AutismKB 2.0

Annotation Detail for APOBEC3C


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Basic Information Top
Gene Symbol:APOBEC3C ( APOBEC1L,ARDC2,ARDC4,ARP5,MGC19485,PBI,bK150C2.3 )
Gene Full Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
Band: 22q13.1
Quick LinksEntrez ID:27350; OMIM: 607750; Uniprot ID:ABC3C_HUMAN; ENSEMBL ID: ENSG00000179750,ENSG00000244509; HGNC ID: 17353
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of APOBEC3C mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of APOBEC3C mRNAincreases expression 20382639
D004317 Doxorubicin APOBEC3C protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D005047 Etoposide APOBEC3C protein affects the susceptibility to Etoposideaffects response to substance 16217747
D005472 Fluorouracil APOBEC3C protein affects the susceptibility to Fluorouracilaffects response to substance 15352031
D005472 Fluorouracil Fluorouracil results in decreased expression of APOBEC3C proteindecreases expression 15352031
D005472 Fluorouracil Fluorouracil results in increased expression of APOBEC3C mRNAincreases expression 16510598
D016685 Mitomycin APOBEC3C protein affects the susceptibility to Mitomycinaffects response to substance 16217747
D008942 Mitoxantrone APOBEC3C protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D017239 Paclitaxel APOBEC3C protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
C004648 testosterone enanthate testosterone enanthate affects the expression of APOBEC3C mRNAaffects expression 17440010
D019772 Topotecan APOBEC3C protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014747 Vinblastine APOBEC3C protein affects the susceptibility to Vinblastineaffects response to substance 16217747
D014810 Vitamin E Vitamin E results in decreased expression of APOBEC3C mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3020464547 20127859
MESH:D000230 Adenocarcinoma Doxorubicin 7.3017418594
MESH:D000230 Adenocarcinoma Fluorouracil 7.3017638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D000419 Albuminuria Doxorubicin 4.6721441931
MESH:D000740 Anemia Fluorouracil 3.8115504547 16511603 17963324
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 12.7514601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 12.7514601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.6815867366
MESH:D001932 Brain Neoplasms Doxorubicin 3.9117150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4017474063 20146248
MESH:D001943 Breast Neoplasms Doxorubicin 2.4017983394 19526202 11325840 15136595 15668708 16264153 16096432 16595493 16115903 18382427 17369602 15692762 18628466 15993339 15994142 18234424 17426702 18695136 16826403 16322301 15939500 15567936 15634643 16935488
MESH:D001943 Breast Neoplasms Etoposide 2.4016322251
MESH:D001943 Breast Neoplasms Fluorouracil 2.4015136595 16595493 16110121 19217205 16557594 18357371 18608205
MESH:D001943 Breast Neoplasms Paclitaxel 2.4016115903 15136595 11325840 16273361 18234424 16244791 18223236 18323546
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D002276 Carcinoid Tumor Doxorubicin 12.9416051944
MESH:D002276 Carcinoid Tumor Fluorouracil 12.9416051944
MESH:D002277 Carcinoma Fluorouracil 3.6517121937
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.8616234567 16023760 18059187 17876044
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.8616332177 18930000 17045692 16799960 17088986 17971768
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 4.8616313753
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 11.211485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 11.2118695887
MESH:D002292 Carcinoma, Renal Cell Vinblastine 11.211485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.7420419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.746189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.7416280240 18986760 16757204 17066447
MESH:D009202 Cardiomyopathies Doxorubicin 3.6016109756 17924179 17007740 15792986 16242529 17382496 17131338 16612575 17308081 15811867 17519947 18627295 17329180 17974986 16269455 16952015 16455267 17351982 16364871 16651473 15476868 16731534 15505089 17928571 16278810
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9817334414 16243910
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8020889678
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2517016597 17287894 17169374 16340194 17018589 17172411 18772588 17725105 16510598 15001691
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.9518802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 4.9518448328 14970324 16391804 18949393 17695437 17016601 16282729 17594712 16524972 16303861 17401013 18383874 20501625 18509181 16331619 17255274 18802399 18288408 15148649 17454858 17094418 15289873
MESH:D015179 Colorectal Neoplasms Paclitaxel 4.9518802399
MESH:D015179 Colorectal Neoplasms Vinblastine 4.9518802399
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D007644 Darier Disease Fluorouracil 4.9516733453
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.4717416283
MESH:D004362 Drug Toxicity Doxorubicin 3.7518602426
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.5217359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.3318037988
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.6520426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.6516530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.6516481741 17638652 15173087 16785472 16337965
MESH:D004938 Esophageal Neoplasms Paclitaxel 10.6516481741
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7419069698
MESH:D005909 Glioblastoma Doxorubicin 3.4217150277
MESH:D005910 Glioma Fluorouracil 2.9116145905
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.1615692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.1618337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8720471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.8716080930
MESH:D006331 Heart Diseases Doxorubicin 8.3216707910 16879835 18674790 16144979 16330681 17888722 18006777 16244371 16244372 12587719 16495754 14766674 17875725
MESH:D006331 Heart Diseases Mitoxantrone 8.3216019553
MESH:D006333 Heart Failure Doxorubicin 3.4117481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.0115692506
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D006561 Herpes Simplex Etoposide 4.7210809021
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.9217440010
MESH:D006689 Hodgkin Disease Doxorubicin 13.0717606976 18501091 15147373
MESH:D006689 Hodgkin Disease Etoposide 13.0717606976 16200630 15147373 16135485 18180244
MESH:D006689 Hodgkin Disease Vinblastine 13.0718180244 18501091
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D007251 Influenza, Human Vitamin E 4.3916624496
MESH:D007674 Kidney Diseases Doxorubicin 6.4816775033 15369732 15699352
MESH:D007674 Kidney Diseases Vitamin E 6.4812488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2616707910
MESH:D007680 Kidney Neoplasms Fluorouracil 3.4016985049
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.3316085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.8318172266
MESH:D008080 Liposarcoma Paclitaxel 4.9417353645
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.7016595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.7016169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8320195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 7.8318383874 15113037 17045692 16603448
MESH:D008113 Liver Neoplasms Mitomycin 7.8315113037
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.0817085340 16842330
MESH:D008171 Lung Diseases Vitamin E 3.2516863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9820869020 18569708 20064080 20464547 20135361 18816296 18520028 6695378 17053015
MESH:D008175 Lung Neoplasms Doxorubicin 4.9817418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 4.9815246190
MESH:D008175 Lung Neoplasms Vitamin E 4.9811062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9515086387
MESH:D008223 Lymphoma Doxorubicin 8.1716098063
MESH:D008223 Lymphoma Etoposide 8.1712854902 12556972
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 9.2717654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 9.2714749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.7015621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.1015458769
MESH:D008545 Melanoma Doxorubicin 5.4616827129
MESH:D008545 Melanoma Paclitaxel 5.4616342250 12040289 12025231
MESH:D008545 Melanoma Vinblastine 5.4618332650 12374674 18176117 18505091 16432458 15577320 15577323 16248763 17761969 16809738
MESH:D008654 Mesothelioma Doxorubicin 3.1017638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.6115792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.8116381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.8116757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.9417415656
MESH:D009101 Multiple Myeloma Paclitaxel 3.7614749477
MESH:D009203 Myocardial Infarction Doxorubicin 2.9915857846 19429709
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.2718259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.2715867366
MESH:D009369 Neoplasms Benzo(a)pyrene 8.7211141357
MESH:D009369 Neoplasms Fluorouracil 8.7218600527 16928823 18239605
MESH:D009369 Neoplasms Mitoxantrone 8.7216640825
MESH:D009401 Nephrosis Doxorubicin 4.9116899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1015640375 16889571
MESH:D009447 Neuroblastoma Doxorubicin 7.4715555623
MESH:D009447 Neuroblastoma Topotecan 7.4715176712
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5116436463
MESH:D009503 Neutropenia Vinblastine 4.6917378895
MESH:D010014 Osteolysis Paclitaxel 5.1315867366
MESH:D012516 Osteosarcoma Doxorubicin 4.2015930896
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0211161223
MESH:D010190 Pancreatic Neoplasms Etoposide 9.0919003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 9.0916500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Mitomycin 9.0915113037
MESH:D003557 Phyllodes Tumor Doxorubicin 5.3317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.3317638057
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9016888761 18437689 16729912 15897917 15749863 16868541
MESH:D011471 Prostatic Neoplasms Etoposide 1.9017172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.9018626508 19082440
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.9017136230 16729912 17172428 16356831
MESH:D011471 Prostatic Neoplasms Vitamin E 1.9015084515
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1118286688 18722050 15538739 16160472
MESH:D051437 Renal Insufficiency Doxorubicin 4.3617922066
MESH:D012509 Sarcoma Doxorubicin 4.0917710206 17203757 15675481 15625365 16767912 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 10.9814601052 16326096
MESH:D012512 Sarcoma, Ewing's Etoposide 10.9814601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9417846226
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9719755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 5.9715692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.7017203757 15625365 16767912
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.5020155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 3.5016424979 19084572 18567086 17498489 18396642 17522103 19015929 15786421 16951190 17172411
MESH:D013274 Stomach Neoplasms Paclitaxel 3.5018506536 18396642
MESH:D020521 Stroke Vitamin E 3.6116517955
MESH:D024801 Tauopathies Paclitaxel 4.9716930453
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.4516010429 17909728
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0916280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2817053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.2817653716
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9816803524
MESH:D014625 Vaginal Neoplasms Vinblastine 5.1815577323
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.3617638931 17334414 17678736 16364871
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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