AutismKB 2.0

Annotation Detail for BIN1


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Basic Information Top
Gene Symbol:BIN1 ( AMPH2,AMPHL,DKFZp547F068,MGC10367,SH3P9 )
Gene Full Name: bridging integrator 1
Band: 2q14.3
Quick LinksEntrez ID:274; OMIM: 601248; Uniprot ID:BIN1_HUMAN; ENSEMBL ID: ENSG00000136717; HGNC ID: 1052
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200046Arf6 trafficking events
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
No data
No data
Desease Name
Myopathy, centronuclear, autosomal recessive
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of BIN1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of BIN1 mRNAaffects expression 17562736
C000188 alachlor alachlor results in increased expression of BIN1 mRNAincreases expression 12419858
D000643 Ammonium Chloride Ammonium Chloride affects the expression of BIN1 mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in increased expression of BIN1 mRNAincreases expression 20106945
D018021 Lithium Chloride Lithium Chloride results in increased expression of BIN1 mRNAincreases expression 19410610
D017239 Paclitaxel Paclitaxel results in increased expression of BIN1 mRNAincreases expression 19682730
D011374 Progesterone Progesterone results in increased expression of BIN1 mRNAincreases expression 18037150
D012643 Selenium Selenium results in increased expression of BIN1 mRNAincreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of BIN1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000382 Agricultural Workers' Diseases alachlor 4.8914769641 11874814
MESH:D000544 Alzheimer Disease marker/mechanism 21460841
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001859 Bone Neoplasms Paclitaxel 4.7515867366
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6017868700
MESH:D001930 Brain Injuries Progesterone 4.4715845082 15380490 15665606
MESH:D001943 Breast Neoplasms Paclitaxel 2.4815136595 16115903 18323546 11325840 16273361 18234424 18223236 16244791
MESH:D001943 Breast Neoplasms Progesterone 2.4815562024 16175315 17614352
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.743084413
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 4.7416313753
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.966135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9612371664
MESH:D002779 Cholestasis Cyclosporine 3.0419486331
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4418802399
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.2318551238
MESH:D017449 Dermatitis, Allergic Contact alachlor 4.408428444
MESH:D003929 Diabetic Neuropathies Progesterone 4.7117187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4612705907 16177239 12153990 19739265 11739529 11287661 17906064 16081117 12540782 16109766 18071297 14986274 11743745 11461765 18713872 16781746 16393943 14725611 12958197 19416960 11529661 10915739 19164858 15968718 10663392 19085960 15619225 14550746 19370779 16227642 17522070 12594235 11834606 17562736 10774834 16485898 19923254 11421492 2444490 12392966 19420014
MESH:D056486 Drug-Induced Liver Injury Selenium 6.4615131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9817692515
MESH:D004715 Endometriosis Progesterone 3.9316134523
MESH:D004938 Esophageal Neoplasms Paclitaxel 2.9316481741
MESH:D005234 Fatty Liver Cyclosporine 3.0319224547
MESH:D005355 Fibrosis Cyclosporine 3.3612639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0716080930
MESH:D006333 Heart Failure Selenium 3.1717162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006869 Hydronephrosis Lithium Chloride 6.2819797860
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6215869954
MESH:D007248 Infertility, Male alachlor 4.2512948887 17049205 16466525
MESH:D007249 Inflammation Progesterone 2.6815869954
MESH:D007251 Influenza, Human Selenium 11.8616624496
MESH:D007251 Influenza, Human Vitamin E 11.8616624496
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 10.5512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.5510903974 8314463 18776723
MESH:D007674 Kidney Diseases Vitamin E 10.5512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.7612371664
MESH:D007938 Leukemia alachlor 4.0914769641
MESH:D008080 Liposarcoma Paclitaxel 5.0117353645
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Acetaminophen 1.6616610002 12969438 12587719 16611625 11587558 19460945 19784758 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.217678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.642876784 6135515 2876786
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.2314749477
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.4817203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.4815318939
MESH:D008545 Melanoma Paclitaxel 2.6116342250 12025231 12040289
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009101 Multiple Myeloma alachlor 8.3414769641
MESH:D009101 Multiple Myeloma Paclitaxel 8.3414749477
MESH:D020914 Myopathies, Structural, Congenital marker/mechanism 17676042
OMIM:255200 MYOPATHY, CENTRONUCLEAR, 2 marker/mechanism
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.107678174 18551238
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.3115867366
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009669 Nose Neoplasms alachlor 5.0614563481 11127290 16698726 15580706 16178123
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5916049721
MESH:D010014 Osteolysis Paclitaxel 5.2215867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 5.3111161223
MESH:D010051 Ovarian Neoplasms Progesterone 5.3117393432 16525653
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D011141 Polyuria Lithium Chloride 6.2419692487
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.4716356831 16729912 17172428 17136230
MESH:D011471 Prostatic Neoplasms Vitamin E 3.4715084515
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D012135 Respiratory Sounds alachlor 5.1611874814
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6418551238
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D013119 Spinal Cord Injuries Progesterone 4.5216503802 15862959
MESH:D013274 Stomach Neoplasms Paclitaxel 2.4418506536 18396642
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D024801 Tauopathies Paclitaxel 5.0516930453
MESH:D013964 Thyroid Neoplasms alachlor 4.408812207
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3416049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5610091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:03015 mRNA surveillance pathway
KEGG:03013 RNA transport
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25355
    • No data
    No data
    Releated drug ID Related drug Name
    PA448976choline
    PA164743471adenosine triphosphate
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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