AutismKB 2.0

Annotation Detail for GNRHR


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Basic Information Top
Gene Symbol:GNRHR ( GNRHR1,GRHR,LHRHR,LRHR )
Gene Full Name: gonadotropin-releasing hormone receptor
Band: 4q13.2
Quick LinksEntrez ID:2798; OMIM: 138850; Uniprot ID:GNRHR_HUMAN; ENSEMBL ID: ENSG00000109163; HGNC ID: 4421
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04912GnRH signaling pathway
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
hypogonaotropic hypogonadism
METABOLIC
No data
Desease Name
Fertile eunuch syndrome
Hypogonadotropic hypogonadism
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of GNRHR mRNAincreases expression 18280221
C119737 8-prenylnaringenin 8-prenylnaringenin results in decreased expression of GNRHR mRNAdecreases expression 16522720
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GNRHR mRNAaffects expression 16483693
D001554 Benzene Benzene analog binds to and results in decreased activity of GNRHR proteinaffects binding|decreases activity 18282756
C006780 bisphenol A bisphenol A results in increased expression of GNRHR mRNAincreases expression 18280221
D002064 Buserelin Buserelin binds to and results in increased activity of GNRHR proteinaffects binding|increases activity 15212170
D002064 Buserelin Buserelin inhibits the reaction [GNRHR protein results in increased transport of deslorelin]decreases reaction|increases transport 15212170
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GNRHR mRNAaffects expression 15963342
D002330 Carmustine Carmustine results in increased expression of GNRHR mRNAincreases expression 15980968
C062876 cetrorelix cetrorelix binds to and results in decreased activity of GNRHR proteinaffects binding|decreases activity 16914592
C066438 deslorelin 2,4-Dinitrophenol inhibits the reaction [GNRHR protein results in increased transport of deslorelin]decreases reaction|increases transport 15212170
C066438 deslorelin Buserelin inhibits the reaction [GNRHR protein results in increased transport of deslorelin]decreases reaction|increases transport 15212170
C066438 deslorelin GNRHR protein results in increased transport of deslorelinincreases transport 15212170
D004054 Diethylstilbestrol Diethylstilbestrol results in decreased expression of GNRHR mRNAdecreases expression 12653219
D019297 2,4-Dinitrophenol 2,4-Dinitrophenol inhibits the reaction [GNRHR protein results in increased transport of deslorelin]decreases reaction|increases transport 15212170
D004317 Doxorubicin GNRHR protein affects the susceptibility to Doxorubicinaffects response to substance 17943530
C074283 estradiol 3-benzoate estradiol 3-benzoate results in decreased expression of GNRHR mRNAdecreases expression 15223135
D004958 Estradiol GNRHR protein inhibits the reaction [Estradiol promotes the reaction [TNF protein results in increased expression of IL8 mRNA]]decreases reaction|increases expression|increases reaction 12574206
D004958 Estradiol GNRHR protein inhibits the reaction [Estradiol promotes the reaction [TNF protein results in increased expression of IL8 protein]]decreases reaction|increases expression|increases reaction 12574206
D004958 Estradiol GNRHR protein inhibits the reaction [Estradiol promotes the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]decreases reaction|increases phosphorylation|increases reaction 12574206
D004958 Estradiol Estradiol results in decreased expression of GNRHR mRNAdecreases expression 18280221
D004958 Estradiol [Estradiol co-treated with Progesterone] inhibits the reaction [Triptorelin affects the expression of GNRHR mRNA]affects cotreatment|affects expression|decreases reaction 17185802
D004958 Estradiol [Estradiol co-treated with Progesterone] results in decreased expression of GNRHR mRNAaffects cotreatment|decreases expression 17185802
D004958 Estradiol Estradiol inhibits the reaction [Triptorelin affects the expression of GNRHR mRNA]affects expression|decreases reaction 17185802
D004958 Estradiol Estradiol results in decreased expression of GNRHR mRNAdecreases expression 17185802
D004958 Estradiol Estradiol results in decreased expression of GNRHR mRNAdecreases expression 16614383
16522720
D000431 Ethanol Ethanol results in increased expression of GNRHR mRNAincreases expression 17920746
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GNRHR mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of GNRHR mRNAdecreases expression 15834898
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of GNRHR geneincreases mutagenesis 15625238
C016599 mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate results in increased expression of GNRHR mRNAincreases expression 16809437
D010269 Paraquat Paraquat results in decreased expression of GNRHR mRNAdecreases expression 17077588
D010424 Pentobarbital Pentobarbital results in decreased expression of GNRHR mRNAdecreases expression 7867555
D010852 Picrotoxin Picrotoxin results in increased expression of GNRHR mRNAincreases expression 15170462
D011374 Progesterone [Estradiol co-treated with Progesterone] inhibits the reaction [Triptorelin affects the expression of GNRHR mRNA]affects cotreatment|affects expression|decreases reaction 17185802
D011374 Progesterone [Estradiol co-treated with Progesterone] results in decreased expression of GNRHR mRNAaffects cotreatment|decreases expression 17185802
D011374 Progesterone Progesterone promotes the reaction [Triptorelin affects the expression of GNRHR mRNA]affects expression|increases reaction 17185802
D013629 Tamoxifen Tamoxifen results in increased expression of GNRHR mRNAincreases expression 18280221
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GNRHR mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GNRHR mRNAincreases expression 16267337
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of GNRHR mRNAaffects cotreatment|affects expression 16979875
D017329 Triptorelin [Estradiol co-treated with Progesterone] inhibits the reaction [Triptorelin affects the expression of GNRHR mRNA]affects cotreatment|affects expression|decreases reaction 17185802
D017329 Triptorelin Estradiol inhibits the reaction [Triptorelin affects the expression of GNRHR mRNA]affects expression|decreases reaction 17185802
D017329 Triptorelin Progesterone promotes the reaction [Triptorelin affects the expression of GNRHR mRNA]affects expression|increases reaction 17185802
D017329 Triptorelin Triptorelin affects the expression of GNRHR mRNAaffects expression 17185802
D014415 Tunicamycin Tunicamycin results in decreased expression of GNRHR mRNAdecreases expression 17127020
C025643 vinclozolin vinclozolin results in increased expression of GNRHR mRNAincreases expression 17980475
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of GNRHR mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2614745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.5417676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 9.5418287403
MESH:D000138 Acidosis Ethanol 9.5411192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6617505938
MESH:D000169 Acrodermatitis Zinc 5.1216889938 17190629 17202136
MESH:D000230 Adenocarcinoma Doxorubicin 6.6417418594
MESH:D000230 Adenocarcinoma Estradiol 6.6411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6414692618
MESH:D000236 Adenoma Ethylnitrosourea 3.566695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1016835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.4911874814
MESH:D000419 Albuminuria Doxorubicin 4.2821441931
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0315451039 15451040
MESH:D000544 Alzheimer Disease Zinc 2.7016410023 16325427 16580781 17119284
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2115469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7111748828
MESH:D000741 Anemia, Aplastic Benzene 4.1611369114 14761424 17661222
MESH:D000755 Anemia, Sickle Cell Zinc 4.6316916123
MESH:D000853 Anophthalmos Ethanol 4.5515513904
MESH:D001008 Anxiety Disorders Ethanol 13.7511141031
MESH:D001008 Anxiety Disorders Pentobarbital 13.7518313124 11141031
MESH:D001008 Anxiety Disorders vinclozolin 13.7519015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4915885639
MESH:D001249 Asthma Zinc 2.8717085522
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5915746008
MESH:D001855 Bone Marrow Diseases Benzene 4.9516183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4214601052
MESH:D001862 Bone Resorption bisphenol A 3.6111985600
MESH:D001927 Brain Diseases Ethylnitrosourea 4.6414991843
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0517868700
MESH:D001930 Brain Injuries Progesterone 10.1315845082 15665606 15380490
MESH:D001930 Brain Injuries Zinc 10.1317109824
MESH:D001932 Brain Neoplasms Carmustine 13.4516187019
MESH:D001932 Brain Neoplasms Doxorubicin 13.4517150277
MESH:D001932 Brain Neoplasms Ethylnitrosourea 13.4518412241 16357521 16651633 16436596 15144691
MESH:D001943 Breast Neoplasms Benzene 4.4911921183 17162533
MESH:D001943 Breast Neoplasms bisphenol A 4.4917123778
MESH:D001943 Breast Neoplasms Diethylstilbestrol 4.4915324884 17129689
MESH:D001943 Breast Neoplasms Doxorubicin 4.4917983394 18628466 15692762 15939500 11325840 18695136 15668708 16096432 16322301 16264153 16115903 19526202 16595493 15136595 17426702 18382427 15994142 16935488 15993339 16826403 15634643 17369602 18234424 15567936
MESH:D001943 Breast Neoplasms Estradiol 4.4912948864 18497071 17289903 14630087 17018787 19861407 16675129 17261762
MESH:D001943 Breast Neoplasms Progesterone 4.4917614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 4.4919189210 16273361 20544844 18997820 17893378 20065188 18815881 19289846 18855134 20390343 19115204 18425577 18629630 17440819 19221464 18984771 19011961 17049068 16202921 20005174 19142967 19487384 19084267 21152245 19189212 19103187 18351453 17261762 17242785 21138602 19155303 19244106 20135344 16818667 19059307 16873071 11161223 15565566 20859285 19200415 19066611 19288272 19410462 18821012 15668708
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.4920435547
MESH:D002056 Burns Ethanol 4.3816374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5118705752 15700767 16124888 15673190 16097048 16227642 3786805 15721981 16192424 10355542 16050911 16011737
MESH:D002276 Carcinoid Tumor Doxorubicin 4.5316051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2319066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 10.7618788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 10.7615948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 10.7616234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.7616924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 10.7615289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.7616924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.7117123778
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.0316201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.256189445
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.2518922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 7.2516543248
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3717572228
MESH:D006332 Cardiomegaly Ethanol 6.3319332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3316120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.3516242529 16731534 16952015 16269455 17928571 18627295 17382496 15476868 17007740 17329180 16455267 17308081 16612575 16651473 15811867 17351982 15505089 16364871 16109756 17519947 17974986 17131338 15792986 16278810 17924179
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8516243910 17334414
MESH:D002318 Cardiovascular Diseases Zinc 3.4716936243
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.3818566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 6.3816003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.7017160924
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6717333356 16105132 17681005 16919318 11677210 17110522 15861022
MESH:D002971 Cleft Lip Ethanol 3.4415513904
MESH:D002972 Cleft Palate Ethanol 5.5615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.5612621046 15340226 15668235 8697196 16354765
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8314669216 17141729
MESH:D019465 Craniofacial Abnormalities Benzene 5.2015643154
MESH:D019465 Craniofacial Abnormalities Ethanol 5.2011198716 19302082 11873399 15451039 10194807 15513904 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.2015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Zinc 5.2019302082
MESH:D003456 Cryptorchidism Diethylstilbestrol 10.4812952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 10.4814966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0919031437
MESH:D003872 Dermatitis Benzene 4.4915902427
MESH:D003920 Diabetes Mellitus Zinc 3.9716479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6017107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.0619279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.0619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2217187935
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.294309450 11566570 17522070 15027814 16227642 15998439 16177239 7120509 2869522 19336974 21278145 7179309 19085960 3786805 15968718 3732212 9327722 7440962 10092053 6623471 10915739 6884620
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.2917416283
MESH:D056486 Drug-Induced Liver Injury Ethanol 8.2911566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.2920420201
MESH:D004362 Drug Toxicity Doxorubicin 7.4318602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.4311462148
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.7018357618
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1412711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 6.1415177302 8273558 16716910 9599246 8113982 11698051 7812673
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.7812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 13.7817692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.7819031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.4116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.3115700306 16804899
MESH:D016889 Endometrial Neoplasms Doxorubicin 16.3117359293
MESH:D016889 Endometrial Neoplasms Estradiol 16.3118566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.3117893378 16202921 19155303 20544844
MESH:D004715 Endometriosis Progesterone 8.1316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.1310568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8718037988
MESH:D004938 Esophageal Neoplasms Ethanol 4.6616704527
MESH:D004938 Esophageal Neoplasms Zinc 4.6616543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 16.7412631006 16239168 15959796 19224547 12795759 16045604 61145 17595544
MESH:D005234 Fatty Liver Ethanol 16.7418620774 19236843 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.7415345470
MESH:D005234 Fatty Liver Tamoxifen 16.7414986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3817920746
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.6516534752 16611131 16002989 16513791 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.6516709447
MESH:C537919 Fertile eunuch syndrome marker/mechanism
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0215451040 16946407 10194807 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2514745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.5119069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.5119069698
MESH:D005355 Fibrosis Carbon Tetrachloride 7.6918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.6920067830
MESH:D005756 Gastritis Ethanol 10.5915046732
MESH:D005756 Gastritis Zinc 10.5917241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0216417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.6716452187
MESH:D005909 Glioblastoma Carmustine 11.0916187019
MESH:D005909 Glioblastoma Doxorubicin 11.0917150277
MESH:D005909 Glioblastoma Ethylnitrosourea 11.0916436596
MESH:D005910 Glioma Ethylnitrosourea 3.3816651633 16357521 18412241
MESH:D005911 Gliosis Paraquat 4.8811124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006130 Growth Disorders Zinc 3.7817217573
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.3415692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1810048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.2916244371 16244372 12587719 18006777 16330681 16879835 16144979 16495754 17888722 17875725 14766674 16707910 18674790
MESH:D006333 Heart Failure Doxorubicin 6.8817481944
MESH:D006333 Heart Failure Zinc 6.8817162251
MESH:D006335 Heart Injuries Zinc 5.4917074742
MESH:D016481 Helicobacter Infections Zinc 4.2817241300
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6515692506
MESH:D006402 Hematologic Diseases Benzene 4.4016183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3319900420 19110552
MESH:D006527 Hepatolenticular Degeneration Zinc 4.4217276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6216120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.7515709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.1815147373 17606976 18501091
MESH:D019584 Hot Flashes 8-prenylnaringenin 9.8417088409
MESH:D019584 Hot Flashes Estradiol 9.8417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7615340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Ethanol 3.5018783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2516899240
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1614722030 12960047
MESH:D006973 Hypertension Benzene 4.9517940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8115338365
MESH:D007006 Hypogonadism marker/mechanism 15625238
MESH:D007021 Hypospadias Diethylstilbestrol 10.3316002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.3316945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1315869954
MESH:D007246 Infertility Diethylstilbestrol 4.0915036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.1717937319
MESH:D007248 Infertility, Male Paraquat 10.174850670
MESH:D007248 Infertility, Male vinclozolin 10.1716467254
MESH:D007249 Inflammation Progesterone 10.7815869954
MESH:D007249 Inflammation Tamoxifen 10.7819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.7812878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 10.787812673 7562506 8273558 11698051 15177302
MESH:D007333 Insulin Resistance bisphenol A 6.8416393666
MESH:D007333 Insulin Resistance Estradiol 6.8416393666 16627594
MESH:D007511 Ischemia Zinc 4.3616584753
MESH:D007569 Jaw Abnormalities Ethanol 9.2915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2916580747
MESH:D007674 Kidney Diseases Doxorubicin 9.2916775033 15699352 15369732
MESH:D007674 Kidney Diseases Estradiol 9.2915618244
MESH:D007674 Kidney Diseases Zinc 9.2916960431
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.3516707910
MESH:D007676 Kidney Failure, Chronic Zinc 9.3516518626
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 15.9814681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 15.9815610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 15.9817379185
MESH:D007680 Kidney Neoplasms Tamoxifen 15.9818625569
MESH:D007859 Learning Disorders Diethylstilbestrol 8.8817184923
MESH:D007859 Learning Disorders Ethanol 8.8815451040
MESH:D007938 Leukemia Benzene 3.2514694614 15935818 17119257 18335105
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8716085563
MESH:D007951 Leukemia, Myeloid Benzene 4.0717506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6519478238
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4516417039
MESH:D017880 Limb Deformities, Congenital Ethanol 3.6217676605
MESH:D008064 Lipidoses Tamoxifen 2.9617567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3016943688 17334410 11408273 17157831 16221502 21278145 11903743 16239168 17174718
MESH:D008103 Liver Cirrhosis Ethanol 6.3015289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8218295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.2517640975 16033810 12666154 15057751 17557913 18395095 12898905 16097048 14512876 15931870 15338365 17900296 16136751 11481614 15673190 12609069 18054572 17944888 14620537 18705752 14748882 18166357 17698563 18481824 17922224 18420326 15370692 14716833 17708605 17721639 18412020 18263696 15925388 17766677 17481882 15052691 18376398 12741479 18472332 12586293 12445421 17976157 15818738 16011737 12389079 16027843 18395914 14724832 17869086 12958196 18006644 13678700 17761835 18156304 12445418 17565644 17823541 18429990 18210741 18317297 14716496 15893842 12632514 15996030 16248980 15650968 18472094 16116963 17525996 15959796 12667390 18205269 12649538 16192424 17805973 12632512 15876570 17631135 18277467 10355542 15730626 18339082 18418968 18187930 16015684 15362042 16638106 18279442 17714472 15123356 12546737 20821823 18251166
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.2516595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.2514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 8.2518166357
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.2518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.2512878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0217285989 16964402 16246199 15830285 15720792
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3817347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8915123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 9.8119294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 9.8116712894 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 9.8116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.8116984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 12.7312562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.7315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 12.7316842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.7312151625
MESH:D017563 Lung Diseases, Interstitial Benzene 4.5214698565
MESH:D008175 Lung Neoplasms Benzene 8.0812562636
MESH:D008175 Lung Neoplasms Doxorubicin 8.086189445 17418594
MESH:D008175 Lung Neoplasms Ethylnitrosourea 8.0816019985 6695378 16271038 17703301
MESH:D008175 Lung Neoplasms Tamoxifen 8.0818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.0811884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 8.0811807781
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8715166399
MESH:D008223 Lymphoma Benzene 16.3317584886 17119257
MESH:D008223 Lymphoma Diethylstilbestrol 16.3315700306
MESH:D008223 Lymphoma Doxorubicin 16.3316098063
MESH:D008223 Lymphoma Ethylnitrosourea 16.3315790496
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5717654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 10.7815621674
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 10.7815375218
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2316002989
MESH:D015674 Mammary Neoplasms, Animal Benzene 9.1412562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.1419428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 35.3011921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 35.3015458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 35.3016891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental estradiol 3-benzoate 35.3015375486
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 35.3010767621 18041768 10838139
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 35.3017203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 35.3019196723 11731420 16827153 14580682 19196722
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 35.308985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 35.3012773700
MESH:D020149 Manganese Poisoning Estradiol 11.7019453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.7019453300
MESH:D008545 Melanoma Carmustine 4.9412393984
MESH:D008545 Melanoma Doxorubicin 4.9416827129
MESH:D008545 Melanoma Tamoxifen 4.9412393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9015990972
MESH:D008569 Memory Disorders Ethanol 3.9218411066 15451040
MESH:D008579 Meningioma Ethylnitrosourea 5.7017943659
MESH:D008654 Mesothelioma Doxorubicin 2.9517638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2515792986
MESH:D052016 Mucositis Doxorubicin 4.5117415656
MESH:D009101 Multiple Myeloma Benzene 3.4717119195
MESH:D009203 Myocardial Infarction Doxorubicin 2.8319429709 15857846
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0716810080
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.4918259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4219410462
MESH:D009369 Neoplasms Diethylstilbestrol 2.6415313581
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.1316707424
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7219189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4517289903
MESH:D009401 Nephrosis Doxorubicin 4.4916636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.7715640375 16889571
MESH:D009410 Nerve Degeneration Paraquat 3.5116893418
MESH:D009421 Nervous System Malformations bisphenol A 21.2611399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 21.2611399458
MESH:D009421 Nervous System Malformations Estradiol 21.2616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.2614600291
MESH:D009436 Neural Tube Defects Benzene 3.4915643154
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.1416003739 16651423 17160924
MESH:D009447 Neuroblastoma Doxorubicin 3.1215555623
MESH:D009784 Occupational Diseases Benzene 3.9417479406 15612468 17119257 15935809 17178637 15913788 15576619 15727169 16737584
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.7017160924
MESH:D012516 Osteosarcoma Doxorubicin 3.8915930896
MESH:D010049 Ovarian Diseases bisphenol A 4.7111985600
MESH:D010051 Ovarian Neoplasms Benzene 7.4412562636
MESH:D010051 Ovarian Neoplasms Estradiol 7.4419401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.4416525653 17393432
MESH:D010190 Pancreatic Neoplasms Ethanol 5.3612384795
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 5.3615976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4311578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.0218404319 12065085 8330346 18922899
MESH:D010300 Parkinson Disease Paraquat 2.7112911755 15451049 11124998 11445065 15824117 11181820 16510128 16140633
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1616190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8717983394
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4016977796 15687265
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8717638057
MESH:D011014 Pneumonia Paraquat 4.1712504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011225 Pre-Eclampsia Zinc 3.9617114810
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 20.9510548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 20.9517184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 20.9511118676 11222880 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 20.9519015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.6518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.7220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.7220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8816740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8817136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8816888761 18437689 15749863 15897917 16868541 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011471 Prostatic Neoplasms Zinc 1.8812429649 16606632 16517595 16700911
MESH:D011472 Prostatitis vinclozolin 4.6518629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.0316919318 15861022
MESH:D011629 Puberty, Precocious bisphenol A 4.5110548101
MESH:D011658 Pulmonary Fibrosis Paraquat 2.8116324872 17997886
MESH:D012021 Reflex, Abnormal Pentobarbital 5.7410930210
MESH:D051437 Renal Insufficiency Doxorubicin 3.9517922066
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.6511700416
MESH:D012135 Respiratory Sounds Paraquat 3.7811874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012162 Retinal Degeneration Paraquat 8.5116458197
MESH:D012162 Retinal Degeneration Zinc 8.5116584753
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7618045962
MESH:D012509 Sarcoma Doxorubicin 3.7515625365 15675481 16767912 17203757 17710206 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.9814601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5117846226
MESH:D012640 Seizures Ethanol 9.169754883
MESH:D012640 Seizures Pentobarbital 9.1610087439 9754883
MESH:D012640 Seizures Picrotoxin 9.168954991 8635557
MESH:D012878 Skin Neoplasms Doxorubicin 8.7815692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7816192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 8.788330346 12065085 11807781 8985016 18404319
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2917203757 16767912 15625365
MESH:D013088 Spermatocele Diethylstilbestrol 18.4816709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 18.4816709447
MESH:D013088 Spermatocele Tamoxifen 18.4816709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.9415862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.9419457130
MESH:D013274 Stomach Neoplasms Benzene 2.7812562636
MESH:D013274 Stomach Neoplasms Ethanol 2.7818456281
MESH:D013276 Stomach Ulcer Ethanol 3.2916755016 11906479 17189318 17918041 9211565 9562338
MESH:D019966 Substance-Related Disorders bisphenol A 3.7116045194 16684133
MESH:D013375 Substance Withdrawal Syndrome Ethanol 9.459754883
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 9.4511529278 9754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9215669648
MESH:D013953 Thymus Neoplasms Benzene 11.2710850423
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 11.2715790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.1616010429 17909728
MESH:D013978 Tibial Fractures Estradiol 4.4019048282
MESH:D014062 Tongue Neoplasms Zinc 4.1616543248
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 7.7616452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 7.7617653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.7616712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.7916175088
MESH:D014591 Uterine Diseases bisphenol A 12.8714652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 12.8714652134
MESH:D014594 Uterine Neoplasms Benzene 14.5612562636
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 14.5615809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 14.5614692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1616513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2914671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9517334414 17638931 17678736 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
Pathway ID Pathway Name
KEGG:04912 GnRH signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00007 agonist Leuprolide Antineoplastic Agents;Anti-Estrogen Agents
DB00014 agonist Goserelin Antineoplastic Agents;Antineoplastic Agents, Hormonal
DB00050 antagonist Cetrorelix Infertility Agents;Hormone Antagonists
DB00106 antagonist Abarelix Antineoplastic Agents;Anti-Testosterone Agents
DB00644 agonist Gonadorelin Fertility Agents, Female
DB00666 agonist Nafarelin Fertility Agents, Female;Gonadotropin-releasing hormones;Antiendometriotic agent
DB01406 negative modulator Danazol Estrogen Antagonists
DB06699 antagonist Degarelix Antineoplastic Agents;Antineoplastic Agents, Hormonal;Antineoplastics
DB06719 - Buserelin
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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