AutismKB 2.0

Annotation Detail for PCDH17


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Basic Information Top
Gene Symbol:PCDH17 ( PCDH68,PCH68 )
Gene Full Name: protocadherin 17
Band: 13q21.1
Quick LinksEntrez ID:27253; OMIM: 611760; Uniprot ID:PCD17_HUMAN; ENSEMBL ID: ENSG00000118946; HGNC ID: 14267
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PCDH17 mRNAaffects expression 17562736
D001151 Arsenic Arsenic results in decreased expression of PCDH17 mRNAdecreases expression 19654921
D001241 Aspirin Aspirin results in increased expression of PCDH17 mRNAincreases expression 11906190
D016589 Astemizole Astemizole results in decreased expression of PCDH17 mRNAdecreases expression 20221588
C006253 pirinixic acid pirinixic acid results in increased expression of PCDH17 mRNAincreases expression 18301758
D013467 Sulindac Sulindac results in decreased expression of PCDH17 mRNAdecreases expression 11906190
C004648 testosterone enanthate testosterone enanthate affects the expression of PCDH17 mRNAaffects expression 17440010
D014635 Valproic Acid Valproic Acid results in increased expression of PCDH17 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.8714745880
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.828875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D058186 Acute Kidney Injury Sulindac 4.567897758
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Sulindac 3.1611910360
MESH:D000236 Adenoma Sulindac 3.9110223192
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.8311535846 15623613 11874996 16460482 12394442 19003578 17611924
MESH:D018246 Adrenocortical Adenoma Arsenic 5.5917306315
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D000799 Angioedema Acetaminophen 13.3210982225
MESH:D000799 Angioedema Astemizole 13.322883202
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D020261 Arsenic Poisoning Arsenic 2.9218414634 12569548 16835338 16251483
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.9012372130 20485159
MESH:D050197 Atherosclerosis Arsenic 3.3819371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618985861 17157402 17507914 16609825 19232924 18775368 18396377 18940202 15238991 18177632 20603192 17688650 19460635 18316065 18558336
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.548888407
MESH:D001913 Bowen's Disease Sulindac 5.7311207687
MESH:D001932 Brain Neoplasms Aspirin 4.6415481559
MESH:D001943 Breast Neoplasms Aspirin 2.8415161893
MESH:D001943 Breast Neoplasms Sulindac 2.8416642371
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7117687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.113084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.1117306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7417687452 15504454 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3018640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.6115738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.5216973168 18022660
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D003110 Colonic Neoplasms Aspirin 4.4812411196
MESH:D003110 Colonic Neoplasms Sulindac 4.4812902858 12458338
MESH:D015179 Colorectal Neoplasms Aspirin 3.1717047198
MESH:D015179 Colorectal Neoplasms Sulindac 3.1711076880 11197048 18059344 10666051
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 8888407 16575769
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003930 Diabetic Retinopathy Sulindac 5.4612861449 17621415
MESH:D004244 Dizziness Astemizole 6.843105558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9919739265 18713872 16109766 12392966 17522070 10774834 11529661 12958197 11739529 19923254 11287661 12153990 19416960 19420014 18071297 14550746 10915739 10663392 15968718 14986274 11743745 16485898 11461765 19370779 11421492 17562736 19085960 19164858 16177239 11834606 14725611 16393943 12705907 16227642 16081117 2444490 16781746 15619225 17906064 12540782 12594235
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.991733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004487 Edema Aspirin 7.9117259670
MESH:D004487 Edema pirinixic acid 7.9112083418
MESH:D004715 Endometriosis Sulindac 4.7015652904
MESH:D004802 Eosinophilia Astemizole 5.101355641
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0418234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.806254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D004938 Esophageal Neoplasms Sulindac 3.1812235107
MESH:D005234 Fatty Liver pirinixic acid 8.5419236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 8.5414986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4118558336 8888407
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.8214745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.4719069698
MESH:D005499 Folliculitis Astemizole 6.291671328
MESH:D005534 Foot Diseases Arsenic 5.946392382
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005764 Gastroesophageal Reflux Sulindac 5.2911910360
MESH:D005909 Glioblastoma Aspirin 4.1012870263
MESH:D006261 Headache Aspirin 5.3415240983
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3018467677 19772884 19176532 16221962
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 6.1217440010
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D012001 Hyperacusis Aspirin 6.1415240983
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6817050553
MESH:D006973 Hypertension Arsenic 2.9416076760 9931084 11953799
MESH:D006987 Hypesthesia Arsenic 5.9416093927
MESH:D007249 Inflammation Sulindac 3.413291741
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007414 Intestinal Neoplasms Sulindac 4.8610223192 12584176 12351151 10213222 12663524 12628509
MESH:D007417 Intestinal Polyps Sulindac 5.2511245490 12394442
MESH:D007642 Keratosis Arsenic 5.3316930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7017339181
MESH:D017513 Lichen Nitidus Astemizole 6.842563723
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.3612468960
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 6.9716610002 19784758 12587719 19014921 11587558 19460945 12969438 16611625
MESH:D008107 Liver Diseases Arsenic 6.9711134558
MESH:D008107 Liver Diseases Sulindac 6.9716867024 14986274
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms Arsenic 4.8616368122
MESH:D008113 Liver Neoplasms pirinixic acid 4.8615890375 16377806 20007298
MESH:D008133 Long QT Syndrome Astemizole 4.7811989578 18472280
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008175 Lung Neoplasms Arsenic 3.0117306315 17976673 19168569
MESH:D008175 Lung Neoplasms Sulindac 3.0115713900 19359593
MESH:D008288 Malaria Astemizole 4.9016816845
MESH:D008545 Melanoma Sulindac 2.8516642371
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008881 Migraine Disorders Aspirin 8.4315240983
MESH:D008881 Migraine Disorders Valproic Acid 8.4318765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D009203 Myocardial Infarction Aspirin 6.2212692751
MESH:D009203 Myocardial Infarction pirinixic acid 6.2219151258
MESH:D017202 Myocardial Ischemia Arsenic 4.1815371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009325 Nausea Aspirin 5.5915240983
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009436 Neural Tube Defects Arsenic 7.9516620997
MESH:D009436 Neural Tube Defects Valproic Acid 7.958888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.2118514411
MESH:D019636 Neurodegenerative Diseases Sulindac 9.2117266991 16850258
MESH:D020078 Neurogenic Inflammation Arsenic 4.6417056641
MESH:D009759 Nystagmus, Pathologic Astemizole 6.846135121
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010003 Osteoarthritis Aspirin 4.197009135
MESH:D010051 Ovarian Neoplasms Arsenic 2.8017306315
MESH:D010146 Pain Acetaminophen 12.6516870215
MESH:D010146 Pain Aspirin 12.656995502 6363464
MESH:D010146 Pain Sulindac 12.653291741
MESH:D010190 Pancreatic Neoplasms Sulindac 3.4216820089 11504793
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.8811156591
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.4616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.3315371236 16905509 6392382
MESH:D020795 Photophobia Aspirin 6.1415240983
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1720603192
MESH:D011471 Prostatic Neoplasms Arsenic 3.5716140617
MESH:D011507 Proteinuria Arsenic 4.2621343184
MESH:D019310 Pseudolymphoma Valproic Acid 4.9212752131 11422049
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012220 Rhinitis Aspirin 4.6012372130
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 5.8010822083
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.891511512 16876388 3137016 11738929 14763951 15475178 11044598 17978042
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.5712269725
MESH:D012871 Skin Diseases Arsenic 2.8017548696 15952646 17938729 19834688 6392382 17050553 18709164 16759981 16353154 16702368 17453740
MESH:D012878 Skin Neoplasms Arsenic 3.1017976673 17050553 16251483 17029826 19538983 15504454
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D020521 Stroke Aspirin 4.5716403987
MESH:D013927 Thrombosis Aspirin 4.7317672075
MESH:D016171 Torsades de Pointes Astemizole 5.549583453 8256756
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8915987713 18640142 11144890 17306315 17976673 19429237 19322015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014581 Urticaria Acetaminophen 16.5110982225
MESH:D014581 Urticaria Aspirin 16.5120485159 10982225
MESH:D014581 Urticaria Astemizole 16.512568189 2565098 2859714 3080510 2147912 1976298 2885854 1683191 2568013 2883202 3134034 3097109
MESH:D014594 Uterine Neoplasms Sulindac 4.8818645019
MESH:D014652 Vascular Diseases Arsenic 5.0717056641
MESH:D014717 Vertigo Astemizole 6.843105558
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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