AutismKB 2.0

Annotation Detail for GLO1


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Basic Information Top
Gene Symbol:GLO1 ( GLOD1,GLYI )
Gene Full Name: glyoxalase I
Band: 6p21.2
Quick LinksEntrez ID:2739; OMIM: 138750; Uniprot ID:LGUL_HUMAN; ENSEMBL ID: ENSG00000124767; HGNC ID: 4323
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5386methylglyoxal degradation I
Pathway IDPathway Name
hsa00620Pyruvate metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1766Renal Cell cancer
1831Prostate cancer
1836Panic disorder
1877Multiple sclerosis
2029Tuberculosis
2040Hyperglycemia
2124Autistic disorder
No data
No data
Desease Name
Autism, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049325 1,2-dithiol-3-thione 1,2-dithiol-3-thione results in decreased expression of GLO1 mRNAdecreases expression 15302862
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of GLO1 mRNAaffects expression 18343893
C026784 acemetacin acemetacin results in decreased activity of GLO1 proteindecreases activity 17243824
D000082 Acetaminophen Acetaminophen affects the expression of GLO1 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of GLO1 mRNAincreases expression 20458559
D003931 Diacetyl Diacetyl affects the activity of GLO1 proteinaffects activity 11513095
D003931 Diacetyl hexylglutathione inhibits the reaction [Diacetyl affects the activity of GLO1 protein]affects activity|decreases reaction 11513095
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of GLO1 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of GLO1 mRNA]decreases reaction|increases expression 17942915
D004047 Diethyl Pyrocarbonate Diethyl Pyrocarbonate affects the activity of GLO1 proteinaffects activity 11513095
D004047 Diethyl Pyrocarbonate hexylglutathione inhibits the reaction [Diethyl Pyrocarbonate affects the activity of GLO1 protein]affects activity|decreases reaction 11513095
D004317 Doxorubicin GLO1 mRNA results in decreased susceptibility to Doxorubicindecreases response to substance 16085563
D004317 Doxorubicin troglitazone inhibits the reaction [GLO1 mRNA results in decreased susceptibility to Doxorubicin]decreases reaction|decreases response to substance 16085563
D004317 Doxorubicin [troglitazone results in decreased expression of GLO1 mRNA] which results in increased susceptibility to Doxorubicindecreases expression|increases response to substance 16085563
D004317 Doxorubicin GLO1 protein results in decreased susceptibility to [Indomethacin co-treated with Doxorubicin]affects cotreatment|decreases response to substance 17243824
D004317 Doxorubicin [Indomethacin results in decreased activity of GLO1 protein] which results in increased susceptibility to Doxorubicindecreases activity|increases response to substance 17243824
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GLO1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GLO1 mRNAincreases expression 17108234
C033550 hexylglutathione hexylglutathione inhibits the reaction [Diacetyl affects the activity of GLO1 protein]affects activity|decreases reaction 11513095
C033550 hexylglutathione hexylglutathione inhibits the reaction [Diethyl Pyrocarbonate affects the activity of GLO1 protein]affects activity|decreases reaction 11513095
D007213 Indomethacin GLO1 protein results in decreased susceptibility to [Indomethacin co-treated with Doxorubicin]affects cotreatment|decreases response to substance 17243824
D007213 Indomethacin Indomethacin binds to and results in decreased activity of GLO1 proteinaffects binding|decreases activity 17243824
D007213 Indomethacin [Indomethacin results in decreased activity of GLO1 protein] which results in increased susceptibility to Doxorubicindecreases activity|increases response to substance 17243824
C006253 pirinixic acid pirinixic acid results in decreased expression of GLO1 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of GLO1 mRNAincreases expression 18301758
D011794 Quercetin Quercetin results in increased expression of GLO1 proteinincreases expression 17292933
D013467 Sulindac Sulindac results in decreased activity of GLO1 proteindecreases activity 17243824
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of GLO1 mRNAaffects expression 18343893
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GLO1 mRNAdecreases expression 16922920
18796159
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GLO1 mRNAincreases expression 15328365
D014046 Tolmetin Tolmetin results in decreased activity of GLO1 proteindecreases activity 17243824
C057693 troglitazone troglitazone inhibits the reaction [GLO1 mRNA results in decreased susceptibility to Doxorubicin]decreases reaction|decreases response to substance 16085563
C057693 troglitazone troglitazone results in decreased activity of GLO1 proteindecreases activity 12572858
C057693 troglitazone troglitazone results in decreased expression of GLO1 mRNAdecreases expression 12572858
C057693 troglitazone [troglitazone results in decreased expression of GLO1 mRNA] which results in increased susceptibility to Doxorubicindecreases expression|increases response to substance 16085563
D014501 Uranium Uranium affects the expression of GLO1 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of GLO1 mRNAaffects expression 15672453
C020549 zomepirac zomepirac results in decreased activity of GLO1 proteindecreases activity 17243824
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.3914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7415322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8417505938
MESH:D058186 Acute Kidney Injury Sulindac 14.507897758
MESH:D058186 Acute Kidney Injury Tolmetin 14.506375363
MESH:D058186 Acute Kidney Injury zomepirac 14.503901736 7078269 6375363
MESH:D055371 Acute Lung Injury pirinixic acid 3.0118653653
MESH:D000230 Adenocarcinoma arsenic trioxide 13.2811798837 19825857
MESH:D000230 Adenocarcinoma Doxorubicin 13.2817418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 13.2814692618
MESH:D000230 Adenocarcinoma Indomethacin 13.2816537180
MESH:D000230 Adenocarcinoma Sulindac 13.2811910360
MESH:D000236 Adenoma Diethylnitrosamine 11.0110737359 6695378
MESH:D000236 Adenoma Indomethacin 11.0111497255
MESH:D000236 Adenoma Sulindac 11.0110223192
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.6519052882 19061943 17620307 16434500 17162532 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.6516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.6516835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.5015623613 11874996 17611924 11535846 12394442 19003578 16460482
MESH:D000419 Albuminuria Doxorubicin 4.4421441931
MESH:D016301 Alveolar Bone Loss Indomethacin 5.2717225004
MESH:D000544 Alzheimer Disease Indomethacin 2.6817627676 15579461
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.1417084956
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.7410231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.7610388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3611256880
MESH:D018771 Arthralgia Indomethacin 5.062160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6015885639
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8011248219
MESH:D001260 Ataxia Telangiectasia Quercetin 4.8715336622
MESH:D001321 Autistic Disorder marker/mechanism 15386471
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001327 Autoimmune Diseases Quercetin 4.3019761891
MESH:D001477 Bartter Syndrome Indomethacin 4.8710684365
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.6916206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.6919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.6912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6915746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5914601052
MESH:D001913 Bowen's Disease Sulindac 5.2511207687
MESH:D001929 Brain Edema Indomethacin 4.9211481608
MESH:D002545 Brain Ischemia Indomethacin 4.3112524144
MESH:D001932 Brain Neoplasms Doxorubicin 3.7117150277
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9217474063
MESH:D001943 Breast Neoplasms Doxorubicin 2.9216096432 17983394 15668708 18382427 18234424 16115903 18628466 15994142 16264153 16595493 15939500 17369602 19526202 16322301 18695136 16826403 15634643 15993339 15136595 17426702 16935488 11325840 15692762 15567936
MESH:D001943 Breast Neoplasms Indomethacin 2.9217401462
MESH:D001943 Breast Neoplasms Quercetin 2.9218628248
MESH:D001943 Breast Neoplasms Sulindac 2.9216642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9220435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2211589617
MESH:D002056 Burns Indomethacin 4.5910459503
MESH:D002100 Cachexia Indomethacin 4.9015141370 16537180 15625704 11239499
MESH:D002105 Cadmium Poisoning Quercetin 5.4416962696
MESH:D002276 Carcinoid Tumor Doxorubicin 4.7016051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7116835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.173084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.1715553829 11135700 15073043 16217749 14691202
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.1720101231 19539802 20007298 17138121 19383236 16328049 20524982 17173139 19107877 19919837 17428255 16502159 19519916 18785209 19394651 20514400 18494052 20727157 3581430 16807293 20432363 17761372 18056438 16878318 18971187 18506893 18691550 19208518 16681979 16569478 20935162 10672840 18665156 17055752 21159647 19052882 10737359 16288022 19335982 18210153 11831363 3084413 19418558 19701751 16779866 17978847 20084675 18393292 19822196 18788625 16540662 19171122 17162532 16935385 20512989 16830150 16698587 20214788 18978308
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 11.1716023760 18059187 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 11.1716391822
MESH:D006528 Carcinoma, Hepatocellular Quercetin 11.1719519916 12508355
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.6211053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.2411352223 14736730 18791128
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.8517234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7719014326
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.6416201981 1485588
MESH:D002292 Carcinoma, Renal Cell Indomethacin 6.6417341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0212490120
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.886189445
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 4.8815482327 12636206
MESH:D006332 Cardiomegaly Quercetin 6.6019794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.6018670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.4615792986 17351982 16651473 16269455 17308081 17519947 16612575 18627295 16455267 15476868 15811867 17329180 17382496 15505089 17924179 16109756 16952015 17131338 17974986 16731534 16242529 16364871 16278810 17928571 17007740
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9117334414 16243910
MESH:D002386 Cataract Acetaminophen 2.5210977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.7817174075 21159647 7505956 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.0119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.0116835633
MESH:D002764 Cholecystitis Indomethacin 5.0611181007
MESH:D002779 Cholestasis Ethinyl Estradiol 7.4716105132 15861022 17681005 17110522 16919318 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 7.4719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0616354765 15340226 12621046 8697196 15668235
MESH:D003110 Colonic Neoplasms Indomethacin 5.9115625704 15936596 15963497 15786552 15637740 11260862
MESH:D003110 Colonic Neoplasms Quercetin 5.9111134977 19056647 17191121 16640504 19440933 15741050 17148506
MESH:D003110 Colonic Neoplasms Sulindac 5.9112458338 12902858
MESH:D015179 Colorectal Neoplasms arsenic trioxide 6.3920501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 6.3918802399 18259882
MESH:D015179 Colorectal Neoplasms Indomethacin 6.3917054584 12606626 18059344 11197048
MESH:D015179 Colorectal Neoplasms Quercetin 6.3918852136 18095365
MESH:D015179 Colorectal Neoplasms Sulindac 6.3918059344 10666051 11197048 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9617141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0812609071
MESH:D003328 Coronary Thrombosis zomepirac 6.026188907
MESH:D003329 Coronary Vasospasm zomepirac 6.506610944
MESH:D018352 Coronavirus Infections Indomethacin 5.6117302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.4410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4410048152 20055451 15322242
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9915213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.6419496084
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.0920387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.0917107852
MESH:D003924 Diabetes Mellitus, Type 2 troglitazone 7.0916023994
MESH:D003925 Diabetic Angiopathies troglitazone 5.5112601628
MESH:D003930 Diabetic Retinopathy Sulindac 5.0712861449 17621415
MESH:D003967 Diarrhea Indomethacin 3.697907874 7237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.6916081117 19370779 17522070 18713872 11421492 11529661 12705907 12594235 12958197 2444490 16177239 19420014 19739265 12392966 19085960 14550746 19416960 16109766 15968718 10663392 14986274 11739529 11461765 17562736 14725611 16485898 16781746 19923254 11834606 10774834 16227642 19164858 12153990 11743745 10915739 16393943 17906064 15619225 18071297 12540782 11287661
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.6919107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.6917416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.6920420201
MESH:D056486 Drug-Induced Liver Injury troglitazone 11.6914986274
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004362 Drug Toxicity Doxorubicin 7.8418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.8411462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.0416326151 12774134 18043480 16133044 18446180 17190690
MESH:D004381 Duodenal Ulcer Indomethacin 4.0317329845 11595431 17045617 16699067 17151854 17202747 11535926 17351913 11595415 11991626 10671773
MESH:D004487 Edema Indomethacin 10.8619703484 8985016 16100529 8273558 7907874 7990266 10653021
MESH:D004487 Edema pirinixic acid 10.8612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.8611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0812538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.3817359293
MESH:D004715 Endometriosis Indomethacin 14.8315652904
MESH:D004715 Endometriosis Sulindac 14.8315652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.8310568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0518037988
MESH:D019446 Endotoxemia Indomethacin 4.3918509659
MESH:D004751 Enteritis Indomethacin 4.6410567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.8717980183
MESH:D004802 Eosinophilia Indomethacin 3.9411298111
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0116302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.3012903497
MESH:D004938 Esophageal Neoplasms Indomethacin 7.3011005569
MESH:D004938 Esophageal Neoplasms Sulindac 7.3012235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005234 Fatty Liver arsenic trioxide 17.9215073043
MESH:D005234 Fatty Liver Diethylnitrosamine 17.9220387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.9215345470
MESH:D005234 Fatty Liver pirinixic acid 17.9220131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005334 Fever Indomethacin 4.0211852909 10431976 17627676
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.3714745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 11.4319069698
MESH:D018222 Fibromatosis, Aggressive Sulindac 11.4319069698
MESH:D005354 Fibrosarcoma Indomethacin 4.7810962813
MESH:D005355 Fibrosis Indomethacin 14.2717994277
MESH:D005355 Fibrosis Quercetin 14.2719474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.2720067830
MESH:D005499 Folliculitis Indomethacin 5.0611298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1516904648
MESH:D005756 Gastritis Acetaminophen 10.7916983495
MESH:D005756 Gastritis Indomethacin 10.7915046732
MESH:D005764 Gastroesophageal Reflux Sulindac 4.9011910360
MESH:D005909 Glioblastoma Doxorubicin 11.6117150277
MESH:D005909 Glioblastoma Indomethacin 11.6112870263
MESH:D005909 Glioblastoma Quercetin 11.6119804834
MESH:D005910 Glioma Indomethacin 6.1718371953 16487511
MESH:D005910 Glioma Quercetin 6.1717643826
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.1911849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006073 Gout Indomethacin 5.2411248219
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.8015692506
MESH:D006258 Head and Neck Neoplasms Indomethacin 7.8015482327
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 6.7911294989
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7910048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.4116244371 16244372 16330681 18006777 16707910 17875725 16144979 16495754 17888722 14766674 18674790 16879835 12587719
MESH:D006333 Heart Failure Doxorubicin 6.8317481944
MESH:D006333 Heart Failure pirinixic acid 6.8320558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8015692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.4715633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.5715135802
MESH:D006529 Hepatomegaly pirinixic acid 7.9016221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.9016120746 15340226 12621046
MESH:D006689 Hodgkin Disease Doxorubicin 3.3117606976 18501091 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9415340226 8697196 16959395 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.5416870215
MESH:D006930 Hyperalgesia Indomethacin 7.5412727271
MESH:D034321 Hyperamylasemia Indomethacin 5.6117883296
MESH:D006940 Hyperemia Indomethacin 4.9012524144
MESH:D006943 Hyperglycemia pirinixic acid 8.9120558911
MESH:D006943 Hyperglycemia Quercetin 8.9111834736 18262572
MESH:D006949 Hyperlipidemias Indomethacin 4.0617546600
MESH:D006973 Hypertension Quercetin 5.0918356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7016945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.9218306037 10574470
MESH:D007079 Ileitis Indomethacin 5.2410651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.2716133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4117937319
MESH:D007249 Inflammation Diethylnitrosamine 15.3218785209
MESH:D007249 Inflammation Indomethacin 15.3212568917 7812673 3291741
MESH:D007249 Inflammation Sulindac 15.323291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.3212200463 12878042
MESH:D007249 Inflammation Tolmetin 15.323291741
MESH:D007251 Influenza, Human Quercetin 4.4016624496
MESH:D007333 Insulin Resistance pirinixic acid 2.5616306350
MESH:D007410 Intestinal Diseases Indomethacin 4.2217994277 15831440 11686837 11713966 15610444 17329856 10210152 18236018 11855677
MESH:D007414 Intestinal Neoplasms Sulindac 4.5412628509 12584176 12351151 10213222 12663524 10223192
MESH:D007417 Intestinal Polyps Sulindac 4.8811245490 12394442
MESH:D019586 Intracranial Hypertension Indomethacin 5.2715241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2316580747
MESH:D007579 Jejunal Diseases Indomethacin 4.9210574470 16133968 18306037
MESH:D007627 Keloid Quercetin 4.8517086741
MESH:D007674 Kidney Diseases Acetaminophen 13.9812587719 15629191
MESH:D007674 Kidney Diseases Doxorubicin 13.9815369732 16775033 15699352
MESH:D007674 Kidney Diseases Indomethacin 13.9817190690
MESH:D007674 Kidney Diseases Quercetin 13.9816962696
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0516707910
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.8112228301 10320625 11703811
MESH:D007938 Leukemia arsenic trioxide 6.3015070760
MESH:D007938 Leukemia Quercetin 6.3017468513
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 13.8816085563
MESH:D004915 Leukemia, Erythroblastic, Acute troglitazone 13.8816085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6912560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.2814633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 8.2810785260 15631656 16572323
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6619077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0216467208 16968895 19850784 17050201 20471514
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 4.0218360721
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1411161223 19642359 17869043 17712046 15748426 9834237 12712474 16112521 16331271 11468182 15336539 17107899 17217047 16891316 12018890 15213294 16330433 19035177 15622746 19075265 12679006 19225113 16823087 17649720 16966277
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2416882451
MESH:D007964 Leukocytosis Indomethacin 5.2716537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.6117980183
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.6111479899
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.7619638242 18665156 18407596 18522880 20032147
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.1612468960
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.6016439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 6.6018194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.6015474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.6012741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6012878042
MESH:D008107 Liver Diseases Acetaminophen 6.4319460945 11587558 19014921 16610002 12969438 12587719 19784758 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 6.4317034775
MESH:D008107 Liver Diseases Sulindac 6.4314986274 16867024
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1416871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 13.8014682389
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.8019256749 21167192 20118626 19850985 19642983 19255062 10737359 20583210 18978307 19294768 16942905 20434301 19833225 19996281 20405173 12112319 2422723 19426721 15885732 19690152 19090486 18648771 20492335 12771043 9163691 18977376 2862719 15175105 19427195 21278145 19073162 19638242 19551842 21047994 20501860 20101389 21071580 20137499 19254457 19499222 18644402 19812893 20452335 18754104
MESH:D008113 Liver Neoplasms pirinixic acid 13.8015890375 16377806 20007298
MESH:D008113 Liver Neoplasms Quercetin 13.8018980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.8016984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 17.9320377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.9317942915 19539802 17174075 18079962 21159647 18775883 19126423 18544905 18164116 19009564 18253720 3124819 18093689 16267830 19004024 18282651 19519916 16842330 9362446 17854601 2563599 18308698
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 17.9316842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Quercetin 17.9319519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.9312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2615213294
MESH:D008175 Lung Neoplasms arsenic trioxide 10.5111798837 19825857
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.5120970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Doxorubicin 10.5117418594 6189445
MESH:D008175 Lung Neoplasms Indomethacin 10.5111053908 11497255 16537180
MESH:D008175 Lung Neoplasms Quercetin 10.5116280456
MESH:D008175 Lung Neoplasms Sulindac 10.5115713900 19359593
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.5111884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.3816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7017654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4615621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 2.9615458769
MESH:D008545 Melanoma Doxorubicin 3.7016827129
MESH:D008545 Melanoma Sulindac 3.7016642371
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D008654 Mesothelioma Doxorubicin 3.0217638057
MESH:D008881 Migraine Disorders Indomethacin 3.6011903285
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4015792986
MESH:D009062 Mouth Neoplasms Indomethacin 3.9012636206
MESH:D052016 Mucositis Doxorubicin 4.6817415656
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0314977855 19417148 15949261 11468182 19549372
MESH:D009135 Muscular Diseases pirinixic acid 3.4016239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0816105982 16882451
MESH:D009203 Myocardial Infarction Doxorubicin 9.2415857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 9.2419151258
MESH:D009203 Myocardial Infarction Quercetin 9.2419595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1516411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.1519207477
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8516624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.363581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.3618259882
MESH:D009362 Neoplasm Metastasis Indomethacin 9.3611239499 16537180 11053908
MESH:D009369 Neoplasms pirinixic acid 4.8717405874
MESH:D009369 Neoplasms Quercetin 4.8715185748
MESH:D009374 Neoplasms, Experimental Indomethacin 4.0315625704 10663608
MESH:D009395 Nephritis, Interstitial Tolmetin 11.716375363
MESH:D009395 Nephritis, Interstitial zomepirac 11.716375363
MESH:D009401 Nephrosis Doxorubicin 4.6616636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.9015640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1114600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.0410525206
MESH:D009447 Neuroblastoma Doxorubicin 3.2115555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 25.4118514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 25.4120387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 25.4112349958
MESH:D019636 Neurodegenerative Diseases Sulindac 25.4117266991 16850258
MESH:D019636 Neurodegenerative Diseases Tolmetin 25.4117266991 16850258
MESH:D020078 Neurogenic Inflammation Quercetin 4.2617929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0120387270
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.066374098
MESH:D010003 Osteoarthritis Indomethacin 3.607009135
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.1119495926
MESH:D012516 Osteosarcoma Doxorubicin 4.0215930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.9019769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Quercetin 4.9019005980
MESH:D010146 Pain Acetaminophen 20.3216870215
MESH:D010146 Pain Indomethacin 20.323291741 13679232 17627676 17440234
MESH:D010146 Pain Sulindac 20.323291741
MESH:D010146 Pain Tolmetin 20.323291741
MESH:D010146 Pain zomepirac 20.326776300 121342 20225289 6995502 6363464
MESH:D010149 Pain, Postoperative Indomethacin 4.5718702446 12538197
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.0715580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 12.0716540662
MESH:D010190 Pancreatic Neoplasms Quercetin 12.0716965848
MESH:D010190 Pancreatic Neoplasms Sulindac 12.0716820089 11504793
MESH:D010195 Pancreatitis Indomethacin 3.8215028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5811578682
MESH:D010235 Paraganglioma arsenic trioxide 4.0619927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.6116537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.0212349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.6111903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010437 Peptic Ulcer Indomethacin 5.0411148446
MESH:D010518 Periodontitis Indomethacin 4.8117225004
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0517983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.0517638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.912563599
MESH:D011230 Precancerous Conditions Quercetin 8.9119056647
MESH:D047928 Premature Birth Indomethacin 5.0217000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0811118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7019131511
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.7016729912 18437689 15897917 15749863 16868541 16888761
MESH:D011471 Prostatic Neoplasms Quercetin 2.7017292933 14715546
MESH:D011507 Proteinuria Indomethacin 15.4811849393
MESH:D011507 Proteinuria Tolmetin 15.486375363
MESH:D011507 Proteinuria zomepirac 15.486375363
MESH:D011537 Pruritus Ethinyl Estradiol 3.2016919318 15861022
MESH:D011658 Pulmonary Fibrosis troglitazone 3.8518162602
MESH:D051437 Renal Insufficiency Doxorubicin 4.1117922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.3319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012509 Sarcoma Doxorubicin 3.8917710206 16767912 17203757 15625365 15675481 18313854
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.9216646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.9216326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6817846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.4416862918
MESH:D012878 Skin Neoplasms Doxorubicin 5.5215692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5216192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4615625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8416709447
MESH:D013272 Stomach Diseases Indomethacin 4.3118209964 10486359 10192188 15472012 16280098 10215738 16113693 17160473 16184426 17207306 17638125 15038085 18545984
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.7217007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.7218456281
MESH:D013274 Stomach Neoplasms Indomethacin 4.7215609394
MESH:D013274 Stomach Neoplasms troglitazone 4.7215930296
MESH:D013276 Stomach Ulcer Indomethacin 3.4818543354 11595415 15138204 17654042 18237397 18087811 16150113 16252198 10750652 12500499 17135157 18726076 18431645 11729361 15104355 18299717 16755016 11145282 17627676 12787963 10423059 18181030 17977527 14567935 17895592 12467913 11906479 18209962 11523592 12498302 15255614 11595431 1323529 16934674 10878458 17918041 12077510 18193104 16397915 17657623 16631530 16169175
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 16.4519014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 16.457505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 16.4517909728 16010429
MESH:D013964 Thyroid Neoplasms Indomethacin 16.4518791128 11352223 14736730
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8515213294
MESH:D014456 Ulcer Indomethacin 4.7810574470 17380554
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.1911780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.1917653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.1916720314
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.3114692618
MESH:D014594 Uterine Neoplasms Sulindac 9.3118645019
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1117678736 16364871 17334414 17638931
MESH:D014839 Vomiting Indomethacin 4.6411897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
Pathway ID Pathway Name
KEGG:00620 Pyruvate metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28724
    • No data
    Releated disease ID Related disease Name
    PA445528Restless Legs Syndrome
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00143 - BSS Plus Dietary supplement;Micronutrient
    DB00328 inhibitor Indomethacin Anti-inflammatory Agents;Cyclooxygenase Inhibitors;Tocolytic Agents;Cardiovascular Agents;Nonsteroidal Anti-inflammatory Agents (NSAIAs);Gout Suppressants
    DB03130 - S-P-Nitrobenzyloxycarbonylglutathione
    DB03330 - S-(N-Hydroxy-N-Iodophenylcarbamoyl)Glutathione
    DB03345 - 2-Sulfhydryl-Ethanol
    DB03602 - S-Benzyl-Glutathione
    DB04132 - S-Hexylglutathione Enzyme Inhibitors
    DB08179 - methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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