AutismKB 2.0

Annotation Detail for GNB2


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Basic Information Top
Gene Symbol:GNB2 ( - )
Gene Full Name: guanine nucleotide binding protein (G protein), beta polypeptide 2
Band: 7q22.1
Quick LinksEntrez ID:2783; OMIM: 139390; Uniprot ID:GBB2_HUMAN; ENSEMBL ID: ENSG00000172354; HGNC ID: 4398
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Synaptic Transmission
Diabetes pathways
Transmembrane transport of small molecules
Hemostasis
Opioid Signalling
Integration of energy metabolism
No data
Pathway IDPathway Name
P04378Beta2 adrenergic receptor signaling pathway
P00039Metabotropic glutamate receptor group III pathway
P04385Histamine H1 receptor mediated signaling pathway
P04391Oxytocin receptor mediated signaling pathway
P04379Beta3 adrenergic receptor signaling pathway
P04377Beta1 adrenergic receptor signaling pathway
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00028Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P04394Thyrotropin-releasing hormone receptor signaling pathway
P043745HT2 type receptor mediated signaling pathway
P05730Endogenous cannabinoid signaling
P04386Histamine H2 receptor mediated signaling pathway
P04380Cortocotropin releasing factor receptor signaling pathway
P00040Metabotropic glutamate receptor group II pathway
P043765HT4 type receptor mediated signaling pathway
P00048PI3 kinase pathway
P00043Muscarinic acetylcholine receptor 2 and 4 signaling pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
P05731GABA-B receptor II signaling
P043735HT1 type receptor mediated signaling pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of GNB2 mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of GNB2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GNB2 mRNAaffects expression 16483693
D001464 Barium [GNB2 protein binds to GNG2 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]affects binding|decreases reaction|increases transport 11007869
D001464 Barium [GNB2 protein binds to GNG3 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]affects binding|decreases reaction|increases transport 11007869
D001464 Barium [GNB2 protein binds to GNGT1 protein] inhibits the reaction [CACNA1B protein results in increased transport of Barium]affects binding|decreases reaction|increases transport 11007869
D003907 Dexamethasone Dexamethasone affects the localization of GNB2 proteinaffects localization 15955845
D004041 Dietary Fats Dietary Fats results in decreased expression of GNB2 mRNAdecreases expression 15238619
D005472 Fluorouracil Fluorouracil results in decreased expression of GNB2 mRNAdecreases expression 16709241
D005473 Fluoxetine Fluoxetine results in decreased expression of GNB2 mRNAdecreases expression 17105902
C419708 gefitinib gefitinib results in decreased expression of GNB2 mRNAdecreases expression 16685379
D019833 Genistein Genistein results in decreased expression of GNB2 mRNAdecreases expression 16705744
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of GNB2 mRNAdecreases expression 12419474
D012643 Selenium Selenium results in increased expression of GNB2 mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite results in decreased expression of GNB2 mRNAdecreases expression 12760830
D013004 Somatostatin Somatostatin affects the localization of GNB2 proteinaffects localization 15955845
C025643 vinclozolin vinclozolin affects the expression of GNB2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000230 Adenocarcinoma Fluorouracil 4.6117638652
MESH:D000230 Adenocarcinoma Genistein 4.6111473722
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9616712894 17306315
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 4.1210965797
MESH:D000740 Anemia Fluorouracil 3.7417963324 15504547 16511603
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001008 Anxiety Disorders Fluoxetine 9.4318083778
MESH:D001008 Anxiety Disorders vinclozolin 9.4319015723
MESH:D001161 Arteriosclerosis Dietary Fats 3.9315238619
MESH:D001169 Arthritis, Experimental Dexamethasone 3.5517659584
MESH:D001321 Autistic Disorder Acetaminophen 2.3518445737
MESH:D001321 Autistic Disorder Fluoxetine 2.3519232924 18775368
MESH:D001943 Breast Neoplasms Dietary Fats 1.9820435547
MESH:D001943 Breast Neoplasms Fluorouracil 1.9816595493 19217205 16557594 15136595 16110121 18357371 18608205
MESH:D001943 Breast Neoplasms Genistein 1.9816873071 16541309 17200150
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7316051944
MESH:D002277 Carcinoma Fluorouracil 3.5917121937
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.633084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.6317045692 17971768 16332177 16799960 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.6316924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.6316507464 17306315 15276417
MESH:D002289 Carcinoma, Non-Small-Cell Lung gefitinib 3.9616230376 15496427 17290066 18347146 19233551 20005069
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0318695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.7917066447 16280240 18986760 16757204
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7918572023
MESH:D002318 Cardiovascular Diseases Genistein 7.5916332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 7.5916936243
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.0120056578 19524636
MESH:D003092 Colitis Selenium 3.8217936198
MESH:D003110 Colonic Neoplasms Dexamethasone 5.9415824018
MESH:D003110 Colonic Neoplasms Fluorouracil 5.9417725105 16510598 17016597 15001691 17287894 17172411 16340194 17169374 17018589 18772588
MESH:D003110 Colonic Neoplasms Genistein 5.9417182828
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.0617695437 18949393 18802399 17016601 17401013 18288408 16331619 17594712 18383874 17094418 16303861 17255274 18509181 18448328 16282729 16391804 17454858 15289873 15148649 14970324 16524972 20501625
MESH:D015179 Colorectal Neoplasms gefitinib 3.0617594712
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.2817728286
MESH:D003456 Cryptorchidism vinclozolin 4.3814966744
MESH:D007644 Darier Disease Fluorouracil 4.8416733453
MESH:D003866 Depressive Disorder Fluoxetine 4.6215014590
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.4512438553
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.4916647724
MESH:D003967 Diarrhea Dexamethasone 3.737237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.8210915739 15968718 11461765 17522070 18071297 11421492 11834606 12392966 19416960 16393943 16227642 19923254 11287661 11529661 14986274 18713872 12958197 12540782 16177239 19370779 19739265 19420014 12705907 10663392 19085960 17562736 16109766 15619225 16081117 11739529 14725611 11743745 16781746 12153990 12594235 10774834 2444490 14550746 16485898 19164858 17906064
MESH:D056486 Drug-Induced Liver Injury Selenium 3.8215131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D050171 Dyslipidemias Dietary Fats 3.4718367378
MESH:D004485 Eczema Dexamethasone 4.5012438553
MESH:D004487 Edema Dexamethasone 7.7119703484
MESH:D004487 Edema Fluoxetine 7.7112798668
MESH:D004714 Endometrial Hyperplasia Genistein 4.6416402032
MESH:D016889 Endometrial Neoplasms Genistein 3.3811473722
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4516785472 15173087 16481741 16337965 17638652
MESH:D005234 Fatty Liver Dietary Fats 3.2718296743 17967931 19551842 19004024
MESH:D005355 Fibrosis Dietary Fats 3.5718296743
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3616417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7316452187
MESH:D005909 Glioblastoma Genistein 3.2816598420
MESH:D005910 Glioma Fluorouracil 2.8816145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4015102660 15162350 18337622
MESH:D006333 Heart Failure Selenium 3.0917162251
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.087520565
MESH:D006689 Hodgkin Disease sodium arsenite 3.1812676792
MESH:D019584 Hot Flashes Fluoxetine 5.3714716179
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6521332399
MESH:D006973 Hypertension Dexamethasone 2.9417042910
MESH:D006976 Hypertension, Pulmonary gefitinib 4.7118424623
MESH:D017380 Hypertrophy, Right Ventricular gefitinib 6.2918424623
MESH:D007248 Infertility, Male sodium arsenite 6.9112646999 15346721
MESH:D007248 Infertility, Male vinclozolin 6.9116467254
MESH:D007249 Inflammation Dexamethasone 8.708960868 11099482
MESH:D007249 Inflammation Dietary Fats 8.7020412841
MESH:D007249 Inflammation Fluoxetine 8.7012798668
MESH:D007251 Influenza, Human Selenium 4.2616624496
MESH:D007333 Insulin Resistance Dietary Fats 3.1211836018 18457598
MESH:D007674 Kidney Diseases Acetaminophen 6.0112587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 6.0120008137
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 10.1216518626
MESH:D007676 Kidney Failure, Chronic Selenium 10.1216518626
MESH:D007680 Kidney Neoplasms Fluorouracil 8.1416985049
MESH:D007680 Kidney Neoplasms gefitinib 8.1418625569
MESH:D007938 Leukemia Genistein 3.0418980019 17468513
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7816417039
MESH:D008064 Lipidoses Fluoxetine 4.6717567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8918296743
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 2.7816718785
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.7817823541
MESH:D008107 Liver Diseases Acetaminophen 1.6312969438 11587558 19014921 16610002 19460945 16611625 12587719 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2617185352 16871587
MESH:D008113 Liver Neoplasms Fluorouracil 4.7616603448 17045692 15113037 18383874
MESH:D008113 Liver Neoplasms sodium arsenite 4.7616712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.1919095001
MESH:D008175 Lung Neoplasms Dexamethasone 3.5811195469 15824018
MESH:D008175 Lung Neoplasms Fluorouracil 3.5815246190
MESH:D008175 Lung Neoplasms sodium arsenite 3.5816712894 15276417 17306315 17077188 19931552
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8415086387
MESH:D008325 Mammary Neoplasms, Experimental gefitinib 10.3218375820
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.3212929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.3215318939
MESH:D008545 Melanoma sodium arsenite 2.0316487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D001523 Mental Disorders Fluoxetine 4.6816856516
MESH:D008654 Mesothelioma Selenium 2.8015107826
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6516757204 18986760
MESH:D009101 Multiple Myeloma Dexamethasone 3.5215744524 15867202 16118317
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.569809623
MESH:D009203 Myocardial Infarction Genistein 2.8717141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.6817141266
MESH:D009207 Myoclonus Fluoxetine 5.938041377
MESH:D009369 Neoplasms Fluorouracil 5.2316928823 18600527 18239605
MESH:D009369 Neoplasms sodium arsenite 5.2311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7120056578
MESH:D009421 Nervous System Malformations Genistein 4.0716427766
MESH:D009436 Neural Tube Defects sodium arsenite 3.1612854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4516436463
MESH:D009765 Obesity Dietary Fats 2.2917217161 11836018 19632207 20518802 21332399 18457598 16723640 20132043 18674790
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 5.4720418887
MESH:D010024 Osteoporosis Genistein 3.2719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1216169203
MESH:D010051 Ovarian Neoplasms Genistein 5.0019005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.0017306315 15276417
MESH:D010146 Pain Acetaminophen 7.1916870215
MESH:D010146 Pain Fluoxetine 7.1912798668
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.6716929163 15113037 16500647 19003803
MESH:D010212 Papilloma Hydrogen Peroxide 4.1312065085
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.5611550810
MESH:D020774 Pick Disease of the Brain Fluoxetine 6.048041377
MESH:D010954 Plasmacytoma Selenium 4.9515087411
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.5621297632
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.9518220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.9818220299
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1618626508 19082440
MESH:D011471 Prostatic Neoplasms gefitinib 2.1617914592 15651060 16685379
MESH:D011471 Prostatic Neoplasms Genistein 2.1616925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1616039940
MESH:D011472 Prostatitis vinclozolin 4.9818629315
MESH:D011658 Pulmonary Fibrosis gefitinib 4.0118424623
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0418286688 16160472 15538739 18722050
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.0518379247 11700416
MESH:D020230 Serotonin Syndrome Fluoxetine 5.968704074
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 6.0112065085
MESH:D012878 Skin Neoplasms sodium arsenite 6.0118572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8212854658
MESH:D013272 Stomach Diseases Dexamethasone 4.3715472012
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0019015929 19084572 18567086 17172411 17522103 17498489 18396642 15786421 16424979 16951190
MESH:D013276 Stomach Ulcer Dexamethasone 3.5115138204
MESH:D013964 Thyroid Neoplasms gefitinib 4.4916940797
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0216280240
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5217306315 11723127 16712894 16452187
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.5716803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.5711813266
MESH:D014605 Uveitis Dexamethasone 4.881336536
MESH:D014652 Vascular Diseases sodium arsenite 4.4717056641
MESH:D015430 Weight Gain Dietary Fats 3.7616723640
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
REACT:15380 Diabetes pathways
KEGG:04724 Glutamatergic synapse
REACT:604 Hemostasis
REACT:1505 Integration of energy metabolism
REACT:15295 Opioid Signalling
REACT:14797 Signaling by GPCR
REACT:13685 Synaptic Transmission
REACT:15518 Transmembrane transport of small molecules
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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