AutismKB 2.0

Annotation Detail for GMDS


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Basic Information Top
Gene Symbol:GMDS ( GMD,SDR3E1 )
Gene Full Name: GDP-mannose 4,6-dehydratase
Band: 6p25.3
Quick LinksEntrez ID:2762; OMIM: 602884; Uniprot ID:GMDS_HUMAN; ENSEMBL ID: ENSG00000112699; HGNC ID: 4369
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-66GDP-L-fucose biosynthesis I (from GDP-D-mannose)
COLANSYN-PWYcolanic acid building blocks biosynthesis
Pathway IDPathway Name
hsa00520Amino sugar and nucleotide sugar metabolism
hsa01100Metabolic pathways
hsa00051Fructose and mannose metabolism
No data
No data
Pathway IDPathway Name
P02752Mannose metabolism
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GMDS proteinaffects expression 20106945
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GMDS mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GMDS mRNAdecreases expression 20106945
20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GMDS mRNAdecreases expression 20713471
C459604 candoxin candoxin results in decreased expression of GMDS mRNAdecreases expression 16309724
C014347 decitabine decitabine results in decreased expression of GMDS mRNAdecreases expression 19194470
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GMDS mRNAaffects cotreatment|increases expression 18164116
C006253 pirinixic acid pirinixic acid results in increased expression of GMDS mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GMDS mRNAdecreases expression 20106945
D019772 Topotecan GMDS protein affects the susceptibility to Topotecanaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1311752688 15322242 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 11.866695378
MESH:D000236 Adenoma beta-Naphthoflavone 11.8619389873
MESH:D000236 Adenoma Diethylnitrosamine 11.8610737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 19.0319052882 17620307 16434500 19061943 18056438 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.0316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.0316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.4612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9620146248 17474063
MESH:D001943 Breast Neoplasms decitabine 1.9619208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9617474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1421507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1416681979 17173139 18691550 18506893 3581430 10672840 19335982 18210153 19394651 17761372 18665156 16502159 20084675 16878318 19519916 19171122 20432363 17978847 16807293 19052882 11831363 19919837 16779866 3084413 19418558 16935385 20935162 20214788 19822196 20727157 17428255 17138121 20007298 19208518 10737359 20514400 20524982 19701751 18978308 19539802 18971187 18393292 18785209 16328049 21159647 18788625 18056438 16569478 18494052 16288022 16830150 17162532 19107877 16540662 17055752 16698587 20101231 20512989 19383236
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8520419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.8519215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.992727394 17174075 21159647 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.9419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.9416835633
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1812621046 15340226 16354765 8697196 15668235
MESH:D003110 Colonic Neoplasms decitabine 2.3617616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3617107852
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.9019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 15322242 18230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4319294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Diethylnitrosamine 8.3721071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 8.3720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.6219215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly pirinixic acid 9.1416221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1415340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 16959395 15340226 16354765 18606429
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718670907 18850075
MESH:D007248 Infertility, Male decitabine 3.3317581917
MESH:D007249 Inflammation Diethylnitrosamine 5.2218785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2212200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007938 Leukemia decitabine 3.1618980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.2119117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4118704418 18460780 19387464 17679729 18206229 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.7818055864
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9320032147 19638242 18522880 18665156 18407596
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1912878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1417034775
MESH:D008113 Liver Neoplasms Aflatoxin B1 18.9015890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.9020195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 18.9019389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.9015175105 19073162 19812893 19090486 19254457 20492335 19690152 10737359 18644402 20405173 18648771 16942905 20101389 18978307 21278145 21047994 18977376 21167192 19427195 21071580 12112319 20118626 19294768 19642983 19426721 19256749 19499222 19833225 18754104 20501860 20137499 9163691 12771043 19551842 20452335 2862719 19638242 2422723 20434301 19255062 20583210 19850985 19996281 15885732
MESH:D008113 Liver Neoplasms pirinixic acid 18.9016377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.9016984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 15.168603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 15.1618164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.1618282651 19009564 21159647 18253720 17854601 18775883 16842330 19539802 19004024 18544905 17942915 18164116 19126423 16267830 18308698 18079962 19519916 17174075 3124819 18093689 9362446 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.1612151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9920464547 17053015 18816296 20869020 18569708 20064080 20135361 18520028 6695378
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.9920512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9911884234 19555203
MESH:D008223 Lymphoma decitabine 3.5619470736
MESH:D008545 Melanoma decitabine 2.2716505122 17785578
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009101 Multiple Myeloma decitabine 3.4918172295
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4919157545 18608210 19010910 16882708
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.643581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 8.7711141357
MESH:D009369 Neoplasms decitabine 8.7717925555 19116145 19470736
MESH:D009369 Neoplasms pirinixic acid 8.7717405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009447 Neuroblastoma Topotecan 3.9415176712
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010051 Ovarian Neoplasms decitabine 2.7019259094 19331143
MESH:D010190 Pancreatic Neoplasms decitabine 5.5719294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.5716540662
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811399792 11118676 11222880 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.9917616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9417292933
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.6219155313
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7610029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.462093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 3.4619037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.4618456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms decitabine 7.8017967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.807505956
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3617053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.3617616700 19087683
MESH:D014604 Uveal Neoplasms decitabine 5.2317785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
KEGG:00520 Amino sugar and nucleotide sugar metabolism
KEGG:00051 Fructose and mannose metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02547 - Guanosine-5'-Diphosphate-Rhamnose
DB04315 - Guanosine-5'-Diphosphate
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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