AutismKB 2.0

Annotation Detail for STK39


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Basic Information Top
Gene Symbol:STK39 ( DCHT,DKFZp686K05124,PASK,SPAK )
Gene Full Name: serine threonine kinase 39
Band: 2q24.3
Quick LinksEntrez ID:27347; OMIM: 607648; Uniprot ID:STK39_HUMAN; ENSEMBL ID: ENSG00000198648; HGNC ID: 17717
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200022TCR signaling in naive CD4+ T cells
No data
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Related Diseases/Disorders Top
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Desease Name
CARDIOVASCULAR
blood pressure
Desease Name
Blood pressure
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of STK39 mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of STK39 mRNAaffects expression 17562736
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of STK39 mRNAincreases expression 17131305
D013196 Dihydrotestosterone PD 98059 inhibits the reaction [Dihydrotestosterone results in increased expression of STK39 mRNA]decreases reaction|increases expression 17131305
D000643 Ammonium Chloride Ammonium Chloride affects the expression of STK39 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of STK39 mRNAdecreases expression 20064835
20106945
D003520 Cyclophosphamide [Doxorubicin co-treated with Cyclophosphamide] affects the expression of STK39 mRNAaffects cotreatment|affects expression 16322899
C004742 daidzein daidzein results in decreased expression of STK39 mRNAdecreases expression 16865672
D016190 Carboplatin Carboplatin results in decreased expression of STK39 mRNAdecreases expression 18172885
D002945 Cisplatin Cisplatin results in decreased expression of STK39 mRNAdecreases expression 18172885
D002117 Calcitriol Calcitriol results in increased expression of STK39 mRNAincreases expression 16002434
D004317 Doxorubicin [Doxorubicin co-treated with Cyclophosphamide] affects the expression of STK39 mRNAaffects cotreatment|affects expression 16322899
C007610 equol equol results in decreased expression of STK39 mRNAdecreases expression 16865672
D004958 Estradiol Estradiol results in increased expression of STK39 mRNAincreases expression 17131305
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in increased expression of STK39 mRNA]decreases reaction|increases expression 17131305
D004958 Estradiol PD 98059 inhibits the reaction [Estradiol results in increased expression of STK39 mRNA]decreases reaction|increases expression 17131305
D005419 Flavonoids Flavonoids results in decreased expression of STK39 mRNAdecreases expression 18035473
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in increased expression of STK39 mRNA]decreases reaction|increases expression 17131305
D019833 Genistein Genistein results in decreased expression of STK39 mRNAdecreases expression 16865672
15378649
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in decreased expression of STK39 mRNAdecreases expression 12634122
D015741 Metribolone Metribolone results in increased expression of STK39 mRNAincreases expression 17131305
C093973 PD 98059 PD 98059 inhibits the reaction [Dihydrotestosterone results in increased expression of STK39 mRNA]decreases reaction|increases expression 17131305
C093973 PD 98059 PD 98059 inhibits the reaction [Estradiol results in increased expression of STK39 mRNA]decreases reaction|increases expression 17131305
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of STK39 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of STK39 mRNAincreases expression 18301758
C052785 rebamipide rebamipide results in increased expression of STK39 mRNAincreases expression 18299717
C010327 salinomycin salinomycin results in decreased expression of STK39 mRNAdecreases expression 19682730
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of STK39 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of STK39 mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of STK39 mRNAincreases expression 20159946
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7011752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D058186 Acute Kidney Injury Cisplatin 3.8215814532 17670903 12690470
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 16.6420127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 16.6411798837 17638652
MESH:D000230 Adenocarcinoma daidzein 16.6411473722
MESH:D000230 Adenocarcinoma Doxorubicin 16.6417418594
MESH:D000230 Adenocarcinoma Estradiol 16.6411473722
MESH:D000230 Adenocarcinoma Genistein 16.6411473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.576695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3916835633
MESH:D000419 Albuminuria Doxorubicin 4.4021441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9219183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.4515014928
MESH:D001284 Atrophy fulvestrant 4.7011514358
MESH:D001321 Autistic Disorder marker/mechanism 18348195
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 11.5514601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 11.5514601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.6817150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 8.1617474063 20146248
MESH:D001943 Breast Neoplasms Calcitriol 8.1611237771
MESH:D001943 Breast Neoplasms Cisplatin 8.1618382427 19526202
MESH:D001943 Breast Neoplasms Cyclophosphamide 8.1615093573 18234424 15136595 11325840 17020986 16978400 12006526 17388661 18323546
MESH:D001943 Breast Neoplasms Doxorubicin 8.1616826403 15939500 17369602 18628466 19526202 16322301 17983394 18695136 18234424 18382427 15668708 16935488 11325840 16595493 15993339 15994142 16115903 15567936 17426702 16264153 15692762 15634643 16096432 15136595
MESH:D001943 Breast Neoplasms equol 8.1616898868
MESH:D001943 Breast Neoplasms Estradiol 8.1612948864 19861407 17018787 14630087 17289903 17261762 18497071 16675129
MESH:D001943 Breast Neoplasms fulvestrant 8.1618984771
MESH:D001943 Breast Neoplasms Genistein 8.1616541309 17200150 16873071
MESH:D001943 Breast Neoplasms salinomycin 8.1619682730
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 8.1620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6616051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.083084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 11.0817982673
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 11.0819701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 11.0816023760 18059187 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.0816924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.0816924424
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.7416152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung Carboplatin 5.9816685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.9812023789 16685392
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 6.6316201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.6316201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.4720419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 10.4711237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 10.476189445 18337622 17066447
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.476189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818850075 16120746 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.4315811867 16455267 17351982 17382496 16269455 16952015 15792986 17308081 17131338 16278810 16651473 16242529 18627295 17519947 15505089 17974986 17329180 17007740 16731534 16612575 16109756 17924179 15476868 17928571 16364871
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8916243910 17334414
MESH:D002318 Cardiovascular Diseases daidzein 7.4516332659
MESH:D002318 Cardiovascular Diseases Genistein 7.4516332659
MESH:D002386 Cataract Acetaminophen 2.4910977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7718566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 6.772727394
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002779 Cholestasis pirinixic acid 2.7119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.048697196 12621046 16354765 15340226 15668235
MESH:D003110 Colonic Neoplasms Genistein 2.2617182828
MESH:D015179 Colorectal Neoplasms Cisplatin 2.7315273666
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.7318802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 20055451 10048152
MESH:D003556 Cystitis Cyclophosphamide 4.8317979934 16413132 10700343 10498854 18483878 16614059 12161096 12388444 11948286 16989017 18433785 18372110 15643279 15276878 18295254 18093676 12913760 18710439 16651033 17010015
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.9411751995 15331540 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1718772604
MESH:D003924 Diabetes Mellitus, Type 2 daidzein 7.0516647724
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 7.0516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.0517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2819279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.9115968718 14550746 10774834 10915739 2444490 11739529 19923254 11287661 11421492 19416960 16485898 11461765 17562736 14986274 12392966 14725611 11834606 11529661 16109766 19739265 12958197 16781746 16393943 17906064 15619225 12705907 16227642 12540782 19370779 18071297 18713872 11743745 12594235 10663392 12153990 16177239 19164858 16081117 17522070 19085960 19420014
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 5.9117416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.9120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Cisplatin 13.1315033597 12649298 12231392 19839026
MESH:D004362 Drug Toxicity Doxorubicin 13.1318602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 13.1311462148
MESH:D004487 Edema pirinixic acid 6.0812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.7915138306
MESH:D004714 Endometrial Hyperplasia Genistein 4.4416402032
MESH:D016889 Endometrial Neoplasms daidzein 17.0511473722
MESH:D016889 Endometrial Neoplasms Doxorubicin 17.0517359293
MESH:D016889 Endometrial Neoplasms Estradiol 17.0519148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Genistein 17.0511473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8910568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0118037988
MESH:D004802 Eosinophilia Cyclophosphamide 4.0711006010
MESH:D007172 Erectile Dysfunction daidzein 4.8714972507
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4816530937
MESH:D004938 Esophageal Neoplasms Cisplatin 4.4816481741 17638652 16785472 15464296 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver pirinixic acid 2.6320131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4419069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8020067830
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D005909 Glioblastoma Doxorubicin 7.0117150277
MESH:D005909 Glioblastoma Genistein 7.0116598420
MESH:D018316 Gliosarcoma Cyclophosphamide 5.3611389073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.8816376943 11014644 15172196
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.7015464296 15102660
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.7015692506
MESH:D034381 Hearing Loss Cisplatin 4.1719898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2915464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1810048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.3816707910 16495754 18674790 14766674 17888722 16244372 16144979 18006777 16244371 17875725 12587719 16879835 16330681
MESH:D006333 Heart Failure Doxorubicin 6.7417481944
MESH:D006333 Heart Failure pirinixic acid 6.7420558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7615692506
MESH:D006467 Hemophilia A Cyclophosphamide 5.1411918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.3814986274
MESH:D006529 Hepatomegaly pirinixic acid 7.7619772884 18467677 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7616120746 12621046 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D006689 Hodgkin Disease Cisplatin 11.6816200630 16170182
MESH:D006689 Hodgkin Disease Cyclophosphamide 11.6817606976 16135485
MESH:D006689 Hodgkin Disease Doxorubicin 11.6818501091 17606976 15147373
MESH:D019584 Hot Flashes Estradiol 3.6017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8915340226 16959395 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5816870215
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006973 Hypertension daidzein 5.3317169123
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3318670907 18850075
MESH:D007154 Immune System Diseases Cyclophosphamide 5.1816076520
MESH:D007248 Infertility, Male Cyclophosphamide 7.007193160 16517039
MESH:D007248 Infertility, Male fulvestrant 7.0011514358
MESH:D007249 Inflammation Flavonoids 4.7417296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.7412200463 12878042
MESH:D007333 Insulin Resistance Estradiol 6.8716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 6.8716306350
MESH:D007410 Intestinal Diseases rebamipide 5.0311686837
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.9915464296
MESH:D007674 Kidney Diseases Acetaminophen 13.7615629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 13.7612649298 15190930 19839026 18289764 12231392
MESH:D007674 Kidney Diseases Doxorubicin 13.7615699352 16775033 15369732
MESH:D007674 Kidney Diseases Estradiol 13.7615618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0116707910
MESH:D007680 Kidney Neoplasms Estradiol 2.8615610895
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.6411231351
MESH:D007938 Leukemia Cyclophosphamide 6.4310602166
MESH:D007938 Leukemia Genistein 6.4317468513 18980019
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0116085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4318172266 17008537 18587576 17658394 17296974 17802794
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 5.0816972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.9810373061
MESH:D007970 Leukopenia Cyclophosphamide 4.8111830472 10052129
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.5316439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.5317823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5312878042
MESH:D008107 Liver Diseases Acetaminophen 1.5919784758 12587719 12969438 16611625 19460945 16610002 19014921 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1017185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 6.9820195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 6.9820007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.9816984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 5.6016842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.6012151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.7217053015 18816296 6695378 18569708 20464547 20135361 20869020 18520028 20064080
MESH:D008175 Lung Neoplasms Cisplatin 4.726189445 17225452 11798837
MESH:D008175 Lung Neoplasms Doxorubicin 4.726189445 17418594
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7219555203 11884234
MESH:D008223 Lymphoma Cyclophosphamide 7.5212854902
MESH:D008223 Lymphoma Doxorubicin 7.5216098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.4516675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 8.5711911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.5717654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4215621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 13.5515458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.5517203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 13.5512929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 13.5519682730
MESH:D020149 Manganese Poisoning Estradiol 4.3319453300
MESH:D008545 Melanoma Carboplatin 5.2516225601 16342250 11712820 12040289
MESH:D008545 Melanoma Cisplatin 5.2516432458 17761969 15577323 16248763 18505091 11135225 16809738 12883367 18176117 18332650 12393984 12374674 17023156
MESH:D008545 Melanoma Doxorubicin 5.2516827129
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.6215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 10.3319513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 10.3316388313
MESH:D008654 Mesothelioma Cisplatin 6.2617638057
MESH:D008654 Mesothelioma Doxorubicin 6.2617638057
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.7417671175
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3615792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0716381670
MESH:D052016 Mucositis Doxorubicin 4.6417415656
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009203 Myocardial Infarction Doxorubicin 9.1219429709 15857846
MESH:D009203 Myocardial Infarction Genistein 9.1217141266
MESH:D009203 Myocardial Infarction pirinixic acid 9.1219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.5016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.5017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.5016411023
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.8918259882
MESH:D009369 Neoplasms Benzo(a)pyrene 14.9811141357
MESH:D009369 Neoplasms Carboplatin 14.9818854779 17925555
MESH:D009369 Neoplasms Cisplatin 14.9816773208
MESH:D009369 Neoplasms Cyclophosphamide 14.9818854779
MESH:D009369 Neoplasms pirinixic acid 14.9817405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5817289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.3415464296
MESH:D009401 Nephrosis Doxorubicin 4.6216899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8716889571 15640375
MESH:D009421 Nervous System Malformations Estradiol 15.5111399458 16427766
MESH:D009421 Nervous System Malformations Genistein 15.5116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.5114600291
MESH:D009447 Neuroblastoma Cisplatin 11.118761367
MESH:D009447 Neuroblastoma Cyclophosphamide 11.1115176712 8761367 16115947
MESH:D009447 Neuroblastoma Doxorubicin 11.1115555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7518514411
MESH:D017599 Neuroectodermal Tumors Carboplatin 18.3512837982
MESH:D017599 Neuroectodermal Tumors Cisplatin 18.358761367
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 18.358761367 12837982
MESH:D009503 Neutropenia Cyclophosphamide 4.188291058
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D009845 Oligospermia Cyclophosphamide 4.5616517039
MESH:D010024 Osteoporosis Genistein 3.1619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9416169203
MESH:D012516 Osteosarcoma Doxorubicin 3.9915930896
MESH:D010051 Ovarian Neoplasms Cisplatin 7.6915464296 19769630 17225452 6897625
MESH:D010051 Ovarian Neoplasms Estradiol 7.6919401270
MESH:D010051 Ovarian Neoplasms Genistein 7.6919005980
MESH:D010146 Pain Acetaminophen 6.4416870215
MESH:D010146 Pain Cyclophosphamide 6.4412161096 18093676
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.5519003803
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.5511332152
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.1615464296
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0117983394
MESH:D010997 Pleural Neoplasms Cisplatin 13.4317638057
MESH:D010997 Pleural Neoplasms Doxorubicin 13.4317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.7221297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0411222880 11118676 11399792 11896295
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.6315572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0817292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0816644109 18247401 16289102 15754350 12479363
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.0817136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.0816729912 15749863 18437689 15897917 16888761 16868541
MESH:D011471 Prostatic Neoplasms equol 2.0816898868 16925846
MESH:D011471 Prostatic Neoplasms Estradiol 2.0816740699
MESH:D011471 Prostatic Neoplasms Genistein 2.0815256057 16925846 15378649
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.2316636934
MESH:D051437 Renal Insufficiency Cisplatin 9.8815464296
MESH:D051437 Renal Insufficiency Doxorubicin 9.8817922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012509 Sarcoma Doxorubicin 3.8616767912 17710206 17203757 18313854 15675481 15625365
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.9614601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.9616326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6417846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.6816636934
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.0219755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 9.0215692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.0216192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.1915464296
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4216767912 15625365 17203757
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.3616517039
MESH:D013272 Stomach Diseases rebamipide 5.1216184426
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.5120155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 3.5117522103 18396642 15958060
MESH:D013274 Stomach Neoplasms rebamipide 3.5115993841
MESH:D015173 Supratentorial Neoplasms Carboplatin 11.9712837982
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 11.9712837982
MESH:D013736 Testicular Neoplasms Cisplatin 4.4915464296 17225452
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.2616010429 17909728
MESH:D013978 Tibial Fractures Estradiol 4.5319048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.5117053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 11.5112973940 17225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 11.5114692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.5117653716
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.0716803524
MESH:D014625 Vaginal Neoplasms Cisplatin 4.4615577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0717334414 16364871 17678736 17638931
MESH:D014839 Vomiting Cisplatin 4.5711897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA38243
    • No data
    Releated disease ID Related disease Name
    PA444552Hypertension
    Releated drug ID Related drug Name
    PA449899hydrochlorothiazide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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