AutismKB 2.0

Annotation Detail for GLUD1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GLUD1 ( GDH,GDH1,GLUD,MGC132003 )
Gene Full Name: glutamate dehydrogenase 1
Band: 10q23.2
Quick LinksEntrez ID:2746; OMIM: 138130; Uniprot ID:DHE3_HUMAN; ENSEMBL ID: ENSG00000148672; HGNC ID: 4335
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5766glutamate degradation X
ARGININE-SYN4-PWYarginine biosynthesis IV
GLUTAMATE-SYN2-PWYglutamate biosynthesis II
Pathway IDPathway Name
hsa00250Alanine, aspartate and glutamate metabolism
hsa00910Nitrogen metabolism
hsa00330Arginine and proline metabolism
hsa04964Proximal tubule bicarbonate reclamation
hsa01100Metabolic pathways
hsa00471D-Glutamine and D-glutamate metabolism
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
Pathway IDPathway Name
P02745Glutamine glutamate conversion
Pathway IDPathway Name
500779Amino acid synthesis and interconversion (transamination)
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1727Pancreas disease
1889Hyperinsulinism
2126Encephalopathies
No data
No data
Desease Name
Hyperinsulinism-hyperammonemia syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C004726 2-dichlorobenzene cyclohexanone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]increases activity|increases reaction 2554539
C004726 2-dichlorobenzene methylethyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]increases activity|increases reaction 2554539
C004726 2-dichlorobenzene methyl isobutyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]increases activity|increases reaction 2554539
C004726 2-dichlorobenzene 2-dichlorobenzene results in increased activity of GLUD1 proteinincreases activity 3012827
C004726 2-dichlorobenzene cyclohexanone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]increases activity|increases reaction 2554539
C004726 2-dichlorobenzene methylethyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]increases activity|increases reaction 2554539
C004726 2-dichlorobenzene methyl isobutyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]increases activity|increases reaction 2554539
D000082 Acetaminophen Acetaminophen results in decreased expression of GLUD1 mRNAdecreases expression 11793227
D000082 Acetaminophen Acetaminophen results in increased expression of GLUD1 proteinincreases expression 16538043
16687475
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GLUD1 proteinaffects expression 20106945
C010845 aluminum chloride aluminum chloride binds to and affects the folding of and results in decreased activity of GLUD1 proteinaffects binding|affects folding|decreases activity 14625697
C010845 aluminum chloride Citric Acid inhibits the reaction [aluminum chloride binds to and results in decreased activity of GLUD1 protein]affects binding|decreases activity|decreases reaction 14625697
C010845 aluminum chloride Sodium Fluoride inhibits the reaction [aluminum chloride binds to and results in decreased activity of GLUD1 protein]affects binding|decreases activity|decreases reaction 14625697
D000638 Amiodarone Amiodarone results in increased expression of GLUD1 proteinincreases expression 16538043
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GLUD1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of GLUD1 proteindecreases expression 19364129
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GLUD1 mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of GLUD1 proteinincreases expression 17292933
C032036 bromobenzene bromobenzene results in increased activity of GLUD1 proteinincreases activity 3012827
D002110 Caffeine Caffeine results in decreased expression of GLUD1 mRNAdecreases expression 11793227
C459604 candoxin candoxin results in decreased expression of GLUD1 mRNAdecreases expression 16309724
D002211 Capsaicin Capsaicin results in increased expression of GLUD1 proteinincreases expression 18991268
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of GLUD1 proteinincreases expression 16538043
D019343 Citric Acid Citric Acid inhibits the reaction [aluminum chloride binds to and results in decreased activity of GLUD1 protein]affects binding|decreases activity|decreases reaction 14625697
C036468 cyclohexanone cyclohexanone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]increases activity|increases reaction 2554539
C036468 cyclohexanone cyclohexanone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]increases activity|increases reaction 2554539
D016572 Cyclosporine Cyclosporine results in decreased expression of GLUD1 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GLUD1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GLUD1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GLUD1 mRNAaffects cotreatment|increases expression 17942748
C005222 methylethyl ketone methylethyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]increases activity|increases reaction 2554539
C005222 methylethyl ketone methylethyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]increases activity|increases reaction 2554539
C005458 methyl isobutyl ketone methyl isobutyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]increases activity|increases reaction 2554539
C005458 methyl isobutyl ketone methyl isobutyl ketone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]increases activity|increases reaction 2554539
C023036 perfluorooctanoic acid perfluorooctanoic acid affects the expression of GLUD1 mRNAaffects expression 18281256
D012643 Selenium Selenium affects the expression of GLUD1 proteinaffects expression 19351701
D012969 Sodium Fluoride Sodium Fluoride inhibits the reaction [aluminum chloride binds to and results in decreased activity of GLUD1 protein]affects binding|decreases activity|decreases reaction 14625697
D018038 Sodium Selenite Sodium Selenite results in increased expression of GLUD1 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen results in decreased expression of GLUD1 proteindecreases expression 17098229
D013629 Tamoxifen [Tretinoin co-treated with Tamoxifen] results in decreased expression of GLUD1 proteinaffects cotreatment|decreases expression 17098229
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GLUD1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GLUD1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GLUD1 mRNAdecreases expression 18796159
16960034
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GLUD1 mRNAdecreases expression 16054898
18796159
16960034
18465118
D013752 Tetracycline Tetracycline results in increased expression of GLUD1 proteinincreases expression 16538043
D013853 Thioacetamide Thioacetamide results in decreased expression of GLUD1 mRNAdecreases expression 11793227
D014212 Tretinoin [Tretinoin co-treated with Tamoxifen] results in decreased expression of GLUD1 proteinaffects cotreatment|decreases expression 17098229
D014212 Tretinoin Tretinoin results in decreased expression of GLUD1 proteindecreases expression 17098229
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3014745880
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 7.8818926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.8815322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6917505938
MESH:D058186 Acute Kidney Injury Capsaicin 4.3218460982
MESH:D000230 Adenocarcinoma arsenic trioxide 6.6511798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.6520464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6514692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.516695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1316835633
MESH:D000505 Alopecia Capsaicin 8.9417569567
MESH:D000505 Alopecia Tretinoin 8.9415955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7311748828
MESH:D000799 Angioedema Acetaminophen 3.5910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8319183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5918057881 18218290 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7115885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Tretinoin 2.2716456186
MESH:D001281 Atrial Fibrillation Amiodarone 3.7219698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001471 Barrett Esophagus Tretinoin 4.1716935849
MESH:D001778 Blood Coagulation Disorders Amiodarone 26.4719483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 26.4716206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 26.4712125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 26.4719483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 26.4716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6115746008
MESH:D001919 Bradycardia Capsaicin 4.8118207255
MESH:D002545 Brain Ischemia Capsaicin 4.7319211983
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8820146248 17474063
MESH:D001943 Breast Neoplasms Tamoxifen 1.8818821012 19084267 20005174 20544844 20065188 19189212 16873071 19189210 17242785 16202921 18997820 18629630 19059307 18855134 17049068 19011961 16273361 17893378 18425577 18815881 17440819 19142967 21138602 15668708 20390343 19221464 17261762 15565566 19200415 11161223 21152245 19155303 20859285 19066611 18984771 19244106 19288272 20135344 19289846 16818667 19115204 18351453 19103187 19487384 19410462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D001943 Breast Neoplasms Tretinoin 1.8816873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3416813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1011589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5416227642 16192424 15700767 16011737 15721981 10355542 15673190 16097048 16050911 3786805 16124888 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2619066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9116168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.443084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.4412907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.4416217749 11135700 14691202 15553829 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.4418788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.4416924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 13.4417997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.441917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6319014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9012490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.3220419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.3216051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2316120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8119225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8418974383
MESH:D002386 Cataract Acetaminophen 6.7510977129
MESH:D002386 Cataract Tretinoin 6.7517460283
MESH:D002418 Cattle Diseases Citric Acid 6.001108409
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.3612371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3416129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8616835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.8618291259
MESH:D002779 Cholestasis Cyclosporine 7.1819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.1816919318 17333356 17681005 17110522 16105132 15861022 11677210
MESH:D002822 Choriocarcinoma Tretinoin 4.9116461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.5115894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4212621046 8697196 16354765 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 5.429407595
MESH:D003092 Colitis Selenium 8.6917936198
MESH:D003092 Colitis Tretinoin 8.6917035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8517141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9512609071
MESH:D003371 Cough Capsaicin 11.0510350223
MESH:D003371 Cough Citric Acid 11.059413022
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.6010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6020055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.6010589399 9664655 17551590 14991402 9142499 8800419 16925845 9224671 9125849 9211117
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8715213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1219031437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.5716285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6117107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.2719279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 24.4611743745 11421492 12153990 16109766 19370779 19416960 15619225 10915739 19164858 18071297 11529661 11287661 16781746 19739265 16393943 11461765 16485898 15968718 12540782 16081117 14550746 12705907 17562736 17906064 12392966 17522070 18713872 14986274 10663392 11834606 14725611 16177239 10774834 16227642 2444490 19085960 19923254 12958197 12594235 19420014 11739529
MESH:D056486 Drug-Induced Liver Injury Amiodarone 24.4615265979 18218290
MESH:D056486 Drug-Induced Liver Injury bromobenzene 24.4612628495 10092053
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 24.464309450 7120509 9327722 15968718 2869522 19085960 16227642 6623471 21278145 6884620 7440962 3732212 17522070 10092053 10915739 3786805 15027814 11566570 7179309 19336974 16177239 15998439
MESH:D056486 Drug-Induced Liver Injury Selenium 24.4615131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 24.4615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 24.4620420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 24.4617522070
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 24.4612963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5811462148
MESH:D004381 Duodenal Ulcer Capsaicin 4.4611535926 10671773
MESH:D004487 Edema perfluorooctanoic acid 6.2217259670 12083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.1116714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.1118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.1712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.1719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.9117893378 16202921 19155303 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 6.9116569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.819294722 10568697
MESH:D004716 Endometritis Citric Acid 6.491108409
MESH:D004935 Esophageal Diseases Capsaicin 5.4619566590
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.2212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.2411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.249664655 16938888
MESH:D005218 Fat Necrosis Thioacetamide 5.4716456712
MESH:D005234 Fatty Liver Amiodarone 33.5914986274
MESH:D005234 Fatty Liver arsenic trioxide 33.5915073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 33.5912631006 17595544 12795759 61145 15959796 19224547 16045604 16239168
MESH:D005234 Fatty Liver Cyclosporine 33.5919224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 33.5915345470
MESH:D005234 Fatty Liver Tamoxifen 33.5914986274 19224547
MESH:D005234 Fatty Liver Tetracycline 33.5919224547 16917069
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2111858732
MESH:D005317 Fetal Growth Retardation marker/mechanism 19500843
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9419069698
MESH:D005355 Fibrosis Carbon Tetrachloride 19.1418705752
MESH:D005355 Fibrosis Cyclosporine 19.1412639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.1420067830
MESH:D005355 Fibrosis Tretinoin 19.1417994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0316904648
MESH:D005756 Gastritis Acetaminophen 3.4316983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.978708960
MESH:D005909 Glioblastoma Capsaicin 7.0018405923
MESH:D005909 Glioblastoma Tretinoin 7.0017312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9116084493
MESH:D006356 Heartburn Capsaicin 5.4619566590
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.3420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.3410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.3414991402 9664655
MESH:D006333 Heart Failure Selenium 2.9317162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1211000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.3518665440 15929193 17276928
MESH:D006505 Hepatitis Caffeine 14.5611394713
MESH:D006505 Hepatitis Carbon Tetrachloride 14.5619110552 19900420
MESH:D006505 Hepatitis Thioacetamide 14.5616456712
MESH:D006529 Hepatomegaly Amiodarone 13.1715265979
MESH:D006529 Hepatomegaly perfluorooctanoic acid 13.173609246
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.1715340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8015340226 16959395 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 17.1416870215
MESH:D006930 Hyperalgesia Capsaicin 17.1417434803 17043245
MESH:D006930 Hyperalgesia perfluorooctanoic acid 17.1412083418
MESH:D006930 Hyperalgesia Tretinoin 17.1416870215
MESH:D022124 Hyperammonemia marker/mechanism 9571255
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2816899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.658137927 9751232
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3316778211
MESH:C538375 Hyperinsulinemic hypoglycemia, familial, 6 marker/mechanism
MESH:D006946 Hyperinsulinism marker/mechanism 9571255
MESH:D006973 Hypertension Cyclosporine 4.6310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6318850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5716569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 4.2717991464 18020914
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2312013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3317937319
MESH:D007249 Inflammation Capsaicin 10.9816956363
MESH:D007249 Inflammation perfluorooctanoic acid 10.9812083418
MESH:D007249 Inflammation Tamoxifen 10.9819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.9812200463 12878042
MESH:D007251 Influenza, Human Selenium 3.9516624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.1214714311
MESH:D007410 Intestinal Diseases Tretinoin 3.5317994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.2015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1915604871
MESH:D007674 Kidney Diseases 2-dichlorobenzene 9.458440869
MESH:D007674 Kidney Diseases Acetaminophen 9.4515629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.4518776723 10903974 8314463
MESH:D007676 Kidney Failure, Chronic Selenium 3.6716518626
MESH:D007680 Kidney Neoplasms Cyclosporine 6.6412371664
MESH:D007680 Kidney Neoplasms Tamoxifen 6.6418625569
MESH:D007938 Leukemia arsenic trioxide 5.9315070760
MESH:D007938 Leukemia Tretinoin 5.9317143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.7419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.7416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7216968895 17050201 16467208 19850784 20471514
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7219850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.1115748426 12712474 16331271 17649720 17869043 19642359 12018890 16891316 11161223 15213294 19075265 9834237 15622746 17712046 19225113 17107899 12679006 16823087 15336539 11468182 16330433 17217047 16966277 16112521 19035177
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.1112679006 19035177 16140955 16766008 17368321 16331271 19225113 15748426 17217047 9834237 19029980 17107899 16891316 17649720 17506722 16788101 17301526 17339181 16935935 19075265 17361223 19642359 17294898 17712046 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1216882451
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.988812269
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.139224671
MESH:D008064 Lipidoses Amiodarone 7.3415342952 17567588
MESH:D008064 Lipidoses Tamoxifen 7.3417567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6711408273 21278145 16943688 17334410 16221502 17174718 11903743 16239168 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.3911481614 17708605 18395095 18376398 18472094 18006644 17900296 15370692 12609069 17714472 14724832 15338365 14716833 16248980 18277467 15931870 16033810 18472332 20821823 12666154 12649538 18412020 16097048 14512876 18420326 17823541 12586293 17481882 18481824 17805973 15362042 17698563 18156304 17869086 17525996 12632514 17721639 16015684 18339082 17922224 18187930 17557913 18166357 14620537 16011737 16136751 15123356 15818738 12667390 14748882 17766677 18210741 15876570 15925388 17640975 18251166 17565644 13678700 16192424 15730626 12632512 18395914 17631135 17761835 18418968 18205269 17944888 16638106 18279442 18054572 16116963 12445418 15057751 12898905 18705752 12546737 15650968 15673190 15893842 12389079 12445421 14716496 10355542 18263696 18429990 15996030 12958196 15052691 17976157 15959796 16027843 12741479 18317297
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.3918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3912878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 6.3918606216 15288472 15465738 16248980 12679928 18295389 18263696 17629604 12557150 17355460 18615449 15316131 14739098 18032466 15362042 16343077 12891558 16126171 12175628 18031379 15288473 11682029 10677585 15158331 16511523 16097051 15334695 11172339 17127702 17292413 16098781 16489207 12085344 15078482 15095483 15474484 17050028 18458672 18416461 18380797 12531686 15716488 11481614 18395095 15075984
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.3916248980 18397230
MESH:D008107 Liver Diseases 2-dichlorobenzene 11.871949037 8440869 1853346 8661352
MESH:D008107 Liver Diseases Acetaminophen 11.8712969438 16610002 19014921 16611625 19784758 12587719 19460945 11587558
MESH:D008107 Liver Diseases Capsaicin 11.8716956363
MESH:D008107 Liver Diseases Carbon Tetrachloride 11.8717285989 16246199 15830285 15720792 16964402
MESH:D008107 Liver Diseases Thioacetamide 11.8718374380 16337175 15158337
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 15.0216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 15.0214706259 16899240
MESH:D017114 Liver Failure, Acute Thioacetamide 15.0215633222 12479984 15313186 17276928
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.459163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms arsenic trioxide 20.4514682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.4520195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.4519294768
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 20.4514757943 18709148
MESH:D008113 Liver Neoplasms Tamoxifen 20.4516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.4516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.868603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 12.8620377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.8612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.8612151625
MESH:D008133 Long QT Syndrome Amiodarone 7.5817391786 11989578 15350150
MESH:D008133 Long QT Syndrome arsenic trioxide 7.5815213294
MESH:D008171 Lung Diseases Amiodarone 3.2112587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.2318516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.2414755239
MESH:D008175 Lung Neoplasms arsenic trioxide 6.2411798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.2420064080 18569708 20135361 18816296 20869020 20464547 18520028 17053015 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 6.2418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.2411884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.8314737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5119428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 5.5315318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.5314580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.3019453300
MESH:D008527 Medulloblastoma Tretinoin 2.6917453147
MESH:D008545 Melanoma Tamoxifen 3.1419393235 12393984
MESH:D008545 Melanoma Tretinoin 3.1416752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3319513568
MESH:D008591 Meningomyelocele Tretinoin 4.1816940565
MESH:D008654 Mesothelioma Selenium 2.6915107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5416801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0016381670
MESH:D009101 Multiple Myeloma arsenic trioxide 7.1015949261 11468182 14977855 19417148 19549372
MESH:D009101 Multiple Myeloma Capsaicin 7.1017505005
MESH:D009181 Mycoses Amiodarone 4.6512754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.9316882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.9317596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8312213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7316624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.5911141357
MESH:D009369 Neoplasms Tretinoin 4.5916594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7519200415 19189210 19196722
MESH:D009395 Nephritis, Interstitial Tetracycline 4.549884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0819348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.7314600291
MESH:D009421 Nervous System Malformations Tretinoin 8.739125849
MESH:D009436 Neural Tube Defects arsenic trioxide 6.7710525206
MESH:D009436 Neural Tube Defects Tretinoin 6.779142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6718514411
MESH:D020078 Neurogenic Inflammation Capsaicin 4.8617961222
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.719802331
MESH:D009765 Obesity Capsaicin 3.3319056576
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.6116624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Tretinoin 4.6116936753
MESH:D010146 Pain Acetaminophen 10.2016870215
MESH:D010146 Pain Capsaicin 10.2019081190 17434803 17084039 16996476 17043245 18987195
MESH:D010146 Pain Tretinoin 10.2016870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 4.9915580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 4.9915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4611578682
MESH:D010235 Paraganglioma arsenic trioxide 3.9319927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0012520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.1811026799
MESH:D010954 Plasmacytoma Selenium 4.6415087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0212371664
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 8.8517132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.8511896295 11118676 11399792 11222880
MESH:D017096 Prion Diseases Tetracycline 5.1710903871
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1119131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1117292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.1118760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1115067354
MESH:D011507 Proteinuria Tretinoin 3.3816636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0715861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011625 Pterygium Tretinoin 4.5516723453
MESH:D011645 Puerperal Infection Citric Acid 6.491108409
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7612832656 11597910 12490602
MESH:D015427 Reperfusion Injury Capsaicin 3.8419211983 18460982
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8716283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7316646077
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8418724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.7110029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7116192470
MESH:D012878 Skin Neoplasms Tretinoin 8.7116467112
MESH:D012893 Sleep Disorders Caffeine 5.0719395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Caffeine 4.8517225163
MESH:D013088 Spermatocele Ethinyl Estradiol 10.7316709447
MESH:D013088 Spermatocele Tamoxifen 10.7316709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7919457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.2017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.2020155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 3.2017261132
MESH:D013276 Stomach Ulcer Amiodarone 3.1018087811
MESH:D013610 Tachycardia Amiodarone 4.0511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9519225199
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.4717997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9515669648
MESH:D013959 Thyroid Diseases Amiodarone 11.2219731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.2212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.6019014326
MESH:D013964 Thyroid Neoplasms Tretinoin 6.6017045167 16026305
MESH:D013971 Thyrotoxicosis Amiodarone 4.6219584973 18020914
MESH:D014062 Tongue Neoplasms Tretinoin 3.5716051514
MESH:D016171 Torsades de Pointes Amiodarone 9.4411989578 17467628
MESH:D016171 Torsades de Pointes arsenic trioxide 9.4415213294
MESH:D014376 Tuberculosis Tretinoin 3.0816040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.7320435036 11780464 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.7317053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.7316712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 2.7510982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4616129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3616752155
MESH:D014605 Uveitis Cyclosporine 3.731336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3214671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0015886252
MESH:D009396 Wilms Tumor Tretinoin 3.7616287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1917120751
Pathway ID Pathway Name
KEGG:00250 Alanine, aspartate and glutamate metabolism
KEGG:00330 Arginine and proline metabolism
KEGG:00471 D-Glutamine and D-glutamate metabolism
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00910 Nitrogen metabolism
KEGG:04964 Proximal tubule bicarbonate reclamation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28737
    • No data
    No data
    Releated drug ID Related drug Name
    PA10090l-glutamine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00157 - NADH Dietary supplement;Micronutrient
    DB00756 antagonist Hexaphenyl Anti-Infectives;Anti-Infective Agents, Local
    DB01907 - Nicotinamide-Adenine-Dinucleotide
    DB03431 - Adenosine-5'-Diphosphate
    DB03806 - 2-Oxyglutaric Acid
    DB04137 - Guanosine-5'-Triphosphate
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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