AutismKB 2.0

Annotation Detail for KCNMB4


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Basic Information Top
Gene Symbol:KCNMB4 ( - )
Gene Full Name: potassium large conductance calcium-activated channel, subfamily M, beta member 4
Band: 12q15
Quick LinksEntrez ID:27345; OMIM: 605223; Uniprot ID:KCMB4_HUMAN; ENSEMBL ID: ENSG00000135643; HGNC ID: 6289
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
Pathway IDPathway Name
Hemostasis
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KCNMB4 mRNAaffects expression 16483693
D001241 Aspirin Aspirin results in decreased expression of KCNMB4 mRNAdecreases expression 11906190
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of KCNMB4 mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of KCNMB4 mRNAdecreases expression 20106945
D010269 Paraquat Paraquat affects the expression of KCNMB4 mRNAaffects expression 16854511
D014635 Valproic Acid Valproic Acid results in increased expression of KCNMB4 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2519490988
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D000382 Agricultural Workers' Diseases Paraquat 4.2211874814
MESH:D000550 Amblyopia Valproic Acid 5.7517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8317497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.9720485159 12372130
MESH:D001321 Autistic Disorder Valproic Acid 1.9917157402 18985861 19232924 20603192 18396377 15238991 18775368 18316065 17688650 18558336 16609825 17507914 19460635 18940202 18177632
MESH:D001714 Bipolar Disorder Valproic Acid 3.2120046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.598888407
MESH:D001932 Brain Neoplasms Aspirin 4.7215481559
MESH:D001943 Breast Neoplasms Aspirin 2.4215161893
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4220146248 17474063
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7312371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8020734317
MESH:D002779 Cholestasis Cyclosporine 3.1419486331
MESH:D003110 Colonic Neoplasms Aspirin 3.0212411196
MESH:D015179 Colorectal Neoplasms Aspirin 2.7517047198
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 16575769 8888407
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.2419641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.401851702
MESH:D004487 Edema Aspirin 4.2117259670
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.573659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.4416628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0718234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.877562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.533659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver Cyclosporine 8.8619224547
MESH:D005234 Fatty Liver Valproic Acid 8.8619224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.4116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.518888407 18558336
MESH:D005355 Fibrosis Cyclosporine 3.5612168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D005909 Glioblastoma Aspirin 4.1412870263
MESH:D005911 Gliosis Paraquat 5.6811124998
MESH:D006261 Headache Aspirin 5.4815240983
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006849 Hydrocephalus Valproic Acid 5.3317688650
MESH:D012001 Hyperacusis Aspirin 6.2815240983
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007248 Infertility, Male Paraquat 3.454850670
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0012371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1320195826 21137059
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7817228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720135361 18520028 6695378 17053015 18569708 20064080 20464547 20869020 18816296
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D008881 Migraine Disorders Aspirin 8.6015240983
MESH:D008881 Migraine Disorders Valproic Acid 8.6018803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.358888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3117596541
MESH:D009203 Myocardial Infarction Aspirin 3.6612692751
MESH:D009325 Nausea Aspirin 5.7315240983
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3011141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D009410 Nerve Degeneration Paraquat 3.9616893418
MESH:D009436 Neural Tube Defects Valproic Acid 3.3216359493 8888407
MESH:D010003 Osteoarthritis Aspirin 4.237009135
MESH:D010146 Pain Aspirin 4.116363464 6995502
MESH:D010300 Parkinson Disease Paraquat 2.9115824117 11445065 11124998 12911755 16140633 15451049 16510128 11181820
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.8516190885
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 6.0011156591
MESH:D020795 Photophobia Aspirin 6.2815240983
MESH:D011014 Pneumonia Paraquat 4.9112504350
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2920603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9217292933
MESH:D019310 Pseudolymphoma Valproic Acid 5.0611422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D011658 Pulmonary Fibrosis Paraquat 3.0117997886 16324872
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 4.2611700416
MESH:D012135 Respiratory Sounds Paraquat 4.4711874814
MESH:D012162 Retinal Degeneration Paraquat 4.1016458197
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5319155313
MESH:D012220 Rhinitis Aspirin 4.6812372130
MESH:D012559 Schizophrenia Valproic Acid 2.1015737665 19110320
MESH:D012640 Seizures Valproic Acid 2.9414763951 16876388 3137016 17978042 11044598 15475178 1511512 11738929
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.6812269725
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4910029692 19755658
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0219490988
MESH:D013226 Status Epilepticus Valproic Acid 5.0612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Aspirin 4.6316403987
MESH:D013927 Thrombosis Aspirin 4.8017672075
MESH:D014178 Translocation, Genetic Valproic Acid 5.7517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.983119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2817053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.068888407
MESH:D014581 Urticaria Aspirin 4.7910982225 20485159
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
REACT:604 Hemostasis
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01110 antagonist Miconazole Antifungal Agents
No data
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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