AutismKB 2.0

Annotation Detail for GPD2


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Basic Information Top
Gene Symbol:GPD2 ( GDH2,GPDM,mGPDH )
Gene Full Name: glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
Band: 2q24.1
Quick LinksEntrez ID:2820; OMIM: 138430; Uniprot ID:GPDM_HUMAN; ENSEMBL ID: ENSG00000115159; HGNC ID: 4456
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6118glycerol-3-phosphate shuttle
PWY-4261glycerol degradation IV
Pathway IDPathway Name
hsa00564Glycerophospholipid metabolism
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500800Fatty acid, triacylglycerol, and ketone body metabolism
Related Diseases/Disorders Top
No data
No data
Desease Name
METABOLIC
diabetes, type 2
No data
Desease Name
Diabetes, type 2, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GPD2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GPD2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of GPD2 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GPD2 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GPD2 mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in increased expression of GPD2 mRNAincreases expression 17103032
C015001 arsenite arsenite results in increased expression of GPD2 mRNAincreases expression 18191166
D003314 Corn Oil Corn Oil affects the expression of GPD2 mRNAaffects expression 16360708
D016572 Cyclosporine Cyclosporine results in decreased expression of GPD2 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of GPD2 mRNAincreases expression 16357043
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of GPD2 mRNAaffects cotreatment|increases expression 17347304
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of GPD2 mRNAaffects cotreatment|increases expression 17347304
D005419 Flavonoids Flavonoids results in decreased expression of GPD2 mRNAdecreases expression 18035473
D009151 Mustard Gas Mustard Gas results in increased expression of GPD2 mRNAincreases expression 15674844
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of GPD2 mRNAincreases expression 17616710
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of GPD2 mRNAincreases expression 16221955
C006253 pirinixic acid pirinixic acid results in increased expression of GPD2 mRNAincreases expression 18301758
18445702
16357043
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GPD2 mRNAdecreases expression 16611356
15800033
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GPD2 mRNAdecreases expression 19490992
D013752 Tetracycline Tetracycline results in increased expression of GPD2 mRNAincreases expression 16917069
C052342 topiramate topiramate results in increased expression of GPD2 mRNAincreases expression 16979414
C025643 vinclozolin vinclozolin affects the expression of GPD2 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.1117676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.1114514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 10.1118287403
MESH:D000138 Acidosis Ethanol 10.1111192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.0118653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.5416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.5416835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.2115451039 15451040
MESH:D000437 Alcoholism topiramate 4.9419331489 17925516 18552399
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D000853 Anophthalmos Ethanol 4.7115513904
MESH:D001008 Anxiety Disorders Ethanol 8.7211141031
MESH:D001008 Anxiety Disorders vinclozolin 8.7219015723
MESH:D001161 Arteriosclerosis Dietary Fats 3.7815238619
MESH:D001249 Asthma Mustard Gas 2.6810378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001768 Blister Mustard Gas 5.0519167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.4319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.4312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6915746008
MESH:D001943 Breast Neoplasms Dietary Fats 2.0120435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.0515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.8717687719 10378619
MESH:D002056 Burns Ethanol 4.5416374292
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.6816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.6816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.683084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.6821507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Ethanol 8.6815763234 18788625 15289165
MESH:D006332 Cardiomegaly Ethanol 6.6419332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.6418850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.5210977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.326135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.3212371664
MESH:D002659 Child Development Disorders, Pervasive topiramate 4.0615650499
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002779 Cholestasis Cyclosporine 7.4919486331
MESH:D002779 Cholestasis pirinixic acid 7.4919176532
MESH:D002971 Cleft Lip Ethanol 3.5315513904
MESH:D002972 Cleft Palate Ethanol 5.8015513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8016354765 8697196 15668235 12621046 15340226
MESH:D003110 Colonic Neoplasms arsenite 2.5715037631
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9614669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 2.6015513904 15451040 10194807 19302082 11873399 15451039 11198716
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6015322242 10048152 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.2314966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.5318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.5318551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003924 Diabetes Mellitus, Type 2 marker/mechanism
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6817107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 4.6816979414
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.8421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 14.8421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.8416485898 16109766 19164858 16177239 19420014 14725611 12153990 17906064 2444490 16781746 12540782 19739265 19370779 12958197 10663392 12705907 11743745 14986274 10774834 11287661 16393943 11834606 12594235 16227642 12392966 19085960 19923254 16081117 11529661 11461765 11739529 18071297 14550746 19416960 17562736 17522070 18713872 11421492 15619225 10915739 15968718
MESH:D056486 Drug-Induced Liver Injury Ethanol 14.8411566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.8420420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 14.8417522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3718367378
MESH:D004487 Edema Mustard Gas 15.639260866 11402378 11428631 11428647
MESH:D004487 Edema perfluorooctanoic acid 15.6312083418 17259670
MESH:D004487 Edema pirinixic acid 15.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 15.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8018230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9210568697 9294722
MESH:D004827 Epilepsy topiramate 4.2719148780
MESH:D004833 Epilepsy, Temporal Lobe topiramate 6.1716499746
MESH:D004890 Erythema Mustard Gas 5.059357497
MESH:D004938 Esophageal Neoplasms Ethanol 4.7916704527
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.7915878914 16805852 16510608 15623463 15547733 15547721 15264214 16704527 15150132
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005234 Fatty Liver arsenite 35.4518296743
MESH:D005234 Fatty Liver Cyclosporine 35.4519224547
MESH:D005234 Fatty Liver Dietary Fats 35.4517967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Ethanol 35.4516409862 18620774 19236843
MESH:D005234 Fatty Liver Fish Oils 35.4518620774
MESH:D005234 Fatty Liver pirinixic acid 35.4520131406 19236843
MESH:D005234 Fatty Liver Tetracycline 35.4519224547 16917069
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.5617920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.1916946407 15451040 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005355 Fibrosis arsenite 20.2718296743
MESH:D005355 Fibrosis Cyclosporine 20.2712639820 12168785
MESH:D005355 Fibrosis Dietary Fats 20.2718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 20.2720067830
MESH:D005756 Gastritis Acetaminophen 10.7816983495
MESH:D005756 Gastritis Ethanol 10.7815046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1916417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.118708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006529 Hepatomegaly perfluorooctanoic acid 13.833609246
MESH:D006529 Hepatomegaly pirinixic acid 13.8316221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.8315340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9415340226 16354765 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 12.6416870215
MESH:D006930 Hyperalgesia Ethanol 12.6418783367
MESH:D006930 Hyperalgesia perfluorooctanoic acid 12.6412083418
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4921332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0820558911
MESH:D006949 Hyperlipidemias Dietary Fats 9.2121332399
MESH:D006949 Hyperlipidemias Fish Oils 9.2115752949
MESH:D006968 Hypersensitivity, Delayed Corn Oil 12.3411484837
MESH:D006968 Hypersensitivity, Delayed Fish Oils 12.3411484837
MESH:D006973 Hypertension Cyclosporine 4.8110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8118670907 18850075
MESH:D007248 Infertility, Male vinclozolin 2.9716467254
MESH:D007249 Inflammation Dietary Fats 15.2820412841
MESH:D007249 Inflammation Flavonoids 15.2817296493
MESH:D007249 Inflammation Mustard Gas 15.288975870 16001271 9260866 11428647 17524151 11428631 11428620 9357497 11402378
MESH:D007249 Inflammation perfluorooctanoic acid 15.2812083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.2812200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.0111836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.0116306350
MESH:D007569 Jaw Abnormalities Ethanol 9.7815513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.7816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3415604871
MESH:D007674 Kidney Diseases Acetaminophen 5.5812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.588314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.8416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.8416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.8412371664
MESH:D007859 Learning Disorders Ethanol 4.1015451040
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 12.578812269
MESH:D007984 Leydig Cell Tumor vinclozolin 12.5716417039
MESH:D017880 Limb Deformities, Congenital Ethanol 3.7317676605
MESH:D008103 Liver Cirrhosis arsenite 10.8318296743
MESH:D008103 Liver Cirrhosis Dietary Fats 10.8318296743
MESH:D008103 Liver Cirrhosis Ethanol 10.8315289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.9918295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.3918166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3912878042
MESH:D008107 Liver Diseases Acetaminophen 1.6019460945 12587719 19784758 11587558 12969438 16610002 19014921 16611625
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.5417207112 17347304
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.807678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.802125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 13.8018709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 13.8016377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.8016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.402876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.408603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.4012151625
MESH:D008171 Lung Diseases Mustard Gas 3.3718161513 18702808
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.7814755239
MESH:D008175 Lung Neoplasms arsenite 4.7816809336
MESH:D008175 Lung Neoplasms Mustard Gas 4.783148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7819555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D008569 Memory Disorders Ethanol 4.0818411066 15451040
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6816801185
MESH:D008881 Migraine Disorders topiramate 4.5018759728 18803445 16942474 18765137
MESH:D009135 Muscular Diseases pirinixic acid 3.4016239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.9818551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.987678174 18551238
MESH:D009369 Neoplasms pirinixic acid 1.9017405874
MESH:D009389 Neovascularization, Pathologic arsenite 4.3015738583
MESH:D009395 Nephritis, Interstitial Tetracycline 4.689884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1918481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7818514411
MESH:D009503 Neutropenia Mustard Gas 3.8716761898 7688884
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.849802331
MESH:D009765 Obesity Dietary Fats 4.3420132043 21332399 20518802 17217161 18457598 19632207 16723640 11836018 18674790
MESH:D009765 Obesity pirinixic acid 4.3420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.5612819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.5616049721
MESH:D010146 Pain Acetaminophen 2.3016870215
MESH:D010190 Pancreatic Neoplasms Ethanol 2.9312384795
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.3311026799
MESH:D011041 Poisoning Mustard Gas 3.6915727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011230 Precancerous Conditions Corn Oil 9.1814668109
MESH:D011230 Precancerous Conditions Cyclosporine 9.1812371664
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 15.6917132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.6911896295 11222880 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 15.6919015723 18220299 18042343
MESH:D017096 Prion Diseases Tetracycline 5.3010903871
MESH:D011469 Prostatic Diseases vinclozolin 4.8318220299
MESH:D011472 Prostatitis vinclozolin 4.8318629315
MESH:D011537 Pruritus Mustard Gas 3.9818058305
MESH:D011565 Psoriasis Cyclosporine 2.1916882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8917266442 17620002 17894541 10334151 17720292
MESH:D015427 Reperfusion Injury pirinixic acid 2.3319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012640 Seizures 2,4-dinitrotoluene 13.5518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 13.5518551238
MESH:D012640 Seizures Ethanol 13.559754883
MESH:D012640 Seizures topiramate 13.5516499746
MESH:D012871 Skin Diseases Mustard Gas 2.6912880345 15451306 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9916192470
MESH:D013274 Stomach Neoplasms Ethanol 2.7918456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.7912958204 17575124
MESH:D013276 Stomach Ulcer Ethanol 3.4317918041 11906479 9562338 16755016 9211565 17189318
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.169754883
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.8716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.8716049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.6310091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.6310091137
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D014605 Uveitis Cyclosporine 3.881336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D015430 Weight Gain Dietary Fats 3.6416723640
MESH:D014985 Xerophthalmia Cyclosporine 4.3417120751
Pathway ID Pathway Name
KEGG:00564 Glycerophospholipid metabolism
REACT:22258 Metabolism of lipids and lipoproteins
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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