AutismKB 2.0

Annotation Detail for GPLD1


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Basic Information Top
Gene Symbol:GPLD1 ( GPIPLD,GPIPLDM,MGC22590,PIGPLD,PIGPLD1 )
Gene Full Name: glycosylphosphatidylinositol specific phospholipase D1
Band: 6p22.3
Quick LinksEntrez ID:2822; OMIM: 602515; Uniprot ID:PHLD_HUMAN; ENSEMBL ID: ENSG00000112293; HGNC ID: 4459
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00563Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
plasma levels of liver enzymes
METABOLIC
Desease Name
Plasma levels of liver enzymes
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GPLD1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of GPLD1 mRNAdecreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GPLD1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of GPLD1 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of GPLD1 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone affects the expression of GPLD1 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GPLD1 mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of GPLD1 mRNAaffects expression 19483382
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in increased expression of GPLD1 mRNAincreases expression 12082028
D002994 Clofibrate PPARA protein affects the reaction [Clofibrate results in decreased expression of GPLD1 mRNA]affects reaction|decreases expression 17585979
D002994 Clofibrate Clofibrate affects the expression of GPLD1 mRNAaffects expression 19483382
D004041 Dietary Fats Dietary Fats results in decreased expression of GPLD1 mRNAdecreases expression 15238619
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of GPLD1 mRNAdecreases expression 19638242
D004610 Ellagic Acid Ellagic Acid results in decreased expression of GPLD1 mRNAdecreases expression 12002526
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GPLD1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of GPLD1 mRNAdecreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GPLD1 mRNAaffects cotreatment|decreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GPLD1 mRNAincreases expression 12082028
D005001 Ethionine Ethionine affects the expression of GPLD1 mRNAaffects expression 19483382
D005632 Fructose Fructose results in increased expression of GPLD1 proteinincreases expression 16219662
D009853 Omeprazole Omeprazole affects the expression of GPLD1 mRNAaffects expression 19483382
D010634 Phenobarbital Phenobarbital results in increased expression of GPLD1 mRNAincreases expression 12082028
C006253 pirinixic acid pirinixic acid results in decreased expression of GPLD1 mRNAdecreases expression 20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of GPLD1 mRNA]decreases expression|increases reaction 20059764
C006253 pirinixic acid pirinixic acid affects the expression of GPLD1 mRNAaffects expression 19483382
C025299 polyphenols polyphenols results in decreased expression of GPLD1 mRNAdecreases expression 16293270
D011441 Propylthiouracil Propylthiouracil affects the expression of GPLD1 mRNAaffects expression 19483382
C059514 resveratrol resveratrol results in decreased expression of GPLD1 mRNAdecreases expression 12002526
D013629 Tamoxifen Tamoxifen affects the expression of GPLD1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GPLD1 mRNAaffects cotreatment|decreases expression 17942748
D013853 Thioacetamide Thioacetamide affects the expression of GPLD1 mRNAaffects expression 19483382
D014280 Triglycerides GPLD1 protein affects the abundance of Triglyceridesaffects abundance 16219662
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.666195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.6615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D058186 Acute Kidney Injury resveratrol 3.6816538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.9418653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7714692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.583712494
MESH:D000236 Adenoma Diethylnitrosamine 10.5810737359 6695378
MESH:D000236 Adenoma resveratrol 10.5815688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.2719061943 16434500 19052882 17162532 17620307 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.2717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.2716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.2716835633
MESH:D000544 Alzheimer Disease resveratrol 2.5316162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6418218290 18057881 20041841
MESH:D001161 Arteriosclerosis Dietary Fats 9.2815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.9715885639
MESH:D001169 Arthritis, Experimental resveratrol 6.9717115116
MESH:D050197 Atherosclerosis resveratrol 3.1616873680 17967414
MESH:D001281 Atrial Fibrillation Amiodarone 3.7618651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8311289319 1440618
MESH:D001778 Blood Coagulation Disorders Amiodarone 54.9819483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 54.9819483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 54.9819483382
MESH:D001778 Blood Coagulation Disorders Ethionine 54.9819483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 54.9819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 54.9819483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 54.9819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 54.9812125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 54.9819483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D002545 Brain Ischemia resveratrol 4.0917600658
MESH:D001943 Breast Neoplasms Dietary Fats 2.2720435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2717474063
MESH:D001943 Breast Neoplasms resveratrol 2.2717651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tamoxifen 2.2718821012 19189212 19066611 19011961 20005174 17893378 18997820 18629630 20135344 18815881 20065188 20544844 17242785 16202921 16818667 19115204 18984771 19084267 19059307 19155303 20859285 15668708 16273361 19487384 19288272 15565566 21138602 18351453 16873071 17440819 19103187 19221464 19289846 19189210 17261762 11161223 21152245 19142967 19410462 17049068 19200415 18855134 20390343 19244106 18425577
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 22.3416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 22.3416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 22.347296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 22.343084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 22.341701930
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 22.3416935385 16779866 19701751 16830150 20214788 18691550 3084413 10737359 18788625 20512989 17055752 16698587 20727157 18494052 16569478 16681979 19052882 17428255 16878318 20514400 19539802 19107877 18393292 16540662 18210153 19418558 16502159 10672840 16328049 11831363 19919837 18056438 19208518 19335982 17978847 18785209 19171122 19383236 20524982 3581430 20007298 18971187 17138121 17162532 16288022 16807293 18506893 18978308 17761372 19394651 17173139 20432363 19822196 21159647 19519916 20935162 20084675 20101231 18665156
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 22.3420007298 20935162 17173139 6705139 1701930
MESH:D006528 Carcinoma, Hepatocellular resveratrol 22.3416227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 22.3416924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 22.3417997003
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4016675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.597296757
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.6616227395
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2618670907 16120746 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8315710769 19225199
MESH:D002318 Cardiovascular Diseases resveratrol 3.3415458977
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8918974383
MESH:D002386 Cataract Acetaminophen 2.4710977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.986135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.987505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 14.981399818
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.9821159647 17174075 7505956 2727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.064080065
MESH:D002637 Chest Pain Omeprazole 4.9115447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 15.1919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 15.1916835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 15.1918291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.569022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.5617110522 16105132 17333356 17681005 11677210 16919318 15861022
MESH:D002779 Cholestasis pirinixic acid 12.5619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0315668235 15340226 12621046 8697196 16354765
MESH:D003092 Colitis resveratrol 3.9416474422
MESH:D003110 Colonic Neoplasms polyphenols 3.9516293270
MESH:D003110 Colonic Neoplasms resveratrol 3.9516338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9017141729 14669216
MESH:D003327 Coronary Disease Fructose 8.3818504504
MESH:D003327 Coronary Disease resveratrol 8.3816507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.2618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.2618551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6211298694 12868966 14531868 18759878 8970840 8156756 11906362 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.312952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental Fructose 8.3218603373
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 8.3216873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.9420387270
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 6.9418603373
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.9417107852
MESH:D003928 Diabetic Nephropathies resveratrol 8.5116286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.5119279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 24.8321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 24.8318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 24.8318289764 6679447 18692083 11289319 1440618 7440962 8291058 6482804 9653073 9022650 16192314 18648102 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 24.8311421492 12705907 15619225 16081117 12392966 11739529 17522070 16781746 19420014 19085960 2444490 10915739 12153990 11834606 12540782 19739265 14550746 18071297 19370779 12958197 19164858 14986274 17562736 19416960 10774834 16109766 16485898 15968718 12594235 16227642 10663392 16177239 19923254 14725611 16393943 11287661 11529661 11743745 18713872 11461765 17906064
MESH:D056486 Drug-Induced Liver Injury Amiodarone 24.8318218290 15265979
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 24.8319107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 24.8319370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 24.8320420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 24.8312963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.1516613094 15991576 21218061 17151854
MESH:D050171 Dyslipidemias Clofibrate 8.3716707586
MESH:D050171 Dyslipidemias Dietary Fats 8.3718367378
MESH:D004421 Dystonia Phenobarbital 3.831851702
MESH:D004487 Edema pirinixic acid 10.4412083418
MESH:D004487 Edema resveratrol 10.448985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.4412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7115322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.2912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 14.2917872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.2919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.9220544844 16202921 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.869294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.6617923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.923659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.683922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.386401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.067750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.833659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.063581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005218 Fat Necrosis Thioacetamide 5.5316456712
MESH:D005234 Fatty Liver Amiodarone 40.3714986274
MESH:D005234 Fatty Liver Clofibrate 40.3719224547
MESH:D005234 Fatty Liver Dietary Fats 40.3719004024 17967931 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 40.3720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 40.3715345470
MESH:D005234 Fatty Liver Fructose 40.3718641190 18395287 19196556
MESH:D005234 Fatty Liver pirinixic acid 40.3719236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 40.3719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.836705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005355 Fibrosis Dietary Fats 13.8318296743
MESH:D005355 Fibrosis Fructose 13.8318504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.8320067830
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D018149 Glucose Intolerance Fructose 5.1419165636
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.867505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.4017276928 18665440 15929193
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.846705139
MESH:D006505 Hepatitis Thioacetamide 8.8416456712
MESH:D006529 Hepatomegaly Amiodarone 19.1215265979
MESH:D006529 Hepatomegaly Phenobarbital 19.1216109766
MESH:D006529 Hepatomegaly pirinixic acid 19.1219176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 19.1212621046 15340226 16120746
MESH:D006561 Herpes Simplex resveratrol 3.9916876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8518606429 8697196 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.5516870215
MESH:D006937 Hypercholesterolemia Amiodarone 14.348137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 14.3421332399
MESH:D006937 Hypercholesterolemia resveratrol 14.3417188708
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006946 Hyperinsulinism Fructose 4.7418563319 19008412 18360027 15752949 14757778
MESH:D006949 Hyperlipidemias Dietary Fats 14.5621332399
MESH:D006949 Hyperlipidemias Fructose 14.5615752949
MESH:D006949 Hyperlipidemias resveratrol 14.5616873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7515034207
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.3417604070
MESH:D006973 Hypertension Fructose 5.2619008412 14573337 14568997 14633139 16843071
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2618670907 18850075
MESH:D015228 Hypertriglyceridemia Fructose 10.8119799862 19342510
MESH:D015228 Hypertriglyceridemia Triglycerides 10.8116979400 16238453
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1317488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6216569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 10.9818020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 10.9818031379 8137927
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.4617600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3617937319
MESH:D007249 Inflammation Dietary Fats 18.6920412841
MESH:D007249 Inflammation Diethylnitrosamine 18.6918785209
MESH:D007249 Inflammation polyphenols 18.6916366677
MESH:D007249 Inflammation resveratrol 18.6916366677
MESH:D007249 Inflammation Tamoxifen 18.6919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.6912200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.3516624496
MESH:D007333 Insulin Resistance Dietary Fats 11.7518457598 11836018
MESH:D007333 Insulin Resistance Fructose 11.7519008412 19799862 14633139 17133782 19586609 14757778 14573337 19342510 18563319 18057795 18981581
MESH:D007333 Insulin Resistance pirinixic acid 11.7516306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.838074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007674 Kidney Diseases Acetaminophen 2.0915629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.4816705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.4816705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.486582329
MESH:D007680 Kidney Neoplasms Tamoxifen 16.4818625569
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.9419248655
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4516087638
MESH:D008064 Lipidoses Amiodarone 7.4715342952 17567588
MESH:D008064 Lipidoses Tamoxifen 7.4717567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 10.4218296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.4218407596 18522880 19638242 18665156 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 10.4221047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.089327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.7518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7512878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 4.7515158331 11682029 15716488 17050028 15075984 15078482 12531686 18031379 18395095 17629604 12891558 15095483 18615449 18032466 14739098 17355460 17127702 18295389 18416461 18380797 12679928 18458672 18263696 16126171 18606216 15316131 16511523 15288472 10677585 15474484 15465738 11172339 15334695 16343077 16098781 17292413 12175628 16248980 11481614 12557150 15288473 12085344 15362042 16489207 16097051
MESH:D008107 Liver Diseases Acetaminophen 12.0016611625 16610002 12587719 19460945 11587558 19784758 12969438 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 12.0017034775
MESH:D008107 Liver Diseases Phenobarbital 12.0019363144
MESH:D008107 Liver Diseases polyphenols 12.0016698588
MESH:D008107 Liver Diseases Thioacetamide 12.0016337175 18374380 15158337
MESH:D017114 Liver Failure, Acute Acetaminophen 9.0817185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 9.0815633222 12479984 15313186 17276928
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 24.707678174
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 24.7018177683
MESH:D008113 Liver Neoplasms Diethylnitrosamine 24.7019254457 19642983 19294768 21167192 18754104 18978307 18977376 19833225 19426721 19850985 20101389 19073162 19690152 20583210 18648771 2422723 15175105 20434301 18644402 2862719 19499222 21071580 19638242 15885732 20137499 19996281 12112319 20405173 20452335 19256749 12771043 10737359 16942905 19551842 21278145 19255062 19812893 20501860 19427195 21047994 20492335 20118626 19090486 9163691
MESH:D008113 Liver Neoplasms Phenobarbital 24.7019812893 15975961 21047994 19073162 8742319 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 24.7020007298 15890375 16377806
MESH:D008113 Liver Neoplasms resveratrol 24.7019812893 19073162 19321006 20405173
MESH:D008113 Liver Neoplasms Tamoxifen 24.7016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.7016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 17.382876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.38598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.3818544905 18775883 18079962 16267830 19126423 19539802 17942915 19009564 18308698 2563599 18253720 18093689 17854601 16842330 18164116 19004024 21159647 3124819 9362446 17174075 18282651 19519916
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 17.3818308698 17172636 6150874 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.3812151625
MESH:D008133 Long QT Syndrome Amiodarone 3.4417391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.2512587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.2918516814
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 4.6919359593 19925653 16337739 11246140 11696405 18597497 15390079
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.6920970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Tamoxifen 4.6918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6919555203 11884234
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1217088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.7114749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 9.3615688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.3619428831
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 9.461500032
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 9.4611606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.4619196723 14580682 16827153 11731420 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.3519453300
MESH:D008545 Melanoma resveratrol 3.3317992120
MESH:D008545 Melanoma Tamoxifen 3.3312393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008659 Metabolic Diseases resveratrol 4.2017112576
MESH:D024821 Metabolic Syndrome X Fructose 4.6617261469 18497449 17098227 19165636 16815490
MESH:D009101 Multiple Myeloma resveratrol 3.3316490592 14749477 17049120 17935668 16267019 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.6817962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009181 Mycoses Amiodarone 4.7117974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 5.4819151258
MESH:D009203 Myocardial Infarction resveratrol 5.4816525036 17015251 17188708 17125593 16317513 16456233
MESH:D017202 Myocardial Ischemia resveratrol 8.5117015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.5112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8016411023
MESH:D009205 Myocarditis resveratrol 4.5717322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2817484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.7118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.717678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.023581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.023581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.0219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms pirinixic acid 1.8617405874
MESH:D009374 Neoplasms, Experimental resveratrol 3.818985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0314600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.796679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 13.1518514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 13.1520387270
MESH:D019636 Neurodegenerative Diseases resveratrol 13.1517652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.2217929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.759802331
MESH:D009765 Obesity Dietary Fats 7.2421332399 17217161 16723640 18457598 11836018 20518802 18674790 19632207 20132043
MESH:D009765 Obesity Fructose 7.2418585860 17707055
MESH:D009765 Obesity pirinixic acid 7.2420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.1016049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.1016049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.106482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.833988306
MESH:D010018 Osteomalacia Phenobarbital 4.1717016548
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0817513867
MESH:D010146 Pain Acetaminophen 2.2416870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.0316540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.0316965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.307296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.286228378
MESH:D011014 Pneumonia Butylated Hydroxytoluene 4.9711893704
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.552563599
MESH:D011230 Precancerous Conditions Phenobarbital 8.552563599
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 8.9516679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9511222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms resveratrol 3.4417636462 16731767 17804756 17718901 17675339 15767336
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.4415067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.1215861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.3012752131
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7812490602 11597910 12832656
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3916325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.2619058328
MESH:D015427 Reperfusion Injury resveratrol 6.2615827377 16317513 17520802 17058453 16314181
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.233692021
MESH:D012640 Seizures 2,4-dinitrotoluene 9.0618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.0618551238
MESH:D012640 Seizures Phenobarbital 9.063137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.636407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8918724381
MESH:D012878 Skin Neoplasms resveratrol 5.428985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9216709447
MESH:D013088 Spermatocele Tamoxifen 10.9216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8519457130
MESH:D013272 Stomach Diseases Omeprazole 4.4218545984
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013276 Stomach Ulcer Amiodarone 7.0118087811
MESH:D013276 Stomach Ulcer Omeprazole 7.0111906479 16755016 10750652 18237397 15991576 17977527
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3116321402
MESH:D013610 Tachycardia Amiodarone 4.1111238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0119225199
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.0617997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013959 Thyroid Diseases Amiodarone 11.4119731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.4112697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 15.946582329 7505956 6587162 1399818 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.947505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 15.941399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 15.9415710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.6718020914 19584973
MESH:D014062 Tongue Neoplasms resveratrol 4.0416227395
MESH:D016171 Torsades de Pointes Amiodarone 4.0017467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.2916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.2916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.298074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.2917572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.3510091137
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.9317473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.8914692618
MESH:D014594 Uterine Neoplasms resveratrol 8.8917044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.1117488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D015430 Weight Gain Dietary Fats 3.5816723640
Pathway ID Pathway Name
KEGG:00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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