AutismKB 2.0

Annotation Detail for ADAMDEC1


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Basic Information Top
Gene Symbol:ADAMDEC1 ( FLJ79219,M12.219 )
Gene Full Name: ADAM-like, decysin 1
Band: 8p21.2
Quick LinksEntrez ID:27299; OMIM: 606393; Uniprot ID:ADEC1_HUMAN; ENSEMBL ID: ENSG00000134028; HGNC ID: 16299
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ADAMDEC1 mRNAincreases expression 18648102
C006632 arsenic trioxide arsenic trioxide results in increased expression of ADAMDEC1 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ADAMDEC1 mRNAincreases expression 20064835
D004391 Dust Dust results in increased expression of ADAMDEC1 mRNAincreases expression 17805423
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ADAMDEC1 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of ADAMDEC1 mRNAdecreases expression 19482888
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of ADAMDEC1 mRNA]affects reaction|increases expression 16891777
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ADAMDEC1 mRNAincreases expression 16891777
18172886
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.886195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.8815322242 11752688 14514962
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5719825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5720127859 20464547
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.153712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.156695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.6717620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.6716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.0716206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8720146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8720435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.837296757 3581430
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.8316217749 14691202 15553829 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.831701930 17173139 20007298 6705139 20935162
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 16120746 18670907
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.967505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.674080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.389022650 19486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115340226 8697196 12621046 16354765 15668235
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5410048152 20055451 15322242
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.218970840 12868966 18759878 14531868 11298694 8156756 11906362 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.843621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.947440962 9328219 9022650 1440618 8291058 18289764 16192314 6482804 6679447 11289319 18648102 9653073 18692083
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004421 Dystonia Phenobarbital 4.361851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.533659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.393922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.836401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.483659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.613581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.6112903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.6116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver arsenic trioxide 3.6115073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9311294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006529 Hepatomegaly Phenobarbital 9.8716109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.8716120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 18606429 16959395 15340226 16354765
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912878042 12200463
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.548074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.236582329
MESH:D007938 Leukemia arsenic trioxide 2.9615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1816467208 16968895 20471514 19850784 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4116823087 17712046 17869043 15336539 16966277 17217047 15622746 9834237 19225113 12018890 11161223 12712474 17649720 15748426 19642359 16331271 19035177 16330433 15213294 12679006 16891316 17107899 19075265 16112521 11468182
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0521047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.389327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Phenobarbital 2.2319363144
MESH:D008113 Liver Neoplasms arsenic trioxide 11.5314682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.5321137059 20195826
MESH:D008113 Liver Neoplasms Phenobarbital 11.5321047994 19812893 8742319 15975961 19482888 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.5316984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 15.66598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 15.6620377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.661399818 2563599 17172636 6150874 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.6612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5915213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5111798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5118816296 20869020 18569708 20064080 18520028 6695378 20464547 17053015 20135361
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5111884234 19555203
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3214977855 19549372 15949261 11468182 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3016882451 16105982
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.9417484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3011141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.906679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.9010525206
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.726482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010018 Osteomalacia Phenobarbital 4.8317016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4819769630 16624393 12452020
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.6115580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.6116965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.912563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1119131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1117292933
MESH:D019310 Pseudolymphoma Phenobarbital 5.0212752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.3416646077
MESH:D012640 Seizures Phenobarbital 2.893137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.286407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9010029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9016192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4317007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4320155912 2093021
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 13.401399818 6582329 7505956 3712494 6587162
MESH:D013964 Thyroid Neoplasms arsenic trioxide 13.4019014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 13.401399818
MESH:D016171 Torsades de Pointes arsenic trioxide 4.4215213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.908074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.9011780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.9017053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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