AutismKB 2.0

Annotation Detail for HPGDS


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Basic Information Top
Gene Symbol:HPGDS ( GSTS,PGDS )
Gene Full Name: hematopoietic prostaglandin D synthase
Band: 4q22.3
Quick LinksEntrez ID:27306; OMIM: 602598; Uniprot ID:HPGDS_HUMAN; ENSEMBL ID: ENSG00000163106; HGNC ID: 17890
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY66-374prostanoid biosynthesis
Pathway IDPathway Name
hsa00590Arachidonic acid metabolism
hsa01100Metabolic pathways
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of HPGDS mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen results in decreased expression of HPGDS mRNAdecreases expression 19784758
D000082 Acetaminophen Acetaminophen results in increased expression of HPGDS mRNAincreases expression 19784758
C103303 alitretinoin alitretinoin results in increased expression of HPGDS mRNAincreases expression 16648578
D000643 Ammonium Chloride Ammonium Chloride affects the expression of HPGDS mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of HPGDS mRNAdecreases expression 19128835
C095105 bexarotene bexarotene results in increased expression of HPGDS mRNAincreases expression 16648578
C012842 Cibacron Blue F 3GA Cibacron Blue F 3GA results in decreased activity of HPGDS proteindecreases activity 9657971
C007164 cumene hydroperoxide HPGDS protein results in increased metabolism of cumene hydroperoxideincreases metabolic processing 9657971
D015230 Prostaglandin D2 HPGDS protein results in increased chemical synthesis of Prostaglandin D2increases chemical synthesis 9657971
D003907 Dexamethasone Dexamethasone affects the expression of HPGDS mRNAaffects expression 15102944
D005978 Glutathione HPGDS protein results in increased metabolism of Glutathioneincreases metabolic processing 9657971
D007501 Iron Iron deficiency results in increased expression of HPGDS mRNAincreases expression 20368581
C099406 L 742694 L 742694 affects the expression of HPGDS mRNAaffects expression 15102944
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3019825857 11798837
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.803712494
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.7716640825
MESH:D000544 Alzheimer Disease Iron 3.0216563566 16640825
MESH:D000740 Anemia Iron 4.4416566752 16434484
MESH:D018798 Anemia, Iron-Deficiency Iron 4.7217163184 16569441 17375513 17162259 17147795
MESH:D000756 Anemia, Sideroblastic Iron 4.8916910769
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001145 Arrhythmias, Cardiac Iron 4.4416604332
MESH:D001169 Arthritis, Experimental Dexamethasone 3.5917659584
MESH:D001260 Ataxia Telangiectasia Iron 5.5715336622
MESH:D050197 Atherosclerosis Iron 3.7516640825 16632123
MESH:D001321 Autistic Disorder Acetaminophen 2.3618445737
MESH:D001321 Autistic Disorder Glutathione 2.3619267885 16917939 19056591 18929414
MESH:D001321 Autistic Disorder Iron 2.3617352947
MESH:D001424 Bacterial Infections Iron 5.3116640825
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.151440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.7516206674
MESH:D001943 Breast Neoplasms alitretinoin 2.7616344269
MESH:D001943 Breast Neoplasms bexarotene 2.7616344269 16818667
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4211589617
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.603581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.603084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6015073043 14691202 15553829 16217749 11135700
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.2516247446
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0119014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1912490120
MESH:D002294 Carcinoma, Squamous Cell Glutathione 3.3917015178
MESH:D009202 Cardiomyopathies Iron 4.0916640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.4816604332
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.817505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.2119486331 9022650
MESH:D003110 Colonic Neoplasms Dexamethasone 4.2215824018
MESH:D003110 Colonic Neoplasms Iron 4.2216640825
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.8710525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.8717728286
MESH:D003550 Cystic Fibrosis Glutathione 4.5619747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1815213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.3914531868 2524372 12868966 11906362 8156756 11298694 18759878 8970840
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 7.3912438553
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.583621924 2952479
MESH:D003920 Diabetes Mellitus Iron 4.5216640825 16604332
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.3816506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 3.1116506275
MESH:D003967 Diarrhea Dexamethasone 3.797237001
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.789022650 18289764 1440618 18692083 8291058 11289319 6482804 16192314 6679447 9653073 9328219 18648102 7440962
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7817562736 18071297 15619225 16177239 14550746 19416960 10774834 14986274 12594235 10915739 12153990 16781746 2444490 19739265 16393943 17906064 11529661 11461765 19420014 12958197 12540782 11287661 11743745 16227642 12392966 15968718 19923254 19085960 11739529 17522070 16485898 19164858 19370779 14725611 10663392 12705907 18713872 11834606 16109766 16081117 11421492
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004485 Eczema Dexamethasone 4.5512438553
MESH:D004487 Edema Dexamethasone 3.4819703484
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.543581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5412903497
MESH:D005234 Fatty Liver arsenic trioxide 8.4815073043
MESH:D005234 Fatty Liver Iron 8.4816640825
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005621 Friedreich Ataxia Iron 5.5316640825 16604332
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3616904648
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006432 Hemochromatosis Iron 4.5516574947 16604332 16640825 17236123 17053826 17255318
MESH:D006486 Hemosiderosis Iron 5.3516604332
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006525 Hepatitis, Viral, Human Iron 5.6016640825
MESH:D006527 Hepatolenticular Degeneration Iron 5.0417182432
MESH:D006529 Hepatomegaly Iron 4.4216890145
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.097520565
MESH:D015658 HIV Infections Iron 3.7116597321
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006973 Hypertension Dexamethasone 2.9617042910
MESH:D007006 Hypogonadism Iron 4.4616640825
MESH:D007037 Hypothyroidism Iron 5.1916640825
MESH:D007249 Inflammation Dexamethasone 2.9211099482 8960868
MESH:D019189 Iron Metabolism Disorders Iron 5.1217163184
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.159022650 8074119
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.7516144296
MESH:D007674 Kidney Diseases Acetaminophen 2.2412587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.036582329
MESH:D007938 Leukemia arsenic trioxide 2.8715070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1516467208 16968895 17050201 20471514 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2615622746 12679006 9834237 15748426 17649720 16331271 19035177 16966277 16112521 17217047 12712474 19225113 19642359 16330433 11468182 11161223 17107899 15336539 16891316 12018890 15213294 17869043 19075265 16823087 17712046
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4516882451
MESH:D020961 Lewy Body Disease Iron 5.5316563566
MESH:D008103 Liver Cirrhosis Iron 3.7716640825
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.249327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 2.2716718785
MESH:D008107 Liver Diseases marker/mechanism 19784758
MESH:D008107 Liver Diseases Acetaminophen 1.6519014921 16611625 19460945 11587558 19784758 12587719 12969438 16610002
MESH:D008108 Liver Diseases, Alcoholic Iron 5.1116737972 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3117185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 5.0614682389
MESH:D008113 Liver Neoplasms Iron 5.0616640825 20302851
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.121399818 598648 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.1220377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4115213294
MESH:D008175 Lung Neoplasms alitretinoin 6.7416413115
MESH:D008175 Lung Neoplasms arsenic trioxide 6.7419825857 11798837
MESH:D008175 Lung Neoplasms bexarotene 6.7417849452
MESH:D008175 Lung Neoplasms Dexamethasone 6.7415824018 11195469
MESH:D008175 Lung Neoplasms Iron 6.7416640825
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.2511161223
MESH:D008268 Macular Degeneration Iron 4.0216640825
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 3.4615591091 19196723 19196722
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D009101 Multiple Myeloma arsenic trioxide 7.6319417148 11468182 15949261 19549372 14977855
MESH:D009101 Multiple Myeloma Dexamethasone 7.6316118317 15867202 15744524
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.8117086897
MESH:D009181 Mycoses Iron 5.6016640825
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.7116882451 16105982
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.719809623
MESH:D017202 Myocardial Ischemia Iron 4.5116604332
MESH:D015428 Myocardial Reperfusion Injury Iron 4.3316604332
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0516624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.503581430
MESH:D009369 Neoplasms alitretinoin 3.2916946489
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.9219196722
MESH:D009404 Nephrotic Syndrome Iron 4.5917178036
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.426679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.4210525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7418514411
MESH:D019636 Neurodegenerative Diseases Iron 8.7416604332 17296847
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.504026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010003 Osteoarthritis Iron 4.0116640825
MESH:D010024 Osteoporosis Iron 3.9016640825 16648989
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4316624393 19769630 12452020
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5515580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 16.467296757
MESH:D010212 Papilloma cumene hydroperoxide 16.4612065085 17234724
MESH:D010212 Papilloma Iron 16.4612065085
MESH:D010235 Paraganglioma arsenic trioxide 4.2519927285
MESH:D020447 Parasomnias Iron 6.1517352947
MESH:D010300 Parkinson Disease Iron 3.3516563566 16640825
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D010900 Pituitary Diseases Iron 5.8116604332
MESH:D011041 Poisoning Iron 4.3816604332
MESH:D017499 Porokeratosis alitretinoin 6.1416144296
MESH:D017119 Porphyria Cutanea Tarda Iron 5.0816640825
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.5921297632
MESH:D011225 Pre-Eclampsia Iron 4.4816640825
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2619131511
MESH:D011528 Protozoan Infections Iron 6.1516640825
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.1011700416 18379247
MESH:D012148 Restless Legs Syndrome Iron 4.6116930377
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0516646077
MESH:D012878 Skin Neoplasms cumene hydroperoxide 6.838532709 12065085 17234724
MESH:D012878 Skin Neoplasms Iron 6.8312065085
MESH:D013272 Stomach Diseases Dexamethasone 4.4415472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013276 Stomach Ulcer Dexamethasone 3.5715138204
MESH:D013398 Sudden Infant Death Iron 5.5716640825
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.366582329 6587162 3712494 1399818 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.3619014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0815213294
MESH:D014376 Tuberculosis Iron 4.1316597321
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.188074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.1812973940 20435036 11780464 12845720
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014605 Uveitis Dexamethasone 4.951336536
Pathway ID Pathway Name
KEGG:00590 Arachidonic acid metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA164747514
    • No data
    No data
    Releated drug ID Related drug Name
    PA449345dinoprostone
    PA449479epoprostenol
    PA164712740Epoxides
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00143 - BSS Plus Dietary supplement;Micronutrient
    DB01897 - 2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride
    DB04077 - Glycerol Solvents;Cryoprotective Agents
    DB07613 - 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole
    DB07614 - PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE
    DB07615 - 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid
    DB07616 - 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid
    DB07917 - 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE
    DB08313 - nocodazole
    DB08695 - 3-(4-nitrophenyl)-1H-pyrazole
    DB08790 - 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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