AutismKB 2.0

Annotation Detail for RAB30


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Basic Information Top
Gene Symbol:RAB30 ( - )
Gene Full Name: RAB30, member RAS oncogene family
Band: 11q14.1
Quick LinksEntrez ID:27314; OMIM: 605693; Uniprot ID:RAB30_HUMAN; ENSEMBL ID: ENSG00000137502; HGNC ID: 9770
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of RAB30 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the expression of RAB30 mRNAaffects expression 20127859
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of RAB30 mRNAaffects expression 20382639
C006780 bisphenol A bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of RAB30 mRNA]decreases reaction|increases expression 19228888
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of RAB30 mRNAaffects expression 17484886
D004041 Dietary Fats Dietary Fats results in decreased expression of RAB30 mRNAdecreases expression 18042831
D004041 Dietary Fats Dietary Fats results in increased expression of RAB30 mRNAincreases expression 18457598
D004958 Estradiol Estradiol inhibits the reaction [hydroxytamoxifen results in increased expression of RAB30 mRNA]decreases reaction|increases expression 16849584
C070081 fulvestrant fulvestrant inhibits the reaction [hydroxytamoxifen results in increased expression of RAB30 mRNA]decreases reaction|increases expression 16849584
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of RAB30 mRNAaffects cotreatment|increases expression 17183730
C475919 hydroxytamoxifen ESR2 protein inhibits the reaction [hydroxytamoxifen results in increased expression of RAB30 mRNA]decreases reaction|increases expression 16849584
C475919 hydroxytamoxifen Estradiol inhibits the reaction [hydroxytamoxifen results in increased expression of RAB30 mRNA]decreases reaction|increases expression 16849584
C475919 hydroxytamoxifen fulvestrant inhibits the reaction [hydroxytamoxifen results in increased expression of RAB30 mRNA]decreases reaction|increases expression 16849584
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of RAB30 mRNAincreases expression 16849584
C041786 palm oil palm oil results in decreased expression of RAB30 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RAB30 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of RAB30 mRNAincreases expression 18445702
18301758
D014284 Triiodothyronine bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of RAB30 mRNA]decreases reaction|increases expression 19228888
D014284 Triiodothyronine Triiodothyronine results in increased expression of RAB30 mRNAincreases expression 19228888
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of RAB30 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.578875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9819490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3220127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.3211473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.686695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5616434500
MESH:D000550 Amblyopia Valproic Acid 5.3317688650
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6217497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.9615238619
MESH:D001284 Atrophy fulvestrant 4.9111514358
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8517507914 18396377 20603192 18558336 18316065 17688650 18985861 16609825 18940202 19232924 17157402 19460635 18775368 18177632 15238991
MESH:D001714 Bipolar Disorder Valproic Acid 3.1020046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2019483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.438888407
MESH:D001862 Bone Resorption bisphenol A 3.9211985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3617474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 2.3617123778
MESH:D001943 Breast Neoplasms Dietary Fats 2.3620435547
MESH:D001943 Breast Neoplasms Estradiol 2.3617261762 18497071 12948864 17018787 16675129 17289903 14630087 19861407
MESH:D001943 Breast Neoplasms fulvestrant 2.3618984771
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.853786805 15721981 16227642 18705752 15673190 15700767 16011737 10355542 16192424 16097048 16050911 16124888
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.563084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.5618788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5616924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.0717123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0620419170
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7720889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7718566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D002779 Cholestasis pirinixic acid 2.8619176532
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.898888407 17688650 16575769
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3011529661 10915739 19416960 2444490 17562736 12958197 11743745 19923254 10774834 12705907 16781746 17906064 12153990 16081117 11739529 12594235 16393943 19739265 18713872 11287661 14550746 16227642 12540782 14986274 14725611 19164858 16485898 17522070 11461765 15619225 10663392 11421492 19370779 12392966 16109766 18071297 19420014 11834606 15968718 19085960 16177239
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.3017522070 2869522 4309450 9327722 7120509 19085960 3786805 7179309 6623471 10915739 11566570 16177239 15998439 7440962 3732212 10092053 15968718 15027814 19336974 21278145 6884620 16227642
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.3019641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D050171 Dyslipidemias Dietary Fats 3.4918367378
MESH:D004421 Dystonia Valproic Acid 4.111851702
MESH:D004487 Edema pirinixic acid 2.5312083418
MESH:D016889 Endometrial Neoplasms Estradiol 3.0118566989 19148513 11473722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.233659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0116628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.636426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.377750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.153659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3916530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.2561145 16239168 12795759 16045604 12631006 17595544 19224547 15959796
MESH:D005234 Fatty Liver Dietary Fats 19.2519004024 18296743 19551842 17967931
MESH:D005234 Fatty Liver pirinixic acid 19.2520131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 19.2519224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 4.9816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.198888407 18558336
MESH:D005355 Fibrosis Carbon Tetrachloride 9.0518705752
MESH:D005355 Fibrosis Dietary Fats 9.0518296743
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6820471113
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6619110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.0719772884 16221962 19176532 18467677
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019584 Hot Flashes Estradiol 3.8517088409
MESH:D006849 Hydrocephalus Valproic Acid 4.9517688650
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6521332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6721332399
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7016612254
MESH:D007248 Infertility, Male fulvestrant 3.7811514358
MESH:D007249 Inflammation Dietary Fats 2.4620412841
MESH:D007333 Insulin Resistance bisphenol A 17.9316393666
MESH:D007333 Insulin Resistance Dietary Fats 17.9318457598 11836018
MESH:D007333 Insulin Resistance Estradiol 17.9316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 17.9316306350
MESH:D007674 Kidney Diseases Acetaminophen 5.9815629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.9815618244
MESH:D007680 Kidney Neoplasms Estradiol 3.0215610895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1617596541 16294345
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.7216221502 11408273 17157831 11903743 17174718 16943688 16239168 21278145 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 6.7218296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4815052691 15876570 16011737 15818738 17869086 17525996 16027843 15925388 18166357 12632514 17631135 18251166 12632512 14512876 16192424 12898905 18472094 17761835 18279442 15338365 17565644 17640975 16097048 12445418 18705752 18412020 17900296 17714472 15057751 18210741 16116963 14620537 18263696 13678700 12741479 18395914 16136751 16015684 18339082 18418968 17944888 12958196 18317297 14716496 14748882 17805973 12666154 17823541 18472332 15673190 18420326 17698563 18277467 17557913 17922224 12667390 12609069 16248980 18187930 15730626 17766677 18006644 16033810 12445421 15123356 15370692 12586293 18376398 17481882 12546737 20821823 17708605 14716833 18054572 11481614 12389079 15362042 18156304 16638106 18481824 18205269 18429990 17976157 12649538 15996030 18395095 15931870 17721639 14724832 15893842 10355542 15650968 15959796
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4815474484
MESH:D008107 Liver Diseases Acetaminophen 3.9416610002 19784758 12587719 12969438 19014921 16611625 19460945 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9417285989 15830285 16964402 15720792 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5817185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5816899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.4920195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.4919294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.4915890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.6415583823 12014681
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3617228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5618520028 20135361 17053015 18816296 20464547 20869020 18569708 6695378 20064080
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5911408345 17203775 11807958 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008881 Migraine Disorders Valproic Acid 3.2318765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.088888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3916411023
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9011141357
MESH:D009369 Neoplasms pirinixic acid 4.9017405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009421 Nervous System Malformations bisphenol A 9.9616427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 9.9616427766 11399458
MESH:D009436 Neural Tube Defects Valproic Acid 3.168888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009765 Obesity Dietary Fats 4.4716723640 20518802 18457598 11836018 21332399 18674790 17217161 20132043 19632207
MESH:D009765 Obesity pirinixic acid 4.4720558911
MESH:D010049 Ovarian Diseases bisphenol A 5.0711985600
MESH:D010051 Ovarian Neoplasms Estradiol 2.2319401270
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.0210548101
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 10.0220603192
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.7420887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.7420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5317292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5316740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.5316740699
MESH:D019310 Pseudolymphoma Valproic Acid 4.6412752131 11422049
MESH:D011629 Puberty, Precocious bisphenol A 4.8710548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2319155313
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures Valproic Acid 2.771511512 16876388 17978042 11738929 3137016 11044598 15475178 14763951
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3919755658 10029692
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8219490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6412833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019966 Substance-Related Disorders bisphenol A 4.0716684133 16045194
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.3317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.603119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2017053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.718888407
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014591 Uterine Diseases bisphenol A 5.1114652134
MESH:D015430 Weight Gain Dietary Fats 3.7916723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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