AutismKB 2.0

Annotation Detail for AMY2B


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Basic Information Top
Gene Symbol:AMY2B ( AMY2 )
Gene Full Name: amylase, alpha 2B (pancreatic)
Band: 1p21.1
Quick LinksEntrez ID:280; OMIM: 104660; Uniprot ID:AMY2B_HUMAN; ENSEMBL ID: ENSG00000197839; HGNC ID: 478
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-842starch degradation
Pathway IDPathway Name
hsa04973Carbohydrate digestion and absorption
hsa04972Pancreatic secretion
hsa01100Metabolic pathways
hsa00500Starch and sucrose metabolism
Pathway IDPathway Name
Metabolism of carbohydrates
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of AMY2B mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of AMY2B mRNAdecreases expression 20106945
D015032 Zinc Zinc results in increased activity of AMY2B proteinincreases activity 17093223
D015034 Zinc Oxide Zinc Oxide results in increased activity of AMY2B proteinincreases activity 17093223
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4711752688 15322242 14514962
MESH:D000169 Acrodermatitis Zinc 6.0316889938 17202136 17190629
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000544 Alzheimer Disease Zinc 2.8216325427 17119284 16580781 16410023
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D000755 Anemia, Sickle Cell Zinc 5.4116916123
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001249 Asthma Zinc 3.0417085522
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001930 Brain Injuries Zinc 5.2517109824
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8620146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.1020419170
MESH:D002294 Carcinoma, Squamous Cell Zinc 5.1016543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5616120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases Zinc 3.9216936243
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.248697196 12621046 16354765 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7610048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Zinc 2.7619302082
MESH:D003920 Diabetes Mellitus Zinc 4.5716479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6215322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4210568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.9016530937
MESH:D004938 Esophageal Neoplasms Zinc 4.9016543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.5120067830
MESH:D005756 Gastritis Zinc 5.5217241300
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006130 Growth Disorders Zinc 4.1917217573
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.0520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0511294989 10048152
MESH:D006333 Heart Failure Zinc 3.8317162251
MESH:D006335 Heart Injuries Zinc 6.4917074742
MESH:D016481 Helicobacter Infections Zinc 5.0017241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006527 Hepatolenticular Degeneration Zinc 5.2517276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4516120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7718606429 15340226 16354765 8697196 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0312200463 12878042
MESH:D007511 Ischemia Zinc 5.1916584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007674 Kidney Diseases Zinc 3.5216960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.8516518626
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7320195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2720869020 20464547 20064080 17053015 18569708 18520028 20135361 6695378 18816296
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2719555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.5312773700
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3311141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011225 Pre-Eclampsia Zinc 4.4817114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3017292933
MESH:D011471 Prostatic Neoplasms Zinc 3.3016517595 16606632 12429649 16700911
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012162 Retinal Degeneration Zinc 4.4216584753
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0019755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0016192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D014062 Tongue Neoplasms Zinc 4.7916543248
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3017053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
Pathway ID Pathway Name
KEGG:04973 Carbohydrate digestion and absorption
KEGG:01100 Metabolic pathways
REACT:474 Metabolism of carbohydrates
KEGG:04972 Pancreatic secretion
KEGG:00500 Starch and sucrose metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01870 - 1,4-Dithio-Alpha-D-Mannose
DB02218 - N-[4-Hydroxymethyl-Cyclohexan-6-Yl-1,2,3-Triol]-4,6-Dideoxy-4-Aminoglucopyranoside
DB02379 - Beta-D-Glucose Sweetening Agents
DB02730 - 4-Methylthio-Alpha-D-Mannose
DB02944 - Alpha-D-Mannose
DB03088 - Pyroglutamic Acid
DB03092 - 5-Hydroxymethyl-Chonduritol
DB03277 - Amylotriose
DB03323 - Maltose Sweetening Agents
DB04417 - P-Nitrophenol
No data
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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