AutismKB 2.0

Annotation Detail for TMEM97


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Basic Information Top
Gene Symbol:TMEM97 ( MAC30 )
Gene Full Name: transmembrane protein 97
Band: 17q11.2
Quick LinksEntrez ID:27346; OMIM: 612912; Uniprot ID:TMM97_HUMAN; ENSEMBL ID: ENSG00000109084; HGNC ID: 28106
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
2053Colon cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TMEM97 mRNAincreases expression 19933214
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of TMEM97 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen results in decreased expression of TMEM97 mRNAdecreases expression 11793227
D000082 Acetaminophen Acetaminophen affects the expression of TMEM97 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone affects the expression of TMEM97 mRNAaffects expression 19483382
C006632 arsenic trioxide arsenic trioxide results in increased expression of TMEM97 mRNAincreases expression 20458559
D001553 Benzbromarone Benzbromarone affects the expression of TMEM97 mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TMEM97 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TMEM97 mRNAdecreases expression 20018196
C006780 bisphenol A bisphenol A results in increased expression of TMEM97 mRNAincreases expression 16474171
D002110 Caffeine Caffeine results in decreased expression of TMEM97 mRNAdecreases expression 11793227
D002784 Cholesterol TMEM97 protein affects the metabolism of Cholesterolaffects metabolic processing 18070364
D002994 Clofibrate Clofibrate affects the expression of TMEM97 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in decreased expression of TMEM97 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of TMEM97 mRNAdecreases expression 18042831
D004317 Doxorubicin TMEM97 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004958 Estradiol Estradiol results in increased expression of TMEM97 mRNAincreases expression 16474171
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TMEM97 mRNAaffects expression 17351261
D005001 Ethionine Ethionine affects the expression of TMEM97 mRNAaffects expression 19483382
D005047 Etoposide TMEM97 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D019833 Genistein Genistein results in increased expression of TMEM97 mRNAincreases expression 16474171
D016685 Mitomycin TMEM97 protein affects the susceptibility to Mitomycinaffects response to substance 16217747
C044361 M-VAC protocol TMEM97 protein results in increased susceptibility to M-VAC protocolincreases response to substance 15814643
D009853 Omeprazole Omeprazole affects the expression of TMEM97 mRNAaffects expression 19483382
C041786 palm oil palm oil results in decreased expression of TMEM97 mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of TMEM97 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of TMEM97 mRNAincreases expression 19482888
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TMEM97 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid affects the expression of TMEM97 mRNAaffects expression 19483382
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of TMEM97 mRNAincreases expression 16474171
D011374 Progesterone Progesterone results in increased expression of TMEM97 mRNAincreases expression 18070364
D011441 Propylthiouracil Propylthiouracil affects the expression of TMEM97 mRNAaffects expression 19483382
D012402 Rotenone Rotenone results in increased expression of TMEM97 mRNAincreases expression 19013527
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TMEM97 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of TMEM97 mRNAdecreases expression 20159946
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TMEM97 mRNAincreases expression 19933214
D013853 Thioacetamide Thioacetamide results in decreased expression of TMEM97 mRNAdecreases expression 11793227
D013853 Thioacetamide Thioacetamide affects the expression of TMEM97 mRNAaffects expression 19483382
D019772 Topotecan TMEM97 protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014303 Trinitrotoluene Trinitrotoluene affects the expression of TMEM97 mRNAaffects expression 21346803
D014747 Vinblastine TMEM97 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in decreased expression of TMEM97 mRNAaffects cotreatment|decreases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 17.367525203
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 17.366195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 17.3615322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 17.367525203
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5717505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.479612607
MESH:D055371 Acute Lung Injury pirinixic acid 2.7818653653
MESH:D000230 Adenocarcinoma arsenic trioxide 15.7619825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 15.7620127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 15.7617418594
MESH:D000230 Adenocarcinoma Estradiol 15.7611473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 15.7614692618
MESH:D000230 Adenocarcinoma Genistein 15.7611473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.446695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 15.1517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.1516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.1516835633
MESH:D000419 Albuminuria Doxorubicin 4.1921441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6311748828
MESH:D000799 Angioedema Acetaminophen 3.4710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7119183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.4920041841 18218290 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 8.7115238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.7111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4415885639
MESH:D050197 Atherosclerosis Cholesterol 4.0216632123
MESH:D001281 Atrial Fibrillation Amiodarone 3.6318651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4618445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 58.9819483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 58.9816206674
MESH:D001778 Blood Coagulation Disorders Benzbromarone 58.9819483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 58.9819483382
MESH:D001778 Blood Coagulation Disorders Ethionine 58.9819483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 58.9819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 58.9819483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 58.9819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 58.9812125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 58.9819483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5315746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 10.9114601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 10.9114601052
MESH:D001862 Bone Resorption bisphenol A 3.5411985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9617868700
MESH:D001930 Brain Injuries Progesterone 3.9015665606 15845082 15380490
MESH:D001932 Brain Neoplasms Doxorubicin 3.4917150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.4217474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 5.4217123778
MESH:D001943 Breast Neoplasms Dietary Fats 5.4220435547
MESH:D001943 Breast Neoplasms Doxorubicin 5.4216935488 16096432 16322301 16264153 15634643 18234424 16595493 18628466 17426702 19526202 15692762 17369602 15567936 15668708 18382427 16115903 15993339 11325840 15136595 18695136 16826403 17983394 15994142 15939500
MESH:D001943 Breast Neoplasms Estradiol 5.4216675129 17018787 17289903 17261762 12948864 14630087 18497071 19861407
MESH:D001943 Breast Neoplasms Etoposide 5.4216322251
MESH:D001943 Breast Neoplasms Genistein 5.4216541309 16873071 17200150
MESH:D001943 Breast Neoplasms Progesterone 5.4215562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.4220435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9911589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0916111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.4416051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5116835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.723084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 15.7215073043 14691202 15553829 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 15.721701930
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 15.7216023760 16234567 17876044 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.7216924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 15.7216924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 15.726705139 1701930 17173139 20935162 20007298
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 15.7217997003
MESH:D002278 Carcinoma in Situ bisphenol A 4.6217123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5019014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.3616201981 1485588
MESH:D002292 Carcinoma, Renal Cell Vinblastine 6.361485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8012490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.3020419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.306189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1618670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.2917329180 16109756 15476868 16731534 16455267 17928571 17308081 17924179 17519947 17351982 17131338 17382496 16364871 16242529 18627295 16651473 16278810 16269455 16952015 16612575 15811867 17007740 17974986 15505089 15792986
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.5319225199 15710769
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 5.5317334414 16243910
MESH:D002318 Cardiovascular Diseases Genistein 3.0516332659
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7218974383
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 11.2114694615
MESH:D002386 Cataract Acetaminophen 11.2110977129
MESH:D002386 Cataract Trinitrotoluene 11.2115817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 13.9520889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 13.951399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 13.9512371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 13.9518566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.894080065
MESH:D002637 Chest Pain Omeprazole 4.7315447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5216835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.5218291259
MESH:D002779 Cholestasis Cyclosporine 11.7719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.7715861022 17333356 17110522 16919318 11677210 17681005 16105132
MESH:D002779 Cholestasis pirinixic acid 11.7719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.958697196 12621046 16354765 15340226 15668235
MESH:D003110 Colonic Neoplasms Genistein 2.2217182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.5520501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.5518802399 18259882
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 4.5515531428
MESH:D015179 Colorectal Neoplasms Vinblastine 4.5518802399
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 13.8215095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 13.8214669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 13.8215095906
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8412609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.3410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3420055451 10048152 15322242
MESH:D003490 Cyanosis Trinitrotoluene 4.5618551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7615213294
MESH:D003704 Dementia Polychlorinated Biphenyls 4.3716140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2518249437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 3.9916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1317187935
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 16.8221346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 16.8211834606 12392966 11421492 19370779 15619225 11529661 15968718 16393943 16227642 19923254 16177239 2444490 12958197 18713872 10774834 14725611 14986274 11743745 16081117 17562736 16109766 19164858 17522070 11287661 19085960 16485898 19420014 10915739 17906064 14550746 10663392 11739529 16781746 19416960 11461765 12705907 19739265 12153990 18071297 12540782 12594235
MESH:D056486 Drug-Induced Liver Injury Amiodarone 16.8215265979 18218290
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 16.8217416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 16.8220420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 16.8212963478
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 16.8221346803 18551238
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7219426721
MESH:D004362 Drug Toxicity Doxorubicin 12.2218602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.2211462148
MESH:D004362 Drug Toxicity Zidovudine 12.2215040536
MESH:D004381 Duodenal Ulcer Omeprazole 3.9821218061 17151854 16613094 15991576
MESH:D050171 Dyslipidemias Clofibrate 7.9416707586
MESH:D050171 Dyslipidemias Dietary Fats 7.9418367378
MESH:D004421 Dystonia Phenobarbital 3.671851702
MESH:D004487 Edema pirinixic acid 5.4712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.4711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5318230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.8812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 7.8817692515
MESH:D004714 Endometrial Hyperplasia Genistein 4.2216402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 11.1117359293
MESH:D016889 Endometrial Neoplasms Estradiol 11.1111473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 11.1111473722
MESH:D004715 Endometriosis Progesterone 7.8716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.8710568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.7818037988
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.753659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.503922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.246401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.897750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.653659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.5920426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.5912903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.5916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7411564622
MESH:D005218 Fat Necrosis Thioacetamide 5.3516456712
MESH:D005234 Fatty Liver Amiodarone 37.5914986274
MESH:D005234 Fatty Liver arsenic trioxide 37.5915073043
MESH:D005234 Fatty Liver Clofibrate 37.5919224547
MESH:D005234 Fatty Liver Cyclosporine 37.5919224547
MESH:D005234 Fatty Liver Dietary Fats 37.5918296743 19551842 17967931 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 37.5915345470
MESH:D005234 Fatty Liver pirinixic acid 37.5920131406 19236843
MESH:D005234 Fatty Liver Zidovudine 37.5918299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1011858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.2219069698
MESH:D005355 Fibrosis Cyclosporine 12.6412639820 12168785
MESH:D005355 Fibrosis Dietary Fats 12.6418296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.6420067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9116904648
MESH:D005756 Gastritis Acetaminophen 3.3016983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.858708960
MESH:D005909 Glioblastoma Doxorubicin 6.5317150277
MESH:D005909 Glioblastoma Genistein 6.5316598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2210696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.2815692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.7920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.7911294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.2314766674 16495754 18674790 16244372 16144979 16330681 16879835 16244371 16707910 17888722 17875725 12587719 18006777
MESH:D006333 Heart Failure Doxorubicin 6.2917481944
MESH:D006333 Heart Failure pirinixic acid 6.2920558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.5715692506
MESH:D006402 Hematologic Diseases Zidovudine 4.3712579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0515720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0111000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2415929193 18665440 17276928
MESH:D006505 Hepatitis Caffeine 8.8311394713
MESH:D006505 Hepatitis Thioacetamide 8.8316456712
MESH:D006529 Hepatomegaly Amiodarone 23.3215265979
MESH:D006529 Hepatomegaly Phenobarbital 23.3216109766
MESH:D006529 Hepatomegaly pirinixic acid 23.3218467677 19772884 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 23.3215340226 12621046 16120746
MESH:D006529 Hepatomegaly Trinitrotoluene 23.3215817613
MESH:D006558 Herpes Genitalis Estradiol 4.6615709030
MESH:D006561 Herpes Simplex Etoposide 4.2010809021
MESH:D015658 HIV Infections Zidovudine 3.3011698656 11141242 20032539 17358032 11363243
MESH:D006689 Hodgkin Disease Doxorubicin 10.7318501091 15147373 17606976
MESH:D006689 Hodgkin Disease Etoposide 10.7318180244 17606976 16135485 16200630 15147373
MESH:D006689 Hodgkin Disease Vinblastine 10.7318180244 18501091
MESH:D019584 Hot Flashes Estradiol 3.3817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.678697196 15340226 18606429 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.4216870215
MESH:D006937 Hypercholesterolemia Amiodarone 13.588137927 9751232
MESH:D006937 Hypercholesterolemia Cholesterol 13.5816933029
MESH:D006937 Hypercholesterolemia Dietary Fats 13.5821332399
MESH:D006943 Hyperglycemia pirinixic acid 2.8720558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.2821332399
MESH:D006973 Hypertension Cyclosporine 4.4510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.4518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4516569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 10.4218020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 10.428137927 18031379
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0415869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.0817937319
MESH:D007248 Infertility, Male Trinitrotoluene 6.0812150543
MESH:D007249 Inflammation Dietary Fats 7.1620412841
MESH:D007249 Inflammation Progesterone 7.1615869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.1612878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 15.6516393666
MESH:D007333 Insulin Resistance Dietary Fats 15.6511836018 18457598
MESH:D007333 Insulin Resistance Estradiol 15.6516393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 15.6516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0715604871
MESH:D007674 Kidney Diseases Acetaminophen 12.6512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 12.658314463 18776723 10903974
MESH:D007674 Kidney Diseases Doxorubicin 12.6515369732 15699352 16775033
MESH:D007674 Kidney Diseases Estradiol 12.6515618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.8316707910
MESH:D007680 Kidney Neoplasms Cyclosporine 10.7612371664
MESH:D007680 Kidney Neoplasms Estradiol 10.7615610895
MESH:D007680 Kidney Neoplasms Zidovudine 10.7612579204
MESH:D007859 Learning Disorders Cholesterol 4.7417134702
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.8019248655
MESH:D007938 Leukemia arsenic trioxide 5.8015070760
MESH:D007938 Leukemia Genistein 5.8018980019 17468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.7816085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.7512560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 8.7520370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.4319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.0716467208 17050201 16968895 20471514 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 2.9711468182 16966277 19642359 17869043 12712474 15213294 9834237 11161223 16112521 12679006 19035177 19075265 17107899 16823087 17712046 15336539 17649720 15748426 16331271 16891316 15622746 19225113 12018890 17217047 16330433
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0016882451
MESH:D008064 Lipidoses Amiodarone 3.2515342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 5.9718296743
MESH:D008103 Liver Cirrhosis Phenobarbital 5.9721047994
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.0516595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.0514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.0517823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.0515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.0512878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 8.0510677585 14739098 18606216 18263696 17292413 11481614 11172339 16126171 15078482 17050028 15095483 15075984 12557150 15334695 12175628 18395095 16248980 11682029 15288472 18416461 16343077 12531686 18458672 16098781 15316131 15288473 18615449 17127702 16489207 12679928 18031379 17355460 15465738 12891558 18380797 12085344 16511523 18032466 16097051 18295389 15716488 17629604 15158331 15362042 15474484
MESH:D008107 Liver Diseases Acetaminophen 5.9412969438 19784758 12587719 11587558 19460945 16611625 16610002 19014921
MESH:D008107 Liver Diseases Phenobarbital 5.9419363144
MESH:D008107 Liver Diseases Thioacetamide 5.9416337175 18374380 15158337
MESH:D017114 Liver Failure, Acute Acetaminophen 8.5817185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 8.5815313186 15633222 17276928 12479984
MESH:D008113 Liver Neoplasms arsenic trioxide 16.0414682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.0421137059 20195826
MESH:D008113 Liver Neoplasms Mitomycin 16.0415113037
MESH:D008113 Liver Neoplasms Phenobarbital 16.0419073162 8742319 21047994 15975961 19482888 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 16.0420007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.0416984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 16.2020377131
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 16.2016842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 16.206150874 2563599 17172636 18308698 1399818
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 16.201423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.2012151625
MESH:D008133 Long QT Syndrome Amiodarone 7.2711989578 15350150 17391786
MESH:D008133 Long QT Syndrome arsenic trioxide 7.2715213294
MESH:D008171 Lung Diseases Amiodarone 3.1312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1018516814
MESH:D008175 Lung Neoplasms arsenic trioxide 6.0519825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.0520464547 18520028 17053015 18816296 20135361 20064080 6695378 20869020 18569708
MESH:D008175 Lung Neoplasms Doxorubicin 6.056189445 17418594
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.0519555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 6.0518800350
MESH:D008223 Lymphoma Doxorubicin 7.0416098063
MESH:D008223 Lymphoma Etoposide 7.0412854902 12556972
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.4917654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2115621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 12.3415458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.3411408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.3414578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.3411408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.1119453300
MESH:D008545 Melanoma Doxorubicin 3.5616827129
MESH:D008545 Melanoma Vinblastine 3.5616809738 17761969 15577320 16248763 16432458 18332650 18505091 15577323 12374674 18176117
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2119513568
MESH:D008654 Mesothelioma Doxorubicin 2.9117638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4116801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.4617358032
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1715792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9116381670
MESH:D052016 Mucositis Doxorubicin 4.4217415656
MESH:D009101 Multiple Myeloma arsenic trioxide 2.8511468182 19417148 19549372 14977855 15949261
MESH:D009135 Muscular Diseases pirinixic acid 3.1516239165
MESH:D009181 Mycoses Amiodarone 4.5312754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.9316105982 16882451
MESH:D009203 Myocardial Infarction Doxorubicin 8.5519429709 15857846
MESH:D009203 Myocardial Infarction Genistein 8.5517141266
MESH:D009203 Myocardial Infarction pirinixic acid 8.5519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.5516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.5517141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.5516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.1117484760
MESH:D009336 Necrosis Trinitrotoluene 4.4018551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6116624393
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.8018259882
MESH:D009369 Neoplasms Benzo(a)pyrene 4.2011141357
MESH:D009369 Neoplasms pirinixic acid 4.2017405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3717289903
MESH:D009401 Nephrosis Doxorubicin 4.4116899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.2719348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.2716889571 15640375
MESH:D009410 Nerve Degeneration Rotenone 3.6017356569 18619942 15790535
MESH:D009421 Nervous System Malformations bisphenol A 20.5716427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 20.5711399458 16427766
MESH:D009421 Nervous System Malformations Genistein 20.5716427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 20.5714600291
MESH:D009436 Neural Tube Defects arsenic trioxide 2.8810525206
MESH:D009447 Neuroblastoma Doxorubicin 6.6415555623
MESH:D009447 Neuroblastoma Topotecan 6.6415176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5818514411
MESH:D009503 Neutropenia Vinblastine 4.2317378895
MESH:D052556 Niemann-Pick Disease, Type C Cholesterol 11.1420557099 9802331
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 11.149802331
MESH:D009765 Obesity Dietary Fats 4.0919632207 21332399 18674790 20132043 17217161 16723640 11836018 20518802 18457598
MESH:D009765 Obesity pirinixic acid 4.0920558911
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 8.4114694615
MESH:D009784 Occupational Diseases Trinitrotoluene 8.4114694615 17852074 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.0017016548
MESH:D010024 Osteoporosis Genistein 3.0319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.7516169203
MESH:D012516 Osteosarcoma Doxorubicin 3.8215930896
MESH:D010049 Ovarian Diseases bisphenol A 4.6211985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.2619769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 10.2619401270
MESH:D010051 Ovarian Neoplasms Genistein 10.2619005980
MESH:D010051 Ovarian Neoplasms Progesterone 10.2616525653 17393432
MESH:D010146 Pain Acetaminophen 2.1116870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.2515580305
MESH:D010190 Pancreatic Neoplasms Etoposide 11.2519003803
MESH:D010190 Pancreatic Neoplasms Mitomycin 11.2515113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 11.2516965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3511578682
MESH:D010235 Paraganglioma arsenic trioxide 3.8219927285
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 5.3116702228
MESH:D010300 Parkinson Disease Rotenone 5.3111445065 19232380 11535288 16412576 15451049 18619942 18191903 19114014 16140633
MESH:D020734 Parkinsonian Disorders Rotenone 3.7618197244 15927086 15574749 15795934
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8712520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.7817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.7817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2118163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.9512371664
MESH:D011230 Precancerous Conditions Phenobarbital 7.952563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.2910548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.2911118676 11399792 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.4620887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.4620887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.3619131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.3617292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.3616740699
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.3615897917 15749863 16868541 16888761 16729912 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 2.3616740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.3617172428
MESH:D011471 Prostatic Neoplasms Genistein 2.3615256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.3615721890
MESH:D011537 Pruritus Ethinyl Estradiol 2.9516919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.1212752131
MESH:D011565 Psoriasis Cyclosporine 2.1016882103
MESH:D011629 Puberty, Precocious bisphenol A 4.4210548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7112490602 11597910 12832656
MESH:D051437 Renal Insufficiency Doxorubicin 3.8617922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4918990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7218045962
MESH:D012509 Sarcoma Doxorubicin 3.6717203757 16767912 18313854 17710206 15675481 15625365
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 15.3016646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 15.3014601052 16326096
MESH:D012512 Sarcoma, Ewing's Etoposide 15.3014601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4217846226
MESH:D012640 Seizures Phenobarbital 5.4316876388 3137016 4039156 11442880
MESH:D012640 Seizures Trinitrotoluene 5.4318551238
MESH:D003294 Seizures, Febrile Phenobarbital 4.456407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7218724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.3810029692 19755658
MESH:D012878 Skin Neoplasms Doxorubicin 8.3815692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.3816192470
MESH:D012893 Sleep Disorders Caffeine 4.9519395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Caffeine 4.7317225163
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2116767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 3.5716709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.9116503802 15862959
MESH:D013163 Splenomegaly Trinitrotoluene 4.8415817613
MESH:D013272 Stomach Diseases Omeprazole 4.2418545984
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.2117007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.212093021 20155912
MESH:D013274 Stomach Neoplasms Zidovudine 3.2117696246
MESH:D013276 Stomach Ulcer Amiodarone 6.5018087811
MESH:D013276 Stomach Ulcer Omeprazole 6.5018237397 15991576 10750652 17977527 16755016 11906479
MESH:D019966 Substance-Related Disorders bisphenol A 3.6216045194 16684133
MESH:D013610 Tachycardia Amiodarone 3.9411238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8419225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8515669648
MESH:D013959 Thyroid Diseases Amiodarone 10.8019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.8012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 14.8719014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 14.8717909728 16010429
MESH:D013964 Thyroid Neoplasms Phenobarbital 14.871399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 14.8715710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.5019584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.3119048282
MESH:D016171 Torsades de Pointes Amiodarone 9.0411989578 17467628
MESH:D016171 Torsades de Pointes arsenic trioxide 9.0415213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.4620435036 12973940 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.4617053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 7.4617653716
MESH:D014571 Urologic Neoplasms M-VAC protocol 5.7117933135
MESH:D014581 Urticaria Acetaminophen 2.6410982225
MESH:D014591 Uterine Diseases bisphenol A 4.6314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9514692618
MESH:D014605 Uveitis Cyclosporine 3.611336536
MESH:D014625 Vaginal Neoplasms Vinblastine 10.1615577323
MESH:D014625 Vaginal Neoplasms Zidovudine 10.1612579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2114671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.8617678736 17638931 17334414 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8715886252
MESH:D015430 Weight Gain Dietary Fats 3.4316723640
MESH:D014985 Xerophthalmia Cyclosporine 4.0717120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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