AutismKB 2.0

Annotation Detail for GNA12


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Basic Information Top
Gene Symbol:GNA12 ( MGC104623,MGC99644,NNX3,RMP,gep )
Gene Full Name: guanine nucleotide binding protein (G protein) alpha 12
Band: 7p22.3-p22.2
Quick LinksEntrez ID:2768; OMIM: 604394; Uniprot ID:GNA12_HUMAN; ENSEMBL ID: ENSG00000146535; HGNC ID: 4380
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
hsa04010MAPK signaling pathway
hsa04730Long-term depression
hsa04810Regulation of actin cytoskeleton
Pathway IDPathway Name
Signaling by GPCR
Hemostasis
Pathway IDPathway Name
200035S1P3 pathway
200181S1P2 pathway
200004Endothelins
200063S1P5 pathway
200011LPA receptor mediated events
200043S1P4 pathway
200104Sphingosine 1-phosphate (S1P) pathway
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1790Hyperaldosteronism
1831Prostate cancer
1832Congenital abnormality
1944Breast cancer
1969Azoospermia
2051Leukemia
2237Neoplasm metastasis
Desease Name
height
DEVELOPMENTAL
Desease Name
Height
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of GNA12 mRNAincreases expression 20826375
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GNA12 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GNA12 mRNAdecreases expression 19150397
C006780 bisphenol A bisphenol A results in increased expression of GNA12 mRNAincreases expression 20826375
D004390 Chlorpyrifos Chlorpyrifos affects the expression of GNA12 mRNAaffects expression 17452286
D003024 Clozapine Clozapine results in decreased expression of GNA12 mRNAdecreases expression 15860345
D003976 Diazinon Diazinon affects the expression of GNA12 mRNAaffects expression 17452286
D004958 Estradiol Estradiol results in increased expression of GNA12 mRNAincreases expression 20826375
D005419 Flavonoids Flavonoids results in increased expression of GNA12 mRNAincreases expression 18035473
D006220 Haloperidol Haloperidol results in decreased expression of GNA12 mRNAdecreases expression 15860345
D007657 Ketone Bodies Ketone Bodies results in decreased expression of GNA12 mRNAdecreases expression 16807920
D001556 Lindane Lindane affects the expression of GNA12 mRNAaffects expression 17785943
D010126 Ozone Ozone results in decreased expression of GNA12 mRNAdecreases expression 16330353
D010634 Phenobarbital Phenobarbital results in decreased expression of GNA12 mRNAdecreases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of GNA12 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in increased expression of GNA12 mRNAincreases expression 18301758
C017947 sodium arsenite sodium arsenite results in decreased expression of GNA12 mRNAdecreases expression 20308225
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GNA12 mRNAincreases expression 15800033
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.276195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2715322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D000230 Adenocarcinoma Estradiol 2.0911473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.2517620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.2516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.2516835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9017306315 16712894
MESH:D000380 Agranulocytosis Clozapine 5.0414617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 14.6011874814 16611668 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 14.6016487989
MESH:D000382 Agricultural Workers' Diseases Lindane 14.6012661182
MESH:D000544 Alzheimer Disease Ozone 2.4315513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5515570426
MESH:D001249 Asthma Ozone 2.6317854713 16373670
MESH:D001321 Autistic Disorder Haloperidol 2.7419368416 18080171
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.7112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7515746008
MESH:D001862 Bone Resorption bisphenol A 3.8411985600
MESH:D001943 Breast Neoplasms bisphenol A 1.9817123778
MESH:D001943 Breast Neoplasms Estradiol 1.9818497071 17289903 17018787 12948864 16675129 17261762 14630087 19861407
MESH:D001943 Breast Neoplasms Lindane 1.9814688026
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6615516495 16777450 18315731 19059883 18417511 17626835 14754758
MESH:D002100 Cachexia Ozone 4.7316183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5916924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.5917173139 20935162 1701930 20007298 6705139
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.5916507464 17306315 15276417
MESH:D002278 Carcinoma in Situ bisphenol A 4.9817123778
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3718572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518670907 18850075 16120746
MESH:D002375 Catalepsy Haloperidol 4.901977408 15215559
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.1120889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.1118566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.1120056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.244080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1416835633
MESH:D002779 Cholestasis pirinixic acid 2.8119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0912621046 15340226 15668235 8697196 16354765
MESH:D003072 Cognition Disorders Clozapine 4.9517123785
MESH:D003093 Colitis, Ulcerative marker/mechanism 21297633
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.8220210726
MESH:D003704 Dementia Haloperidol 4.5611575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.4916402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3919279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.5515331141
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D050171 Dyslipidemias Clozapine 4.1716402076
MESH:D004417 Dyspnea Diazinon 4.8016487989
MESH:D004421 Dystonia Phenobarbital 3.991851702
MESH:D004487 Edema pirinixic acid 6.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9018230668 15322242 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 2.9711473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0010568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.093659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.873922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.526401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.247750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.013659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0720426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver pirinixic acid 2.7520131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9320067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6716452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3211294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006505 Hepatitis Diazinon 4.5616487989
MESH:D006529 Hepatomegaly Phenobarbital 14.3116109766
MESH:D006529 Hepatomegaly pirinixic acid 14.3119176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.3115340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.0315709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.1312676792
MESH:D019584 Hot Flashes Estradiol 3.7517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.058697196 18606429 15340226 16959395 16354765
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D006948 Hyperkinesis Clozapine 4.9016046005
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9018850075 18670907
MESH:D007248 Infertility, Male Diazinon 7.0912948887 16466525
MESH:D007248 Infertility, Male sodium arsenite 7.0912646999 15346721
MESH:D007249 Inflammation Flavonoids 4.9617296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9612200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 12.2416393666
MESH:D007333 Insulin Resistance Estradiol 12.2416393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 12.2416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007674 Kidney Diseases Estradiol 6.0615618244
MESH:D007674 Kidney Diseases sodium arsenite 6.0620008137
MESH:D007680 Kidney Neoplasms Estradiol 2.9615610895
MESH:D008064 Lipidoses Clozapine 3.9417567588
MESH:D008103 Liver Cirrhosis Phenobarbital 2.8821047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3612878042
MESH:D008107 Liver Diseases Chlorpyrifos 6.7815991261
MESH:D008107 Liver Diseases Lindane 6.781715830
MESH:D008107 Liver Diseases Phenobarbital 6.7819363144
MESH:D008113 Liver Neoplasms Phenobarbital 10.6219812893 8742319 19482888 21047994 15975961 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 10.6220007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 10.6216712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.6216984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 5.751399818 6150874 17172636 2563599 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.7512151625
MESH:D008171 Lung Diseases Ozone 7.478266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 7.4719095001
MESH:D055370 Lung Injury Ozone 3.8320417186
MESH:D008175 Lung Neoplasms Ozone 3.428597069 7614698
MESH:D008175 Lung Neoplasms sodium arsenite 3.4219931552 15276417 17306315 17077188 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4219555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5411807958 11408345 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.4819453300
MESH:D008545 Melanoma sodium arsenite 2.0319082730 16487513
MESH:D001523 Mental Disorders Clozapine 8.3416856516
MESH:D001523 Mental Disorders Haloperidol 8.3416856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.3919142101
MESH:D008679 Metaplasia Ozone 5.1110496685
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.1916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4717484760
MESH:D009369 Neoplasms Lindane 8.3112807735 16818664
MESH:D009369 Neoplasms pirinixic acid 8.3117405874
MESH:D009369 Neoplasms sodium arsenite 8.3111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6520056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7217289903
MESH:D009421 Nervous System Malformations bisphenol A 16.2711399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 16.2716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.2714600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1312854658
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.1515081274
MESH:D009765 Obesity Clozapine 4.6819142110 18515891
MESH:D009765 Obesity pirinixic acid 4.6820558911
MESH:D010018 Osteomalacia Phenobarbital 4.3617016548
MESH:D010049 Ovarian Diseases bisphenol A 4.9811985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.8219401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.8217306315 15276417
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.4816965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010538 Peritonitis Ozone 4.1216369182
MESH:D011014 Pneumonia Ozone 4.3918929643 18007984 18381685
MESH:D011041 Poisoning Diazinon 4.3317603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.602563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.4810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4811399792 11118676 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.4920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.4920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1316740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.1316740699
MESH:D011471 Prostatic Neoplasms Lindane 2.1314688026 12661182
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1316039940
MESH:D019310 Pseudolymphoma Phenobarbital 4.5012752131
MESH:D011595 Psychomotor Agitation Haloperidol 4.9411575062
MESH:D011618 Psychotic Disorders Clozapine 9.1115331141
MESH:D011618 Psychotic Disorders Haloperidol 9.1111575062
MESH:D011629 Puberty, Precocious bisphenol A 4.7810548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.6217119214 16611668 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.8916611668 17119214
MESH:D012559 Schizophrenia Clozapine 4.0918855531 16141801 20521326 19369910 20168265 17667964 20580759 18806925 17726453 17123785 20452607 11151749 20107430 20521320 11763009
MESH:D012559 Schizophrenia Haloperidol 4.0919369910 20107430 1830565 18513383
MESH:D012640 Seizures Lindane 6.2815475178 12842176 7539098
MESH:D012640 Seizures Phenobarbital 6.283137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.816407741
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.096418539
MESH:D012878 Skin Neoplasms sodium arsenite 5.5619524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5616192470
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7812854658
MESH:D019966 Substance-Related Disorders bisphenol A 3.9716684133 16045194
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.6920210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.041399818
MESH:D013978 Tibial Fractures Estradiol 4.6919048282
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5017306315 16452187 16712894 11723127
MESH:D014570 Urologic Diseases Diazinon 5.2816487989
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7511813266
MESH:D014591 Uterine Diseases bisphenol A 5.0114652134
MESH:D014652 Vascular Diseases sodium arsenite 4.4217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D015430 Weight Gain Clozapine 4.4516402076 17502770 16141801 20107430 20564506 20521320
MESH:D015431 Weight Loss Clozapine 5.0717933447
Pathway ID Pathway Name
REACT:604 Hemostasis
KEGG:04730 Long-term depression
KEGG:04010 MAPK signaling pathway
KEGG:04810 Regulation of actin cytoskeleton
REACT:14797 Signaling by GPCR
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28765
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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