6.8217627676 15579461
MESH:D000544 Alzheimer Disease Raloxifene 6.8215800139
MESH:D000707 Anaphylaxis Ibuprofen 5.239532969
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D001014 Aortic Aneurysm Indomethacin 4.8310231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.8610388637
MESH:D018771 Arthralgia Indomethacin 5.172160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8211248219
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4411922910
MESH:D001477 Bartter Syndrome Indomethacin 4.9710684365
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.1816206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.1819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001859 Bone Neoplasms Phenol 11.0110556009
MESH:D001859 Bone Neoplasms zoledronic acid 11.0119442620 15867366 11697798 16778634 16121404 17312309
MESH:D001862 Bone Resorption zoledronic acid 4.6818496637 11869084 8053405 18404659 16769263 15845617
MESH:D001913 Bowen's Disease Phenol 5.7519293009
MESH:D001929 Brain Edema Indomethacin 5.0211481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3417868700
MESH:D001930 Brain Injuries Progesterone 10.9215845082 15665606 15380490
MESH:D001930 Brain Injuries Raloxifene 10.9216580743
MESH:D002545 Brain Ischemia Ibuprofen 10.5515837124
MESH:D002545 Brain Ischemia Indomethacin 10.5512524144
MESH:D001943 Breast Neoplasms Calcitriol 5.8211237771
MESH:D001943 Breast Neoplasms Estradiol 5.8212948864 14630087 16675129 18497071 17289903 17018787 19861407 17261762
MESH:D001943 Breast Neoplasms Indomethacin 5.8217401462
MESH:D001943 Breast Neoplasms Methylcholanthrene 5.8217474063
MESH:D001943 Breast Neoplasms Progesterone 5.8216175315 17614352 15562024
MESH:D001943 Breast Neoplasms Raloxifene 5.8217242785 17049068 16912660 17440819 16837676 15572757 17595753 17261762 15758505 17893378 17952589 15775269
MESH:D001943 Breast Neoplasms Tamoxifen 5.8218425577 21152245 16818667 17261762 19244106 17893378 19059307 19155303 18821012 20859285 16873071 15565566 17242785 19410462 16273361 20544844 19066611 18815881 20005174 20135344 18855134 17440819 18984771 19200415 19103187 17049068 18997820 15668708 20065188 11161223 19289846 21138602 19142967 19189210 16202921 19115204 18351453 19084267 18629630 19288272 19189212 19221464 20390343 19011961 19487384
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.8220435547
MESH:D001943 Breast Neoplasms zoledronic acid 5.8218695136 16096432
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3111589617
MESH:D002056 Burns Indomethacin 4.6910459503
MESH:D002100 Cachexia Ibuprofen 12.6415141370
MESH:D002100 Cachexia Indomethacin 12.6411239499 15141370 16537180 15625704
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4516111702
MESH:D002277 Carcinoma Methylcholanthrene 8.2810545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.2816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4919066611
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.5814691202 16217749 11135700 15553829 15073043
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.5816924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 6.5816391822
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.5816924424
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.7211053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.3414736730 18791128 11352223
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.5319233551
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8719014326
MESH:D002292 Carcinoma, Renal Cell Indomethacin 7.0317341418
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 7.0318507039
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1012490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.9611237771
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 4.9615482327 12636206
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.4417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.4417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3516120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.4315775269
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.1820889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.1818566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 11.1816192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002764 Cholecystitis Indomethacin 5.1711181007
MESH:D002779 Cholestasis pirinixic acid 2.8119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0915668235 8697196 12621046 16354765 15340226
MESH:D003072 Cognition Disorders Raloxifene 4.6015800139
MESH:D003110 Colonic Neoplasms Indomethacin 2.5915637740 15936596 11260862 15786552 15625704 15963497
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6720501625
MESH:D015179 Colorectal Neoplasms Indomethacin 2.6712606626 18059344 17054584 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0414669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1712609071
MESH:D018352 Coronavirus Infections Indomethacin 5.7217302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4620055451 15322242 10048152
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0815213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3519031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1417474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.9219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.9215920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.9219279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.4817187935
MESH:D003967 Diarrhea Indomethacin 3.787907874 7237001
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 13.2018446180 16133044 18450898
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 13.2012774134 18043480 16326151 18446180 16133044 17190690
MESH:D004381 Duodenal Ulcer Indomethacin 4.1211595431 11595415 17202747 10671773 17045617 17151854 11991626 17329845 17351913 16699067 11535926
MESH:D004487 Edema Indomethacin 16.3110653021 16100529 7990266 8985016 8273558 19703484 7907874
MESH:D004487 Edema pirinixic acid 16.3112083418
MESH:D004487 Edema Raloxifene 16.3115860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.3111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9018230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 21.8515138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 21.8517692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 21.8515845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 21.8519031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.3411473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.3416202921 17893378 20544844 19155303
MESH:D004715 Endometriosis Ibuprofen 21.7315652904
MESH:D004715 Endometriosis Indomethacin 21.7315652904
MESH:D004715 Endometriosis Progesterone 21.7316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 21.739294722 10568697
MESH:D019446 Endotoxemia Ibuprofen 10.8311545620
MESH:D019446 Endotoxemia Indomethacin 10.8318509659
MESH:D004751 Enteritis Indomethacin 4.7516328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.9717980183
MESH:D004802 Eosinophilia Indomethacin 4.0411298111
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2920426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.2912903497
MESH:D004938 Esophageal Neoplasms Indomethacin 7.2911005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver arsenic trioxide 18.6515073043
MESH:D005234 Fatty Liver pirinixic acid 18.6520131406 19236843
MESH:D005234 Fatty Liver Raloxifene 18.6517473493
MESH:D005234 Fatty Liver Tamoxifen 18.6519224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2216709447
MESH:D005264 Femoral Fractures zoledronic acid 5.8216234978
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005334 Fever Ibuprofen 9.5016997862
MESH:D005334 Fever Indomethacin 9.5017627676 10431976 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1719069698
MESH:D005354 Fibrosarcoma Indomethacin 12.0710962813
MESH:D005354 Fibrosarcoma Methylcholanthrene 12.0714633661 10962813
MESH:D005355 Fibrosis Indomethacin 8.7817994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7820067830
MESH:D005499 Folliculitis Indomethacin 5.1711298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2416904648
MESH:D005756 Gastritis Indomethacin 4.7515046732
MESH:D005909 Glioblastoma biochanin A 7.8116598420
MESH:D005909 Glioblastoma Indomethacin 7.8112870263
MESH:D005910 Glioma Indomethacin 3.2216487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.2711849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006073 Gout Indomethacin 5.3411248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.7315482327
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3210048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.5211110106
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.5515633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.6615135802
MESH:D006529 Hepatomegaly pirinixic acid 8.2219772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.2215340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.0315709030
MESH:D019584 Hot Flashes Estradiol 3.7517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0516354765 15340226 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Indomethacin 8.3412727271
MESH:D006930 Hyperalgesia zoledronic acid 8.3416769263
MESH:D034321 Hyperamylasemia Indomethacin 5.7217883296
MESH:D006934 Hypercalcemia zoledronic acid 5.0318089816 19622757
MESH:D006940 Hyperemia Indomethacin 5.0012524144
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006949 Hyperlipidemias Indomethacin 4.1417546600
MESH:D006973 Hypertension Raloxifene 5.2017577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2018670907 18850075
MESH:D006984 Hypertrophy Ibuprofen 4.9616672835
MESH:D006996 Hypocalcemia zoledronic acid 6.1912669777
MESH:D007077 Ileal Diseases Indomethacin 5.0218306037 10574470
MESH:D007079 Ileitis Indomethacin 5.3416133968 10647630 10651667
MESH:D007235 Infant, Premature, Diseases Ibuprofen 14.2016133044
MESH:D007235 Infant, Premature, Diseases Indomethacin 14.2016133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3915869954
MESH:D007249 Inflammation Ibuprofen 15.783291741
MESH:D007249 Inflammation Indomethacin 15.783291741 7812673 12568917
MESH:D007249 Inflammation Progesterone 15.7815869954
MESH:D007249 Inflammation Tamoxifen 15.7819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.7812200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.1516627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.1516306350
MESH:D007410 Intestinal Diseases Indomethacin 4.3111686837 11713966 11855677 17329856 10210152 15831440 18236018 15610444 17994277
MESH:D019586 Intracranial Hypertension Indomethacin 5.3715241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007579 Jejunal Diseases Indomethacin 5.0216133968 18306037 10574470
MESH:D055623 Keratosis, Actinic Phenol 6.4419293009
MESH:D007674 Kidney Diseases Estradiol 6.2415618244
MESH:D007674 Kidney Diseases Indomethacin 6.2417190690
MESH:D007680 Kidney Neoplasms Estradiol 7.3315610895
MESH:D007680 Kidney Neoplasms Tamoxifen 7.3318625569
MESH:D007889 Leiomyoma Raloxifene 4.4816973256
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.8811703811 12228301 10320625
MESH:D007938 Leukemia arsenic trioxide 7.0115070760
MESH:D007938 Leukemia SN50 peptide 7.0112970779
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.9117077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 9.9118089816
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.5014633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 8.5010785260 16572323 15631656
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0717050201 19850784 20471514 16467208 16968895
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 4.0718360721
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2015748426 9834237 12018890 19035177 17107899 11161223 16330433 16966277 17869043 17649720 17712046 16112521 12712474 15213294 16331271 16891316 15622746 16823087 17217047 19642359 15336539 12679006 11468182 19075265 19225113
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3416882451
MESH:D007964 Leukocytosis Indomethacin 5.3716537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.7217980183
MESH:D008064 Lipidoses Tamoxifen 3.1415342952 17567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.7211479899
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.7114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 6.7118194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.7115474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.7118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.7112878042
MESH:D008113 Liver Neoplasms arsenic trioxide 10.6114682389
MESH:D008113 Liver Neoplasms pirinixic acid 10.6120007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 10.6116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.6116984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.8220377131
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 9.82598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.8212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 6.5819825857 11798837
MESH:D008175 Lung Neoplasms Indomethacin 6.5811497255 11053908 16537180
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.5817909032 6695378 20970405 16337739 10545420 20512841 16271038 21163286 15390079 9230183 1399818 11893704 7750092
MESH:D008175 Lung Neoplasms Tamoxifen 6.5818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5811884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 18.7211408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 18.7210697514
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 18.7211408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 18.7219196722 11731420 19196723 14580682 16827153
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 18.7217312309
MESH:D020149 Manganese Poisoning Estradiol 12.6519453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.6519453300
MESH:D008545 Melanoma Tamoxifen 1.8819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1715990972
MESH:D008654 Mesothelioma zoledronic acid 3.7416675582
MESH:D008881 Migraine Disorders Indomethacin 3.6611903285
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5515863610
MESH:D009062 Mouth Neoplasms Indomethacin 3.9712636206
MESH:D009101 Multiple Myeloma arsenic trioxide 12.1915949261 19549372 14977855 11468182 19417148
MESH:D009101 Multiple Myeloma Raloxifene 12.1916497877
MESH:D009101 Multiple Myeloma zoledronic acid 12.1916996129 19621390 18089719
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1316105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1916411023
MESH:D009232 Myxoma Raloxifene 5.5516343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9416624393
MESH:D009362 Neoplasm Metastasis Indomethacin 9.6511239499 16537180 11053908
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.6519393235
MESH:D009362 Neoplasm Metastasis zoledronic acid 9.6515867366 17312309 19139120
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5119410462
MESH:D009369 Neoplasms pirinixic acid 1.9417405874
MESH:D009374 Neoplasms, Experimental Indomethacin 4.1210663608 15625704
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0019196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7217289903
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.986375363
MESH:D009410 Nerve Degeneration Ibuprofen 4.3710961664
MESH:D009421 Nervous System Malformations Estradiol 9.4111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.4114600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1010525206
MESH:D019636 Neurodegenerative Diseases Indomethacin 3.9212349958
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.176374098
MESH:D010003 Osteoarthritis Ibuprofen 8.007009135
MESH:D010003 Osteoarthritis Indomethacin 8.007009135
MESH:D010014 Osteolysis zoledronic acid 5.3615867366
MESH:D010024 Osteoporosis Raloxifene 7.5817882678 15775268 19059307
MESH:D010024 Osteoporosis zoledronic acid 7.5817882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2117893378 17823083 15758505 15579764
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.8616624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 7.8619401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.8616525653 17393432
MESH:D010146 Pain Ibuprofen 16.153291741
MESH:D010146 Pain Indomethacin 16.153291741 13679232 17440234 17627676
MESH:D010146 Pain Phenol 16.1517610455
MESH:D010146 Pain zoledronic acid 16.1516475674
MESH:D010149 Pain, Postoperative Ibuprofen 11.4816678543
MESH:D010149 Pain, Postoperative Indomethacin 11.4818702446 12538197
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.6415580305
MESH:D010190 Pancreatic Neoplasms Ibuprofen 5.6412384795
MESH:D010195 Pancreatitis Indomethacin 3.9017883296 15028970
MESH:D010235 Paraganglioma arsenic trioxide 4.1419927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.7216537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.1012349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.7211903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010392 Pemphigus Phenol 6.4417163923 16522979
MESH:D010437 Peptic Ulcer Indomethacin 5.1411148446
MESH:D010518 Periodontitis Indomethacin 4.9117225004
MESH:D010864 Pilonidal Sinus Phenol 6.4415622588 19655223
MESH:D011041 Poisoning Phenol 4.708825745
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D047928 Premature Birth Indomethacin 5.1117000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1811222880 11896295 11118676 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.7715572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8720887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 11753679
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.4719131511
MESH:D011471 Prostatic Neoplasms biochanin A 2.4712111696
MESH:D011471 Prostatic Neoplasms Calcitriol 2.4718247401 12479363 15754350 16289102 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 2.4716740699
MESH:D011471 Prostatic Neoplasms Ibuprofen 2.4717409433
MESH:D011471 Prostatic Neoplasms Raloxifene 2.4716220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4715067354
MESH:D011471 Prostatic Neoplasms zoledronic acid 2.4719103299 12438248
MESH:D011507 Proteinuria Ibuprofen 9.656375363
MESH:D011507 Proteinuria Indomethacin 9.6511849393
MESH:D011693 Purpura Raloxifene 5.5515770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012175 Retinoblastoma SN50 peptide 6.4812466137
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8518045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 10.4816646077
MESH:D012512 Sarcoma, Ewing's zoledronic acid 10.4816121404
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0316192470
MESH:D013088 Spermatocele Phenol 12.1918646496
MESH:D013088 Spermatocele Tamoxifen 12.1916709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.8415862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.8419457130
MESH:D013272 Stomach Diseases Indomethacin 4.4116184426 17160473 16113693 17207306 17638125 10192188 15472012 18209964 18545984 10215738 15038085 10486359 16280098
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.6617007042
MESH:D013274 Stomach Neoplasms Indomethacin 2.6615609394
MESH:D013276 Stomach Ulcer Indomethacin 3.5715138204 11145282 15255614 18181030 12500499 17654042 18543354 10423059 16150113 16934674 17135157 12498302 16755016 12787963 16252198 12467913 10750652 11523592 16397915 17895592 18431645 17657623 12077510 17977527 15104355 11729361 11595415 18299717 17627676 18209962 16169175 18237397 11595431 17918041 10878458 18193104 1323529 11906479 16631530 18087811 14567935 18726076
MESH:D020521 Stroke Raloxifene 3.8016837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.3619014326
MESH:D013964 Thyroid Neoplasms Indomethacin 7.3614736730 18791128 11352223
MESH:D013978 Tibial Fractures Estradiol 13.7119048282
MESH:D013978 Tibial Fractures Raloxifene 13.7119048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9515213294
MESH:D014277 Trigeminal Neuralgia Phenol 6.4410223447 16527771
MESH:D014456 Ulcer Indomethacin 4.8810574470 17380554
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.3412845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.3417572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.3416712894 17572228 8653321
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D020301 Vasospasm, Intracranial Ibuprofen 5.1819057314
MESH:D054556 Venous Thromboembolism Raloxifene 5.2116837676
MESH:D014839 Vomiting Indomethacin 4.7511897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5516343187
MESH:D014860 Warts Phenol 6.1019122958
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37775
    • No data
    Releated disease ID Related disease Name
    PA447212Panic Disorder
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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