AutismKB 2.0

Annotation Detail for GNAZ


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Basic Information Top
Gene Symbol:GNAZ ( - )
Gene Full Name: guanine nucleotide binding protein (G protein), alpha z polypeptide
Band: 22q11.22-q11.23
Quick LinksEntrez ID:2781; OMIM: 139160; Uniprot ID:GNAZ_HUMAN; ENSEMBL ID: ENSG00000128266; HGNC ID: 4395
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04730Long-term depression
Pathway IDPathway Name
Signaling by GPCR
Opioid Signalling
No data
No data
Pathway IDPathway Name
500435G alpha (z) signalling events
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of GNAZ mRNAaffects expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GNAZ mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GNAZ mRNAdecreases expression 20106945
D002713 Chlorine Chlorine results in increased expression of GNAZ mRNAincreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of GNAZ mRNAaffects cotreatment|increases expression 18636392
D003976 Diazinon Diazinon affects the expression of GNAZ mRNAaffects expression 17452286
C013038 hydroxyhydroquinone hydroxyhydroquinone results in increased expression of GNAZ mRNAincreases expression 17572062
D007657 Ketone Bodies Ketone Bodies results in increased expression of GNAZ mRNAincreases expression 15469884
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of GNAZ mRNAaffects cotreatment|increases expression 18636392
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of GNAZ mRNAincreases expression 18087596
D014810 Vitamin E Vitamin E results in increased expression of GNAZ mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D055371 Acute Lung Injury Chlorine 4.5120601635
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220464547 20127859
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.7915814487
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.913712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.916695378
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.5716487989
MESH:D000544 Alzheimer Disease Ozone 2.4715513908
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001172 Arthritis, Rheumatoid Ozone 5.1315570426
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 5.1319898480
MESH:D001249 Asthma Ozone 2.6817854713 16373670
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.281440618 11289319
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8118315731 17626835 18417511 14754758 15516495 19059883 16777450
MESH:D002100 Cachexia Ozone 4.9816183385
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.767296757 3581430
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.4711212258
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.0520419170
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 5.0511212258
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.877505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.2719486331 9022650
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0118759878 2524372 12868966 8970840 8156756 14531868 11298694 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.672952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.009653073 7440962 6482804 6679447 11289319 18692083 16192314 18289764 18648102 9328219 9022650 8291058 1440618
MESH:D004417 Dyspnea Chlorine 11.5820016425
MESH:D004417 Dyspnea Diazinon 11.5816487989
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.493581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4916530937
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005739 Gas Poisoning Chlorine 5.2720016425
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9620471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9616080930
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.256705139
MESH:D006505 Hepatitis Diazinon 10.2516487989
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D007248 Infertility, Male Diazinon 3.9312948887 16466525
MESH:D007249 Inflammation Tobacco Smoke Pollution 3.4218590791
MESH:D007251 Influenza, Human Vitamin E 4.4816624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.289022650 8074119
MESH:D007674 Kidney Diseases Vitamin E 2.8912488133
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.116582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.0920195826 21137059
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.63598648 3712494 6587162 1399818
MESH:D008171 Lung Diseases Ozone 7.898266340 19066396
MESH:D008171 Lung Diseases Vitamin E 7.8916863852
MESH:D055370 Lung Injury Ozone 4.0620417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0618569708 18816296 20464547 20064080 20869020 20135361 18520028 6695378 17053015
MESH:D008175 Lung Neoplasms Ozone 5.067614698 8597069
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 5.063440675 16288123 12111688 11091918
MESH:D008175 Lung Neoplasms Vitamin E 5.0611062179
MESH:D008679 Metaplasia Ozone 5.3710496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.2416381670
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 9.2415006635
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2411141357
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.584026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010538 Peritonitis Ozone 4.3516369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D011014 Pneumonia Ozone 4.6318929643 18381685 18007984
MESH:D011041 Poisoning Diazinon 4.5317603234
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1517292933
MESH:D011471 Prostatic Neoplasms Vitamin E 3.1515084515
MESH:D012120 Respiration Disorders Chlorine 5.4818579056
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.8418410779
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.2619755658 10029692
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 6.2618590791
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.013712494 6587162 6582329 7505956 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.768074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7617053015
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 8.7612846360
MESH:D014570 Urologic Diseases Diazinon 5.5416487989
Pathway ID Pathway Name
KEGG:04730 Long-term depression
REACT:15295 Opioid Signalling
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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