AutismKB 2.0

Annotation Detail for PPPDE2


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Basic Information Top
Gene Symbol:PPPDE2 ( D15Wsu75e,DJ347H13.4,FAM152B,MGC138384 )
Gene Full Name: PPPDE peptidase domain containing 2
Band: 22q13.2
Quick LinksEntrez ID:27351; OMIM: NA; Uniprot ID:PPDE2_HUMAN; ENSEMBL ID: ENSG00000100418; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PPPDE2 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of PPPDE2 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of PPPDE2 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PPPDE2 mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen affects the expression of PPPDE2 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.4320127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.4311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.4314692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8517474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 1.8517261762 14630087 17289903 12948864 19861407 18497071 16675129 17018787
MESH:D001943 Breast Neoplasms Tamoxifen 1.8521152245 17893378 19288272 19011961 20390343 18629630 17261762 19066611 19189212 18855134 18425577 18351453 19103187 11161223 19200415 18821012 15565566 20065188 20005174 20135344 20859285 19244106 16873071 16818667 19289846 19221464 18984771 15668708 16273361 18815881 17049068 19142967 19487384 19155303 17440819 19084267 19115204 19059307 21138602 17242785 19410462 16202921 20544844 18997820 19189210
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0016111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1116924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1116924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9617572228
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.3612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.3618566989
MESH:D002779 Cholestasis Cyclosporine 8.6519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.6515861022 11677210 16105132 17110522 17681005 17333356 16919318
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D003928 Diabetic Nephropathies Estradiol 9.9419279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.9419279558
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.4512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.4519031437
MESH:D016889 Endometrial Neoplasms Estradiol 8.1218566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 8.1219155303 17893378 16202921 20544844
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005234 Fatty Liver Cyclosporine 15.3219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.3215345470
MESH:D005234 Fatty Liver Tamoxifen 15.3219224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D005355 Fibrosis Cyclosporine 3.6212168785 12639820
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006558 Herpes Genitalis Estradiol 5.6415709030
MESH:D019584 Hot Flashes Estradiol 4.3617088409
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation Tamoxifen 2.5119457130
MESH:D007333 Insulin Resistance Estradiol 3.1816393666 16627594
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 6.558314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.5515618244
MESH:D007680 Kidney Neoplasms Cyclosporine 14.2012371664
MESH:D007680 Kidney Neoplasms Estradiol 14.2015610895
MESH:D007680 Kidney Neoplasms Tamoxifen 14.2018625569
MESH:D008064 Lipidoses Tamoxifen 3.4017567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5318564211
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8821137059 20195826
MESH:D008113 Liver Neoplasms Tamoxifen 4.8816684651
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.456695378 18816296 20135361 17053015 20064080 18520028 18569708 20464547 20869020
MESH:D008175 Lung Neoplasms Tamoxifen 2.4518625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6916891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.6919196723 11731420 16827153 19196722 14580682
MESH:D020149 Manganese Poisoning Estradiol 14.7819453300
MESH:D020149 Manganese Poisoning Tamoxifen 14.7819453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5516810080
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.6119189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 4.2717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 4.0911399458 16427766
MESH:D010051 Ovarian Neoplasms Estradiol 2.3019401270
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4417292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.4416740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4415067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.8515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5110029692 19755658
MESH:D013088 Spermatocele Ethinyl Estradiol 13.6916709447
MESH:D013088 Spermatocele Tamoxifen 13.6916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D013978 Tibial Fractures Estradiol 5.3019048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3817053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.3816712894 17572228 8653321
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9115869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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