AutismKB 2.0

Annotation Detail for GNAO1


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Basic Information Top
Gene Symbol:GNAO1 ( DKFZp686O0962,G-ALPHA-o,GNAO )
Gene Full Name: guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Band: 16q13
Quick LinksEntrez ID:2775; OMIM: 139311; Uniprot ID:GNAO_HUMAN; ENSEMBL ID: ENSG00000087258; HGNC ID: 4389
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa05142Chagas disease
hsa05145Toxoplasmosis
hsa04730Long-term depression
Pathway IDPathway Name
Diabetes pathways
Opioid Signalling
Integration of energy metabolism
No data
Pathway IDPathway Name
P05730Endogenous cannabinoid signaling
P00040Metabotropic glutamate receptor group II pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
P05731GABA-B receptor II signaling
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C038699 acetophenone [acetophenone co-treated with OLFR151 co-treated with GNAO1 co-treated with P2RY1] results in increased phosphorylation of MAPK1 proteinaffects cotreatment|increases phosphorylation 17472961
C038699 acetophenone [acetophenone co-treated with OLFR151 co-treated with GNAO1 co-treated with P2RY1] results in increased phosphorylation of MAPK3 proteinaffects cotreatment|increases phosphorylation 17472961
C038699 acetophenone [acetophenone co-treated with OLFR151 co-treated with GNAO1 co-treated with P2RY2] results in increased phosphorylation of MAPK1 proteinaffects cotreatment|increases phosphorylation 17472961
C038699 acetophenone [acetophenone co-treated with OLFR151 co-treated with GNAO1 co-treated with P2RY2] results in increased phosphorylation of MAPK3 proteinaffects cotreatment|increases phosphorylation 17472961
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GNAO1 mRNAaffects expression 16483693
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in increased expression of GNAO1 mRNAincreases expression 15912405
D002713 Chlorine Chlorine results in decreased expression of GNAO1 mRNAdecreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of GNAO1 mRNAaffects cotreatment|affects expression 18636392
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of GNAO1 mRNAdecreases expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GNAO1 mRNAincreases expression 15212814
D005419 Flavonoids Flavonoids results in increased expression of GNAO1 mRNAincreases expression 18035473
D019833 Genistein Genistein results in decreased expression of GNAO1 mRNAdecreases expression 16169203
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of GNAO1 mRNAdecreases expression 12057914
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of GNAO1 mRNAaffects cotreatment|affects expression 18636392
D010269 Paraquat Paraquat affects the expression of GNAO1 mRNAaffects expression 15206577
D010424 Pentobarbital Pentobarbital affects the expression of GNAO1 mRNAaffects expression 12199159
D010634 Phenobarbital Phenobarbital results in increased expression of GNAO1 mRNAincreases expression 12807726
D011794 Quercetin Quercetin affects the expression of GNAO1 mRNAaffects expression 18178720
D013629 Tamoxifen Tamoxifen affects the expression of GNAO1 mRNAaffects expression 17555576
C025643 vinclozolin vinclozolin affects the expression of GNAO1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6114745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.496195326
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D055371 Acute Lung Injury Chlorine 9.5920601635
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.5911850527 18653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3814692618
MESH:D000230 Adenocarcinoma Genistein 4.3811473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.0217620307
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.8111874814
MESH:D000544 Alzheimer Disease Ozone 2.4415513908
MESH:D000743 Anemia, Hemolytic Quercetin 4.2717084956
MESH:D001008 Anxiety Disorders Pentobarbital 9.3518313124 11141031
MESH:D001008 Anxiety Disorders vinclozolin 9.3519015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5615570426
MESH:D001249 Asthma Ozone 2.6417854713 16373670
MESH:D001260 Ataxia Telangiectasia Quercetin 5.0315336622
MESH:D001327 Autoimmune Diseases Quercetin 4.4519761891
MESH:D001943 Breast Neoplasms Genistein 1.9916873071 16541309 17200150
MESH:D001943 Breast Neoplasms Quercetin 1.9918628248
MESH:D001943 Breast Neoplasms Tamoxifen 1.9911161223 18984771 19084267 17049068 15668708 18997820 18855134 18821012 19011961 20390343 17893378 17242785 19221464 21152245 20544844 17261762 19189210 19200415 16202921 19487384 18351453 19066611 19115204 16818667 16873071 17440819 19142967 19103187 15565566 19289846 19189212 21138602 20135344 18425577 19410462 20065188 18815881 19288272 16273361 20859285 19155303 20005174 19059307 19244106 18629630
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7015516495 16777450 18417511 17626835 19059883 18315731 14754758
MESH:D002100 Cachexia Ozone 4.7916183385
MESH:D002105 Cadmium Poisoning Quercetin 5.6116962696
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5519066611
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.6516924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.6517173139 6705139 1701930 20007298 20935162
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.6519519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.6516924424
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.0017234771
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6417572228
MESH:D006332 Cardiomegaly Quercetin 3.3319794523
MESH:D002318 Cardiovascular Diseases Genistein 3.3216332659
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.294080065
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8917333356 16919318 15861022 17681005 11677210 16105132 17110522
MESH:D003110 Colonic Neoplasms Genistein 3.9417182828
MESH:D003110 Colonic Neoplasms Quercetin 3.9415741050 11134977 19440933 16640504 17148506 17191121 19056647
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818095365 18852136
MESH:D003456 Cryptorchidism vinclozolin 4.3814966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4019031437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.7519496084
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.4916647724
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5019279558
MESH:D004417 Dyspnea Chlorine 4.6920016425
MESH:D004421 Dystonia Phenobarbital 4.041851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.0719031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.6416402032
MESH:D016889 Endometrial Neoplasms Genistein 7.5911473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.5917893378 19155303 16202921 20544844
MESH:D019446 Endotoxemia Lipopolysaccharides 4.4517637181 15328337 15821434
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.153659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.933922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.576401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.297750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.073659116
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.7915345470
MESH:D005234 Fatty Liver Tamoxifen 7.7919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2516709447
MESH:D005334 Fever Lipopolysaccharides 4.049205823 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2319069698
MESH:D005355 Fibrosis Quercetin 3.9419474275
MESH:D005739 Gas Poisoning Chlorine 5.0720016425
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3616417039
MESH:D005909 Glioblastoma Genistein 7.4116598420
MESH:D005909 Glioblastoma Quercetin 7.4119804834
MESH:D005910 Glioma Quercetin 3.0617643826
MESH:D005911 Gliosis Paraquat 5.2311124998
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4116366002
MESH:D006529 Hepatomegaly Phenobarbital 3.5316109766
MESH:D006943 Hyperglycemia Quercetin 4.0611834736 18262572
MESH:D006973 Hypertension Quercetin 2.8718356687
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.3517937319
MESH:D007248 Infertility, Male Paraquat 11.354850670
MESH:D007248 Infertility, Male vinclozolin 11.3516467254
MESH:D007249 Inflammation Flavonoids 8.5217296493
MESH:D007249 Inflammation Lipopolysaccharides 8.5212878042 17237260 9205823 17963957 17255318
MESH:D007249 Inflammation Tamoxifen 8.5219457130
MESH:D007251 Influenza, Human Quercetin 4.5716624496
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.6617255318
MESH:D007627 Keloid Quercetin 5.0017086741
MESH:D007674 Kidney Diseases Quercetin 3.1116962696
MESH:D007680 Kidney Neoplasms Tamoxifen 3.0718625569
MESH:D007938 Leukemia Genistein 6.6017468513 18980019
MESH:D007938 Leukemia Quercetin 6.6017468513
MESH:D007970 Leukopenia Lipopolysaccharides 4.7515821434
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7816417039
MESH:D008064 Lipidoses Tamoxifen 3.1715342952 17567588
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9121047994
MESH:D008106 Liver Cirrhosis, Experimental Genistein 5.0517823541
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 5.0512878042
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 5.0512741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.0518564211
MESH:D008107 Liver Diseases Phenobarbital 2.1819363144
MESH:D008113 Liver Neoplasms Phenobarbital 7.5919812893 8742319 19073162 19482888 15975961 21047994
MESH:D008113 Liver Neoplasms Quercetin 7.5918980244
MESH:D008113 Liver Neoplasms Tamoxifen 7.5916684651
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.202563599 1399818 6150874 17172636 18308698
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.2019519916
MESH:D008171 Lung Diseases Ozone 3.398266340 19066396
MESH:D055370 Lung Injury Lipopolysaccharides 9.3821114838
MESH:D055370 Lung Injury Ozone 9.3820417186
MESH:D008175 Lung Neoplasms Ozone 3.568597069 7614698
MESH:D008175 Lung Neoplasms Quercetin 3.5616280456
MESH:D008175 Lung Neoplasms Tamoxifen 3.5618625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8119428831
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.1712929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.1711731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.6119453300
MESH:D008545 Melanoma Tamoxifen 1.8819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2315990972
MESH:D008679 Metaplasia Ozone 5.1710496685
MESH:D009203 Myocardial Infarction Genistein 6.0317141266
MESH:D009203 Myocardial Infarction Quercetin 6.0319595682
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.7717141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.7719207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5317484760
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms Quercetin 2.8115185748
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0619200415 19189210 19196722
MESH:D009410 Nerve Degeneration Paraquat 3.7416893418
MESH:D009421 Nervous System Malformations Genistein 4.0716427766
MESH:D020078 Neurogenic Inflammation Quercetin 4.3917929310
MESH:D010018 Osteomalacia Phenobarbital 4.4117016548
MESH:D010024 Osteoporosis Genistein 3.2719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.2516169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 10.2519495926
MESH:D010051 Ovarian Neoplasms Genistein 5.1119005980
MESH:D010051 Ovarian Neoplasms Quercetin 5.1119005980
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4516965848
MESH:D010190 Pancreatic Neoplasms Quercetin 5.4516965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010300 Parkinson Disease Paraquat 2.8211445065 11124998 15451049 11181820 12911755 16510128 15824117 16140633
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.4716190885
MESH:D010538 Peritonitis Ozone 4.1716369182
MESH:D011014 Pneumonia Lipopolysaccharides 18.8912224865 11605937
MESH:D011014 Pneumonia Ozone 18.8918007984 18929643 18381685
MESH:D011014 Pneumonia Paraquat 18.8912504350
MESH:D011230 Precancerous Conditions Phenobarbital 9.332563599
MESH:D011230 Precancerous Conditions Quercetin 9.3319056647
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.9519015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.9818220299
MESH:D011471 Prostatic Neoplasms Genistein 2.6416925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Quercetin 2.6414715546 17292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6415067354
MESH:D011472 Prostatitis vinclozolin 4.9818629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.3616919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.5612752131
MESH:D011658 Pulmonary Fibrosis Paraquat 2.9216324872 17997886
MESH:D012021 Reflex, Abnormal Pentobarbital 6.0710930210
MESH:D012120 Respiration Disorders Chlorine 5.2718579056
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.9411700416
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7510835634
MESH:D012135 Respiratory Sounds Paraquat 4.1011874814
MESH:D012162 Retinal Degeneration Paraquat 3.8916458197
MESH:D012554 Schistosomiasis japonica Quercetin 5.6116862918
MESH:D012640 Seizures Pentobarbital 6.4910087439 9754883
MESH:D012640 Seizures Phenobarbital 6.493137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.876407741
MESH:D013088 Spermatocele Ethinyl Estradiol 11.7716709447
MESH:D013088 Spermatocele Tamoxifen 11.7716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0919457130
MESH:D013375 Substance Withdrawal Syndrome marker/mechanism 12199159
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 5.009754883 11529278
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.1915821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.071399818
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.2616720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.2617572228 16712894 8653321
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
Pathway ID Pathway Name
KEGG:05142 Chagas disease (American trypanosomiasis)
REACT:15380 Diabetes pathways
KEGG:04724 Glutamatergic synapse
REACT:1505 Integration of energy metabolism
KEGG:04730 Long-term depression
KEGG:04916 Melanogenesis
REACT:15295 Opioid Signalling
KEGG:05145 Toxoplasmosis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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