Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
---|
D004958 |
Estradiol |
ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to CECR6 gene]] | affects binding|affects reaction|increases reaction | 17962382
|
D004958 |
Estradiol |
ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to CECR6 gene]] | affects binding|affects reaction|increases reaction | 17962382
|
D004958 |
Estradiol |
ESR1 protein affects the reaction [Estradiol promotes the reaction [NCOA3 protein binds to CECR6 gene]] | affects binding|affects reaction|increases reaction | 17962382
|
D004958 |
Estradiol |
ESR2 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to CECR6 gene]] | affects binding|affects reaction|increases reaction | 17962382
|
D004958 |
Estradiol |
Estradiol promotes the reaction [ESR1 protein binds to CECR6 gene] | affects binding|increases reaction | 17962382
|
D004958 |
Estradiol |
Estradiol promotes the reaction [ESR2 protein binds to CECR6 gene] | affects binding|increases reaction | 17962382
|
D004958 |
Estradiol |
Estradiol results in increased expression of CECR6 mRNA | increases expression | 17962382
|
D013629 |
Tamoxifen |
Tamoxifen results in increased expression of CECR6 mRNA | increases expression | 17962382
|
Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
---|
MESH:D000008 |
Abdominal Neoplasms |
|
Tamoxifen |
5.62 | 14745880 |
MESH:D000230 |
Adenocarcinoma |
|
Estradiol |
2.18 | 11473722 |
MESH:D001943 |
Breast Neoplasms |
|
Estradiol |
2.08 | 17018787 17289903 16675129 19861407 14630087 12948864 18497071 17261762 |
MESH:D001943 |
Breast Neoplasms |
|
Tamoxifen |
2.08 | 18821012 19011961 18997820 19221464 19244106 18855134 16273361 17893378 17242785 18815881 19059307 18351453 19066611 18629630 20065188 19142967 20135344 19189210 16818667 19189212 19155303 16202921 11161223 19084267 20859285 19487384 15668708 19200415 18425577 19289846 19115204 20390343 20544844 17049068 19410462 21152245 17440819 17261762 21138602 19288272 16873071 18984771 20005174 15565566 19103187 |
MESH:D002181 |
Candidiasis, Vulvovaginal |
|
Estradiol |
5.35 | 16111702 |
MESH:D018270 |
Carcinoma, Ductal, Breast |
|
Tamoxifen |
5.27 | 19066611 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Estradiol |
3.15 | 16924424 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Tamoxifen |
3.15 | 16924424 |
MESH:D002295 |
Carcinoma, Transitional Cell |
|
Tamoxifen |
4.12 | 17572228 |
MESH:D002471 |
Cell Transformation, Neoplastic |
|
Estradiol |
3.09 | 18566989 |
MESH:D003711 |
Demyelinating Diseases |
|
Tamoxifen |
5.13 | 19031437 |
MESH:D003928 |
Diabetic Nephropathies |
|
Estradiol |
10.44 | 19279558 |
MESH:D003928 |
Diabetic Nephropathies |
|
Tamoxifen |
10.44 | 19279558 |
MESH:D004681 |
Encephalomyelitis, Autoimmune, Experimental |
|
Tamoxifen |
4.21 | 19031437 |
MESH:D016889 |
Endometrial Neoplasms |
|
Estradiol |
8.39 | 11473722 18566989 19148513 |
MESH:D016889 |
Endometrial Neoplasms |
|
Tamoxifen |
8.39 | 19155303 20544844 17893378 16202921 |
MESH:D005234 |
Fatty Liver |
|
Tamoxifen |
3.71 | 19224547 14986274 |
MESH:D052776 |
Female Urogenital Diseases |
|
Tamoxifen |
3.50 | 16709447 |
MESH:D018221 |
Fibromatosis, Abdominal |
|
Tamoxifen |
5.41 | 14745880 |
MESH:D018222 |
Fibromatosis, Aggressive |
|
Tamoxifen |
5.07 | 19069698 |
MESH:D006558 |
Herpes Genitalis |
|
Estradiol |
6.10 | 15709030 |
MESH:D019584 |
Hot Flashes |
|
Estradiol |
4.82 | 17088409 |
MESH:D007249 |
Inflammation |
|
Tamoxifen |
2.57 | 19457130 |
MESH:D007333 |
Insulin Resistance |
|
Estradiol |
3.26 | 16627594 16393666 |
MESH:D007674 |
Kidney Diseases |
|
Estradiol |
2.83 | 15618244 |
MESH:D007680 |
Kidney Neoplasms |
|
Estradiol |
8.86 | 15610895 |
MESH:D007680 |
Kidney Neoplasms |
|
Tamoxifen |
8.86 | 18625569 |
MESH:D008064 |
Lipidoses |
|
Tamoxifen |
3.50 | 17567588 15342952 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Estradiol |
2.55 | 14659978 14716833 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Tamoxifen |
2.55 | 18564211 |
MESH:D008113 |
Liver Neoplasms |
|
Tamoxifen |
2.35 | 16684651 |
MESH:D008175 |
Lung Neoplasms |
|
Tamoxifen |
1.75 | 18625569 |
MESH:D015674 |
Mammary Neoplasms, Animal |
|
Tamoxifen |
4.64 | 19428831 |
MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Estradiol |
6.95 | 17203775 11807958 11408345 16891317 |
MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Tamoxifen |
6.95 | 19196722 11731420 16827153 14580682 19196723 |
MESH:D020149 |
Manganese Poisoning |
|
Estradiol |
16.66 | 19453300 |
MESH:D020149 |
Manganese Poisoning |
|
Tamoxifen |
16.66 | 19453300 |
MESH:D008545 |
Melanoma |
|
Tamoxifen |
1.93 | 19393235 12393984 |
MESH:D018328 |
Melanoma, Amelanotic |
|
Tamoxifen |
5.07 | 15990972 |
MESH:D015428 |
Myocardial Reperfusion Injury |
|
Estradiol |
3.66 | 16810080 |
MESH:D009362 |
Neoplasm Metastasis |
|
Tamoxifen |
2.70 | 19393235 |
MESH:D009364 |
Neoplasm Recurrence, Local |
|
Tamoxifen |
2.63 | 19410462 |
MESH:D009376 |
Neoplasms, Hormone-Dependent |
|
Tamoxifen |
5.07 | 19200415 19196722 19189210 |
MESH:D009389 |
Neovascularization, Pathologic |
|
Estradiol |
4.62 | 17289903 |
MESH:D009421 |
Nervous System Malformations |
|
Estradiol |
4.32 | 16427766 11399458 |
MESH:D010051 |
Ovarian Neoplasms |
|
Estradiol |
2.33 | 19401270 |
MESH:D019048 |
Prostatic Intraepithelial Neoplasia |
|
Estradiol |
4.44 | 20887781 |
MESH:D011471 |
Prostatic Neoplasms |
|
Estradiol |
3.08 | 16740699 |
MESH:D011471 |
Prostatic Neoplasms |
|
Tamoxifen |
3.08 | 15067354 |
MESH:D013088 |
Spermatocele |
|
Tamoxifen |
5.36 | 16709447 |
MESH:D013119 |
Spinal Cord Injuries |
|
Tamoxifen |
4.92 | 19457130 |
MESH:D013978 |
Tibial Fractures |
|
Estradiol |
5.76 | 19048282 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
Tamoxifen |
2.50 | 8653321 17572228 16712894 |