AutismKB 2.0

Annotation Detail for GLI1


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Basic Information Top
Gene Symbol:GLI1 ( GLI )
Gene Full Name: GLI family zinc finger 1
Band: 12q13.3
Quick LinksEntrez ID:2735; OMIM: 165220; Uniprot ID:GLI1_HUMAN; ENSEMBL ID: ENSG00000111087; HGNC ID: 4317
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04340Hedgehog signaling pathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200147Hedgehog signaling events mediated by Gli proteins
Pathway IDPathway Name
P00025Hedgehog signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GLI1 mRNAaffects expression 16483693
D019256 Cadmium Chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GLI1 mRNAaffects cotreatment|decreases expression 12634122
C023600 chromium oxide [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GLI1 mRNAaffects cotreatment|decreases expression 12634122
C017133 chromous chloride [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GLI1 mRNAaffects cotreatment|decreases expression 12634122
C014347 decitabine [[decitabine affects the methylation of HHIP promoter] which affects the expression of HHIP protein] which affects the expression of GLI1 mRNAaffects expression|affects methylation 18559595
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of GLI1 mRNAdecreases expression 15289156
D004958 Estradiol Estradiol results in decreased expression of GLI1 mRNAdecreases expression 15289156
D004958 Estradiol Estradiol results in decreased expression of GLI1 mRNAdecreases expression 15328011
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GLI1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of GLI1 mRNAdecreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GLI1 mRNAaffects cotreatment|decreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GLI1 mRNAaffects expression 17109907
D005472 Fluorouracil Fluorouracil results in decreased expression of GLI1 mRNAdecreases expression 18776995
D005472 Fluorouracil GLI1 protein inhibits the reaction [Fluorouracil affects the localization of PTCH1 protein]affects localization|decreases reaction 18776995
D019833 Genistein Genistein results in decreased expression of GLI1 mRNAdecreases expression 15289156
C525593 JK184 JK184 affects the activity of GLI1 proteinaffects activity 19222062
C008261 lead acetate [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GLI1 mRNAaffects cotreatment|decreases expression 12634122
C467746 propyl pyrazole triol propyl pyrazole triol results in decreased expression of GLI1 mRNAdecreases expression 17109907
C017947 sodium arsenite [sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of GLI1 mRNAaffects cotreatment|decreases expression 12634122
D013629 Tamoxifen Tamoxifen affects the expression of GLI1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GLI1 mRNAaffects cotreatment|decreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GLI1 mRNAdecreases expression 17942748
D014212 Tretinoin [Tretinoin co-treated with SHH protein co-treated with FGF8 protein] results in increased expression of GLI1 mRNAaffects cotreatment|increases expression 17085092
D014635 Valproic Acid Valproic Acid results in increased expression of GLI1 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.1915322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.198875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8919490988
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D000230 Adenocarcinoma Estradiol 10.1011473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.1014692618
MESH:D000230 Adenocarcinoma Fluorouracil 10.1017638652
MESH:D000230 Adenocarcinoma Genistein 10.1011473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8717306315 16712894
MESH:D000505 Alopecia Tretinoin 3.5815955085
MESH:D000550 Amblyopia Valproic Acid 5.2017688650
MESH:D000686 Amyloidosis Diethylstilbestrol 4.4415469931
MESH:D000740 Anemia Fluorouracil 8.5515504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.5511748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.5417497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.1115885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.1116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 2.3316456186
MESH:D001321 Autistic Disorder Valproic Acid 2.0118316065 17507914 16609825 20603192 17157402 18985861 18396377 18558336 18775368 19460635 18177632 15238991 18940202 19232924 17688650
MESH:D001471 Barrett Esophagus Tretinoin 4.3616935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.0520046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.8016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.9315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.938888407
MESH:D001943 Breast Neoplasms decitabine 4.7119208741 18320071
MESH:D001943 Breast Neoplasms Diethylstilbestrol 4.7117129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 4.7117289903 17261762 12948864 14630087 19861407 16675129 17018787 18497071
MESH:D001943 Breast Neoplasms Fluorouracil 4.7116595493 18357371 18608205 16110121 16557594 19217205 15136595
MESH:D001943 Breast Neoplasms Genistein 4.7117200150 16873071 16541309
MESH:D001943 Breast Neoplasms Tamoxifen 4.7120859285 19155303 17049068 16202921 17242785 19084267 21138602 19142967 18984771 18815881 19410462 17893378 19103187 19189212 19487384 19221464 16873071 18629630 17261762 19189210 11161223 19115204 16818667 18351453 18425577 18855134 20065188 15565566 19200415 20135344 19059307 20544844 18821012 19011961 19288272 15668708 20390343 16273361 21152245 19244106 19066611 19289846 20005174 17440819 18997820
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.7120435547
MESH:D001943 Breast Neoplasms Tretinoin 4.7116873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5516813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4316111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.6416051944
MESH:D002277 Carcinoma Fluorouracil 8.0617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.0616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4719066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1316168501
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 14.0016924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 14.0016924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 14.0018930000 16332177 17088986 17045692 17971768 16799960
MESH:D006528 Carcinoma, Hepatocellular Genistein 14.0016924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 14.0016507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 14.0016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 14.001917145
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0018695887
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.7219215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.7217066447 16757204 18986760 16280240
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.7218572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.7216096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3416120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.2716332659
MESH:D002386 Cataract Tretinoin 3.0717460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.6418566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.6420056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5516129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6920734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8411677210 16919318 15861022 16105132 17333356 17681005 17110522
MESH:D002822 Choriocarcinoma Tretinoin 5.1316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7016354765 15340226 12621046 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 5.709407595
MESH:D003092 Colitis Tretinoin 3.6617035595
MESH:D003110 Colonic Neoplasms decitabine 5.8417616700
MESH:D003110 Colonic Neoplasms Fluorouracil 5.8417725105 17018589 16510598 17016597 15001691 18772588 17169374 16340194 17287894 17172411
MESH:D003110 Colonic Neoplasms Genistein 5.8417182828
MESH:D015179 Colorectal Neoplasms decitabine 2.6218981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6218448328 16391804 18949393 15148649 18288408 18509181 14970324 16524972 17094418 18802399 17255274 16282729 17594712 20501625 15289873 18383874 17016601 17695437 17454858 17401013 16331619 16303861
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0214669216 17141729
MESH:D019465 Craniofacial Abnormalities lead acetate 5.4219769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.4210048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.429224671 10589399 8800419 17551590 14991402 16925845 9142499 9125849 9211117 9664655
MESH:D019465 Craniofacial Abnormalities Valproic Acid 5.428888407 17688650 16575769
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.5216002989 12952375
MESH:D007644 Darier Disease Fluorouracil 4.7616733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3219031437
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2917107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.7119279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.7119279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7320420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.731733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D004421 Dystonia Valproic Acid 4.011851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.8515322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.8518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.8112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.8119031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.0919294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.7716402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.7716402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 23.0415700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 23.0418566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 23.0411473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 23.0420544844 17893378 16202921 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 23.0416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.989294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.113659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.8916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.556254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.267750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.033659116
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4416337965 16481741 15173087 17638652 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.7216938888 9664655
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.8815345470
MESH:D005234 Fatty Liver Tamoxifen 12.8819224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 12.8814986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 8.1216534752 16513791 15751030 16611131 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 8.1216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8616575769
MESH:D005317 Fetal Growth Retardation lead acetate 11.0619769572
MESH:D005317 Fetal Growth Retardation Valproic Acid 11.068888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1519069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4920067830
MESH:D005355 Fibrosis Tretinoin 8.4917994277
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 12.7016452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 12.7016452187
MESH:D005909 Glioblastoma Genistein 7.1116598420
MESH:D005909 Glioblastoma Tretinoin 7.1117312396
MESH:D005910 Glioma Fluorouracil 2.8516145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms decitabine 12.8019215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.8015162350 18337622 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.8016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4611294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.469664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8515340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0015709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.1112676792
MESH:D019584 Hot Flashes Estradiol 3.7217088409
MESH:D006849 Hydrocephalus Valproic Acid 4.8317688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.028697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.1816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5316778211
MESH:D006965 Hyperplasia Diethylstilbestrol 4.4012960047 14722030
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8918850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 11.1116002989
MESH:D007021 Hypospadias Ethinyl Estradiol 11.1116945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.3115036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male decitabine 11.0617581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.0617937319
MESH:D007248 Infertility, Male sodium arsenite 11.0615346721 12646999
MESH:D007249 Inflammation Tamoxifen 4.8119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8112878042 12200463
MESH:D007333 Insulin Resistance Estradiol 2.9416627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.7317994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.8015992940 17551590
MESH:D007674 Kidney Diseases Cadmium Chloride 10.0616962696
MESH:D007674 Kidney Diseases Estradiol 10.0615618244
MESH:D007674 Kidney Diseases sodium arsenite 10.0620008137
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 17.4915003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 17.4915610895
MESH:D007680 Kidney Neoplasms Fluorouracil 17.4916985049
MESH:D007680 Kidney Neoplasms Tamoxifen 17.4918625569
MESH:D007859 Learning Disorders Diethylstilbestrol 4.0217184923
MESH:D007938 Leukemia decitabine 10.4119235587 18980019
MESH:D007938 Leukemia Genistein 10.4118980019 17468513
MESH:D007938 Leukemia Tretinoin 10.4117143497
MESH:D007951 Leukemia, Myeloid decitabine 9.4317236224 19117987 18454857
MESH:D007951 Leukemia, Myeloid Tretinoin 9.4316932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.1117679729 18704418 18460780 19387464 19010910 18206229
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.1117596541 19850784 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 6.1116294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4318055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1219075265 19029980 19642359 16140955 17339181 17301526 17649720 16935935 17294898 16766008 17107899 12679006 16823087 16331271 9834237 17506722 16788101 17217047 17712046 15748426 19035177 17368321 19225113 17361223 16891316
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.279224671
MESH:D008064 Lipidoses Tamoxifen 3.1217567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.6814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.6817823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.6818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.6818397230 16248980
MESH:D008113 Liver Neoplasms Diethylstilbestrol 14.0816712894 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 14.0816603448 17045692 15113037 18383874
MESH:D008113 Liver Neoplasms sodium arsenite 14.0815276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 14.0816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.0816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0812151625
MESH:D008171 Lung Diseases sodium arsenite 3.1419095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2317228818
MESH:D008175 Lung Neoplasms Fluorouracil 4.8015246190
MESH:D008175 Lung Neoplasms sodium arsenite 4.8015276417 17306315 19931552 16712894 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 4.8018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8019555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7615086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.1115166399
MESH:D008223 Lymphoma decitabine 7.6219470736
MESH:D008223 Lymphoma Diethylstilbestrol 7.6215700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.4916002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7219428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.8216891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.8212929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.8214580682 19196722 11731420 16827153 19196723
MESH:D020149 Manganese Poisoning Estradiol 12.5519453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.5519453300
MESH:D008527 Medulloblastoma Tretinoin 2.7717453147
MESH:D008545 Melanoma decitabine 7.2417785578 16505122
MESH:D008545 Melanoma sodium arsenite 7.2416487513 19082730
MESH:D008545 Melanoma Tamoxifen 7.2419393235 12393984
MESH:D008545 Melanoma Tretinoin 7.2416752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1515990972
MESH:D008591 Meningomyelocele Tretinoin 4.3916940565
MESH:D008881 Migraine Disorders Valproic Acid 3.1618765137 18803445
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6018986760 16757204
MESH:D009101 Multiple Myeloma decitabine 3.3118172295
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.998888407
MESH:D009190 Myelodysplastic Syndromes decitabine 12.2018608210 19157545 16882708 19010910
MESH:D009190 Myelodysplastic Syndromes Tretinoin 12.2017596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 12.2017596541
MESH:D009203 Myocardial Infarction Genistein 2.8417141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.4016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.4017141266
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5019410462
MESH:D009369 Neoplasms decitabine 15.5317925555 19116145 19470736
MESH:D009369 Neoplasms Diethylstilbestrol 15.5315313581
MESH:D009369 Neoplasms Fluorouracil 15.5318239605 18600527 16928823
MESH:D009369 Neoplasms sodium arsenite 15.5311559025
MESH:D009369 Neoplasms Tretinoin 15.5316594593 16946489
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6320056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9719189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7017289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 30.3311399458
MESH:D009421 Nervous System Malformations Estradiol 30.3311399458 16427766
MESH:D009421 Nervous System Malformations Genistein 30.3316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 30.3314600291
MESH:D009421 Nervous System Malformations Tretinoin 30.339125849
MESH:D009436 Neural Tube Defects sodium arsenite 11.9912854658
MESH:D009436 Neural Tube Defects Tretinoin 11.999142499
MESH:D009436 Neural Tube Defects Valproic Acid 11.9916359493 8888407
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4116436463
MESH:D010024 Osteoporosis Genistein 3.2219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0416169203
MESH:D010051 Ovarian Neoplasms decitabine 14.8419331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 14.8419401270
MESH:D010051 Ovarian Neoplasms Genistein 14.8419005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.8415276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 14.8416936753
MESH:D010146 Pain Tretinoin 2.8716870215
MESH:D010190 Pancreatic Neoplasms decitabine 8.5919294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.5916929163 16500647 15113037 19003803
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.5915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.1414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.6315687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 16.0717184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.0711399792 11118676 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 16.0720603192
MESH:D055728 Primary Myelofibrosis decitabine 4.6917616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8420887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8917136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8919082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 1.8915256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8916039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011507 Proteinuria Tretinoin 3.5616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.5112752131 11422049
MESH:D011625 Pterygium Tretinoin 4.7616723453
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9718286688 18722050 15538739 16160472
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012208 Rhabdomyosarcoma decitabine 18.2919155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 18.2916283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 18.2919155313
MESH:D012559 Schizophrenia Valproic Acid 2.0615737665 19110320
MESH:D012640 Seizures Valproic Acid 2.7115475178 11738929 17978042 16876388 14763951 3137016 11044598 1511512
MESH:D012878 Skin Neoplasms sodium arsenite 9.3118572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3116192470
MESH:D012878 Skin Neoplasms Tretinoin 9.3116467112
MESH:D013088 Spermatocele Diethylstilbestrol 19.9816002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 19.9816709447
MESH:D013088 Spermatocele Tamoxifen 19.9816709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0019457130
MESH:D016135 Spinal Dysraphism sodium arsenite 9.4312854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.4319490988
MESH:D013226 Status Epilepticus Valproic Acid 4.5112833885
MESH:D013274 Stomach Neoplasms decitabine 3.4119037991
MESH:D013274 Stomach Neoplasms Fluorouracil 3.4119084572 17522103 19015929 18396642 17172411 16424979 17498489 18567086 16951190 15786421
MESH:D013274 Stomach Neoplasms Tretinoin 3.4117261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms decitabine 7.1817967635
MESH:D013964 Thyroid Neoplasms Tretinoin 7.1816026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.6619048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.7016280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.7016051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.2017262798
MESH:D014376 Tuberculosis Tretinoin 3.2016040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.493119515
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.8319087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.8316452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.8316712894 11723127 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.8316712894 8653321 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.608888407
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 22.3116175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 22.3116803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 22.3111813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 22.3116129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.1414652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.3415809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.3414692618
MESH:D014604 Uveal Neoplasms decitabine 12.7317785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.7316752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.4016002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.3917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.0216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D009396 Wilms Tumor Tretinoin 3.9316287080
Pathway ID Pathway Name
KEGG:05217 Basal cell carcinoma
KEGG:04340 Hedgehog signaling pathway
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28720
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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