AutismKB 2.0

Annotation Detail for GOT2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GOT2 ( FLJ40994,KAT4,KATIV,mitAAT )
Gene Full Name: glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
Band: 16q21
Quick LinksEntrez ID:2806; OMIM: 138150; Uniprot ID:AATM_HUMAN; ENSEMBL ID: ENSG00000125166; HGNC ID: 4433
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
GLUTDEG-PWYglutamate degradation II
MALATE-ASPARTATE-SHUTTLE-PWYaspartate degradation II
Pathway IDPathway Name
hsa00360Phenylalanine metabolism
hsa00400Phenylalanine, tyrosine and tryptophan biosynthesis
hsa00250Alanine, aspartate and glutamate metabolism
hsa00330Arginine and proline metabolism
hsa00350Tyrosine metabolism
hsa01100Metabolic pathways
hsa00270Cysteine and methionine metabolism
Pathway IDPathway Name
Metabolism of carbohydrates
Metabolism of amino acids and derivatives
No data
Pathway IDPathway Name
P02730Asparagine and aspartate biosynthesis
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
QT interval
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen results in increased expression of GOT2 proteinincreases expression 11752693
D000499 Allylamine Allylamine affects the expression of GOT2 mRNAaffects expression 15910882
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GOT2 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of GOT2 mRNAincreases expression 20458559
D003024 Clozapine Clozapine results in increased expression of GOT2 mRNAincreases expression 15860345
D002945 Cisplatin GOT2 protein results in increased susceptibility to Cisplatinincreases response to substance 16846239
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GOT2 mRNAaffects cotreatment|decreases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of GOT2 mRNAdecreases expression 18035473
D006220 Haloperidol Haloperidol affects the expression of GOT2 mRNAaffects expression 15860345
C029424 hydrazine hydrazine results in increased expression of GOT2 mRNAincreases expression 15282401
D008094 Lithium Lithium inhibits the reaction [Methamphetamine results in decreased expression of GOT2 mRNA]decreases expression|decreases reaction 19149911
D008694 Methamphetamine Lithium inhibits the reaction [Methamphetamine results in decreased expression of GOT2 mRNA]decreases expression|decreases reaction 19149911
D008694 Methamphetamine Methamphetamine results in decreased expression of GOT2 mRNAdecreases expression 19149911
D008694 Methamphetamine Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of GOT2 mRNA]decreases expression|decreases reaction 19149911
D015741 Metribolone Metribolone results in increased expression of GOT2 proteinincreases expression 17626249
C006253 pirinixic acid pirinixic acid results in decreased expression of GOT2 proteindecreases expression 15226431
C006253 pirinixic acid pirinixic acid results in increased expression of GOT2 mRNAincreases expression 18301758
17426115
C089730 rosiglitazone rosiglitazone results in increased expression of GOT2 mRNAincreases expression 16484294
C089730 rosiglitazone rosiglitazone results in increased expression of GOT2 proteinincreases expression 16484294
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GOT2 mRNAdecreases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GOT2 mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GOT2 mRNAaffects cotreatment|decreases expression 17942748
C052342 topiramate topiramate results in increased expression of GOT2 mRNAincreases expression 16979414
D014635 Valproic Acid Valproic Acid inhibits the reaction [Methamphetamine results in decreased expression of GOT2 mRNA]decreases expression|decreases reaction 19149911
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.1911752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.198875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8919490988
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.9212690470 17670903 15814532
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma arsenic trioxide 7.0719825857 11798837
MESH:D000230 Adenocarcinoma Cisplatin 7.0711798837 17638652
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0714692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7816835633
MESH:D000380 Agranulocytosis Clozapine 5.0214617031 12649775 16160616
MESH:D000437 Alcoholism topiramate 4.9919331489 17925516 18552399
MESH:D000544 Alzheimer Disease Lithium 4.8319621015
MESH:D000544 Alzheimer Disease rosiglitazone 4.8319621015
MESH:D000550 Amblyopia Valproic Acid 5.2017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.5417497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D001321 Autistic Disorder Acetaminophen 2.2018445737
MESH:D001321 Autistic Disorder Haloperidol 2.2018080171 19368416
MESH:D001321 Autistic Disorder Valproic Acid 2.2020603192 18177632 18985861 19232924 15238991 17688650 18558336 19460635 18316065 18396377 17507914 18775368 17157402 16609825 18940202
MESH:D001714 Bipolar Disorder Lithium 7.5417594078 20338123 20046352 19153942
MESH:D001714 Bipolar Disorder Valproic Acid 7.5420046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.0516206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.0519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.0512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.9315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.938888407
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.8614601052
MESH:D001943 Breast Neoplasms Cisplatin 2.1918382427 19526202
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2911589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.583084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.5811135700 16217749 15553829 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.5817982673
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.0212023789 16685392
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0812490120
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.816189445 17066447 18337622
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418850075 18670907 16120746
MESH:D002375 Catalepsy Haloperidol 4.8715215559 1977408
MESH:D002386 Cataract Acetaminophen 2.5510977129
MESH:D002659 Child Development Disorders, Pervasive topiramate 6.3715650499
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 6.3720734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6311677210 17110522 17333356 16105132 16919318 17681005 15861022
MESH:D002779 Cholestasis pirinixic acid 7.6319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0812621046 15340226 16354765 8697196 15668235
MESH:D003072 Cognition Disorders Clozapine 4.9217123785
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6620501625
MESH:D015179 Colorectal Neoplasms Cisplatin 2.6615273666
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1412609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7410048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.7416575769 17688650 8888407
MESH:D007644 Darier Disease Lithium 5.8720338123
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 10.7915213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 10.7920210726
MESH:D003704 Dementia Haloperidol 4.5411575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.7119244398
MESH:D003920 Diabetes Mellitus rosiglitazone 4.2617446233
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 10.2916402076
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 10.2912642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 10.2917107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 10.2916979414
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.5315331141
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.0716227642 15619225 19085960 11287661 11834606 19923254 16109766 12153990 16081117 19164858 14986274 16485898 10774834 2444490 16177239 11743745 17906064 11739529 12705907 10915739 17522070 19420014 11421492 17562736 14725611 14550746 18071297 10663392 11461765 12594235 19416960 12540782 16781746 11529661 15968718 19739265 12958197 19370779 16393943 18713872 12392966
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.0720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.071733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004362 Drug Toxicity Cisplatin 8.0719839026 12649298 15033597 12231392
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0711462148
MESH:D050171 Dyslipidemias Clozapine 4.1516402076
MESH:D004421 Dystonia Valproic Acid 4.011851702
MESH:D004487 Edema pirinixic acid 11.2412083418
MESH:D004487 Edema rosiglitazone 11.2412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.2412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9810568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.1117275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.893922381 16628512
MESH:D004827 Epilepsy topiramate 7.1219148780
MESH:D004827 Epilepsy Valproic Acid 7.1218234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.557562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.267750514
MESH:D004833 Epilepsy, Temporal Lobe topiramate 6.2516499746
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.033659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6812903497
MESH:D004938 Esophageal Neoplasms Cisplatin 4.6815173087 16785472 15464296 16481741 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver arsenic trioxide 24.2415073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 24.2415345470
MESH:D005234 Fatty Liver pirinixic acid 24.2420131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 24.2419196556
MESH:D005234 Fatty Liver Valproic Acid 24.2414986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.098888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2216904648
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.6815464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.2619898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3815464296
MESH:D006330 Heart Defects, Congenital Lithium 6.9419638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006529 Hepatomegaly pirinixic acid 8.1316221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.1312621046 15340226 16120746
MESH:D006689 Hodgkin Disease Cisplatin 3.5616200630 16170182
MESH:D006849 Hydrocephalus Valproic Acid 4.8317688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0215340226 16354765 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.7616870215
MESH:D006930 Hyperalgesia rosiglitazone 7.7612083418
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006948 Hyperkinesis Clozapine 11.7116046005
MESH:D006948 Hyperkinesis Methamphetamine 11.7117658665
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4617937319
MESH:D007249 Inflammation Flavonoids 8.2817296493
MESH:D007249 Inflammation rosiglitazone 8.2812083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2812878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 7.4116306350
MESH:D007333 Insulin Resistance rosiglitazone 7.4116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.1115464296
MESH:D007674 Kidney Diseases Acetaminophen 6.0412587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 6.0412649298 15190930 19839026 12231392 18289764
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.7711231351
MESH:D007938 Leukemia arsenic trioxide 2.8115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7512560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7219077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8816467208 19850784 16968895 17050201 20471514
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8817596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1817107899 12679006 17712046 15213294 16823087 11161223 17649720 15622746 19642359 16966277 11468182 16891316 19075265 16330433 12712474 19225113 16112521 17217047 19035177 17869043 9834237 15336539 15748426 12018890 16331271
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3116882451
MESH:D008064 Lipidoses Clozapine 3.9317567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4615474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 3.4615980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008107 Liver Diseases Acetaminophen 1.6219460945 16611625 19784758 16610002 19014921 11587558 12969438 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2017185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 7.2514682389
MESH:D008113 Liver Neoplasms pirinixic acid 7.2516377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.2516984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.7120377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.7112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3115213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2317228818
MESH:D008175 Lung Neoplasms arsenic trioxide 3.4419825857 11798837
MESH:D008175 Lung Neoplasms Cisplatin 3.4411798837 6189445 17225452
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.3616827153
MESH:D008545 Melanoma Cisplatin 2.4717023156 16809738 15577323 12374674 16432458 18332650 16248763 11135225 17761969 18176117 18505091 12393984 12883367
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.7415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D001523 Mental Disorders Clozapine 8.2516856516
MESH:D001523 Mental Disorders Haloperidol 8.2516856516
MESH:D008654 Mesothelioma Cisplatin 3.2317638057
MESH:D024821 Metabolic Syndrome X Clozapine 9.7619142101
MESH:D024821 Metabolic Syndrome X rosiglitazone 9.7617261469
MESH:D008881 Migraine Disorders topiramate 7.9518765137 18803445 16942474 18759728
MESH:D008881 Migraine Disorders Valproic Acid 7.9518765137 18803445
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0719417148 15949261 11468182 14977855 19549372
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.998888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.3316105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.3317596541
MESH:D009203 Myocardial Infarction Lithium 6.0116288908
MESH:D009203 Myocardial Infarction pirinixic acid 6.0119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9116411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9216624393
MESH:D009369 Neoplasms Cisplatin 5.0316773208
MESH:D009369 Neoplasms pirinixic acid 5.0317405874
MESH:D009395 Nephritis, Interstitial Cisplatin 4.4615464296
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1714600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.2310525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.2316359493 8888407
MESH:D009447 Neuroblastoma Cisplatin 3.438761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8318514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.668761367
MESH:D009765 Obesity Clozapine 4.6719142110 18515891
MESH:D009765 Obesity pirinixic acid 4.6720558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.0212452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Cisplatin 5.0215464296 19769630 6897625 17225452
MESH:D010146 Pain Acetaminophen 2.3516870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4315580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.4319003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010235 Paraganglioma arsenic trioxide 4.1219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.2715464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.3117638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.3511896295 11399792 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.3520603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2919131511
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.5112752131 11422049
MESH:D011595 Psychomotor Agitation Haloperidol 4.9211575062
MESH:D011618 Psychotic Disorders Clozapine 9.0515331141
MESH:D011618 Psychotic Disorders Haloperidol 9.0511575062
MESH:D051437 Renal Insufficiency Cisplatin 4.3715464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.1319155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 10.2116646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 10.2114601052
MESH:D012559 Schizophrenia Clozapine 5.6811151749 20580759 19369910 18855531 20521320 11763009 18806925 20521326 20168265 20452607 16141801 17726453 17123785 20107430 17667964
MESH:D012559 Schizophrenia Haloperidol 5.6818513383 19369910 20107430 1830565
MESH:D012559 Schizophrenia Valproic Acid 5.6815737665 19110320
MESH:D012640 Seizures Lithium 10.0519660546
MESH:D012640 Seizures topiramate 10.0516499746
MESH:D012640 Seizures Valproic Acid 10.053137016 17978042 11738929 15475178 14763951 16876388 11044598 1511512
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0216192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.3115464296
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7519490988
MESH:D013226 Status Epilepticus Lithium 12.5719951488 19430551 19570321
MESH:D013226 Status Epilepticus Valproic Acid 12.5712833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.6417007042
MESH:D013274 Stomach Neoplasms Cisplatin 2.6418396642 17522103 15958060
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.6720210726
MESH:D013736 Testicular Neoplasms Cisplatin 4.5915464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.0519014326
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9315213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.2017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.493119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.2720435036 12845720 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.2715464296 12973940 17225452
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.608888407
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.1716803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014625 Vaginal Neoplasms Cisplatin 4.5715577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D014839 Vomiting Cisplatin 4.6911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D015430 Weight Gain Clozapine 4.4317502770 20107430 20564506 16402076 20521320 16141801
MESH:D015431 Weight Loss Clozapine 5.0417933447
Pathway ID Pathway Name
KEGG:00250 Alanine, aspartate and glutamate metabolism
KEGG:00330 Arginine and proline metabolism
KEGG:00270 Cysteine and methionine metabolism
KEGG:04975 Fat digestion and absorption
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
REACT:474 Metabolism of carbohydrates
KEGG:00360 Phenylalanine metabolism
KEGG:00400 Phenylalanine, tyrosine and tryptophan biosynthesis
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28818
    • No data
    No data
    Releated drug ID Related drug Name
    PA448625biotin
    PA10090l-glutamine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00114 - Pyridoxal Phosphate Dietary supplement;Micronutrient;Vitamin B Complex
    DB00128 - L-Aspartic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB02783 - 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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