AutismKB 2.0

Annotation Detail for SESN1


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Basic Information Top
Gene Symbol:SESN1 ( MGC138241,MGC142129,PA26,RP11-787I22.1,SEST1 )
Gene Full Name: sestrin 1
Band: 6q21
Quick LinksEntrez ID:27244; OMIM: 606103; Uniprot ID:SESN1_HUMAN; ENSEMBL ID: ENSG00000080546; HGNC ID: 21595
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04115p53 signaling pathway
No data
Pathway IDPathway Name
200101Direct p53 effectors
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SESN1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SESN1 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SESN1 mRNAincreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SESN1 mRNAincreases expression 20382639
D004041 Dietary Fats Dietary Fats results in decreased expression of SESN1 mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SESN1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SESN1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SESN1 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil results in increased expression of SESN1 mRNAincreases expression 17982676
D005472 Fluorouracil Fluorouracil results in increased expression of SESN1 proteinincreases expression 14665630
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in increased expression of SESN1 mRNA]affects reaction|increases expression 15016801
D005472 Fluorouracil TP53 protein promotes the reaction [Fluorouracil results in increased expression of SESN1 mRNA]increases expression|increases reaction 17982676
D005576 Forskolin AR protein affects the reaction [Forskolin results in decreased expression of SESN1 protein]affects reaction|decreases expression 16751804
D005576 Forskolin Forskolin results in decreased expression of SESN1 mRNAdecreases expression 16751804
D005576 Forskolin Forskolin results in decreased expression of SESN1 proteindecreases expression 16751804
C106014 gedunin gedunin results in decreased expression of SESN1 mRNAdecreases expression 17010675
D019833 Genistein Genistein results in increased expression of SESN1 mRNAincreases expression 18847459
D007529 Isoflavones Isoflavones results in increased expression of SESN1 mRNAincreases expression 17374662
D015741 Metribolone AR protein affects the reaction [Metribolone results in decreased expression of SESN1 protein]affects reaction|decreases expression 16751804
D015741 Metribolone Metribolone results in decreased expression of SESN1 mRNAdecreases expression 16751804
D015741 Metribolone Metribolone results in decreased expression of SESN1 proteindecreases expression 16751804
C042763 olive oil olive oil analog affects the expression of SESN1 mRNAaffects expression 17349074
D010126 Ozone Ozone results in decreased expression of SESN1 mRNAdecreases expression 12763052
C041786 palm oil palm oil results in decreased expression of SESN1 mRNAdecreases expression 18042831
D010269 Paraquat Paraquat results in increased expression of SESN1 mRNAincreases expression 12595580
C494474 perchlorate perchlorate results in increased expression of SESN1 mRNAincreases expression 18801409
D010634 Phenobarbital Phenobarbital results in increased expression of SESN1 mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SESN1 mRNAaffects binding|decreases expression|increases activity 19710929
C059514 resveratrol resveratrol results in increased expression of SESN1 mRNAincreases expression 15767336
D013629 Tamoxifen Tamoxifen affects the expression of SESN1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SESN1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SESN1 mRNAaffects cotreatment|increases expression 17942748
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of SESN1 mRNAdecreases expression 17951470
C050414 tripterine tripterine results in decreased expression of SESN1 mRNAdecreases expression 17010675
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3814745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.726195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7211752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D058186 Acute Kidney Injury resveratrol 3.7016538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.9618653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.8120127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.8114692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.8117638652
MESH:D000230 Adenocarcinoma Genistein 9.8111473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.486695378
MESH:D000236 Adenoma resveratrol 6.4815688382
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.2917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.2916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.2916835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.5911874814
MESH:D000505 Alopecia Isoflavones 4.5817569567
MESH:D000544 Alzheimer Disease Ozone 4.2515513908
MESH:D000544 Alzheimer Disease resveratrol 4.2516162502 16183991
MESH:D000740 Anemia Fluorouracil 8.1817963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.1811748828
MESH:D000799 Angioedema Acetaminophen 3.6710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9019183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.3415238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.3411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.0115885639
MESH:D001169 Arthritis, Experimental resveratrol 7.0117115116
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5215570426
MESH:D001249 Asthma Ozone 2.5917854713 16373670
MESH:D050197 Atherosclerosis olive oil 6.9616216721
MESH:D050197 Atherosclerosis resveratrol 6.9616873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.2519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D002545 Brain Ischemia resveratrol 4.1117600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6620146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 3.6620435547
MESH:D001943 Breast Neoplasms Fluorouracil 3.6616557594 15136595 16110121 16595493 18357371 19217205 18608205
MESH:D001943 Breast Neoplasms Genistein 3.6616541309 16873071 17200150
MESH:D001943 Breast Neoplasms resveratrol 3.6617534123 17651959 16393696
MESH:D001943 Breast Neoplasms Tamoxifen 3.6619066611 21138602 19059307 19189210 19142967 15668708 19289846 19288272 17049068 17261762 16818667 19115204 16873071 19410462 18997820 19189212 19103187 17893378 18425577 21152245 18629630 19200415 16273361 20390343 20065188 19011961 18855134 19084267 17440819 18351453 16202921 19155303 19487384 20859285 18984771 18815881 20005174 20544844 17242785 11161223 19244106 19221464 18821012 15565566 20135344
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6620435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5418315731 14754758 15516495 18417511 17626835 19059883 16777450
MESH:D002100 Cachexia Ozone 4.5716183385
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5016051944
MESH:D002277 Carcinoma Fluorouracil 7.7317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.7316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3419066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.663084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.6621507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 13.6616799960 17971768 17045692 17088986 18930000 16332177
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.6616924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.6620935162 1701930 6705139 20007298 17173139
MESH:D006528 Carcinoma, Hepatocellular resveratrol 13.6616227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.6616924424
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4216675471
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9418695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.2920419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.2918986760 17066447 16757204 16280240
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.2916227395
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4617572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2716120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 16.4816332659
MESH:D002318 Cardiovascular Diseases Isoflavones 16.4817689850
MESH:D002318 Cardiovascular Diseases olive oil 16.4816216721
MESH:D002318 Cardiovascular Diseases resveratrol 16.4815458977
MESH:D002386 Cataract Acetaminophen 2.4810977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.6120889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.084080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.3215861022 11677210 17333356 16105132 17110522 16919318 17681005
MESH:D002779 Cholestasis pirinixic acid 7.3219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.038697196 12621046 16354765 15668235 15340226
MESH:D003092 Colitis resveratrol 3.9616474422
MESH:D003110 Colonic Neoplasms Fluorouracil 5.7116510598 17016597 18772588 17018589 15001691 17287894 17725105 16340194 17172411 17169374
MESH:D003110 Colonic Neoplasms Genistein 5.7117182828
MESH:D003110 Colonic Neoplasms resveratrol 5.7116338953
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.5418448328 17016601 16524972 17401013 18802399 16331619 17094418 17454858 16391804 18288408 16282729 18383874 20501625 15148649 14970324 17594712 17695437 17255274 15289873 18949393 18509181 16303861
MESH:D015179 Colorectal Neoplasms Isoflavones 3.5417116718
MESH:D015179 Colorectal Neoplasms resveratrol 3.5416550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9117141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.6416507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 15322242 10048152
MESH:D007644 Darier Disease Fluorouracil 4.6216733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1919031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6316873680
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.1916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1917107852
MESH:D003928 Diabetic Nephropathies resveratrol 8.5616286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.5619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.3911739529 10663392 12392966 11461765 15968718 18071297 15619225 12540782 12594235 16109766 16393943 16781746 19420014 12705907 18713872 19085960 19923254 14725611 19164858 11529661 17562736 11421492 16485898 17906064 2444490 17522070 10774834 12153990 11743745 10915739 19370779 16081117 14550746 12958197 14986274 16177239 16227642 11287661 11834606 19739265 19416960
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.3920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3318367378
MESH:D004421 Dystonia Phenobarbital 3.841851702
MESH:D004487 Edema pirinixic acid 10.5312083418
MESH:D004487 Edema resveratrol 10.538985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.5312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7318230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.3912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 14.3917872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.3919031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.4216402032
MESH:D016889 Endometrial Neoplasms Genistein 7.1611473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.1620544844 16202921 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8710568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.6817923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.943659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.703922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.406401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.087750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.853659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.9616530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.9616337965 17638652 16481741 16785472 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8911564622
MESH:D005234 Fatty Liver Dietary Fats 17.4719551842 19004024 18296743 17967931
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.4715345470
MESH:D005234 Fatty Liver pirinixic acid 17.4720131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 17.4719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0119069698
MESH:D005355 Fibrosis Dietary Fats 8.0618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.0620067830
MESH:D005756 Gastritis Acetaminophen 3.5016983495
MESH:D005909 Glioblastoma Genistein 3.1516598420
MESH:D005910 Glioma Fluorouracil 2.8016145905
MESH:D005911 Gliosis Paraquat 4.9911124998
MESH:D006042 Goiter perchlorate 5.1418801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.2718337622 15102660 15162350
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1510048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006529 Hepatomegaly Phenobarbital 13.3916109766
MESH:D006529 Hepatomegaly pirinixic acid 13.3918467677 19772884 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.3915340226 16120746 12621046
MESH:D006561 Herpes Simplex resveratrol 4.0116876885
MESH:D019584 Hot Flashes Isoflavones 4.8114716179 17290160
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8716354765 15340226 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.5716870215
MESH:D006937 Hypercholesterolemia Dietary Fats 8.7021332399
MESH:D006937 Hypercholesterolemia resveratrol 8.7017188708
MESH:D006943 Hyperglycemia pirinixic acid 3.0320558911
MESH:D006949 Hyperlipidemias Dietary Fats 8.7521332399
MESH:D006949 Hyperlipidemias resveratrol 8.7516873680
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8418670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1517488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6416569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.4817600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.3617937319
MESH:D007248 Infertility, Male Paraquat 6.364850670
MESH:D007249 Inflammation Dietary Fats 11.2320412841
MESH:D007249 Inflammation resveratrol 11.2316366677
MESH:D007249 Inflammation Tamoxifen 11.2319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.2312878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.3716624496
MESH:D007333 Insulin Resistance Dietary Fats 6.8811836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 6.8816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.1015629191 12587719
MESH:D007680 Kidney Neoplasms Fluorouracil 7.0416985049
MESH:D007680 Kidney Neoplasms Tamoxifen 7.0418625569
MESH:D007938 Leukemia Genistein 2.9418980019 17468513
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4716087638
MESH:D008064 Lipidoses Tamoxifen 3.0315342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 6.3518296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.3521047994
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.7617823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7615474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.7618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7612878042
MESH:D008107 Liver Diseases Acetaminophen 3.7819784758 12587719 12969438 16611625 19014921 16610002 11587558 19460945
MESH:D008107 Liver Diseases Phenobarbital 3.7819363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0816871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 24.8415890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 24.8421137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 24.8416603448 18383874 17045692 15113037
MESH:D008113 Liver Neoplasms Phenobarbital 24.8419812893 8742319 15975961 21047994 19482888 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 24.8420007298 16377806 15890375
MESH:D008113 Liver Neoplasms resveratrol 24.8419812893 19321006 19073162 20405173
MESH:D008113 Liver Neoplasms Tamoxifen 24.8416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.8416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.208603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.206150874 1399818 17172636 18308698 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.2012151625
MESH:D008171 Lung Diseases Ozone 3.2619066396 8266340
MESH:D055370 Lung Injury Ozone 3.6820417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.2714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.2720064080 18520028 20869020 20135361 18816296 6695378 18569708 17053015 20464547
MESH:D008175 Lung Neoplasms Fluorouracil 8.2715246190
MESH:D008175 Lung Neoplasms Ozone 8.278597069 7614698
MESH:D008175 Lung Neoplasms Tamoxifen 8.2718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2711884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6215086387
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1417088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.7314749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.4315688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.4319428831
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.4214578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 9.4211606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.4211731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.3819453300
MESH:D008545 Melanoma resveratrol 3.3417992120
MESH:D008545 Melanoma Tamoxifen 3.3412393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4019513568
MESH:D008659 Metabolic Diseases resveratrol 4.2217112576
MESH:D008679 Metaplasia Ozone 4.9310496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.0916381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.0916757204 18986760
MESH:D009101 Multiple Myeloma resveratrol 3.3517049120 17164350 17935668 16267019 14749477 16490592
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.7017962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009203 Myocardial Infarction Genistein 9.0817141266
MESH:D009203 Myocardial Infarction pirinixic acid 9.0819151258
MESH:D009203 Myocardial Infarction resveratrol 9.0817125593 16456233 17188708 17015251 16525036 16317513
MESH:D017202 Myocardial Ischemia resveratrol 8.5617125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.5612213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.9517141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9516411023
MESH:D009205 Myocarditis resveratrol 4.5917322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3017484760
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4619410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.7311141357
MESH:D009369 Neoplasms Fluorouracil 7.7318239605 18600527 16928823
MESH:D009369 Neoplasms pirinixic acid 7.7317405874
MESH:D009374 Neoplasms, Experimental resveratrol 3.838985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8319189210 19196722 19200415
MESH:D009410 Nerve Degeneration Paraquat 3.5816893418
MESH:D009421 Nervous System Malformations Genistein 9.0516427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.0514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8918514411
MESH:D019636 Neurodegenerative Diseases resveratrol 7.8917652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.2417929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3216436463
MESH:D009765 Obesity Dietary Fats 4.2911836018 19632207 18674790 21332399 20132043 20518802 18457598 16723640 17217161
MESH:D009765 Obesity pirinixic acid 4.2920558911
MESH:D010018 Osteomalacia Phenobarbital 4.1917016548
MESH:D010024 Osteoporosis Genistein 7.2419401787
MESH:D010024 Osteoporosis Isoflavones 7.2416562857
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.6216169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 9.6217513867
MESH:D010051 Ovarian Neoplasms Genistein 2.5519005980
MESH:D010146 Pain Acetaminophen 2.2516870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.1516929163 15113037 16500647 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.1516965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010300 Parkinson Disease Paraquat 2.7512911755 11181820 11445065 15824117 16510128 11124998 16140633 15451049
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.2616190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D010538 Peritonitis Ozone 3.9616369182
MESH:D011014 Pneumonia Ozone 10.4918929643 18007984 18381685
MESH:D011014 Pneumonia Paraquat 10.4912504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.482563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.0216679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0211399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8918626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 1.8915256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Isoflavones 1.8916365062 17219775 17374662 17571952
MESH:D011471 Prostatic Neoplasms resveratrol 1.8917636462 15767336 17804756 17675339 16731767 17718901
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.1416919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.3212752131
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8517997886 16324872
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8618286688 18722050 16160472 15538739
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.4116325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.2919058328
MESH:D015427 Reperfusion Injury resveratrol 6.2916317513 17520802 16314181 17058453 15827377
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.7511700416
MESH:D012135 Respiratory Sounds Paraquat 3.8911874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012162 Retinal Degeneration Paraquat 3.7416458197
MESH:D012640 Seizures Phenobarbital 2.5811442880 16876388 3137016 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.656407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.9810029692 19755658
MESH:D012878 Skin Neoplasms resveratrol 8.9815837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.9816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9816709447
MESH:D013088 Spermatocele Tamoxifen 10.9816709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8719457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.382093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.3817522103 18396642 17172411 18567086 19084572 19015929 15786421 16951190 16424979 17498489
MESH:D013276 Stomach Ulcer olive oil 4.3616252198 12498302
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3316321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7312697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 2.931399818
MESH:D014062 Tongue Neoplasms Fluorouracil 9.4816280240
MESH:D014062 Tongue Neoplasms resveratrol 9.4816227395
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.7717053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.7716712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 2.8210982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.1116803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.1117473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.9514692618
MESH:D014594 Uterine Neoplasms resveratrol 8.9517044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3815869587 14671159
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.1317488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
MESH:D015430 Weight Gain Dietary Fats 3.5916723640
Pathway ID Pathway Name
KEGG:04115 p53 signaling pathway
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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