AutismKB 2.0

Annotation Detail for GLRB


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Basic Information Top
Gene Symbol:GLRB ( - )
Gene Full Name: glycine receptor, beta
Band: 4q32.1
Quick LinksEntrez ID:2743; OMIM: 138492; Uniprot ID:GLRB_HUMAN; ENSEMBL ID: ENSG00000109738; HGNC ID: 4329
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
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Related Diseases/Disorders Top
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Desease Name
Hyperekplexia, autosomal recessive
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of GLRB mRNAincreases expression 17403535
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GLRB mRNAincreases expression 19285098
D020849 Raloxifene Raloxifene affects the expression of GLRB mRNAaffects expression 14699072
D013629 Tamoxifen Tamoxifen affects the expression of GLRB mRNAaffects expression 14699072
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.2714745880
MESH:D000419 Albuminuria Raloxifene 5.1017451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.6015800139
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 5.7115146954
MESH:D001161 Arteriosclerosis Cyclophosphamide 5.1615014928
MESH:D001930 Brain Injuries Raloxifene 5.0416580743
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.0612006526 11325840 17020986 17388661 18323546 18234424 16978400 15136595 15093573
MESH:D001943 Breast Neoplasms Raloxifene 2.0616837676 15572757 16912660 15758505 17595753 17893378 17242785 15775269 17952589 17440819 17049068 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 2.0617242785 18351453 18629630 19189210 19142967 17893378 16202921 18815881 19059307 11161223 16273361 18855134 17440819 19155303 15565566 20544844 19487384 19221464 19200415 19011961 18997820 19084267 16873071 20135344 18425577 19115204 21138602 19189212 17261762 20390343 18821012 15668708 20005174 19244106 20859285 18984771 19066611 19289846 19288272 21152245 19103187 20065188 16818667 19410462 17049068
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 5.0719066611
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 3.4419701751
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.4416924424
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.5216152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 3.6916201981
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.8417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.8417572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.7115775269
MESH:D003072 Cognition Disorders Raloxifene 5.1815800139
MESH:D003556 Cystitis Cyclophosphamide 5.7116989017 12161096 16651033 15643279 17979934 18372110 18483878 10498854 12388444 18093676 16413132 12913760 18710439 18433785 18295254 16614059 10700343 15276878 11948286 17010015
MESH:D003711 Demyelinating Diseases Tamoxifen 4.9219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.5317474826
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.4111751995 10990075 15331540
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.3118772604
MESH:D003928 Diabetic Nephropathies Raloxifene 10.2817451421 15920148 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 10.2819279558
MESH:D004487 Edema Raloxifene 3.7615860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.9815845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.9819031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2916202921 20544844 19155303 17893378
MESH:D004802 Eosinophilia Cyclophosphamide 4.7711006010
MESH:D005234 Fatty Liver Raloxifene 9.4317473493
MESH:D005234 Fatty Liver Tamoxifen 9.4319224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.1614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.8119069698
MESH:D018316 Gliosarcoma Cyclophosphamide 6.1511389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.6016376943 11014644 15172196
MESH:D006331 Heart Diseases Raloxifene 3.8011110106
MESH:D006467 Hemophilia A Cyclophosphamide 5.8511918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 6.2614986274
MESH:D006689 Hodgkin Disease Cyclophosphamide 4.1516135485 17606976
OMIM:149400 HYPEREKPLEXIA, HEREDITARY marker/mechanism
MESH:D006973 Hypertension Raloxifene 2.9815787275 17577099
MESH:D007154 Immune System Diseases Cyclophosphamide 6.0516076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.8716517039 7193160
MESH:D007249 Inflammation Tamoxifen 2.5319457130
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3818625569
MESH:D007889 Leiomyoma Raloxifene 4.9616973256
MESH:D007938 Leukemia Cyclophosphamide 3.6610602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.6318172266 17802794 17296974 17658394 18587576 17008537
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.3810373061
MESH:D007970 Leukopenia Cyclophosphamide 5.6011830472 10052129
MESH:D008064 Lipidoses Tamoxifen 3.4315342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008113 Liver Neoplasms Tamoxifen 2.3316684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D008223 Lymphoma Cyclophosphamide 4.1112854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 5.0616675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.5111911406
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3919428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8611731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 5.2719453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.8115990972
MESH:D008546 Melanoma, Experimental Cyclophosphamide 5.3616388313
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.2815863610
MESH:D009101 Multiple Myeloma Raloxifene 3.7116497877
MESH:D009232 Myxoma Raloxifene 6.2816343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6119410462
MESH:D009369 Neoplasms Cyclophosphamide 3.2918854779
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.7219200415 19196722 19189210
MESH:D009447 Neuroblastoma Cyclophosphamide 3.818761367 15176712 16115947
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.528761367 12837982
MESH:D009503 Neutropenia Cyclophosphamide 4.798291058
MESH:D009845 Oligospermia Cyclophosphamide 5.3416517039
MESH:D010024 Osteoporosis Raloxifene 3.6119059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.6917823083 15579764 17893378 15758505
MESH:D010146 Pain Cyclophosphamide 3.9618093676 12161096
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 3.2911332152
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 4.0021297632
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.6417136230
MESH:D011471 Prostatic Neoplasms Raloxifene 2.6416220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6415067354
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.4016636934
MESH:D011693 Purpura Raloxifene 6.2815770314
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.2816636934
MESH:D013088 Spermatocele Tamoxifen 5.0216709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 6.1516517039
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.6719457130
MESH:D020521 Stroke Raloxifene 4.1516837676
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.6912837982
MESH:D013978 Tibial Fractures Raloxifene 5.9319048282
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 9.2214692829
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 9.2217572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 9.2216712894 8653321 17572228
MESH:D054556 Venous Thromboembolism Raloxifene 5.9316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.2816343187
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00145 - Glycine Dietary supplement;Micronutrient;Non-Essential Amino Acids;Glycine Agents
DB00431 antagonist Dermadex Crm Antiscabies Agent;Scabicide;Insecticides
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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