AutismKB 2.0

Annotation Detail for GNA15


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Basic Information Top
Gene Symbol:GNA15 ( GNA16 )
Gene Full Name: guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Band: 19p13.3
Quick LinksEntrez ID:2769; OMIM: 139314; Uniprot ID:GNA15_HUMAN; ENSEMBL ID: ENSG00000060558; HGNC ID: 4383
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04020Calcium signaling pathway
hsa05142Chagas disease
hsa05146Amoebiasis
Pathway IDPathway Name
Signaling by GPCR
Diabetes pathways
Hemostasis
Integration of energy metabolism
No data
Pathway IDPathway Name
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P00041Metabotropic glutamate receptor group I pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GNA15 mRNAaffects expression 16483693
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GNA15 mRNAincreases expression 17557909
D005419 Flavonoids Flavonoids results in increased expression of GNA15 mRNAincreases expression 18035473
D011794 Quercetin Quercetin results in increased expression of GNA15 mRNAincreases expression 15309432
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.6617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D000743 Anemia, Hemolytic Quercetin 4.6717084956
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 4.0211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8915885639
MESH:D001260 Ataxia Telangiectasia Quercetin 5.6115336622
MESH:D001327 Autoimmune Diseases Quercetin 4.9719761891
MESH:D001943 Breast Neoplasms Quercetin 2.6218628248
MESH:D002105 Cadmium Poisoning Quercetin 6.2716962696
MESH:D006528 Carcinoma, Hepatocellular Quercetin 2.3019519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.5217234771
MESH:D006332 Cardiomegaly Quercetin 3.5119794523
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1715861022 16105132 11677210 17681005 17110522 16919318 17333356
MESH:D003110 Colonic Neoplasms Quercetin 2.4716640504 17191121 11134977 19056647 15741050 17148506 19440933
MESH:D015179 Colorectal Neoplasms Quercetin 2.1918852136 18095365
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 4.0819496084
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.6912538720
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.2415345470
MESH:D005355 Fibrosis Quercetin 4.4619474275
MESH:D005909 Glioblastoma Quercetin 3.6319804834
MESH:D005910 Glioma Quercetin 3.1817643826
MESH:D006943 Hyperglycemia Quercetin 4.4311834736 18262572
MESH:D006973 Hypertension Quercetin 2.9718356687
MESH:D007021 Hypospadias Ethinyl Estradiol 4.3716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.9212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7317937319
MESH:D007249 Inflammation Flavonoids 2.8217296493
MESH:D007251 Influenza, Human Quercetin 5.2316624496
MESH:D007627 Keloid Quercetin 5.5217086741
MESH:D007674 Kidney Diseases Quercetin 3.3016962696
MESH:D007938 Leukemia Quercetin 3.3217468513
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.2012741479
MESH:D008113 Liver Neoplasms Quercetin 2.7818980244
MESH:D008114 Liver Neoplasms, Experimental Quercetin 3.2819519916
MESH:D008175 Lung Neoplasms Quercetin 2.1916280456
MESH:D009203 Myocardial Infarction Quercetin 3.1219595682
MESH:D015428 Myocardial Reperfusion Injury Quercetin 4.1019207477
MESH:D009369 Neoplasms Quercetin 2.9615185748
MESH:D020078 Neurogenic Inflammation Quercetin 4.8217929310
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.6819495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.8219005980
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9616965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.1511578682
MESH:D011230 Precancerous Conditions Quercetin 4.3519056647
MESH:D011471 Prostatic Neoplasms Quercetin 3.5414715546 17292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.9416919318 15861022
MESH:D012554 Schistosomiasis japonica Quercetin 6.2716862918
MESH:D013088 Spermatocele Ethinyl Estradiol 4.6616709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.5215669648
MESH:D001749 Urinary Bladder Neoplasms Quercetin 2.9216720314
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.8014692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9714671159 15869587
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
KEGG:04020 Calcium signaling pathway
KEGG:05142 Chagas disease (American trypanosomiasis)
REACT:15380 Diabetes pathways
REACT:604 Hemostasis
REACT:1505 Integration of energy metabolism
REACT:14797 Signaling by GPCR
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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