AutismKB 2.0

Annotation Detail for GPD1


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Basic Information Top
Gene Symbol:GPD1 ( FLJ26652 )
Gene Full Name: glycerol-3-phosphate dehydrogenase 1 (soluble)
Band: 12q13.12
Quick LinksEntrez ID:2819; OMIM: 138420; Uniprot ID:GPDA_HUMAN; ENSEMBL ID: ENSG00000167588; HGNC ID: 4455
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6118glycerol-3-phosphate shuttle
Pathway IDPathway Name
hsa00564Glycerophospholipid metabolism
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C038864 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased activity of GPD1 proteindecreases activity 15583048
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GPD1 proteinaffects expression 20106945
C029620 alpha-glycerophosphoric acid GPD1 protein results in increased oxidation of alpha-glycerophosphoric acidincreases oxidation 11952153
D000535 Aluminum Aluminum results in increased expression of and results in increased activity of GPD1 proteinincreases activity|increases expression 17762189
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GPD1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GPD1 mRNAdecreases expression 20106945
C032036 bromobenzene bromobenzene metabolite binds to GPD1 proteinaffects binding 17305373
D002104 Cadmium Cadmium results in decreased activity of GPD1 proteindecreases activity 11952153
D002994 Clofibrate PPARA protein affects the reaction [Clofibrate results in increased expression of GPD1 mRNA]affects reaction|increases expression 17585979
D003300 Copper Copper results in decreased activity of GPD1 proteindecreases activity 11952153
D016572 Cyclosporine Cyclosporine results in decreased expression of GPD1 mRNAdecreases expression 20106945
D015084 2,4-Dichlorophenoxyacetic Acid 2,4-Dichlorophenoxyacetic Acid results in decreased activity of GPD1 proteindecreases activity 11952153
C017180 decamethrin decamethrin results in increased expression of GPD1 mRNAincreases expression 19017407
D004041 Dietary Fats Dietary Fats results in increased expression of GPD1 mRNAincreases expression 16357043
D004099 Dihydroxyacetone Phosphate GPD1 protein results in increased reduction of Dihydroxyacetone Phosphateincreases reduction 11952153
D004958 Estradiol Estradiol results in decreased expression of GPD1 mRNAdecreases expression 20106945
D000431 Ethanol Ethanol results in decreased expression of GPD1 mRNAdecreases expression 15513904
D005033 Ethylmaleimide Ethylmaleimide results in decreased activity of GPD1 proteindecreases activity 11952153
D008345 Manganese Manganese results in decreased activity of GPD1 proteindecreases activity 11952153
D008726 Methoprene Methoprene results in increased activity of GPD1 proteinincreases activity 15583048
D009532 Nickel Nickel results in decreased activity of GPD1 proteindecreases activity 11952153
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of GPD1 mRNAincreases expression 16221955
D026023 Permethrin Permethrin results in increased expression of GPD1 mRNAincreases expression 19017407
D010852 Picrotoxin Picrotoxin results in decreased expression of GPD1 mRNAdecreases expression 15170462
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GPD1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of GPD1 mRNAincreases expression 16357043
17426115
18301758
D011188 Potassium Potassium results in decreased activity of GPD1 proteindecreases activity 11952153
D011374 Progesterone Progesterone affects the expression of GPD1 mRNAaffects expression 17251523
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GPD1 mRNAdecreases expression 20106945
D014212 Tretinoin Tretinoin results in decreased expression of GPD1 mRNAdecreases expression 16604517
D014212 Tretinoin Tretinoin results in decreased activity of GPD1 proteindecreases activity 15583048
D014638 Vanadates Vanadates results in increased expression of GPD1 proteinincreases expression 17874149
C025643 vinclozolin vinclozolin affects the expression of GPD1 mRNAaffects expression 19015723
D015032 Zinc Zinc results in decreased activity of GPD1 proteindecreases activity 11952153
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.4417676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4411752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 9.4318287403
MESH:D000138 Acidosis Ethanol 9.4311192467
MESH:D000169 Acrodermatitis Zinc 5.0916889938 17190629 17202136
MESH:D055371 Acute Lung Injury Nickel 8.2916166738
MESH:D055371 Acute Lung Injury pirinixic acid 8.2918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.0020127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.0011473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.476695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.8716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.8716835633
MESH:D000382 Agricultural Workers' Diseases 2,4-Dichlorophenoxyacetic Acid 4.8116132792
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0015451040 15451039
MESH:D000505 Alopecia Tretinoin 3.3715955085
MESH:D000544 Alzheimer Disease Aluminum 6.5510721010 17662457
MESH:D000544 Alzheimer Disease Copper 6.5516886094 17119284 16962711 16410023 16866297 16325427
MESH:D000544 Alzheimer Disease Zinc 6.5516580781 16325427 16410023 17119284
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 4.1010694572
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6811748828
MESH:D018798 Anemia, Iron-Deficiency Copper 4.6116614410
MESH:D000755 Anemia, Sickle Cell Zinc 4.6116916123
MESH:D000756 Anemia, Sideroblastic Manganese 4.5916910769
MESH:D000853 Anophthalmos Ethanol 4.5215513904
MESH:D001008 Anxiety Disorders Ethanol 8.2011141031
MESH:D001008 Anxiety Disorders vinclozolin 8.2019015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7719183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.5915238619
MESH:D001169 Arthritis, Experimental Tretinoin 2.8916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1916292516
MESH:D001249 Asthma Tretinoin 4.7316456186
MESH:D001249 Asthma Zinc 4.7317085522
MESH:D050197 Atherosclerosis Cadmium 3.4615687053
MESH:D001471 Barrett Esophagus Tretinoin 4.1116935849
MESH:D001778 Blood Coagulation Disorders Clofibrate 19.6919483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 19.6919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 19.6912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 19.6916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5715746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0217868700
MESH:D001930 Brain Injuries Progesterone 10.0315665606 15380490 15845082
MESH:D001930 Brain Injuries Zinc 10.0317109824
MESH:D001932 Brain Neoplasms Copper 4.2917079463
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.4617474063 20146248
MESH:D001943 Breast Neoplasms Copper 4.4617079463 15986119
MESH:D001943 Breast Neoplasms Dietary Fats 4.4620435547
MESH:D001943 Breast Neoplasms Estradiol 4.4614630087 12948864 17018787 17289903 19861407 16675129 18497071 17261762
MESH:D001943 Breast Neoplasms Nickel 4.4615986119
MESH:D001943 Breast Neoplasms Progesterone 4.4615562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.4620435547
MESH:D001943 Breast Neoplasms Tretinoin 4.4616166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2816813970
MESH:D002056 Burns Ethanol 4.3516374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8416168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.1621507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.1616924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 6.1615289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.161917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.0120419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.0116096774 16051514
MESH:D002294 Carcinoma, Squamous Cell Zinc 7.0116543248
MESH:D006332 Cardiomegaly Copper 10.5517327471
MESH:D006332 Cardiomegaly Ethanol 10.5519332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.5518850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Zinc 3.4516936243
MESH:D002386 Cataract Tretinoin 2.9117460283
MESH:D002471 Cell Transformation, Neoplastic Cadmium 14.3417332340
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 14.341399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.3412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.3418566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9016835633
MESH:D002779 Cholestasis Cyclosporine 7.0019486331
MESH:D002779 Cholestasis pirinixic acid 7.0019176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8416461808
MESH:D002971 Cleft Lip Ethanol 3.4215513904
MESH:D002972 Cleft Palate Ethanol 9.0715513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.0715668235 8697196 16354765 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 9.079407595
MESH:D003092 Colitis Tretinoin 3.4017035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8017141729 14669216
MESH:D019465 Craniofacial Abnormalities decamethrin 8.9919861644
MESH:D019465 Craniofacial Abnormalities Ethanol 8.9919302082 11873399 15451039 15513904 15451040 10194807 11198716
MESH:D019465 Craniofacial Abnormalities Permethrin 8.9919861644
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 8.9920055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 8.9914991402 16925845 9142499 10589399 8800419 17551590 9211117 9224671 9125849 9664655
MESH:D019465 Craniofacial Abnormalities Zinc 8.9919302082
MESH:D003456 Cryptorchidism vinclozolin 4.0514966744
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.6617100760 19470301 17244072
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2818249437
MESH:D003877 Dermatitis, Contact Nickel 9.142952479
MESH:D003877 Dermatitis, Contact Permethrin 9.1414617103
MESH:D003920 Diabetes Mellitus Zinc 3.9516479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1917187935
MESH:D056486 Drug-Induced Liver Injury bromobenzene 5.8412628495 10092053
MESH:D056486 Drug-Induced Liver Injury Ethanol 5.8411566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.8420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5311462148
MESH:D050171 Dyslipidemias Clofibrate 8.0816707586
MESH:D050171 Dyslipidemias Dietary Fats 8.0818367378
MESH:D004487 Edema perfluorooctanoic acid 9.8717259670 12083418
MESH:D004487 Edema pirinixic acid 9.8712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.8711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.8916714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 10.8918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.4917692515
MESH:D016889 Endometrial Neoplasms Estradiol 6.7418566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 6.7416569247
MESH:D004715 Endometriosis Progesterone 8.0416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.049294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.8716530937
MESH:D004938 Esophageal Neoplasms Ethanol 6.8716704527
MESH:D004938 Esophageal Neoplasms Zinc 6.8716543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.0811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.0816938888 9664655
MESH:D005234 Fatty Liver Clofibrate 21.7219224547
MESH:D005234 Fatty Liver Cyclosporine 21.7219224547
MESH:D005234 Fatty Liver Dietary Fats 21.7217967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Ethanol 21.7219236843 16409862 18620774
MESH:D005234 Fatty Liver pirinixic acid 21.7219236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3517920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9916946407 15513904 10194807 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1511858732
MESH:D005355 Fibrosis Cyclosporine 18.6312168785 12639820
MESH:D005355 Fibrosis Dietary Fats 18.6318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.6320067830
MESH:D005355 Fibrosis Tretinoin 18.6317994277
MESH:D005756 Gastritis Ethanol 10.4915046732
MESH:D005756 Gastritis Zinc 10.4917241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6216973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9816417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.918708960
MESH:D005909 Glioblastoma Manganese 6.7817043766
MESH:D005909 Glioblastoma Tretinoin 6.7817312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2810696789
MESH:D006130 Growth Disorders Zinc 3.7617217573
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8416084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.1320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.1310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.1314991402 9664655
MESH:D006333 Heart Failure pirinixic acid 6.5120558911
MESH:D006333 Heart Failure Zinc 6.5117162251
MESH:D006335 Heart Injuries Zinc 5.4517074742
MESH:D016481 Helicobacter Infections Zinc 4.2517241300
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0611000095
MESH:D006521 Hepatitis, Chronic Copper 4.9617338147
MESH:D006527 Hepatolenticular Degeneration Copper 10.3717109627 16607473 17182432 19888908 17276780
MESH:D006527 Hepatolenticular Degeneration Zinc 10.3717276780
MESH:D006529 Hepatomegaly perfluorooctanoic acid 12.703609246
MESH:D006529 Hepatomegaly pirinixic acid 12.7016221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.7012621046 16120746 15340226
MESH:D006558 Herpes Genitalis Estradiol 4.7215709030
MESH:D015658 HIV Infections Nickel 3.6517263646
MESH:D019584 Hot Flashes Estradiol 3.4417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7315340226 16354765 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Ethanol 11.8218783367
MESH:D006930 Hyperalgesia perfluorooctanoic acid 11.8212083418
MESH:D006930 Hyperalgesia Tretinoin 11.8216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3221332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2616778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9220558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.3321332399
MESH:D006973 Hypertension Cyclosporine 4.5410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.5418670907 18850075
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 5.5519822448
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1015869954
MESH:D007248 Infertility, Male 2,4-Dichlorophenoxyacetic Acid 6.7612948887
MESH:D007248 Infertility, Male vinclozolin 6.7616467254
MESH:D007249 Inflammation Aluminum 17.8516052892
MESH:D007249 Inflammation Dietary Fats 17.8520412841
MESH:D007249 Inflammation Nickel 17.8516166738
MESH:D007249 Inflammation perfluorooctanoic acid 17.8512083418
MESH:D007249 Inflammation Progesterone 17.8515869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 17.8512878042 12200463
MESH:D007299 Insect Bites and Stings decamethrin 12.0915189238
MESH:D007299 Insect Bites and Stings Permethrin 12.0912749493 15189238 12971516
MESH:D007333 Insulin Resistance Dietary Fats 11.1211836018 18457598
MESH:D007333 Insulin Resistance Estradiol 11.1216393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.1216306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4617994277
MESH:D007511 Ischemia Zinc 4.3316584753
MESH:D007569 Jaw Abnormalities Ethanol 15.5815513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 15.5816580747
MESH:D007569 Jaw Abnormalities Tretinoin 15.5815992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1315604871
MESH:D007674 Kidney Diseases Cadmium 13.0216322080 16962696 16226777
MESH:D007674 Kidney Diseases Cyclosporine 13.028314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 13.0215618244
MESH:D007674 Kidney Diseases Zinc 13.0216960431
MESH:D007676 Kidney Failure, Chronic Copper 9.5316518626
MESH:D007676 Kidney Failure, Chronic Zinc 9.5316518626
MESH:D007680 Kidney Neoplasms Cyclosporine 6.4512371664
MESH:D007680 Kidney Neoplasms Estradiol 6.4515610895
MESH:D007859 Learning Disorders Copper 9.0517134702
MESH:D007859 Learning Disorders Ethanol 9.0515451040
MESH:D007938 Leukemia Permethrin 6.3012937054
MESH:D007938 Leukemia Tretinoin 6.3017143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4216482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0216294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9512679006 17294898 16331271 16140955 15748426 9834237 17301526 17107899 17217047 19642359 19029980 19035177 16766008 17339181 19225113 16823087 17368321 17649720 17506722 17712046 16935935 17361223 16788101 16891316 19075265
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 11.908812269
MESH:D007984 Leydig Cell Tumor vinclozolin 11.9016417039
MESH:D017880 Limb Deformities, Congenital Ethanol 7.5817676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.589224671
MESH:D008103 Liver Cirrhosis Dietary Fats 6.2618296743
MESH:D008103 Liver Cirrhosis Ethanol 6.2615289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7818295389
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.2714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 6.2718166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.2715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.2712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.2716248980 18397230
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3517207112 17347304
MESH:D008113 Liver Neoplasms Aflatoxin B1 16.3918177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.3920195826 21137059
MESH:D008113 Liver Neoplasms Copper 16.3920302851
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 16.3914757943 18709148
MESH:D008113 Liver Neoplasms pirinixic acid 16.3920007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.3916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.178603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.1712151625
MESH:D008171 Lung Diseases Aluminum 4.4416052892
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.1414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.1418569708 17053015 20464547 6695378 18816296 18520028 20869020 20135361 20064080
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.1419555203 11884234
MESH:D008228 Lymphoma, Non-Hodgkin 2,4-Dichlorophenoxyacetic Acid 4.9016132792
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.9116891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.9111408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Zinc 8.9112773700
MESH:D020149 Manganese Poisoning Estradiol 11.9519453300
MESH:D020149 Manganese Poisoning Manganese 11.9519453300 16551646 16568477
MESH:D008527 Medulloblastoma Tretinoin 2.6617453147
MESH:D008545 Melanoma Tretinoin 1.9016752155
MESH:D008569 Memory Disorders Ethanol 3.8915451040 18411066
MESH:D008591 Meningomyelocele Tretinoin 4.1216940565
MESH:D007706 Menkes Kinky Hair Syndrome Copper 5.5717109627 17268249
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4716801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9616381670
MESH:D009069 Movement Disorders Manganese 4.7216551646
MESH:D020528 Multiple Sclerosis, Chronic Progressive Aluminum 6.0617086897
MESH:D020529 Multiple Sclerosis, Relapsing-Remitting Aluminum 6.0617086897
MESH:D009135 Muscular Diseases pirinixic acid 3.2016239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9017596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.4716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.4716411023
MESH:D009369 Neoplasms Benzo(a)pyrene 7.2811141357
MESH:D009369 Neoplasms pirinixic acid 7.2817405874
MESH:D009369 Neoplasms Tretinoin 7.2816946489 16594593
MESH:D009389 Neovascularization, Pathologic Copper 9.3117308104
MESH:D009389 Neovascularization, Pathologic Estradiol 9.3117289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0319348381 18481113
MESH:D009410 Nerve Degeneration Manganese 4.0416551646
MESH:D009421 Nervous System Malformations Estradiol 14.6216427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.6214600291
MESH:D009421 Nervous System Malformations Tretinoin 14.629125849
MESH:D009436 Neural Tube Defects Tretinoin 2.859142499
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 11.059802331
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 11.059802331
MESH:D009765 Obesity Dietary Fats 4.1617217161 21332399 20518802 18674790 20132043 16723640 18457598 11836018 19632207
MESH:D009765 Obesity pirinixic acid 4.1620558911
MESH:D010051 Ovarian Neoplasms Estradiol 7.2819401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.2817393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 7.2816936753
MESH:D010146 Pain Tretinoin 2.6616870215
MESH:D010190 Pancreatic Neoplasms Ethanol 5.0712384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.0715976015
MESH:D010300 Parkinson Disease Manganese 3.2611181820
MESH:D020734 Parkinsonian Disorders Manganese 4.2016140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9312520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.0715687053
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2618163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9612371664
MESH:D011225 Pre-Eclampsia Zinc 3.9417114810
MESH:D011248 Pregnancy Complications 2,4-Dichlorophenoxyacetic Acid 5.422087686
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 14.5117132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.5111896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.5119015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.6218220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9217292933
MESH:D011471 Prostatic Neoplasms Cadmium 1.9217075824
MESH:D011471 Prostatic Neoplasms Copper 1.9217079463 17308104
MESH:D011471 Prostatic Neoplasms Estradiol 1.9216740699
MESH:D011471 Prostatic Neoplasms Zinc 1.9216606632 12429649 16700911 16517595
MESH:D011472 Prostatitis vinclozolin 4.6218629315
MESH:D011507 Proteinuria Tretinoin 3.3216636307
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D011625 Pterygium Tretinoin 4.4816723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5418990726
MESH:D012162 Retinal Degeneration Zinc 3.9016584753
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8116116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7418045962
MESH:D012559 Schizophrenia Copper 3.0416842975
MESH:D012640 Seizures Ethanol 5.959754883
MESH:D012640 Seizures Picrotoxin 5.958635557 8954991
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.5219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.5216192470
MESH:D012878 Skin Neoplasms Tretinoin 8.5216467112
MESH:D013119 Spinal Cord Injuries Progesterone 3.9715862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.222093021 20155912
MESH:D013274 Stomach Neoplasms Ethanol 3.2218456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.2217261132
MESH:D013276 Stomach Ulcer Ethanol 3.2616755016 9211565 11906479 9562338 17189318 17918041
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.999754883
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5912697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.8016026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.3719048282
MESH:D014062 Tongue Neoplasms Tretinoin 9.0916051514
MESH:D014062 Tongue Neoplasms Zinc 9.0916543248
MESH:D014376 Tuberculosis Tretinoin 3.0416040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.0617053015
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4116129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.2916752155
MESH:D014605 Uveitis Cyclosporine 3.671336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2812125929
MESH:D014820 Vitiligo Tretinoin 3.7616761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9315886252
MESH:D015430 Weight Gain Dietary Fats 3.4816723640
MESH:D009396 Wilms Tumor Tretinoin 3.7116287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1317120751
Pathway ID Pathway Name
KEGG:00564 Glycerophospholipid metabolism
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00157 - NADH Dietary supplement;Micronutrient
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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