AutismKB 2.0

Annotation Detail for POLM


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:POLM ( FLJ35482,Pol Mu,Tdt-N )
Gene Full Name: polymerase (DNA directed), mu
Band: 7p13
Quick LinksEntrez ID:27434; OMIM: 606344; Uniprot ID:DPOLM_HUMAN; ENSEMBL ID: ENSG00000122678; HGNC ID: 9185
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03450Non-homologous end-joining
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of POLM mRNAaffects expression 17562736
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of POLM mRNAaffects binding|increases activity|increases expression 19710929
D020849 Raloxifene Raloxifene results in increased expression of POLM mRNAincreases expression 16497877
D013654 Taurine Taurine results in increased expression of POLM mRNAincreases expression 16579726
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D000419 Albuminuria Raloxifene 5.1017451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.6015800139
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D001930 Brain Injuries Raloxifene 5.0416580743
MESH:D001943 Breast Neoplasms Raloxifene 2.6317893378 15775269 16912660 17049068 16837676 17440819 15572757 17242785 17595753 17261762 15758505 17952589
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.4717572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.7115775269
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D003072 Cognition Disorders Raloxifene 5.1815800139
MESH:D003865 Depressive Disorder, Major Raloxifene 4.5317474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D058065 Diabetic Cardiomyopathies Taurine 6.6816025228
MESH:D003928 Diabetic Nephropathies Raloxifene 4.3017308373 17451421 15920148
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.6116781746 19370779 17906064 16081117 10663392 16177239 14725611 19923254 10915739 2444490 11461765 16393943 12705907 14550746 14986274 16109766 11421492 12540782 11834606 17562736 19739265 11529661 18071297 15968718 11287661 15619225 19416960 12594235 17522070 19085960 18713872 12392966 12958197 19164858 12153990 10774834 16227642 11743745 11739529 19420014 16485898
MESH:D056486 Drug-Induced Liver Injury Taurine 4.619328219
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004487 Edema pirinixic acid 8.3312083418
MESH:D004487 Edema Raloxifene 8.3315860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 4.5015845917
MESH:D005234 Fatty Liver pirinixic acid 9.2920131406 19236843
MESH:D005234 Fatty Liver Raloxifene 9.2917473493
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006331 Heart Diseases Raloxifene 3.8011110106
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006529 Hepatomegaly pirinixic acid 3.5518467677 16221962 19772884 19176532
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D006973 Hypertension Raloxifene 2.9815787275 17577099
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007674 Kidney Diseases Acetaminophen 2.4012587719 15629191
MESH:D007889 Leiomyoma Raloxifene 4.9616973256
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.9715474484
MESH:D008106 Liver Cirrhosis, Experimental Taurine 2.9715893842 15931870
MESH:D008107 Liver Diseases Acetaminophen 1.7019784758 12587719 19460945 16611625 16610002 11587558 12969438 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.9315890375 20007298 16377806
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.2815863610
MESH:D009101 Multiple Myeloma Raloxifene 3.7116497877
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009232 Myxoma Raloxifene 6.2816343187
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010024 Osteoporosis Raloxifene 3.6119059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.6917823083 15579764 17893378 15758505
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D011471 Prostatic Neoplasms Raloxifene 3.5416220300 16536755 15731164
MESH:D011693 Purpura Raloxifene 6.2815770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D020521 Stroke Raloxifene 4.1516837676
MESH:D013978 Tibial Fractures Raloxifene 5.9319048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.9317572228
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D054556 Venous Thromboembolism Raloxifene 5.9316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.2816343187
Pathway ID Pathway Name
KEGG:03450 Non-homologous end-joining
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved