AutismKB 2.0

Annotation Detail for TNRC6A


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Basic Information Top
Gene Symbol:TNRC6A ( CAGH26,DKFZp666E117,FLJ22043,GW1,GW182,KIAA1460,MGC75384,TNRC6 )
Gene Full Name: trinucleotide repeat containing 6A
Band: 16p12.1
Quick LinksEntrez ID:27327; OMIM: 610739; Uniprot ID:TNR6A_HUMAN; ENSEMBL ID: ENSG00000090905; HGNC ID: 11969
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of TNRC6A mRNAdecreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of TNRC6A mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of TNRC6A mRNAincreases expression 19774075
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNRC6A mRNAdecreases expression 19150397
D008345 Manganese Manganese results in increased expression of TNRC6A mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of TNRC6A mRNAincreases expression 17175027
D010100 Oxygen Oxygen deficiency results in increased expression of TNRC6A mRNAincreases expression 17175027
C006253 pirinixic acid pirinixic acid results in decreased expression of TNRC6A mRNAdecreases expression 18445702
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TNRC6A mRNAincreases expression 19465110
C025643 vinclozolin vinclozolin affects the expression of TNRC6A mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0814514962 15322242 11752688
MESH:D055371 Acute Lung Injury Oxygen 9.8516759491
MESH:D055371 Acute Lung Injury pirinixic acid 9.8518653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000756 Anemia, Sideroblastic Manganese 11.6116910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 11.6116910769
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D000860 Anoxia Oxygen 5.2920872349
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9618218290 18057881 20041841
MESH:D050197 Atherosclerosis Oxygen 3.9016391483
MESH:D001281 Atrial Fibrillation Amiodarone 4.0319698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 16.3419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.3419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.3412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Oxygen 2.3217263869
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.8916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.893084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9415710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.3218974383
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.036135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0320889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.168697196 15340226 16354765 15668235 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.3421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3416393943 17522070 12392966 17906064 19164858 16177239 12594235 16781746 15619225 14725611 15968718 16109766 10774834 10915739 16485898 10663392 19370779 18713872 17562736 19739265 2444490 16227642 19923254 11529661 19420014 19085960 11834606 11743745 11287661 12540782 16081117 14986274 19416960 11461765 18071297 12153990 12705907 14550746 12958197 11421492 11739529
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.3415265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004417 Dyspnea Oxygen 5.1020016425
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Amiodarone 8.3814986274
MESH:D005234 Fatty Liver pirinixic acid 8.3819236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005739 Gas Poisoning Oxygen 5.4820016425
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D005909 Glioblastoma Manganese 4.0217043766
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Amiodarone 15.7215265979
MESH:D006529 Hepatomegaly pirinixic acid 15.7218467677 19772884 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.7212621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116354765 15340226 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.048137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007037 Hypothyroidism Amiodarone 4.7318020914 17991464
MESH:D007248 Infertility, Male vinclozolin 3.1516467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1216705839
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008064 Lipidoses Amiodarone 3.6317567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1812878042
MESH:D008107 Liver Diseases Acetaminophen 1.6612587719 16611625 11587558 19784758 12969438 19014921 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.667678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.6615890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.076135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0712151625
MESH:D008133 Long QT Syndrome Amiodarone 3.7117391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.4812587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.7418516814
MESH:D055370 Lung Injury Oxygen 4.7218339021
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D020149 Manganese Poisoning Manganese 5.7916568477 16551646 19453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009069 Movement Disorders Manganese 5.1916551646
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009181 Mycoses Amiodarone 5.1712754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.107678174 18551238
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009410 Nerve Degeneration Manganese 4.4016551646
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5916049721
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010300 Parkinson Disease Manganese 3.4211181820
MESH:D020734 Parkinsonian Disorders Manganese 4.6316140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2911896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.2918042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9112832656 12490602 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.6917627322 18339021
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6418551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.3218724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013276 Stomach Ulcer Amiodarone 3.4818087811
MESH:D013398 Sudden Infant Death Oxygen 5.7812563064
MESH:D013610 Tachycardia Amiodarone 4.4911238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3919225199
MESH:D013959 Thyroid Diseases Amiodarone 12.9519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.9512697716
MESH:D013971 Thyrotoxicosis Amiodarone 5.0818020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.4311989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3416049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5610091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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