AutismKB 2.0

Annotation Detail for SFN


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Basic Information Top
Gene Symbol:SFN ( YWHAS )
Gene Full Name: stratifin
Band: 1p36.11
Quick LinksEntrez ID:2810; OMIM: 601290; Uniprot ID:1433S_HUMAN; ENSEMBL ID: ENSG00000175793; HGNC ID: 10773
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04960Aldosterone-regulated sodium reabsorption
hsa04110Cell cycle
hsa04115p53 signaling pathway
No data
Pathway IDPathway Name
200077Glucocorticoid receptor regulatory network
200101Direct p53 effectors
Pathway IDPathway Name
P00018EGF receptor signaling pathway
P00049Parkinson disease
P00021FGF signaling pathway
P00059p53 pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CANCER
5' CpG island hypermethylation
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of SFN mRNAincreases expression 17547211
C109238 acyline acyline results in increased expression of SFN mRNAincreases expression 17510436
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SFN proteinaffects expression 20106945
D001151 Arsenic Arsenic results in increased expression of SFN mRNAincreases expression 19945496
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of SFN mRNAincreases expression 19737606
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SFN mRNAincreases expression 20106945
C400082 bortezomib [irinotecan co-treated with bortezomib] results in decreased expression of SFN proteinaffects cotreatment|decreases expression 16373703
C459604 candoxin candoxin results in decreased expression of SFN mRNAdecreases expression 16309724
D002699 Chlorambucil Chlorambucil results in increased expression of SFN mRNAincreases expression 18092340
C043561 chrysin chrysin results in increased expression of SFN mRNAincreases expression 18331776
C043561 chrysin chrysin results in increased expression of SFN proteinincreases expression 18331776
D016572 Cyclosporine Cyclosporine results in increased expression of SFN mRNAincreases expression 20106945
C014347 decitabine decitabine results in decreased methylation of SFN promoterdecreases methylation 15979784
C014347 decitabine decitabine results in increased expression of SFN mRNAincreases expression 15979784
D002945 Cisplatin SFN protein affects the susceptibility to [Fluorouracil co-treated with Cisplatin]affects cotreatment|affects response to substance 15999354
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of SFN mRNAincreases expression 16636312
15171707
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of SFN mRNAincreases expression 17547211
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SFN mRNAincreases expression 17942748
17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SFN mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil affects the expression of SFN mRNAaffects expression 16584549
D005472 Fluorouracil Fluorouracil results in increased expression of SFN mRNAincreases expression 16557594
17982676
D005472 Fluorouracil SFN protein affects the susceptibility to [Fluorouracil co-treated with Cisplatin]affects cotreatment|affects response to substance 15999354
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in increased expression of SFN mRNA]affects reaction|increases expression 15016801
D005472 Fluorouracil TP53 protein promotes the reaction [Fluorouracil results in increased expression of SFN mRNA]increases expression|increases reaction 17982676
C419708 gefitinib gefitinib results in decreased expression of SFN mRNAdecreases expression 16685379
C051890 irinotecan [irinotecan co-treated with bortezomib] results in decreased expression of SFN proteinaffects cotreatment|decreases expression 16373703
C006552 kaempferol kaempferol results in increased expression of SFN mRNAincreases expression 18331776
C006552 kaempferol kaempferol results in increased expression of SFN proteinincreases expression 18331776
C533894 LG 100815 LG 100815 results in decreased expression of SFN mRNAdecreases expression 16951191
D047311 Luteolin Luteolin results in increased expression of SFN mRNAincreases expression 18331776
D047311 Luteolin Luteolin results in increased expression of SFN proteinincreases expression 18331776
D008942 Mitoxantrone SFN protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D009151 Mustard Gas Mustard Gas results in increased alkylation of SFN proteinincreases alkylation 18342354
C029938 nickel sulfate nickel sulfate results in increased expression of SFN mRNAincreases expression 16100012
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in decreased expression of SFN mRNAdecreases expression 16951191
D010126 Ozone Ozone results in increased expression of SFN mRNAincreases expression 17095637
12763052
C006253 pirinixic acid pirinixic acid results in decreased expression of SFN mRNAdecreases expression 17426115
D011374 Progesterone Progesterone results in decreased expression of SFN mRNAdecreases expression 16966611
D011374 Progesterone Progesterone results in increased phosphorylation of SFN proteinincreases phosphorylation 17303654
D011794 Quercetin Quercetin results in increased expression of SFN mRNAincreases expression 18331776
D011794 Quercetin Quercetin results in increased expression of SFN proteinincreases expression 18331776
C017947 sodium arsenite sodium arsenite results in decreased expression of SFN mRNAdecreases expression 12760830
D013629 Tamoxifen Tamoxifen results in increased expression of SFN mRNAincreases expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SFN mRNAaffects cotreatment|increases expression 17942748
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in increased expression of SFN mRNAincreases expression 17951470
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2014745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5111752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6017505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.6615814532 12690470 17670903
MESH:D055371 Acute Lung Injury nickel sulfate 8.1016100012 11954676 12718980 19131640
MESH:D055371 Acute Lung Injury pirinixic acid 8.1018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.5420127859 20464547
MESH:D000230 Adenocarcinoma Cisplatin 12.5411798837 17638652
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 12.5416033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.5414692618
MESH:D000230 Adenocarcinoma Fluorouracil 12.5417638652
MESH:D000236 Adenoma Benzo(a)pyrene 10.146695378
MESH:D000236 Adenoma beta-Naphthoflavone 10.1419389873
MESH:D000236 Adenoma Dimethylnitrosamine 10.1419555203
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.7716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.7716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3515276417
MESH:D018246 Adrenocortical Adenoma Arsenic 12.6417306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 12.6417306315 16712894
MESH:D000544 Alzheimer Disease Ozone 2.3615513908
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1615469931
MESH:D000740 Anemia Fluorouracil 7.7116511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.7111748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.9417084956
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7419183758
MESH:D020261 Arsenic Poisoning Arsenic 2.7716251483 18414634 16835338 12569548
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4515885639
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4815570426
MESH:D001249 Asthma Mustard Gas 4.7110378619
MESH:D001249 Asthma Ozone 4.7117854713 16373670
MESH:D001260 Ataxia Telangiectasia Quercetin 4.6415336622
MESH:D050197 Atherosclerosis Arsenic 3.0512928151 19371607
MESH:D001327 Autoimmune Diseases Quercetin 4.0819761891
MESH:D001768 Blister Mustard Gas 4.8219167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.7619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.7612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5515746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.5414601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9917868700
MESH:D001930 Brain Injuries Progesterone 3.9315845082 15665606 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.6020146248 17474063
MESH:D001943 Breast Neoplasms Cisplatin 6.6018382427 19526202
MESH:D001943 Breast Neoplasms decitabine 6.6019208741 18320071
MESH:D001943 Breast Neoplasms Diethylstilbestrol 6.6017129689 15324884
MESH:D001943 Breast Neoplasms Fluorouracil 6.6018608205 16595493 16557594 18357371 15136595 16110121 19217205
MESH:D001943 Breast Neoplasms kaempferol 6.6016756079
MESH:D001943 Breast Neoplasms Progesterone 6.6017614352 15562024 16175315
MESH:D001943 Breast Neoplasms Quercetin 6.6018628248
MESH:D001943 Breast Neoplasms Tamoxifen 6.6019066611 17893378 18425577 20544844 16202921 18855134 16273361 19189212 19155303 16873071 20390343 19189210 18984771 17440819 20005174 15668708 19103187 15565566 20065188 18815881 18997820 19221464 18629630 19142967 18821012 19115204 17261762 20859285 21152245 18351453 20135344 19011961 19410462 19084267 19200415 19288272 19487384 19244106 19289846 21138602 19059307 11161223 16818667 17049068 17242785
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.6020435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4118315731 16777450 15516495 17626835 19059883 14754758 18417511
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8215286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6310378619 17687719
MESH:D002100 Cachexia Ozone 4.4016183385
MESH:D002105 Cadmium Poisoning Quercetin 5.2016962696
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3216051944
MESH:D002277 Carcinoma Dimethylnitrosamine 12.4519555203
MESH:D002277 Carcinoma Fluorouracil 12.4517121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 12.4516835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4017687452 15504454
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1719066611
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 15.8312907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Arsenic 15.8316507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 15.8317982673
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 15.8316924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 15.8317971768 18930000 16799960 16332177 17088986 17045692
MESH:D006528 Carcinoma, Hepatocellular Quercetin 15.8312508355 19519916
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 15.8317306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 15.8316924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung bortezomib 8.6016052434
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 8.6012023789 16685392
MESH:D002289 Carcinoma, Non-Small-Cell Lung gefitinib 8.6017290066 15496427 19233551 16230376 18347146 20005069
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.6217234771
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8618695887
MESH:D002294 Carcinoma, Squamous Cell Arsenic 20.3615504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 20.3620419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 20.3617066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell decitabine 20.3619215824
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 20.3616033868
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 20.3616280240 17066447 16757204 18986760
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 20.3618572023
MESH:D002295 Carcinoma, Transitional Cell Arsenic 8.5318640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.5317572228
MESH:D006332 Cardiomegaly Quercetin 6.1719794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.1718670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 7.1317938729 15738583 19152805
MESH:D002318 Cardiovascular Diseases kaempferol 7.1316756079
MESH:D002340 Carotid Artery Diseases Arsenic 4.0216973168 18022660
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 5.8812371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 5.8820056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8816835633
MESH:D002779 Cholestasis Cyclosporine 11.8919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.8917681005 17333356 16105132 11677210 16919318 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 11.8919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9616354765 15668235 8697196 15340226 12621046
MESH:D003110 Colonic Neoplasms decitabine 7.7517616700
MESH:D003110 Colonic Neoplasms Fluorouracil 7.7517169374 17018589 15001691 17725105 18772588 16510598 17172411 17287894 16340194 17016597
MESH:D003110 Colonic Neoplasms irinotecan 7.7517725105 17287894
MESH:D003110 Colonic Neoplasms Quercetin 7.7511134977 17191121 16640504 15741050 19440933 19056647 17148506
MESH:D015179 Colorectal Neoplasms Cisplatin 7.9115273666
MESH:D015179 Colorectal Neoplasms decitabine 7.9118981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 7.9120501625 16282729 18949393 16391804 16303861 17695437 18509181 17594712 16331619 15289873 16524972 18448328 18288408 17016601 17094418 17401013 18802399 14970324 15148649 18383874 17454858 17255274
MESH:D015179 Colorectal Neoplasms gefitinib 7.9117594712
MESH:D015179 Colorectal Neoplasms irinotecan 7.9117159606 16391804 16303861 18259882 15273666 18509181 17454858
MESH:D015179 Colorectal Neoplasms Quercetin 7.9118852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2410048152 20055451 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.2316002989 12952375
MESH:D007644 Darier Disease Fluorouracil 4.4516733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0319031437
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.3616780908 16823706 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.4619496084
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.1919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1617187935
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 3.648172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.6420420201
MESH:D004362 Drug Toxicity Cisplatin 7.3512649298 19839026 12231392 15033597
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.3511462148
MESH:D004487 Edema Mustard Gas 9.699260866 11402378 11428631 11428647
MESH:D004487 Edema pirinixic acid 9.6912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.6911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5618230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.4512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 13.4517692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 13.4519031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.7719294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.3516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 6.8315700306 16804899
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.8317893378 16202921 20544844 19155303
MESH:D004715 Endometriosis Progesterone 7.9516134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.959294722 10568697
MESH:D004890 Erythema Mustard Gas 4.829357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 9.6616530937
MESH:D004938 Esophageal Neoplasms Cisplatin 9.6615173087 16481741 15464296 16785472 17638652
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 9.6617016578
MESH:D004938 Esophageal Neoplasms Fluorouracil 9.6616481741 16337965 15173087 17638652 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7611564622
MESH:D005234 Fatty Liver Cyclosporine 16.2419224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.2415345470
MESH:D005234 Fatty Liver pirinixic acid 16.2419236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 16.2414986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.5216611131 16513791 15751030 16002989 16534752
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.5216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1211858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8419069698
MESH:D005355 Fibrosis Cyclosporine 12.8512639820 12168785
MESH:D005355 Fibrosis Quercetin 12.8519474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.8520067830
MESH:D005534 Foot Diseases Arsenic 5.216392382
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.6816452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.6816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.888708960
MESH:D005909 Glioblastoma Quercetin 3.1719804834
MESH:D005910 Glioma Fluorouracil 5.7216145905
MESH:D005910 Glioma Quercetin 5.7217643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2510696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 11.7215102660 15464296
MESH:D006258 Head and Neck Neoplasms decitabine 11.7219215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 11.7215162350 15102660 18337622
MESH:D034381 Hearing Loss Cisplatin 4.0119898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.1415464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.8420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.8411294989 10048152
MESH:D006331 Heart Diseases Mitoxantrone 3.9216019553
MESH:D006333 Heart Failure pirinixic acid 2.3320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0311000095
MESH:D006529 Hepatomegaly pirinixic acid 7.1619176532 19772884 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.1612621046 16120746 15340226
MESH:D006689 Hodgkin Disease Cisplatin 6.6116170182 16200630
MESH:D006689 Hodgkin Disease sodium arsenite 6.6112676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7018606429 15340226 16354765 8697196 16959395
MESH:D006934 Hypercalcemia bortezomib 5.1518089816
MESH:D006943 Hyperglycemia kaempferol 14.1018262572
MESH:D006943 Hyperglycemia pirinixic acid 14.1020558911
MESH:D006943 Hyperglycemia Quercetin 14.1018262572 11834736
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.1617050553
MESH:D006965 Hyperplasia Diethylstilbestrol 4.1012960047 14722030
MESH:D006973 Hypertension Arsenic 11.2616076760 9931084 11953799
MESH:D006973 Hypertension Cyclosporine 11.2610903974
MESH:D006973 Hypertension Quercetin 11.2618356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.2618850075 18670907
MESH:D006976 Hypertension, Pulmonary gefitinib 4.4518424623
MESH:D017380 Hypertrophy, Right Ventricular gefitinib 5.8918424623
MESH:D006987 Hypesthesia Arsenic 5.2116093927
MESH:D007021 Hypospadias Diethylstilbestrol 10.1416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.1416569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0715869954
MESH:D007246 Infertility Diethylstilbestrol 4.0315036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1512013081
MESH:D007248 Infertility, Male decitabine 9.9117581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.9117937319
MESH:D007248 Infertility, Male sodium arsenite 9.9115346721 12646999
MESH:D007249 Inflammation Mustard Gas 10.4817524151 16001271 9357497 11428631 11428647 9260866 11428620 8975870 11402378
MESH:D007249 Inflammation Progesterone 10.4815869954
MESH:D007249 Inflammation Tamoxifen 10.4819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.4812200463 12878042
MESH:D007251 Influenza, Human Quercetin 4.1616624496
MESH:D007333 Insulin Resistance pirinixic acid 2.4116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0316580747
MESH:D007627 Keloid Quercetin 4.6217086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0915604871
MESH:D007642 Keratosis Arsenic 4.6512749816 16930632
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7915464296
MESH:D007674 Kidney Diseases Cisplatin 12.8612649298 12231392 15190930 18289764 19839026
MESH:D007674 Kidney Diseases Cyclosporine 12.8618776723 10903974 8314463
MESH:D007674 Kidney Diseases Quercetin 12.8616962696
MESH:D007674 Kidney Diseases sodium arsenite 12.8620008137
MESH:D007680 Kidney Neoplasms Cyclosporine 20.4612371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 20.4615003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Fluorouracil 20.4616985049
MESH:D007680 Kidney Neoplasms gefitinib 20.4618625569
MESH:D007680 Kidney Neoplasms Tamoxifen 20.4618625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.4511231351
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7317184923
MESH:D007938 Leukemia decitabine 9.7219235587 18980019
MESH:D007938 Leukemia kaempferol 9.7217468513
MESH:D007938 Leukemia Quercetin 9.7217468513
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.6418172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell bortezomib 4.8718089816
MESH:D007951 Leukemia, Myeloid decitabine 3.7019117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute bortezomib 4.2720471514
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.2717679729 19387464 18704418 19010910 18460780 18206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1218055864
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.3317339181
MESH:D008064 Lipidoses Tamoxifen 2.9115342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 6.2315067225 18210741 17432682 15798949 15383259 17196135 17036385 17719030 14568256 15366600 15369754 14659978 17666798 14709902 18095165 17203207 16042886 18371158 15744066 18637143 15571005 17640959 14726149 16270385 15723089 12925901 17201889 12918455 16009107 18237412 18364076 17534399 17348192 15591649 15492853 17465448 16570917 15479170 15793283 15161499 17198567 17881167 15942678 18567088 18239293 15138612 16169303 15086199 18629640 15339415 15577212 16544323 15081153 15864749 15504291 15099470 16627068 16603200 14643895 15298665 15763062 15733078 17724770 15842777 18672772
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.2315474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.2312741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.2318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.2312878042
MESH:D008107 Liver Diseases Arsenic 2.4611134558
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.1117457977
MESH:D008113 Liver Neoplasms Aflatoxin B1 39.9115890375 9163691 2125692 18177683
MESH:D008113 Liver Neoplasms Arsenic 39.9116368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 39.9121137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 39.9119389873 21295105
MESH:D008113 Liver Neoplasms Diethylstilbestrol 39.9116712894 15890375
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 39.913113478 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 39.9118383874 17045692 16603448 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 39.9115890375 16377806 20007298
MESH:D008113 Liver Neoplasms Quercetin 39.9118980244
MESH:D008113 Liver Neoplasms sodium arsenite 39.9116712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 39.9116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 39.9116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 16.408603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 16.4018164116
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 16.406150874 1848544 15603536
MESH:D008114 Liver Neoplasms, Experimental Quercetin 16.4019519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.4012151625
MESH:D008171 Lung Diseases Mustard Gas 11.0818161513 18702808
MESH:D008171 Lung Diseases Ozone 11.088266340 19066396
MESH:D008171 Lung Diseases sodium arsenite 11.0819095001
MESH:D055370 Lung Injury Ozone 3.5220417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 22.0814755239
MESH:D008175 Lung Neoplasms Arsenic 22.0817976673 19168569 17306315
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 22.0820464547 18520028 20869020 17053015 18569708 6695378 18816296 20135361 20064080
MESH:D008175 Lung Neoplasms Cisplatin 22.0811798837 17225452 6189445
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 22.0819555203 16061637 11884234
MESH:D008175 Lung Neoplasms Fluorouracil 22.0815246190
MESH:D008175 Lung Neoplasms Mustard Gas 22.088781369 3148597
MESH:D008175 Lung Neoplasms Ozone 22.087614698 8597069
MESH:D008175 Lung Neoplasms Quercetin 22.0816280456
MESH:D008175 Lung Neoplasms sodium arsenite 22.0817306315 19931552 15276417 16712894 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 22.0818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 22.0811884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4515086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8115166399
MESH:D008223 Lymphoma bortezomib 16.0516098063
MESH:D008223 Lymphoma Chlorambucil 16.0510745627
MESH:D008223 Lymphoma decitabine 16.0519470736
MESH:D008223 Lymphoma Diethylstilbestrol 16.0515700306
MESH:D016393 Lymphoma, B-Cell bortezomib 5.0116675587
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.1716002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4219428831
MESH:D008325 Mammary Neoplasms, Experimental gefitinib 8.9118375820
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.9111408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 8.9114580682 19196723 11731420 19196722 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.2019453300
MESH:D008527 Medulloblastoma bortezomib 4.0919213072
MESH:D008545 Melanoma Cisplatin 6.7616432458 18332650 17023156 11135225 18505091 17761969 15577323 12374674 16809738 12393984 18176117 16248763 12883367
MESH:D008545 Melanoma decitabine 6.7617785578 16505122
MESH:D008545 Melanoma sodium arsenite 6.7616487513 19082730
MESH:D008545 Melanoma Tamoxifen 6.7612393984 19393235
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.3715990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 10.3715990972
MESH:D008654 Mesothelioma Cisplatin 3.1117638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4416801185
MESH:D008679 Metaplasia Ozone 4.7610496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.6716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 7.6716757204 18986760
MESH:D052016 Mucositis irinotecan 4.6717159606
MESH:D009101 Multiple Myeloma bortezomib 7.0819372569 19112201 19112817
MESH:D009101 Multiple Myeloma decitabine 7.0818172295
MESH:D009135 Muscular Diseases pirinixic acid 3.1716239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.1919157545 16882708 18608210 19010910
MESH:D009203 Myocardial Infarction pirinixic acid 5.2419151258
MESH:D009203 Myocardial Infarction Quercetin 5.2419595682
MESH:D017202 Myocardial Ischemia Arsenic 8.1115371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.5816411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.5819207477
MESH:D009362 Neoplasm Metastasis irinotecan 5.4818259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 29.5511141357
MESH:D009369 Neoplasms Cisplatin 29.5516773208
MESH:D009369 Neoplasms decitabine 29.5519116145 19470736 17925555
MESH:D009369 Neoplasms Diethylstilbestrol 29.5515313581
MESH:D009369 Neoplasms Fluorouracil 29.5518239605 18600527 16928823
MESH:D009369 Neoplasms Mitoxantrone 29.5516640825
MESH:D009369 Neoplasms pirinixic acid 29.5517405874
MESH:D009369 Neoplasms Quercetin 29.5515185748
MESH:D009369 Neoplasms sodium arsenite 29.5511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3420056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6519189210 19200415 19196722
MESH:D009395 Nephritis, Interstitial Cisplatin 4.1515464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0019348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 8.5711399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.5714600291
MESH:D009436 Neural Tube Defects Arsenic 6.7216620997
MESH:D009436 Neural Tube Defects sodium arsenite 6.7212854658
MESH:D009447 Neuroblastoma Cisplatin 6.638761367
MESH:D009447 Neuroblastoma irinotecan 6.638761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 10.338761367
MESH:D017599 Neuroectodermal Tumors irinotecan 10.338761367
MESH:D020078 Neurogenic Inflammation Arsenic 9.6417056641
MESH:D020078 Neurogenic Inflammation Quercetin 9.6417929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2116436463
MESH:D009503 Neutropenia Mustard Gas 3.6616761898 7688884
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D010024 Osteoporosis kaempferol 4.1416756079
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.9119495926
MESH:D010051 Ovarian Neoplasms Arsenic 21.1817306315
MESH:D010051 Ovarian Neoplasms Cisplatin 21.1819769630 15464296 6897625 17225452
MESH:D010051 Ovarian Neoplasms decitabine 21.1819259094 19331143
MESH:D010051 Ovarian Neoplasms Luteolin 21.1819005980
MESH:D010051 Ovarian Neoplasms Progesterone 21.1816525653 17393432
MESH:D010051 Ovarian Neoplasms Quercetin 21.1819005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 21.1817306315 15276417
MESH:D010190 Pancreatic Neoplasms Cisplatin 11.3319003803
MESH:D010190 Pancreatic Neoplasms decitabine 11.3319294695
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.3315113037 16929163 19003803 16500647
MESH:D010190 Pancreatic Neoplasms Quercetin 11.3316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9012520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 8.9916093927
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 8.9915464296
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.6516905509 6392382 15371236
MESH:D010538 Peritonitis Ozone 3.8016369182
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8214722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3415687265 16977796
MESH:D010997 Pleural Neoplasms Cisplatin 5.0017638057
MESH:D011014 Pneumonia Ozone 4.0518929643 18381685 18007984
MESH:D011041 Poisoning Mustard Gas 3.4915727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2418163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.1612371664
MESH:D011230 Precancerous Conditions Quercetin 8.1619056647
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.4417184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.4411222880 11118676 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.3917616702
MESH:D011471 Prostatic Neoplasms Arsenic 2.3716140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.3717292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.3715046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.3719082440 18626508
MESH:D011471 Prostatic Neoplasms gefitinib 2.3715651060 16685379 17914592
MESH:D011471 Prostatic Neoplasms Quercetin 2.3717292933 14715546
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.3716039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.3715067354
MESH:D011507 Proteinuria Arsenic 3.6921343184
MESH:D011537 Pruritus Ethinyl Estradiol 8.3916919318 15861022
MESH:D011537 Pruritus Mustard Gas 8.3918058305
MESH:D011565 Psoriasis Cyclosporine 2.1116882103
MESH:D011658 Pulmonary Fibrosis gefitinib 5.8118424623
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.8110334151 17894541 17266442 17620002 17720292
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7318286688 16160472 18722050 15538739
MESH:D051437 Renal Insufficiency Cisplatin 4.0815464296
MESH:D015427 Reperfusion Injury pirinixic acid 2.2219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5118990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.0919155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7318045962
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.1114601052
MESH:D012554 Schistosomiasis japonica Quercetin 5.2016862918
MESH:D012871 Skin Diseases Arsenic 4.8218709164 17050553 6392382 19834688 16702368 17938729 17453740 15952646 16353154 17548696 16759981
MESH:D012871 Skin Diseases Mustard Gas 4.8215451306 12880345 16961503
MESH:D012878 Skin Neoplasms Arsenic 12.2017029826 17050553 17976673 16251483 19538983 15504454
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.2019755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 12.2019524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.2016192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.0015464296
MESH:D013088 Spermatocele Diethylstilbestrol 18.1216002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 18.1216709447
MESH:D013088 Spermatocele Tamoxifen 18.1216709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.7416503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.7419457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5412854658
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.9212587719
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 7.792093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 7.7917522103 15958060 18396642
MESH:D013274 Stomach Neoplasms decitabine 7.7919037991
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 7.7916033868
MESH:D013274 Stomach Neoplasms Fluorouracil 7.7917522103 19015929 16424979 19084572 17498489 18567086 15786421 17172411 18396642 16951190
MESH:D013274 Stomach Neoplasms irinotecan 7.7915723263
MESH:D013736 Testicular Neoplasms Cisplatin 4.3217225452 15464296
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5612697716
MESH:D013964 Thyroid Neoplasms decitabine 6.9817967635
MESH:D013964 Thyroid Neoplasms gefitinib 6.9816940797
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7016280240
MESH:D001749 Urinary Bladder Neoplasms Arsenic 26.0917306315 15987713 19322015 11144890 18640142 17976673 19429237
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 26.0917053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 26.0917225452 12973940 15464296
MESH:D001749 Urinary Bladder Neoplasms decitabine 26.0917616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 26.0916712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Quercetin 26.0916720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 26.0911723127 17306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 26.0917572228 16712894 8653321
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 20.2416803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 20.2416175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 20.2416803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 20.2411813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.8214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.4015809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.4014692618
MESH:D014604 Uveal Neoplasms decitabine 4.5717785578
MESH:D014605 Uveitis Cyclosporine 3.641336536
MESH:D014625 Vaginal Neoplasms Cisplatin 9.9715577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 9.9716002989 16513791
MESH:D014652 Vascular Diseases Arsenic 10.7117056641
MESH:D014652 Vascular Diseases sodium arsenite 10.7117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2414671159 15869587
MESH:D014839 Vomiting Cisplatin 4.3711897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.0917120751
Pathway ID Pathway Name
KEGG:04960 Aldosterone-regulated sodium reabsorption
KEGG:04110 Cell cycle
KEGG:04115 p53 signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA177
    • No data
    No data
    Releated drug ID Related drug Name
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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