AutismKB 2.0

Annotation Detail for SGSM3


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Basic Information Top
Gene Symbol:SGSM3 ( DKFZp761D051,MAP,RUSC3,RUTBC3 )
Gene Full Name: small G protein signaling modulator 3
Band: 22q13.1
Quick LinksEntrez ID:27352; OMIM: 610440; Uniprot ID:SGSM3_HUMAN; ENSEMBL ID: ENSG00000100359; HGNC ID: 25228
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014347 decitabine decitabine results in decreased expression of SGSM3 mRNAdecreases expression 19194470
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SGSM3 mRNAaffects expression 17555576
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of SGSM3 mRNAaffects cotreatment|increases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of SGSM3 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of SGSM3 mRNAaffects expression 17555576
D014303 Trinitrotoluene Trinitrotoluene affects the expression of SGSM3 mRNAaffects expression 21346803
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of SGSM3 mRNAaffects cotreatment|increases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 4.587525203
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001943 Breast Neoplasms decitabine 2.2518320071 19208741
MESH:D001943 Breast Neoplasms Tamoxifen 2.2519155303 19066611 19084267 19103187 15668708 16202921 19011961 19059307 19189212 19289846 17893378 11161223 19189210 17242785 17049068 18984771 19487384 20135344 15565566 18351453 20390343 21138602 20544844 20859285 17261762 21152245 19115204 19410462 19221464 20065188 18629630 19200415 19288272 19142967 18815881 17440819 18425577 20005174 18997820 18821012 16273361 16818667 19244106 18855134 16873071
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2916050911
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8516924424
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6519215824
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D002386 Cataract Trinitrotoluene 4.0214694615 15817613
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0717681005 17333356 16105132 15861022 16919318 17110522 11677210
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1115894690
MESH:D003092 Colitis Selenium 4.1417936198
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.6515095906
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis Trinitrotoluene 5.2818551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0316285004
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury Selenium 6.8215131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.8215131321
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 6.8221346803 18551238
MESH:C538011 Eales disease Vitamin E 5.159068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.5619294695
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2119155303 16202921 20544844 17893378
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6415345470
MESH:D005234 Fatty Liver Tamoxifen 8.6419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D006258 Head and Neck Neoplasms decitabine 3.6619215824
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1216080930
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D006529 Hepatomegaly Trinitrotoluene 4.5915817613
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7816490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.4114716179
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male decitabine 12.3717581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 12.3717937319
MESH:D007248 Infertility, Male Trinitrotoluene 12.3712150543
MESH:D007249 Inflammation Tamoxifen 2.4819457130
MESH:D007251 Influenza, Human Selenium 12.4816624496
MESH:D007251 Influenza, Human Vitamin E 12.4816624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.4514714311
MESH:D007674 Kidney Diseases Vitamin E 2.9512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2718625569
MESH:D007938 Leukemia decitabine 3.1918980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.2819117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4118460780 18206229 19010910 18704418 17679729 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9118055864
MESH:D008064 Lipidoses Tamoxifen 3.3517567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5918564211
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5916169303
MESH:D008113 Liver Neoplasms Tamoxifen 2.3016684651
MESH:D008171 Lung Diseases Vitamin E 3.3516863852
MESH:D008175 Lung Neoplasms Tamoxifen 2.5518625569
MESH:D008175 Lung Neoplasms Vitamin E 2.5511062179
MESH:D008223 Lymphoma decitabine 3.6119470736
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3614737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.6015318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.6016827153 11731420 19196723 14580682 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma decitabine 3.5217785578 16505122
MESH:D008545 Melanoma Tamoxifen 3.5219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D009101 Multiple Myeloma decitabine 3.5418172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5219010910 16882708 18608210 19157545
MESH:D009336 Necrosis Trinitrotoluene 5.1618551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms decitabine 2.8317925555 19116145 19470736
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419196722 19200415 19189210
MESH:D009784 Occupational Diseases Trinitrotoluene 4.6017852074 12819281 14694615
MESH:D010051 Ovarian Neoplasms decitabine 2.7219259094 19331143
MESH:D010190 Pancreatic Neoplasms decitabine 2.8419294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D055728 Primary Myelofibrosis decitabine 5.0917616702
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5418760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5415067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5415084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D012208 Rhabdomyosarcoma decitabine 4.7119155313
MESH:D012640 Seizures Trinitrotoluene 3.6218551238
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013163 Splenomegaly Trinitrotoluene 5.5615817613
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D020521 Stroke Vitamin E 3.7416517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013964 Thyroid Neoplasms decitabine 3.5417967635
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.5019087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.5017572228 16712894 8653321
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D014604 Uveal Neoplasms decitabine 5.3617785578
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
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Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162403194
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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