AutismKB 2.0

Annotation Detail for GNRH1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GNRH1 ( GNRH,GRH,LHRH,LNRH )
Gene Full Name: gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Band: 8p21.2
Quick LinksEntrez ID:2796; OMIM: 152760; Uniprot ID:GON1_HUMAN; ENSEMBL ID: ENSG00000147437; HGNC ID: 4419
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04912GnRH signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200145Nongenotropic Androgen signaling
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
periodontitis
bone density
IMMUNE
METABOLIC
No data
Desease Name
Hypogonadotropic hypogonadism due to GNRH deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased expression of GNRH1 mRNAdecreases expression 10537130
C109238 acyline acyline results in decreased activity of GNRH1 proteindecreases activity 15579744
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GNRH1 mRNAaffects expression 16483693
C032739 aroclor 1221 aroclor 1221 affects the expression of GNRH1 mRNAaffects expression 11394642
D001280 Atrazine GNRH1 protein inhibits the reaction [Atrazine results in decreased secretion of LHB protein]decreases reaction|decreases secretion 10696778
C006780 bisphenol A bisphenol A results in decreased expression of GNRH1 mRNAdecreases expression 20621667
D004390 Chlorpyrifos Chlorpyrifos affects the expression of GNRH1 mRNAaffects expression 12088877
D004390 Chlorpyrifos Chlorpyrifos results in increased secretion of GNRH1 proteinincreases secretion 12088877
D004390 Chlorpyrifos fulvestrant inhibits the reaction [Chlorpyrifos results in increased secretion of GNRH1 protein]decreases reaction|increases secretion 12088877
D004390 Chlorpyrifos Chlorpyrifos affects the expression of GNRH1 mRNAaffects expression 11394642
D002996 Clomiphene Clomiphene inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]decreases reaction|increases reaction|increases secretion 17054466
D003300 Copper Copper binds to GNRH1 proteinaffects binding 16892001
D003300 Copper [Copper binds to GNRH1 protein] which results in increased secretion of LHB proteinaffects binding|increases secretion 16892001
D003634 DDT [Lindane co-treated with DDT] results in increased expression of GNRH1affects cotreatment|increases expression 16329587
C074283 estradiol 3-benzoate [estradiol 3-benzoate co-treated with GNRH1 protein] results in increased secretion of LH proteinaffects cotreatment|increases secretion 19574278
D004958 Estradiol Clomiphene inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]decreases reaction|increases reaction|increases secretion 17054466
D004958 Estradiol Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]increases reaction|increases secretion 17054466
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of GNRH1 proteinaffects cotreatment|increases expression 10566683
D004958 Estradiol Raloxifene inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]decreases reaction|increases reaction|increases secretion 17054466
D004958 Estradiol Estradiol results in decreased expression of GNRH1 mRNAdecreases expression 9588692
D004958 Estradiol Estradiol inhibits the reaction [ESR2 protein alternative form results in increased expression of GNRH1 mRNA]decreases reaction|increases expression 16439454
D004958 Estradiol Estradiol results in decreased expression of GNRH1 mRNAdecreases expression 10537130
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in decreased expression of GNRH1 mRNA]decreases expression|decreases reaction 10537130
D004958 Estradiol Estradiol results in increased expression of GNRH1 proteinincreases expression 8812359
D005419 Flavonoids Flavonoids results in decreased expression of GNRH1 mRNAdecreases expression 18035473
C070081 fulvestrant fulvestrant inhibits the reaction [Chlorpyrifos results in increased secretion of GNRH1 protein]decreases reaction|increases secretion 12088877
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in decreased expression of GNRH1 mRNA]decreases expression|decreases reaction 10537130
C070081 fulvestrant fulvestrant inhibits the reaction [Methoxychlor results in increased secretion of GNRH1 protein]decreases reaction|increases secretion 12088877
D007213 Indomethacin Indomethacin inhibits the reaction [GNRH1 protein results in increased abundance of Dinoprostone]decreases reaction|increases abundance 16514196
D007213 Indomethacin Indomethacin inhibits the reaction [GNRH1 protein results in increased expression of PLAT mRNA]decreases reaction|increases expression 16514196
D007213 Indomethacin Indomethacin inhibits the reaction [GNRH1 protein results in increased expression of SERPINB2 mRNA]decreases reaction|increases expression 16514196
D001556 Lindane [Lindane co-treated with DDT] results in increased expression of GNRH1affects cotreatment|increases expression 16329587
D008628 Mercury Mercury results in increased expression of GNRH1 mRNAincreases expression 16823088
D008731 Methoxychlor fulvestrant inhibits the reaction [Methoxychlor results in increased secretion of GNRH1 protein]decreases reaction|increases secretion 12088877
D008731 Methoxychlor Methoxychlor affects the expression of GNRH1 mRNAaffects expression 12088877
D008731 Methoxychlor Methoxychlor metabolite results in decreased expression of GNRH1 mRNAdecreases expression 10537130
D008731 Methoxychlor Methoxychlor results in increased secretion of GNRH1 proteinincreases secretion 12088877
D008731 Methoxychlor Methoxychlor results in decreased expression of GNRH1 mRNAdecreases expression 20621667
D008731 Methoxychlor Methoxychlor affects the expression of GNRH1 mRNAaffects expression 11394642
D009532 Nickel Nickel binds to GNRH1 proteinaffects binding 16892001
D009532 Nickel [Nickel binds to GNRH1 protein] which results in increased secretion of LHB proteinaffects binding|increases secretion 16892001
D009583 Nitrofurazone Nitrofurazone inhibits the reaction [GNRH1 protein results in increased secretion of LHB protein]decreases reaction|increases secretion 3126094
C035988 procymidone procymidone results in decreased expression of GNRH1 mRNAdecreases expression 15686871
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of GNRH1 proteinaffects cotreatment|increases expression 10566683
D011374 Progesterone Progesterone results in decreased secretion of GNRH1 proteindecreases secretion 11159827
D011374 Progesterone Progesterone results in decreased secretion of GNRH1 proteindecreases secretion 15976512
C467746 propyl pyrazole triol [propyl pyrazole triol co-treated with GNRH1 protein] results in increased secretion of LH proteinaffects cotreatment|increases secretion 19574278
D015232 Dinoprostone GNRH1 protein results in increased abundance of Dinoprostoneincreases abundance 17332517
16514196
D015232 Dinoprostone Indomethacin inhibits the reaction [GNRH1 protein results in increased abundance of Dinoprostone]decreases reaction|increases abundance 16514196
D015232 Dinoprostone trilostane inhibits the reaction [GNRH1 protein results in increased abundance of Dinoprostone]decreases reaction|increases abundance 17332517
D015237 Dinoprost GNRH1 protein results in increased abundance of Dinoprostincreases abundance 17332517
D015237 Dinoprost trilostane inhibits the reaction [GNRH1 protein results in increased abundance of Dinoprost]decreases reaction|increases abundance 17332517
D020849 Raloxifene Raloxifene inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]decreases reaction|increases reaction|increases secretion 17054466
D013739 Testosterone Testosterone results in decreased expression of GNRH1 mRNAdecreases expression 12000543
D013739 Testosterone Testosterone results in increased expression of GNRH1 proteinincreases expression 8812359
C009954 trilostane trilostane inhibits the reaction [GNRH1 protein results in increased abundance of Dinoprost]decreases reaction|increases abundance 17332517
C009954 trilostane trilostane inhibits the reaction [GNRH1 protein results in increased abundance of Dinoprostone]decreases reaction|increases abundance 17332517
C009954 trilostane trilostane inhibits the reaction [GNRH1 protein results in increased expression of SERPINB2 mRNA]decreases reaction|increases expression 17332517
C009954 trilostane trilostane inhibits the reaction [GNRH1 protein results in increased expression of SERPINE1 mRNA]decreases reaction|increases expression 17332517
C009954 trilostane trilostane inhibits the reaction [GNRH1 protein results in increased expression of TIMP4 mRNA]decreases reaction|increases expression 17332517
C009954 trilostane trilostane promotes the reaction [GNRH1 protein results in increased expression of HPGD mRNA]increases expression|increases reaction 17332517
C009954 trilostane trilostane promotes the reaction [GNRH1 protein results in increased expression of PLAU mRNA]increases expression|increases reaction 17332517
C025643 vinclozolin vinclozolin results in decreased expression of GNRH1 mRNAdecreases expression 15686871
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D055371 Acute Lung Injury Nickel 4.3416166738
MESH:D000230 Adenocarcinoma Estradiol 4.3411473722
MESH:D000230 Adenocarcinoma Indomethacin 4.3416537180
MESH:D000236 Adenoma Indomethacin 3.3011497255
MESH:D018248 Adenoma, Liver Cell DDT 4.9612597452
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 4.8017942926
MESH:D000382 Agricultural Workers' Diseases Atrazine 18.3711874814
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 18.3711874814 17119214 16611668
MESH:D000382 Agricultural Workers' Diseases DDT 18.3712584743 16487989
MESH:D000382 Agricultural Workers' Diseases Lindane 18.3712661182
MESH:D000419 Albuminuria Raloxifene 4.3417451421 17308373
MESH:D016301 Alveolar Bone Loss Indomethacin 5.1017225004
MESH:D000544 Alzheimer Disease Copper 6.4716325427 16410023 17119284 16866297 16886094 16962711
MESH:D000544 Alzheimer Disease Indomethacin 6.4717627676 15579461
MESH:D000544 Alzheimer Disease Raloxifene 6.4715800139
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 4.1410694572
MESH:D018798 Anemia, Iron-Deficiency Copper 4.6516614410
MESH:D000987 Antisocial Personality Disorder Testosterone 5.597506515
MESH:D001008 Anxiety Disorders vinclozolin 3.4319015723
MESH:D001014 Aortic Aneurysm Dinoprostone 11.3710231640
MESH:D001014 Aortic Aneurysm Indomethacin 11.3710231640
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 11.4210388637
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 11.4210388637
MESH:D018771 Arthralgia Indomethacin 4.902160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.7611248219
MESH:D001284 Atrophy fulvestrant 4.6011514358
MESH:D001321 Autistic Disorder Mercury 2.8117497416
MESH:D001327 Autoimmune Diseases Mercury 4.6116634805
MESH:D001477 Bartter Syndrome Dinoprostone 11.8415976003
MESH:D001477 Bartter Syndrome Indomethacin 11.8410684365
MESH:D001862 Bone Resorption bisphenol A 3.6311985600
MESH:D001929 Brain Edema Indomethacin 4.7611481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0717868700
MESH:D001930 Brain Injuries Progesterone 10.1115665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 10.1116580743
MESH:D002545 Brain Ischemia Indomethacin 4.1612524144
MESH:D001932 Brain Neoplasms Copper 4.3317079463
MESH:D001943 Breast Neoplasms bisphenol A 7.9917123778
MESH:D001943 Breast Neoplasms Copper 7.9917079463 15986119
MESH:D001943 Breast Neoplasms DDT 7.9916792888 12709520
MESH:D001943 Breast Neoplasms Estradiol 7.9918497071 19861407 12948864 17289903 16675129 17261762 17018787 14630087
MESH:D001943 Breast Neoplasms fulvestrant 7.9918984771
MESH:D001943 Breast Neoplasms Indomethacin 7.9917401462
MESH:D001943 Breast Neoplasms Lindane 7.9914688026
MESH:D001943 Breast Neoplasms Nickel 7.9915986119
MESH:D001943 Breast Neoplasms Progesterone 7.9915562024 16175315 17614352
MESH:D001943 Breast Neoplasms Raloxifene 7.9915572757 17049068 15758505 17440819 17893378 17952589 16912660 15775269 16837676 17242785 17595753 17261762
MESH:D001943 Breast Neoplasms Testosterone 7.9917261762
MESH:D002056 Burns Indomethacin 4.4510459503
MESH:D002100 Cachexia Indomethacin 4.7411239499 16537180 15141370 15625704
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2016111702
MESH:D006528 Carcinoma, Hepatocellular DDT 4.5912597452
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5916924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 4.5916391822
MESH:D002278 Carcinoma in Situ bisphenol A 4.7217123778
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.4611053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.0911352223 14736730 18791128
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.2517341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.7812636206 15482327
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.8517572228
MESH:D006332 Cardiomegaly Copper 3.8817327471
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.3610334427
MESH:D002318 Cardiovascular Diseases Raloxifene 3.2715775269
MESH:D002471 Cell Transformation, Neoplastic Dinoprost 10.6216192471
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 10.6216192471
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.6218566989
MESH:D014355 Chagas Disease Nitrofurazone 6.9211354658
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.5820678186
MESH:D002764 Cholecystitis Indomethacin 4.9011181007
MESH:D003072 Cognition Disorders Raloxifene 4.3615800139
MESH:D003110 Colonic Neoplasms Indomethacin 2.5515963497 15936596 15625704 15637740 15786552 11260862
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3512606626 11197048 18059344 17054584
MESH:D000013 Congenital Abnormalities DDT 4.6815095906
MESH:D018352 Coronavirus Infections Indomethacin 5.4517302372
MESH:D003456 Cryptorchidism vinclozolin 4.0914966744
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9417474826
MESH:D017449 Dermatitis, Allergic Contact Mercury 6.7716823706
MESH:D017449 Dermatitis, Allergic Contact Nickel 6.7717244072 17100760 19470301
MESH:D003877 Dermatitis, Contact Nickel 4.392952479
MESH:D003928 Diabetic Nephropathies Estradiol 8.2819279558
MESH:D003928 Diabetic Nephropathies Raloxifene 8.2817308373 17451421 15920148
MESH:D003929 Diabetic Neuropathies Progesterone 4.2317187935
MESH:D003967 Diarrhea Dinoprostone 7.7611488427 7237001 10446763
MESH:D003967 Diarrhea Indomethacin 7.767907874 7237001
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.8817190690 18446180 16133044 18043480 12774134 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 3.8917045617 11991626 11535926 17202747 17329845 16699067 17151854 10671773 11595415 11595431 17351913
MESH:D004417 Dyspnea DDT 4.8916487989
MESH:D004487 Edema Indomethacin 6.507990266 16100529 10653021 7907874 8273558 19703484 8985016
MESH:D004487 Edema Raloxifene 6.5015860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.5017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.5015845917
MESH:D016889 Endometrial Neoplasms Estradiol 2.8118566989 19148513 11473722
MESH:D004715 Endometriosis Indomethacin 8.5915652904
MESH:D004715 Endometriosis Progesterone 8.5916134523
MESH:D019446 Endotoxemia Indomethacin 4.2418509659
MESH:D004751 Enteritis Indomethacin 4.4810567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.7217980183
MESH:D004802 Eosinophilia Indomethacin 3.8011298111
MESH:D004938 Esophageal Neoplasms Indomethacin 2.7411005569
MESH:D005234 Fatty Liver Raloxifene 3.3917473493
MESH:D005334 Fever Dinoprost 14.3211852909
MESH:D005334 Fever Dinoprostone 14.3211852909 16997862
MESH:D005334 Fever Indomethacin 14.3217627676 11852909 10431976
MESH:D005354 Fibrosarcoma Indomethacin 4.6310962813
MESH:D005355 Fibrosis Indomethacin 3.8217994277
MESH:D005391 Firesetting Behavior Testosterone 5.597506515
MESH:D005499 Folliculitis Indomethacin 4.9011298111
MESH:D005756 Gastritis Indomethacin 4.4815046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0316417039
MESH:D005909 Glioblastoma Indomethacin 7.1412870263
MESH:D005909 Glioblastoma Testosterone 7.1417162496
MESH:D005910 Glioma Indomethacin 3.1216487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.0811849393
MESH:D006073 Gout Indomethacin 5.0911248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.5715482327
MESH:D006331 Heart Diseases Raloxifene 3.3611110106
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.3315633222
MESH:D006505 Hepatitis DDT 4.6816487989
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.4315135802
MESH:D006521 Hepatitis, Chronic Copper 5.0117338147
MESH:D006527 Hepatolenticular Degeneration Copper 4.9117109627 17182432 17276780 19888908 16607473
MESH:D006529 Hepatomegaly DDT 4.482387028
MESH:D006558 Herpes Genitalis Estradiol 4.7615709030
MESH:D006628 Hirsutism Testosterone 5.3917019078
MESH:D015658 HIV Infections Nickel 3.6817263646
MESH:D019584 Hot Flashes Estradiol 3.4917088409
MESH:D006930 Hyperalgesia Dinoprostone 7.8216793879
MESH:D006930 Hyperalgesia Indomethacin 7.8212727271
MESH:D034321 Hyperamylasemia Indomethacin 5.4517883296
MESH:D017588 Hyperandrogenism Testosterone 5.0417019078
MESH:D006940 Hyperemia Indomethacin 4.7412524144
MESH:D006949 Hyperlipidemias Indomethacin 3.9217546600
MESH:D006973 Hypertension Raloxifene 2.7717577099 15787275
MESH:D007006 Hypogonadism Testosterone 4.4012002444
MESH:D007018 Hypopituitarism Testosterone 5.9317426086
MESH:D007077 Ileal Diseases Indomethacin 4.7618306037 10574470
MESH:D007079 Ileitis Indomethacin 5.0916133968 10647630 10651667
MESH:D007174 Impulse Control Disorders Testosterone 5.597506515
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.1016133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1415869954
MESH:D007248 Infertility, Male Atrazine 24.1612948887
MESH:D007248 Infertility, Male Clomiphene 24.1619371211
MESH:D007248 Infertility, Male DDT 24.1617192596 17157474
MESH:D007248 Infertility, Male fulvestrant 24.1611514358
MESH:D007248 Infertility, Male Methoxychlor 24.1611955947 16467254
MESH:D007248 Infertility, Male vinclozolin 24.1616467254
MESH:D007249 Inflammation Flavonoids 10.9417296493
MESH:D007249 Inflammation Indomethacin 10.9412568917 3291741 7812673
MESH:D007249 Inflammation Nickel 10.9416166738
MESH:D007249 Inflammation Progesterone 10.9415869954
MESH:D007333 Insulin Resistance bisphenol A 6.8716393666
MESH:D007333 Insulin Resistance Estradiol 6.8716627594 16393666
MESH:D007410 Intestinal Diseases Indomethacin 4.0711686837 15831440 18236018 17329856 11855677 11713966 17994277 15610444 10210152
MESH:D019586 Intracranial Hypertension Indomethacin 5.1015241188
MESH:D007579 Jejunal Diseases Indomethacin 4.7618306037 10574470 16133968
MESH:D007674 Kidney Diseases Estradiol 9.4115618244
MESH:D007674 Kidney Diseases Indomethacin 9.4117190690
MESH:D007674 Kidney Diseases Mercury 9.4117934191
MESH:D007676 Kidney Failure, Chronic Copper 4.6616518626
MESH:D007680 Kidney Neoplasms Estradiol 2.7715610895
MESH:D007859 Learning Disorders Copper 9.4817134702
MESH:D007859 Learning Disorders DDT 9.487589230
MESH:D007889 Leiomyoma Raloxifene 4.2516973256
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.6910320625 11703811 12228301
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.7310785260 16572323 15631656
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.5918360721
MESH:D007964 Leukocytosis Indomethacin 5.1016537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.4517980183
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4716417039
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.4511479899
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 3.5915816358
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 3.5918194892
MESH:D008107 Liver Diseases Chlorpyrifos 9.0215991261
MESH:D008107 Liver Diseases DDT 9.0215729006
MESH:D008107 Liver Diseases Dinoprostone 9.0215816358
MESH:D008107 Liver Diseases Lindane 9.021715830
MESH:D008113 Liver Neoplasms Copper 5.1620302851
MESH:D008113 Liver Neoplasms DDT 5.1611948501 15975961
MESH:D008175 Lung Neoplasms Indomethacin 2.3511497255 16537180 11053908
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.2311807958 17203775 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental estradiol 3-benzoate 9.2315375486
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.2317203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.2219453300
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.6217109627 17268249
MESH:D008654 Mesothelioma Atrazine 3.421916698
MESH:D008881 Migraine Disorders Indomethacin 3.4911903285
MESH:D020326 Migraine without Aura Dinoprostone 5.0111304026
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2915863610
MESH:D009062 Mouth Neoplasms Indomethacin 3.7912636206
MESH:D009101 Multiple Myeloma Raloxifene 3.2616497877
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0816810080
MESH:D009232 Myxoma Raloxifene 5.2916343187
MESH:D009362 Neoplasm Metastasis Indomethacin 3.0611053908 11239499 16537180
MESH:D009369 Neoplasms DDT 8.108820588
MESH:D009369 Neoplasms Lindane 8.1012807735 16818664
MESH:D009369 Neoplasms Nitrofurazone 8.1015488632
MESH:D009374 Neoplasms, Experimental Indomethacin 3.8810663608 15625704
MESH:D009389 Neovascularization, Pathologic Copper 9.4717308104
MESH:D009389 Neovascularization, Pathologic Estradiol 9.4717289903
MESH:D009421 Nervous System Malformations bisphenol A 8.9116427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 8.9116427766 11399458
MESH:D019636 Neurodegenerative Diseases Indomethacin 3.7312349958
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.9915081274
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.906374098
MESH:D010003 Osteoarthritis Indomethacin 3.517009135
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 6.2118500342
MESH:D010024 Osteoporosis Raloxifene 3.2417882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.9817823083 15758505 15579764 17893378
MESH:D010049 Ovarian Diseases bisphenol A 4.7211985600
MESH:D010051 Ovarian Neoplasms Estradiol 7.6619401270
MESH:D010051 Ovarian Neoplasms Nitrofurazone 7.6611026599
MESH:D010051 Ovarian Neoplasms Progesterone 7.6617393432 16525653
MESH:D010146 Pain Indomethacin 3.2617440234 17627676 13679232 3291741
MESH:D010149 Pain, Postoperative Indomethacin 4.4118702446 12538197
MESH:D010195 Pancreatitis Indomethacin 3.6815028970 17883296
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.4516537180
MESH:D010300 Parkinson Disease Atrazine 3.1817218051
MESH:D020734 Parkinsonian Disorders Indomethacin 3.8912349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.4511903285
MESH:D010437 Peptic Ulcer Indomethacin 4.8811148446
MESH:D010518 Periodontitis Indomethacin 4.6517225004
MESH:D047928 Premature Birth Indomethacin 4.8717000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.8910548101
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.8918220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.6718220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 16.6920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 16.6920887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 16.6920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.9016740699
MESH:D011471 Prostatic Neoplasms Copper 1.9017079463 17308104
MESH:D011471 Prostatic Neoplasms DDT 1.9012584743
MESH:D011471 Prostatic Neoplasms Estradiol 1.9016740699
MESH:D011471 Prostatic Neoplasms Lindane 1.9014688026 12661182
MESH:D011471 Prostatic Neoplasms Raloxifene 1.9015731164 16536755 16220300
MESH:D011472 Prostatitis vinclozolin 4.6718629315
MESH:D011507 Proteinuria Indomethacin 3.9211849393
MESH:D011629 Puberty, Precocious bisphenol A 4.5210548101
MESH:D011693 Purpura Raloxifene 5.2915770314
MESH:D012135 Respiratory Sounds Atrazine 9.2511874814
MESH:D012135 Respiratory Sounds Chlorpyrifos 9.2516611668 11874814 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.6317119214 16611668
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7618045962
MESH:D012559 Schizophrenia Copper 3.0516842975
MESH:D012640 Seizures Lindane 3.457539098 15475178 12842176
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.826418539
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.9316631401
MESH:D013119 Spinal Cord Injuries Progesterone 4.0215862959 16503802
MESH:D013272 Stomach Diseases Indomethacin 4.1618545984 15038085 16184426 17207306 17638125 17160473 16280098 15472012 16113693 18209964 10215738 10192188 10486359
MESH:D013274 Stomach Neoplasms Indomethacin 2.3515609394
MESH:D013276 Stomach Ulcer Indomethacin 3.3611906479 18237397 1323529 18726076 18209962 18299717 11595431 11729361 16150113 18087811 15104355 17654042 15138204 15255614 10423059 16252198 17135157 11595415 12077510 18193104 17918041 16934674 16397915 12467913 16631530 11523592 17895592 17657623 16755016 11145282 17977527 18181030 18543354 12500499 10878458 12787963 17627676 16169175 18431645 12498302 10750652 14567935
MESH:D020521 Stroke Raloxifene 3.6216837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.7216045194 16684133
MESH:D013964 Thyroid Neoplasms Indomethacin 3.3914736730 11352223 18791128
MESH:D013978 Tibial Fractures Estradiol 12.8219048282
MESH:D013978 Tibial Fractures Raloxifene 12.8219048282
MESH:D014456 Ulcer Indomethacin 4.6310574470 17380554
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.7117572228
MESH:D014570 Urologic Diseases DDT 5.3716487989
MESH:D014591 Uterine Diseases bisphenol A 4.7414652134
MESH:D054556 Venous Thromboembolism Raloxifene 4.9416837676
MESH:D014839 Vomiting Indomethacin 4.4811897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2916343187
MESH:D014947 Wounds and Injuries Nitrofurazone 5.2018440737 18222664
Pathway ID Pathway Name
KEGG:04912 GnRH signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved