AutismKB 2.0

Annotation Detail for GLI2


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Basic Information Top
Gene Symbol:GLI2 ( HPE9,THP1,THP2 )
Gene Full Name: GLI family zinc finger 2
Band: 2q14.2
Quick LinksEntrez ID:2736; OMIM: 165230; Uniprot ID:GLI2_HUMAN; ENSEMBL ID: ENSG00000074047; HGNC ID: 4318
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04340Hedgehog signaling pathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200144Signaling events mediated by the Hedgehog family
200147Hedgehog signaling events mediated by Gli proteins
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1892Hypopituitarism
2024Basal cell carcinoma
Desease Name
pituitary anomalies and holoprosencephaly-like features.
Desease Name
Erectile dysfunction and prostate cancer treatment
Desease Name
Pituitary anomalies with holoprosencephaly-like features
Holoprosencephaly-9
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GLI2 mRNAdecreases expression 19150397
C014347 decitabine decitabine results in decreased expression of GLI2 mRNAdecreases expression 19363521
C014347 decitabine TP53 protein affects the reaction [decitabine results in decreased expression of GLI2 mRNA]affects reaction|decreases expression 19363521
D004958 Estradiol Estradiol affects the expression of GLI2 mRNAaffects expression 14699072
C525593 JK184 JK184 affects the activity of GLI2 proteinaffects activity 19222062
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of GLI2 mRNAdecreases expression 12057914
D008713 Methimazole Methimazole results in increased expression of GLI2 mRNAincreases expression 17399805
C494474 perchlorate perchlorate results in increased expression of GLI2 mRNAincreases expression 17399805
D011374 Progesterone Progesterone affects the expression of GLI2 mRNAaffects expression 17251523
D011441 Propylthiouracil Propylthiouracil results in increased expression of GLI2 mRNAincreases expression 17399805
D012643 Selenium Selenium results in increased expression of GLI2 mRNAincreases expression 19244175
D014284 Triiodothyronine Triiodothyronine results in increased expression of GLI2 mRNAincreases expression 17403546
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GLI2 mRNAincreases expression 16120747
17586704
D014635 Valproic Acid Valproic Acid results in increased expression of GLI2 mRNAincreases expression 19101580
D014810 Vitamin E Vitamin E results in increased expression of GLI2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5914514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.598875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9819490988
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.0918653653 11850527
MESH:D000230 Adenocarcinoma Estradiol 2.1111473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D000550 Amblyopia Valproic Acid 5.3317688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.6217497229
MESH:D001321 Autistic Disorder Valproic Acid 2.0019460635 15238991 17157402 18558336 18177632 18985861 18940202 18316065 17688650 20603192 18396377 17507914 16609825 19232924 18775368
MESH:D001478 Basal Cell Nevus Syndrome marker/mechanism 16936257
MESH:D001714 Bipolar Disorder Valproic Acid 3.1017594078 20046352
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 9.3619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.1315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.138888407
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4317868700
MESH:D001930 Brain Injuries Progesterone 4.3315665606 15380490 15845082
MESH:D001943 Breast Neoplasms decitabine 1.9619208741 18320071
MESH:D001943 Breast Neoplasms Estradiol 1.9617289903 17018787 12948864 16675129 17261762 14630087 19861407 18497071
MESH:D001943 Breast Neoplasms Progesterone 1.9616175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0016050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D002280 Carcinoma, Basal Cell marker/mechanism 10700170
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7716924424
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6119215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7720889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7718566989
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1215668235 8697196 12621046 15340226 16354765
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D003110 Colonic Neoplasms decitabine 2.3417616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.8016575769 8888407 17688650
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8019769572
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5617187935
MESH:D056486 Drug-Induced Liver Injury Selenium 6.3115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3120420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.311733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004421 Dystonia Valproic Acid 4.111851702
MESH:C538011 Eales disease Vitamin E 4.809068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0015322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.8417692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2119294695
MESH:D016889 Endometrial Neoplasms Estradiol 3.0111473722 18566989 19148513
MESH:D004715 Endometriosis Progesterone 9.1016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.1010568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.4815328337 17637181 15821434
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.233659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0116628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9618234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.637562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.377750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.153659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0920426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Valproic Acid 3.3514986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.9816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.1918558336 8888407
MESH:D005334 Fever Lipopolysaccharides 4.069205823 11852909
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0220067830
MESH:D006042 Goiter perchlorate 5.3618801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.5219215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6610048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.6616080930
MESH:D006333 Heart Failure Selenium 3.1117162251
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4316366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9615340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7216490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D016142 Holoprosencephaly marker/mechanism
MESH:D019584 Hot Flashes Estradiol 10.3817088409
MESH:D019584 Hot Flashes Vitamin E 10.3814716179
MESH:D006849 Hydrocephalus Valproic Acid 4.9517688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.148697196 16354765 15340226 18606429 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218850075 18670907
MESH:D006980 Hyperthyroidism Methimazole 5.6814678291
MESH:D007037 Hypothyroidism Methimazole 12.2018031379
MESH:D007037 Hypothyroidism Propylthiouracil 12.208137927 18031379
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4715869954
MESH:D007248 Infertility, Male decitabine 3.2417581917
MESH:D007249 Inflammation Lipopolysaccharides 8.5317963957 12878042 17255318 17237260 9205823
MESH:D007249 Inflammation Progesterone 8.5315869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5312878042 12200463
MESH:D007251 Influenza, Human Selenium 11.2916624496
MESH:D007251 Influenza, Human Vitamin E 11.2916624496
MESH:D007333 Insulin Resistance Estradiol 3.0016627594 16393666
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.6917255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Estradiol 6.2115618244
MESH:D007674 Kidney Diseases Vitamin E 6.2112488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9416518626
MESH:D007680 Kidney Neoplasms Estradiol 3.0215610895
MESH:D007938 Leukemia decitabine 3.1019235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.0619117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0319010910 18460780 19387464 17679729 18206229 18704418
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0317596541 16294345
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.5618055864
MESH:D007970 Leukopenia Lipopolysaccharides 4.7815821434
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 5.0212878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0212878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.0216169303
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1412151625
MESH:D008171 Lung Diseases Vitamin E 3.2116863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3617228818
MESH:D055370 Lung Injury Lipopolysaccharides 4.0821114838
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3219555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 2.3211062179
MESH:D008223 Lymphoma decitabine 3.4619470736
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.1911807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.1917203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.1915318939
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008545 Melanoma decitabine 2.2516505122 17785578
MESH:D008654 Mesothelioma Selenium 2.8115107826
MESH:D008881 Migraine Disorders Valproic Acid 3.2318803445 18765137
MESH:D009101 Multiple Myeloma decitabine 3.3818172295
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.088888407
MESH:D009190 Myelodysplastic Syndromes decitabine 7.6018608210 19010910 16882708 19157545
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.6017596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3216810080
MESH:D009369 Neoplasms decitabine 2.7319470736 19116145 17925555
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009421 Nervous System Malformations Estradiol 9.6816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6814600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.1616359493 8888407
MESH:D010051 Ovarian Neoplasms decitabine 8.0219259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 8.0219401270
MESH:D010051 Ovarian Neoplasms Progesterone 8.0217393432 16525653
MESH:D010190 Pancreatic Neoplasms decitabine 2.7819294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D011014 Pneumonia Lipopolysaccharides 4.6411605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.7411118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.7420603192
MESH:D055728 Primary Myelofibrosis decitabine 4.8017616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.2216740699
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2215084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.6411422049 12752131
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7610835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012208 Rhabdomyosarcoma decitabine 11.1719155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 11.1719155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8718045962
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures Valproic Acid 2.771511512 15475178 14763951 16876388 3137016 11738929 11044598 17978042
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms marker/mechanism 10700170
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0716192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.3615862959 16503802
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8219490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6412833885
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D020521 Stroke Vitamin E 3.5616517955
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.2115821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms decitabine 7.6817967635
MESH:D013964 Thyroid Neoplasms Propylthiouracil 7.6815710170
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.3317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.603119515
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.7419087683 17616700
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.718888407
MESH:D014604 Uveal Neoplasms decitabine 5.0117785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
Pathway ID Pathway Name
KEGG:05217 Basal cell carcinoma
KEGG:04340 Hedgehog signaling pathway
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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