AutismKB 2.0

Annotation Detail for EIF3K


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Basic Information Top
Gene Symbol:EIF3K ( EIF3-p28,EIF3S12,HSPC029,M9,MSTP001,PLAC-24,PLAC24,PRO1474,PTD001 )
Gene Full Name: eukaryotic translation initiation factor 3, subunit K
Band: 19q13.2
Quick LinksEntrez ID:27335; OMIM: 609596; Uniprot ID:EIF3K_HUMAN; ENSEMBL ID: ENSG00000178982; HGNC ID: 24656
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Metabolism of proteins
Gene Expression
3' -UTR-mediated translational regulation
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of EIF3K mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of EIF3K mRNAaffects cotreatment|affects expression 17602206
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of EIF3K mRNAaffects expression 17555576
D007657 Ketone Bodies Ketone Bodies results in increased expression of EIF3K mRNAincreases expression 16807920
D015741 Metribolone Metribolone affects the splicing of EIF3K mRNAaffects splicing 17010196
D013629 Tamoxifen Tamoxifen affects the expression of EIF3K mRNAaffects expression 17555576
D014810 Vitamin E Vitamin E results in increased expression of EIF3K mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma Diethylnitrosamine 2.996695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3019052882 17620307 17162532 19061943 16434500 18056438
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1317474063
MESH:D001943 Breast Neoplasms Tamoxifen 2.1320005174 18821012 19288272 18815881 20859285 18855134 18425577 19189210 17242785 19244106 19059307 19084267 19289846 18629630 17440819 19155303 16873071 20135344 19200415 15668708 21152245 19189212 19103187 19066611 16273361 19221464 18984771 18997820 17261762 16202921 19410462 16818667 17049068 11161223 20390343 18351453 21138602 15565566 19487384 19011961 19115204 17893378 20544844 20065188 19142967
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2916050911
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1216779866 19383236 10737359 20101231 19335982 16502159 18665156 16681979 16807293 18691550 21159647 18056438 20007298 16328049 19418558 19107877 17173139 20514400 19519916 17162532 18971187 18788625 11831363 16878318 20935162 20432363 19171122 18494052 18785209 20214788 17138121 3084413 16830150 16935385 19394651 18506893 3581430 18210153 20512989 19052882 16288022 16569478 17978847 17055752 19822196 20727157 18978308 19919837 17428255 18393292 20524982 19208518 20084675 19701751 16540662 17761372 16698587 10672840 19539802
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1216924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.0417174075 2727394 21159647 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9319052882
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0716105132 15861022 17681005 17110522 16919318 17333356 11677210
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2420387270
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.1219107877
MESH:C538011 Eales disease Vitamin E 5.159068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2119155303 20544844 16202921 17893378
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D005234 Fatty Liver Diethylnitrosamine 14.8021071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.8015345470
MESH:D005234 Fatty Liver Tamoxifen 14.8019224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1216080930
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7816490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.4114716179
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Diethylnitrosamine 5.5118785209
MESH:D007249 Inflammation Tamoxifen 5.5119457130
MESH:D007251 Influenza, Human Vitamin E 4.6616624496
MESH:D007674 Kidney Diseases Vitamin E 2.9512488133
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2718625569
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9618407596 18665156 19638242 18522880 20032147
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5918564211
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5916169303
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1517034775
MESH:D008113 Liver Neoplasms Clofibric Acid 8.0517602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.0519812893 12112319 19294768 9163691 19426721 12771043 18644402 19427195 18977376 19690152 19499222 20434301 21278145 20405173 18754104 2862719 18648771 19073162 19638242 21047994 20101389 19850985 20452335 19255062 19254457 2422723 15175105 20583210 20501860 19642983 15885732 16942905 20118626 19551842 18978307 10737359 20492335 19833225 21167192 19090486 19256749 21071580 19996281 20137499
MESH:D008113 Liver Neoplasms Tamoxifen 8.0516684651
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7917174075 2563599 19009564 18253720 16267830 17942915 21159647 9362446 19004024 18308698 19539802 17854601 18544905 19519916 18775883 16842330 18079962 3124819 18282651 18164116 18093689 19126423
MESH:D008171 Lung Diseases Vitamin E 3.3516863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.6020512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 3.6018625569
MESH:D008175 Lung Neoplasms Vitamin E 3.6011062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7914580682 19196723 11731420 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 6.043581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.0419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419189210 19196722 19200415
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5016540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.802563599
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1915067354
MESH:D011471 Prostatic Neoplasms Vitamin E 3.1915084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Vitamin E 3.7416517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.197505956
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4416712894 17572228 8653321
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
Pathway ID Pathway Name
REACT:1762 3' -UTR-mediated translational regulation
REACT:71 Gene Expression
REACT:17015 Metabolism of proteins
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162384923
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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