AutismKB 2.0

Annotation Detail for GLUD2


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Basic Information Top
Gene Symbol:GLUD2 ( GDH2,GLUDP1 )
Gene Full Name: glutamate dehydrogenase 2
Band: Xq24
Quick LinksEntrez ID:2747; OMIM: 300144; Uniprot ID:DHE4_HUMAN; ENSEMBL ID: ENSG00000182890; HGNC ID: 4336
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5766glutamate degradation X
ARGININE-SYN4-PWYarginine biosynthesis IV
GLUTAMATE-SYN2-PWYglutamate biosynthesis II
Pathway IDPathway Name
hsa00250Alanine, aspartate and glutamate metabolism
hsa00910Nitrogen metabolism
hsa00330Arginine and proline metabolism
hsa04964Proximal tubule bicarbonate reclamation
hsa01100Metabolic pathways
hsa00471D-Glutamine and D-glutamate metabolism
No data
No data
Pathway IDPathway Name
P02745Glutamine glutamate conversion
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016572 Cyclosporine Cyclosporine results in decreased expression of GLUD2 mRNAdecreases expression 20106945
D011794 Quercetin Quercetin results in decreased expression of GLUD2 proteindecreases expression 15221776
D013629 Tamoxifen Tamoxifen affects the expression of GLUD2 mRNAaffects expression 14699072
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.4114745880
MESH:D000743 Anemia, Hemolytic Quercetin 4.7217084956
MESH:D001260 Ataxia Telangiectasia Quercetin 5.7215336622
MESH:D001327 Autoimmune Diseases Quercetin 5.0619761891
MESH:D001943 Breast Neoplasms Quercetin 2.2718628248
MESH:D001943 Breast Neoplasms Tamoxifen 2.2719221464 21138602 20544844 16273361 16202921 20859285 15668708 19410462 15565566 16873071 18815881 18984771 20135344 19288272 19189210 16818667 19115204 19066611 18351453 20005174 11161223 17242785 18855134 19059307 17893378 17440819 19200415 20065188 17261762 18425577 19189212 20390343 19011961 19487384 21152245 19289846 19084267 17049068 18629630 18821012 19142967 18997820 19155303 19103187 19244106
MESH:D002105 Cadmium Poisoning Quercetin 6.4116962696
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 5.1619066611
MESH:D006528 Carcinoma, Hepatocellular Quercetin 3.3312508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.3316924424
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.6117234771
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 4.0617572228
MESH:D006332 Cardiomegaly Quercetin 3.5319794523
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.8212371664
MESH:D002779 Cholestasis Cyclosporine 3.2419486331
MESH:D003110 Colonic Neoplasms Quercetin 2.4719440933 11134977 16640504 15741050 19056647 17191121 17148506
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D003711 Demyelinating Diseases Tamoxifen 5.0219031437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 4.1219496084
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8919279558
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 4.1219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.3120544844 17893378 19155303 16202921
MESH:D005234 Fatty Liver Cyclosporine 9.3619224547
MESH:D005234 Fatty Liver Tamoxifen 9.3614986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4716709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.2714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.9219069698
MESH:D005355 Fibrosis Cyclosporine 11.1012639820 12168785
MESH:D005355 Fibrosis Quercetin 11.1019474275
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.968708960
MESH:D005909 Glioblastoma Quercetin 3.6619804834
MESH:D005910 Glioma Quercetin 3.1917643826
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.1615720958
MESH:D006943 Hyperglycemia Quercetin 4.4811834736 18262572
MESH:D006973 Hypertension Cyclosporine 5.7410903974
MESH:D006973 Hypertension Quercetin 5.7418356687
MESH:D007249 Inflammation Tamoxifen 2.5519457130
MESH:D007251 Influenza, Human Quercetin 5.3716624496
MESH:D007627 Keloid Quercetin 5.6117086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.3115604871
MESH:D007674 Kidney Diseases Cyclosporine 6.8818776723 10903974 8314463
MESH:D007674 Kidney Diseases Quercetin 6.8816962696
MESH:D007680 Kidney Neoplasms Cyclosporine 8.6112371664
MESH:D007680 Kidney Neoplasms Tamoxifen 8.6118625569
MESH:D007938 Leukemia Quercetin 3.3417468513
MESH:D008064 Lipidoses Tamoxifen 3.4617567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.7312741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.7318564211
MESH:D008113 Liver Neoplasms Quercetin 5.1918980244
MESH:D008113 Liver Neoplasms Tamoxifen 5.1916684651
MESH:D008114 Liver Neoplasms, Experimental Quercetin 3.3119519916
MESH:D008175 Lung Neoplasms Quercetin 2.6916280456
MESH:D008175 Lung Neoplasms Tamoxifen 2.6918625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.5019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8811731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 5.4119453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.9215990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.6516801185
MESH:D009203 Myocardial Infarction Quercetin 3.1319595682
MESH:D015428 Myocardial Reperfusion Injury Quercetin 4.1419207477
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6219410462
MESH:D009369 Neoplasms Quercetin 2.9715185748
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.8719200415 19189210 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.7019348381 18481113
MESH:D020078 Neurogenic Inflammation Quercetin 4.8917929310
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.7519495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.8319005980
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9716965848
MESH:D011230 Precancerous Conditions Cyclosporine 10.5212371664
MESH:D011230 Precancerous Conditions Quercetin 10.5219056647
MESH:D011471 Prostatic Neoplasms Quercetin 3.2714715546 17292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2715067354
MESH:D011565 Psoriasis Cyclosporine 2.3416882103
MESH:D012554 Schistosomiasis japonica Quercetin 6.4116862918
MESH:D013088 Spermatocele Tamoxifen 5.1616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.7819457130
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.6916720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.6917572228 16712894 8653321
MESH:D014605 Uveitis Cyclosporine 4.851336536
MESH:D014985 Xerophthalmia Cyclosporine 5.3117120751
Pathway ID Pathway Name
KEGG:00250 Alanine, aspartate and glutamate metabolism
KEGG:00330 Arginine and proline metabolism
KEGG:00471 D-Glutamine and D-glutamate metabolism
KEGG:01100 Metabolic pathways
KEGG:00910 Nitrogen metabolism
KEGG:04964 Proximal tubule bicarbonate reclamation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28738
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00157 - NADH Dietary supplement;Micronutrient
    DB01907 - Nicotinamide-Adenine-Dinucleotide
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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