Annotation Detail for AMT
Basic Information Top
| Gene Symbol: | AMT ( GCE,GCST,GCVT,NKH ) |
|---|---|
| Gene Full Name: | aminomethyltransferase |
| Band: | 3p21.31 |
| Quick Links | Entrez ID:275; OMIM: 238310; Uniprot ID:GCST_HUMAN; ENSEMBL ID: ENSG00000145020; HGNC ID: 473 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Pathway ID | Pathway Name |
|---|---|
| GLYCLEAV-PWY | glycine cleavage complex |
| Pathway ID | Pathway Name |
|---|---|
| hsa00910 | Nitrogen metabolism |
| hsa00670 | One carbon pool by folate |
| hsa01100 | Metabolic pathways |
| hsa00260 | Glycine, serine and threonine metabolism |
| No data |
| No data |
| No data |
| No data |
| Desease ID | Desease Name |
|---|---|
| Inherited disorders of amino acid metabolism | |
| H00191 | Nonketotic hyperglycinemia |
| Genetic disorders |
| No data |
| No data |
| No data |
| Desease Name |
|---|
| Glycine encephalopathy |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D005472 | Fluorouracil | Fluorouracil results in increased expression of AMT protein | increases expression | 15585135 16803524 |
| C008493 | methylselenic acid | methylselenic acid results in increased expression of AMT mRNA | increases expression | 18548127 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000230 | Adenocarcinoma | Fluorouracil | 2.51 | 17638652 | |
| MESH:D000740 | Anemia | Fluorouracil | 4.22 | 17963324 15504547 16511603 | |
| MESH:D001943 | Breast Neoplasms | Fluorouracil | 2.42 | 18357371 18608205 16557594 16595493 16110121 19217205 15136595 | |
| MESH:D002276 | Carcinoid Tumor | Fluorouracil | 5.74 | 16051944 | |
| MESH:D002277 | Carcinoma | Fluorouracil | 3.97 | 17121937 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Fluorouracil | 2.12 | 16799960 17045692 17971768 16332177 17088986 18930000 | |
| MESH:D002292 | Carcinoma, Renal Cell | Fluorouracil | 3.20 | 18695887 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Fluorouracil | 2.59 | 18986760 16757204 16280240 17066447 | |
| MESH:D003110 | Colonic Neoplasms | Fluorouracil | 2.29 | 16510598 16340194 17725105 18772588 15001691 17169374 17172411 17287894 17016597 17018589 | |
| MESH:D015179 | Colorectal Neoplasms | Fluorouracil | 2.01 | 17594712 17695437 17255274 16524972 17016601 17094418 18288408 20501625 16331619 18802399 18949393 16391804 14970324 18448328 15289873 16282729 15148649 16303861 18509181 17401013 17454858 18383874 | |
| MESH:D007644 | Darier Disease | Fluorouracil | 5.68 | 16733453 | |
| MESH:D004938 | Esophageal Neoplasms | Fluorouracil | 2.54 | 17638652 15173087 16481741 16337965 16785472 | |
| MESH:D005910 | Glioma | Fluorouracil | 3.02 | 16145905 | |
| MESH:D006258 | Head and Neck Neoplasms | Fluorouracil | 3.70 | 15102660 15162350 18337622 | |
| MESH:D020158 | Hyperglycinemia, Nonketotic | marker/mechanism | |||
| MESH:D007680 | Kidney Neoplasms | Fluorouracil | 3.74 | 16985049 | |
| MESH:D008113 | Liver Neoplasms | Fluorouracil | 2.62 | 15113037 16603448 17045692 18383874 | |
| MESH:D008175 | Lung Neoplasms | Fluorouracil | 2.01 | 15246190 | |
| MESH:D008178 | Lupus Erythematosus, Cutaneous | Fluorouracil | 5.68 | 15086387 | |
| MESH:D009062 | Mouth Neoplasms | Fluorouracil | 4.02 | 16757204 18986760 | |
| MESH:D009369 | Neoplasms | Fluorouracil | 2.80 | 18600527 18239605 16928823 | |
| MESH:D020258 | Neurotoxicity Syndromes | Fluorouracil | 3.75 | 16436463 | |
| MESH:D010190 | Pancreatic Neoplasms | Fluorouracil | 2.79 | 15113037 16929163 16500647 19003803 | |
| MESH:D011471 | Prostatic Neoplasms | Fluorouracil | 3.47 | 18626508 19082440 | |
| MESH:D011471 | Prostatic Neoplasms | methylselenic acid | 3.47 | 16205645 | |
| MESH:D012004 | Rectal Neoplasms | Fluorouracil | 4.48 | 18286688 15538739 18722050 16160472 | |
| MESH:D013274 | Stomach Neoplasms | Fluorouracil | 2.00 | 16424979 19015929 18396642 17498489 17522103 18567086 19084572 16951190 15786421 17172411 | |
| MESH:D014062 | Tongue Neoplasms | Fluorouracil | 4.50 | 16280240 | |
| MESH:D002583 | Uterine Cervical Neoplasms | Fluorouracil | 4.38 | 16803524 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:00260 | Glycine, serine and threonine metabolism |
| KEGG:01100 | Metabolic pathways |
| KEGG:00910 | Nitrogen metabolism |
| KEGG:00670 | One carbon pool by folate |