AutismKB 2.0

Annotation Detail for GLDC


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Basic Information Top
Gene Symbol:GLDC ( GCE,GCSP,HYGN1,MGC138198,MGC138200 )
Gene Full Name: glycine dehydrogenase (decarboxylating)
Band: 9p24.1
Quick LinksEntrez ID:2731; OMIM: 238300; Uniprot ID:GCSP_HUMAN; ENSEMBL ID: ENSG00000178445; HGNC ID: 4313
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
GLYCLEAV-PWYglycine cleavage complex
Pathway IDPathway Name
hsa01100Metabolic pathways
hsa00260Glycine, serine and threonine metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of amino acid metabolism
H00191Nonketotic hyperglycinemia
Genetic disorders
Desease IDDesease Name
2001Mental retardation
2040Hyperglycemia
2126Encephalopathies
No data
No data
Desease Name
Glycine encephalopathy
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of GLDC mRNAaffects expression 18343893
D000082 Acetaminophen Acetaminophen affects the expression of GLDC mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GLDC proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GLDC mRNAdecreases expression 20106945
C030123 coumarin coumarin results in decreased expression of GLDC mRNAdecreases expression 18480146
D016572 Cyclosporine Cyclosporine results in decreased expression of GLDC mRNAdecreases expression 20106945
C014347 decitabine decitabine results in increased expression of GLDC mRNAincreases expression 19151715
D004958 Estradiol Estradiol results in decreased expression of GLDC mRNAdecreases expression 20106945
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GLDC mRNAaffects binding|decreases expression|increases activity 19710929
D011794 Quercetin Quercetin results in increased expression of GLDC mRNAincreases expression 16455785
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GLDC mRNAdecreases expression 20106945
18061397
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of GLDC mRNAaffects expression 18343893
C024746 tobacco tar tobacco tar results in increased expression of GLDC mRNAincreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0011752688 15322242 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.3711473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.3517084956
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001260 Ataxia Telangiectasia Quercetin 5.1315336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Quercetin 4.5519761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3620146248 17474063
MESH:D001943 Breast Neoplasms decitabine 2.3619208741 18320071
MESH:D001943 Breast Neoplasms Estradiol 2.3617289903 19861407 12948864 18497071 14630087 17018787 17261762 16675129
MESH:D001943 Breast Neoplasms Quercetin 2.3618628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3620435547
MESH:D002105 Cadmium Poisoning Quercetin 5.7216962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.713084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7121507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7116924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.7119519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0917234771
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7720419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.7719215824
MESH:D006332 Cardiomegaly Quercetin 6.9919794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9918670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.7412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.7418566989
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 11.7419559774
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 8.0319486331
MESH:D002779 Cholestasis pirinixic acid 8.0319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1412621046 15340226 15668235 8697196 16354765
MESH:D003110 Colonic Neoplasms decitabine 4.0017616700
MESH:D003110 Colonic Neoplasms Quercetin 4.0011134977 16640504 19056647 15741050 19440933 17148506 17191121
MESH:D015179 Colorectal Neoplasms decitabine 2.7318981723
MESH:D015179 Colorectal Neoplasms Quercetin 2.7318095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.8219496084
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 4.6719647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6717107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.6519370779 18713872 2444490 10915739 14550746 18071297 10663392 12705907 19923254 17906064 12153990 11834606 10774834 16177239 19420014 19739265 12540782 11287661 11743745 16081117 11529661 14986274 11739529 16109766 19164858 11461765 16393943 19416960 16485898 14725611 12594235 16781746 12392966 17522070 17562736 15968718 15619225 19085960 12958197 11421492 16227642
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.6520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0816714409 15322242 18230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2919294695
MESH:D016889 Endometrial Neoplasms Estradiol 3.0518566989 19148513 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 7.9319224547
MESH:D005234 Fatty Liver pirinixic acid 7.9319236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 15.6112639820 12168785
MESH:D005355 Fibrosis Quercetin 15.6119474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.6120067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D005909 Glioblastoma Quercetin 3.4619804834
MESH:D005910 Glioma Quercetin 3.0917643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.5619215824
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 11.5711294989
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.5720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.5710048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.7316221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7315340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 9.5920558911
MESH:D006943 Hyperglycemia Quercetin 9.5911834736 18262572
MESH:D020158 Hyperglycinemia, Nonketotic marker/mechanism
MESH:D006973 Hypertension Cyclosporine 8.8010903974
MESH:D006973 Hypertension Quercetin 8.8018356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.8018850075 18670907
MESH:D007248 Infertility, Male decitabine 3.2717581917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.6816624496
MESH:D007333 Insulin Resistance Estradiol 7.4316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.4316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007627 Keloid Quercetin 5.0917086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 14.9312587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 14.9318776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 14.9315618244
MESH:D007674 Kidney Diseases Quercetin 14.9316962696
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5812371664
MESH:D007680 Kidney Neoplasms Estradiol 7.5815610895
MESH:D007938 Leukemia decitabine 6.7419235587 18980019
MESH:D007938 Leukemia Quercetin 6.7417468513
MESH:D007951 Leukemia, Myeloid decitabine 4.1118454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3918206229 17679729 19387464 18460780 18704418 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6418055864
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0315474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 5.0312741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0312878042
MESH:D008107 Liver Diseases Acetaminophen 1.6519460945 12587719 12969438 11587558 19014921 16611625 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.6515890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.6520195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 14.6520007298 16377806 15890375
MESH:D008113 Liver Neoplasms Quercetin 14.6518980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.6516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.268603461
MESH:D008114 Liver Neoplasms, Experimental Quercetin 10.2619519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2612151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9418816296 20064080 20464547 18520028 20135361 17053015 6695378 20869020 18569708
MESH:D008175 Lung Neoplasms Quercetin 4.9416280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9411884234 19555203
MESH:D008223 Lymphoma decitabine 3.4919470736
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6211807958 16891317 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008545 Melanoma decitabine 2.2616505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009101 Multiple Myeloma decitabine 3.4218172295
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4419010910 18608210 19157545 16882708
MESH:D009203 Myocardial Infarction pirinixic acid 5.8619151258
MESH:D009203 Myocardial Infarction Quercetin 5.8619595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 14.6916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 14.6916411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 14.6919207477
MESH:D009369 Neoplasms Benzo(a)pyrene 12.3111141357
MESH:D009369 Neoplasms decitabine 12.3119470736 19116145 17925555
MESH:D009369 Neoplasms pirinixic acid 12.3117405874
MESH:D009369 Neoplasms Quercetin 12.3115185748
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.8916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.4817929310
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.3419495926
MESH:D010051 Ovarian Neoplasms decitabine 8.1419331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 8.1419401270
MESH:D010051 Ovarian Neoplasms Quercetin 8.1419005980
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.6419294695
MESH:D010190 Pancreatic Neoplasms Quercetin 5.6416965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.4312371664
MESH:D011230 Precancerous Conditions Quercetin 9.4319056647
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411222880 11896295 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.8717616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5417292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.5416740699
MESH:D011471 Prostatic Neoplasms Quercetin 2.5417292933 14715546
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.5219155313
MESH:D012554 Schistosomiasis japonica Quercetin 5.7216862918
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.482093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 2.4819037991
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013964 Thyroid Neoplasms decitabine 3.4117967635
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.6217053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.6217616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.6216720314
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014604 Uveal Neoplasms decitabine 5.0917785578
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D014689 Venous Insufficiency coumarin 5.9512708602
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:00260 Glycine, serine and threonine metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28716
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00114 - Pyridoxal Phosphate Dietary supplement;Micronutrient;Vitamin B Complex
    DB00145 - Glycine Dietary supplement;Micronutrient;Non-Essential Amino Acids;Glycine Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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