AutismKB 2.0

Annotation Detail for GNAI1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GNAI1 ( Gi )
Gene Full Name: guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Band: 7q21.11
Quick LinksEntrez ID:2770; OMIM: 139310; Uniprot ID:GNAI1_HUMAN; ENSEMBL ID: ENSG00000127955; HGNC ID: 4384
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04670Leukocyte transendothelial migration
hsa04916Melanogenesis
hsa04360Axon guidance
hsa05142Chagas disease
hsa05145Toxoplasmosis
hsa04540Gap junction
hsa04730Long-term depression
hsa04530Tight junction
hsa04971Gastric acid secretion
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Diabetes pathways
Hemostasis
Opioid Signalling
Integration of energy metabolism
Pathway IDPathway Name
200085EGF receptor (ErbB1) signaling pathway
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P05730Endogenous cannabinoid signaling
P00040Metabotropic glutamate receptor group II pathway
P00048PI3 kinase pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P05731GABA-B receptor II signaling
P043735HT1 type receptor mediated signaling pathway
Pathway IDPathway Name
500840Adenylate cyclase inhibitory pathway
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2237Neoplasm metastasis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of GNAI1 mRNAdecreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of GNAI1 mRNAincreases expression 20406850
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GNAI1 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of GNAI1 mRNAincreases expression 18687144
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of GNAI1 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GNAI1 mRNAdecreases expression 19150397
20018196
C006780 bisphenol A bisphenol A results in decreased expression of GNAI1 mRNAdecreases expression 20678512
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GNAI1 mRNAaffects expression 17484886
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of GNAI1 mRNAaffects cotreatment|decreases expression 18636392
D002995 Clofibric Acid Clofibric Acid affects the expression of GNAI1 mRNAaffects expression 17602206
D003024 Clozapine Clozapine results in decreased expression of GNAI1 mRNAdecreases expression 15860345
D016572 Cyclosporine Cyclosporine results in decreased expression of GNAI1 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of GNAI1 mRNAdecreases expression 18042831
D004958 Estradiol Estradiol affects the expression of GNAI1 mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of GNAI1 mRNAdecreases expression 17606305
D006220 Haloperidol Haloperidol results in decreased expression of GNAI1 mRNAdecreases expression 15860345
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of GNAI1 mRNAaffects cotreatment|decreases expression 18636392
C041786 palm oil palm oil results in decreased expression of GNAI1 mRNAdecreases expression 18042831
D010424 Pentobarbital Pentobarbital affects the expression of GNAI1 mRNAaffects expression 12199159
D010852 Picrotoxin Picrotoxin results in decreased expression of GNAI1 mRNAdecreases expression 15170462
C006253 pirinixic acid pirinixic acid results in decreased expression of GNAI1 mRNAdecreases expression 17950772
C006253 pirinixic acid pirinixic acid results in increased expression of GNAI1 mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GNAI1 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GNAI1 mRNAdecreases expression 16120747
19933214
D014801 Vitamin A Vitamin A results in increased expression of GNAI1 proteinincreases expression 16757122
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7014514962 15322242 11752688
MESH:D000015 Abnormalities, Multiple Vitamin A 4.7210992263
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D055371 Acute Lung Injury Chlorine 8.6720601635
MESH:D055371 Acute Lung Injury pirinixic acid 8.6718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.7720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.7711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7714692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.576695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3916835633
MESH:D000380 Agranulocytosis Clozapine 4.9012649775 14617031 16160616
MESH:D000544 Alzheimer Disease Ozone 2.4115513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.5311748828
MESH:D000740 Anemia Vitamin A 8.5316960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.6616960172
MESH:D001008 Anxiety Disorders Pentobarbital 4.6111141031 18313124
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9219183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.4115238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.4111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5715885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5215570426
MESH:D001249 Asthma Ozone 5.1717854713 16373670
MESH:D001249 Asthma Vitamin A 5.1716732791
MESH:D001321 Autistic Disorder Haloperidol 2.7519368416 18080171
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D001862 Bone Resorption bisphenol A 3.7211985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2820146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 2.2817123778
MESH:D001943 Breast Neoplasms Dietary Fats 2.2820435547
MESH:D001943 Breast Neoplasms Estradiol 2.2816675129 12948864 19861407 17289903 14630087 18497071 17018787 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2820435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5618315731 16777450 15516495 19059883 17626835 14754758 18417511
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 5.4517426644 17377406
MESH:D002100 Cachexia Ozone 4.5916183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6316050911 15673190 16011737 15721981 16124888 15700767 16192424 16227642 3786805 16097048 10355542 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.4316705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.4318788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.4316924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.8417123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0120419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2816120746 18670907 18850075
MESH:D002375 Catalepsy Haloperidol 4.761977408 15215559
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.156135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.1520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.1512371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.1518566989
MESH:D015362 Child Nutrition Disorders Vitamin A 5.3216153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002779 Cholestasis Cyclosporine 18.3519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 18.3516919318 17110522 17681005 15861022 16105132 11677210 17333356
MESH:D002779 Cholestasis pirinixic acid 18.3519176532
MESH:D002779 Cholestasis Vitamin A 18.3516175620
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9315340226 12621046 8697196 16354765 15668235
MESH:D002972 Cleft Palate Vitamin A 5.9316054864
MESH:D003072 Cognition Disorders Clozapine 4.8117123785
MESH:D003110 Colonic Neoplasms Vitamin A 3.0216267017 17219422
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7720055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin A 2.7710992263
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8718551238
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.7020210726
MESH:D003704 Dementia Haloperidol 4.4411575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.4616506275
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.3816402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2819279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.4015331141
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 5.9121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.917179309 10915739 15027814 4309450 6623471 3786805 11566570 15998439 19336974 17522070 7120509 9327722 3732212 7440962 10092053 15968718 6884620 16177239 2869522 16227642 21278145 19085960
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.9120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.6516146918
MESH:D050171 Dyslipidemias Clozapine 8.5016402076
MESH:D050171 Dyslipidemias Dietary Fats 8.5018367378
MESH:D004417 Dyspnea Chlorine 4.4720016425
MESH:C538011 Eales disease Vitamin A 5.479068938
MESH:D004480 Ectromelia Vitamin A 5.6716054864
MESH:D004487 Edema pirinixic acid 6.0812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0412538720
MESH:D016889 Endometrial Neoplasms Estradiol 2.8819148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8910568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.2216530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 23.1612795759 19224547 15959796 61145 12631006 17595544 16045604 16239168
MESH:D005234 Fatty Liver Cyclosporine 23.1619224547
MESH:D005234 Fatty Liver Dietary Fats 23.1617967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 23.1615345470
MESH:D005234 Fatty Liver pirinixic acid 23.1620131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005327 Fetal Resorption Vitamin A 5.2116054864
MESH:D005355 Fibrosis Carbon Tetrachloride 19.8918705752
MESH:D005355 Fibrosis Cyclosporine 19.8912639820 12168785
MESH:D005355 Fibrosis Dietary Fats 19.8918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.8920067830
MESH:D005739 Gas Poisoning Chlorine 4.8620016425
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.7720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.7710048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin A 10.7716080930 10992263
MESH:D006333 Heart Failure pirinixic acid 2.4420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4519900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.7616221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7615340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.5716877224 16863852 15707848 17436238 16490937 16292552
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D015658 HIV Infections Vitamin A 3.7416960176
MESH:D006679 HIV Seropositivity Vitamin A 5.4517209195
MESH:D019584 Hot Flashes Estradiol 3.6017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.898697196 18606429 15340226 16354765 16959395
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4521332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006948 Hyperkinesis Clozapine 4.7616046005
MESH:D006949 Hyperlipidemias Dietary Fats 3.4721332399
MESH:D006973 Hypertension Cyclosporine 4.7510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D006986 Hypervitaminosis A Vitamin A 6.0216054864
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6616945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3917937319
MESH:D007249 Inflammation Dietary Fats 4.6620412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.6612200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 16.8316393666
MESH:D007333 Insulin Resistance Dietary Fats 16.8311836018 18457598
MESH:D007333 Insulin Resistance Estradiol 16.8316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 16.8316306350
MESH:D019586 Intracranial Hypertension Vitamin A 5.6715955940
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Cyclosporine 5.6518776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 5.6515618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.6516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.6512371664
MESH:D007680 Kidney Neoplasms Estradiol 11.6515610895
MESH:D017880 Limb Deformities, Congenital Vitamin A 4.2116054864
MESH:D008064 Lipidoses Clozapine 3.8517567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.6811408273 16239168 16221502 21278145 16943688 11903743 17157831 17174718 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 10.6818296743
MESH:D008103 Liver Cirrhosis Vitamin A 10.6816256175
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5315925388 14724832 18277467 15057751 12445418 11481614 12546737 13678700 17557913 16097048 15730626 18376398 15818738 16027843 18006644 17900296 15673190 18339082 12649538 15959796 14620537 16116963 17481882 18705752 12898905 12741479 12632514 15996030 17708605 17714472 18472332 12958196 15370692 18317297 17869086 18205269 16136751 18251166 14512876 15362042 16638106 17631135 14748882 17976157 17761835 18395095 17922224 12632512 18412020 17766677 12389079 18420326 15338365 16033810 17805973 17525996 17698563 18279442 15931870 10355542 18054572 12586293 18210741 15893842 16248980 18429990 18472094 15876570 18395914 16011737 18481824 14716833 17565644 16192424 12666154 15052691 14716496 17944888 17823541 15650968 18166357 12667390 16015684 18263696 12609069 17721639 17640975 18156304 18187930 12445421 20821823 15123356 18418968
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 6.5316248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.3315830285 17285989 15720792 16964402 16246199
MESH:D008107 Liver Diseases Vitamin A 4.3316175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 5.0016762690
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5616899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 17.247678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.2420195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.2419294768
MESH:D008113 Liver Neoplasms Clofibric Acid 17.2417602206
MESH:D008113 Liver Neoplasms pirinixic acid 17.2420007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.2416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.382876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.3812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.3812151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 13.3817113696
MESH:D008171 Lung Diseases Ozone 7.5219066396 8266340
MESH:D008171 Lung Diseases Vitamin A 7.5216863852
MESH:D055370 Lung Injury Asbestos, Crocidolite 8.7417365036
MESH:D055370 Lung Injury Ozone 8.7420417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.2918569708 20135361 20869020 20064080 18816296 18520028 20464547 6695378 17053015
MESH:D008175 Lung Neoplasms Ozone 3.298597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.2911884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.4711807958 11408345 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.3319453300
MESH:D001523 Mental Disorders Clozapine 7.8616856516
MESH:D001523 Mental Disorders Haloperidol 7.8616856516
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1216966607 16166281 18303189
MESH:D024821 Metabolic Syndrome X Clozapine 4.2919142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D008679 Metaplasia Ozone 4.9610496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0716381670
MESH:D009101 Multiple Myeloma Vitamin A 3.9416374440
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.8616411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.7118551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 4.5711141357
MESH:D009369 Neoplasms pirinixic acid 4.5717405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5817289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1518481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 15.5016427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 15.5016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.5014600291
MESH:D009436 Neural Tube Defects Vitamin A 3.9617400914
MESH:D009765 Obesity Clozapine 7.2518515891 19142110
MESH:D009765 Obesity Dietary Fats 7.2517217161 20132043 21332399 20518802 16723640 18457598 18674790 19632207 11836018
MESH:D009765 Obesity pirinixic acid 7.2520558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3016049721
MESH:D010049 Ovarian Diseases bisphenol A 4.8411985600
MESH:D010051 Ovarian Neoplasms Estradiol 2.1719401270
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010538 Peritonitis Ozone 3.9816369182
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.7410923243
MESH:D011014 Pneumonia Ozone 4.2418381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0912371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 9.0010548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0011118676 11399792 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.0920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.0920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5816740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.5816740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.1615861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011595 Psychomotor Agitation Haloperidol 4.8011575062
MESH:D011618 Psychotic Disorders Clozapine 8.8015331141
MESH:D011618 Psychotic Disorders Haloperidol 8.8011575062
MESH:D011629 Puberty, Precocious bisphenol A 4.6310548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9717322281 17365031 15814490 17975199
MESH:D012021 Reflex, Abnormal Pentobarbital 5.8710930210
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D012120 Respiration Disorders Chlorine 5.0618579056
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.6516877224
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012559 Schizophrenia Clozapine 4.0217726453 20168265 20521326 18806925 20452607 16141801 20580759 17667964 11763009 11151749 18855531 19369910 20107430 17123785 20521320
MESH:D012559 Schizophrenia Haloperidol 4.021830565 19369910 18513383 20107430
MESH:D012640 Seizures 2,6-dinitrotoluene 9.5718551238
MESH:D012640 Seizures Pentobarbital 9.579754883 10087439
MESH:D012640 Seizures Picrotoxin 9.578635557 8954991
MESH:D012871 Skin Diseases Vitamin A 3.3218709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.2419755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7916709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.552093021 20155912
MESH:D019966 Substance-Related Disorders bisphenol A 3.8316684133 16045194
MESH:D013375 Substance Withdrawal Syndrome marker/mechanism 12199159
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 4.849754883 11529278
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.5620210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013978 Tibial Fractures Estradiol 4.5319048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.7816049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.7817053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1710091137
MESH:D014591 Uterine Diseases bisphenol A 4.8614652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1514692618
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4014671159 15869587
MESH:D014802 Vitamin A Deficiency Vitamin A 5.1316175781 16146918 16960172
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D015430 Weight Gain Clozapine 9.3916402076 20107430 16141801 17502770 20564506 20521320
MESH:D015430 Weight Gain Dietary Fats 9.3916723640
MESH:D015431 Weight Loss Clozapine 4.9217933447
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
Pathway ID Pathway Name
KEGG:04360 Axon guidance
KEGG:05142 Chagas disease (American trypanosomiasis)
KEGG:04062 Chemokine signaling pathway
REACT:15380 Diabetes pathways
KEGG:04540 Gap junction
KEGG:04971 Gastric acid secretion
KEGG:04724 Glutamatergic synapse
REACT:604 Hemostasis
REACT:1505 Integration of energy metabolism
KEGG:04670 Leukocyte transendothelial migration
KEGG:04730 Long-term depression
KEGG:04916 Melanogenesis
REACT:15295 Opioid Signalling
KEGG:04914 Progesterone-mediated oocyte maturation
REACT:14797 Signaling by GPCR
REACT:13685 Synaptic Transmission
KEGG:04530 Tight junction
KEGG:05145 Toxoplasmosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA172
    • No data
    No data
    Releated drug ID Related drug Name
    PA448497aspirin
    PA448478l-arginine
    PA450635nitric oxide
    PA451123progesterone
    PA164743471adenosine triphosphate
    PA450121isoproterenol
    PA165290926fluticasone/salmeterol
    PA451300salmeterol
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04315 - Guanosine-5'-Diphosphate
    DB04444 - Tetrafluoroaluminate Ion
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved