AutismKB 2.0

Annotation Detail for GNA11


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Basic Information Top
Gene Symbol:GNA11 ( GNA-11 )
Gene Full Name: guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Band: 19p13.3
Quick LinksEntrez ID:2767; OMIM: 139313; Uniprot ID:GNA11_HUMAN; ENSEMBL ID: ENSG00000088256; HGNC ID: 4379
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04020Calcium signaling pathway
hsa05142Chagas disease
hsa05146Amoebiasis
hsa04540Gap junction
hsa04730Long-term depression
Pathway IDPathway Name
Signaling by GPCR
Diabetes pathways
Hemostasis
Integration of energy metabolism
No data
Pathway IDPathway Name
P04385Histamine H1 receptor mediated signaling pathway
P04391Oxytocin receptor mediated signaling pathway
P00019Endothelin signaling pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P043745HT2 type receptor mediated signaling pathway
P04380Cortocotropin releasing factor receptor signaling pathway
P00002Alpha adrenergic receptor signaling pathway
P00048PI3 kinase pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P00041Metabotropic glutamate receptor group I pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1944Breast cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of GNA11 mRNAdecreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GNA11 mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GNA11 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of GNA11 mRNAdecreases expression 15336504
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of GNA11 mRNAincreases expression 15003993
D002118 Calcium GNA11 protein inhibits the reaction [Pyrilamine results in decreased abundance of Calcium]decreases abundance|decreases reaction 15192105
D002118 Calcium HRH1 protein affects the reaction [GNA11 protein inhibits the reaction [Pyrilamine results in decreased abundance of Calcium]]affects reaction|decreases abundance|decreases reaction 15192105
C402665 CP 31398 CP 31398 results in increased expression of GNA11 mRNAincreases expression 15155752
D003976 Diazinon Diazinon results in decreased expression of GNA11 mRNAdecreases expression 17452286
D004958 Estradiol Estradiol results in decreased expression of GNA11 mRNAdecreases expression 20068009
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of GNA11 geneincreases mutagenesis 16724327
D008727 Methotrexate GNA11 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D011374 Progesterone Progesterone affects the expression of GNA11 mRNAaffects expression 17251523
D011738 Pyrilamine GNA11 protein inhibits the reaction [Pyrilamine results in decreased abundance of Calcium]decreases abundance|decreases reaction 15192105
D011738 Pyrilamine HRH1 protein affects the reaction [GNA11 protein inhibits the reaction [Pyrilamine results in decreased abundance of Calcium]]affects reaction|decreases abundance|decreases reaction 15192105
D011738 Pyrilamine Pyrilamine binds to and results in decreased activity of [GNA11 protein binds to HRH1 protein]affects binding|decreases activity 15192105
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.4012039119
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.3711473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 11.603712494
MESH:D000236 Adenoma Benzo(a)pyrene 11.606695378
MESH:D000236 Adenoma Ethylnitrosourea 11.606695378
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.4916487989
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1217286800
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1911289319 1440618
MESH:D001927 Brain Diseases Ethylnitrosourea 4.9814991843
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5117868700
MESH:D001930 Brain Injuries Progesterone 4.4015665606 15380490 15845082
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.3916357521 18412241 15144691 16436596 16651633
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.0112948864 19861407 17289903 17018787 17261762 14630087 16675129 18497071
MESH:D001943 Breast Neoplasms Methotrexate 2.0116978400
MESH:D001943 Breast Neoplasms Progesterone 2.0117614352 15562024 16175315
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.007296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0016924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.697505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.6920889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.6918566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 16.6916003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.1617160924
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.239022650 19486331
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.6612039119 9562676
MESH:D003550 Cystic Fibrosis Methotrexate 4.3419747007
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9412868966 18759878 2524372 8156756 11906362 14531868 11298694 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.612952479 3621924
MESH:D003882 Dermatomyositis Methotrexate 5.2520191521
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6317187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 1.981440618 18289764 6679447 18692083 8291058 6482804 7440962 11289319 16192314 18648102 9653073 9328219 9022650
MESH:D004417 Dyspnea Diazinon 4.9716487989
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.1618357618
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9117692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.0511473722 18566989 19148513
MESH:D004715 Endometriosis Progesterone 3.8716134523
MESH:D004802 Eosinophilia Pyrilamine 6.051355641
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.343581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.3416530937
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D005909 Glioblastoma Ethylnitrosourea 3.9016436596
MESH:D005910 Glioma Ethylnitrosourea 3.5316357521 16651633 18412241
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006086 Graft vs Host Disease Methotrexate 5.2916518429
MESH:D006330 Heart Defects, Congenital marker/mechanism 9687499
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.016705139
MESH:D006505 Hepatitis Diazinon 10.0116487989
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5415869954
MESH:D007248 Infertility, Male Diazinon 3.8912948887 16466525
MESH:D007249 Inflammation Progesterone 2.6515869954
MESH:D007333 Insulin Resistance Estradiol 3.0316393666 16627594
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.199022650 8074119
MESH:D007674 Kidney Diseases Estradiol 2.6415618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.076582329
MESH:D007680 Kidney Neoplasms Estradiol 13.0715610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 13.0717379185
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.2216316344
MESH:D007805 Language Development Disorders Methotrexate 5.229562676
MESH:D008103 Liver Cirrhosis Methotrexate 3.7614986274
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.0820195826 21137059
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.593712494 1399818 6587162 598648
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.2018516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.726695378 18816296 20135361 20464547 18520028 20869020 20064080 18569708 17053015
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.7217703301 16271038 6695378 16019985
MESH:D008223 Lymphoma Ethylnitrosourea 8.3615790496
MESH:D008223 Lymphoma Methotrexate 8.3617352296
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.1915375218
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.5011807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 10.5010767621 10838139 18041768
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.5017203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008579 Meningioma Ethylnitrosourea 6.1617943659
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D052016 Mucositis Methotrexate 5.4317488658
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3616810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.513581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2211141357
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.5416707424
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009421 Nervous System Malformations Estradiol 3.7816427766 11399458
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.986679447
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.5717160924 16651423 16003739
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.524026338 6482804
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.1617160924
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010024 Osteoporosis Calcium 3.8417882678
MESH:D010051 Ovarian Neoplasms Estradiol 4.9719401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.9717393432 16525653
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D011041 Poisoning Diazinon 4.4717603234
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0817292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0816740699
MESH:D011565 Psoriasis Methotrexate 3.4717410198
MESH:D051437 Renal Insufficiency Methotrexate 4.8517352296
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8918045962
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8719755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.878532709
MESH:D013119 Spinal Cord Injuries Progesterone 4.4316503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013576 Syndactyly Methotrexate 5.169562676
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.3115790496
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.976582329 7505956 3712494 6587162 1399818
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.108074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1017053015
MESH:D014570 Urologic Diseases Diazinon 5.4516487989
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
KEGG:04020 Calcium signaling pathway
KEGG:05142 Chagas disease (American trypanosomiasis)
REACT:15380 Diabetes pathways
KEGG:04540 Gap junction
KEGG:04912 GnRH signaling pathway
REACT:604 Hemostasis
REACT:1505 Integration of energy metabolism
KEGG:04730 Long-term depression
KEGG:04916 Melanogenesis
REACT:14797 Signaling by GPCR
REACT:33891 Signaling by GPCR
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28764
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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