AutismKB 2.0

Annotation Detail for LSM3


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Basic Information Top
Gene Symbol:LSM3 ( SMX4,USS2,YLR438C )
Gene Full Name: LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Band: 3p25.1
Quick LinksEntrez ID:27258; OMIM: 607283; Uniprot ID:LSM3_HUMAN; ENSEMBL ID: ENSG00000170860; HGNC ID: 17874
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03040Spliceosome
hsa03018RNA degradation
Pathway IDPathway Name
Metabolism of RNA
No data
No data
Pathway IDPathway Name
500857mRNA Decay by 5' to 3' Exoribonuclease
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of LSM3 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of LSM3 mRNAdecreases expression 12958071
D000082 Acetaminophen Acetaminophen affects the expression of LSM3 mRNAaffects expression 17562736
C099555 CD 437 CD 437 results in decreased expression of LSM3 mRNAdecreases expression 12958071
D004041 Dietary Fats Dietary Fats results in increased expression of LSM3 mRNAincreases expression 18042831
C044361 M-VAC protocol LSM3 protein results in increased susceptibility to M-VAC protocolincreases response to substance 15814643
C041786 palm oil palm oil results in increased expression of LSM3 mRNAincreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of LSM3 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.2620435547
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.9116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.3218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9118071297 11834606 12594235 16781746 14550746 15968718 10663392 16227642 15619225 16109766 2444490 17522070 17562736 11421492 12153990 12958197 10774834 19739265 19370779 19085960 11529661 12705907 17906064 16177239 19420014 16393943 16485898 16081117 11739529 14986274 10915739 11461765 19923254 19416960 19164858 14725611 18713872 12392966 11743745 12540782 11287661
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D005234 Fatty Liver Dietary Fats 8.5217967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver pirinixic acid 8.5220131406 19236843
MESH:D005355 Fibrosis Dietary Fats 3.8318296743
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3019176532 19772884 16221962 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D007249 Inflammation Dietary Fats 2.5420412841
MESH:D007333 Insulin Resistance Dietary Fats 7.7418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.7416306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1716705839
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9918296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6716611625 19014921 16610002 12969438 12587719 19460945 19784758 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.8916377806 20007298 15890375
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.2018551238
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity Dietary Fats 4.6018674790 20518802 16723640 17217161 18457598 11836018 21332399 20132043 19632207
MESH:D009765 Obesity pirinixic acid 4.6020558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6612819281 16049721
MESH:D010051 Ovarian Neoplasms CD 437 3.3717474084
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6818551238
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.6916049721
MESH:D001749 Urinary Bladder Neoplasms CD 437 5.6916720286
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.7910091137
MESH:D014571 Urologic Neoplasms M-VAC protocol 13.7917933135
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
Pathway ID Pathway Name
REACT:21257 Metabolism of RNA
KEGG:03018 RNA degradation
KEGG:03040 Spliceosome
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134881991
    • No data
    Releated disease ID Related disease Name
    PA446847Arrhythmogenic Right Ventricular Dysplasia
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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