AutismKB 2.0

Annotation Detail for SLCO1B3


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Basic Information Top
Gene Symbol:SLCO1B3 ( LST-3TM13,LST3,OATP1B3,OATP8,SLC21A8 )
Gene Full Name: solute carrier organic anion transporter family, member 1B3
Band: 12p12.2
Quick LinksEntrez ID:28234; OMIM: 605495; Uniprot ID:SO1B3_HUMAN; ENSEMBL ID: ENSG00000111700; HGNC ID: 10961
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500831Recycling of bile acids and salts
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1944Breast cancer
2022Liver cancer
2155Leukopenia
Desease Name
height
DEVELOPMENTAL
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLCO1B3 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLCO1B3 mRNAaffects expression 16483693
D001647 Bile Acids and Salts SLCO1B3 protein affects the transport of Bile Acids and Saltsaffects transport 15841457
D001647 Bile Acids and Salts SLCO1B3 protein affects the uptake of Bile Acids and Saltsaffects uptake 15841457
D002220 Carbamazepine Carbamazepine results in increased expression of SLCO1B3 mRNAincreases expression 17112801
D012844 Sincalide SLCO1B3 protein affects the import of Sincalideaffects import 16046661
D012844 Sincalide SLCO1B3 protein affects the uptake of Sincalideaffects uptake 15665139
D016572 Cyclosporine Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of fexofenadine]decreases reaction|increases uptake 18180276
D002117 Calcitriol Calcitriol results in increased expression of SLCO1B3 mRNAincreases expression 16002434
C025483 estradiol-17 beta-glucuronide [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronideaffects cotreatment|increases uptake 18180276
C093230 fexofenadine Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of fexofenadine]decreases reaction|increases uptake 18180276
C093230 fexofenadine Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of fexofenadine]decreases reaction|increases uptake 18180276
C093230 fexofenadine [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of fexofenadineaffects cotreatment|increases uptake 18180276
C093230 fexofenadine SLCO1B3 protein results in increased uptake of fexofenadineincreases uptake 18245269
C065180 fluvastatin SLCO1B3 protein affects the import of fluvastatinaffects import 16046661
C026209 oltipraz oltipraz results in decreased expression of SLCO1B3 mRNAdecreases expression 16837569
D010634 Phenobarbital Phenobarbital results in decreased expression of SLCO1B3 mRNAdecreases expression 16837569
D012293 Rifampin Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of fexofenadine]decreases reaction|increases uptake 18180276
D013448 Sulfobromophthalein SLCO1B3 protein affects the import of Sulfobromophthaleinaffects import 16046661
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SLCO1B3 mRNAdecreases expression 16837569
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 14.658986270
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 14.656195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 14.6515322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.2517620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.2516835633
OMIM:607154 ALLERGIC RHINITIS fexofenadine 5.7916037679
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000855 Anorexia Sincalide 6.6815879057
MESH:D001714 Bipolar Disorder Carbamazepine 4.1517594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001943 Breast Neoplasms Calcitriol 2.1111237771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1120435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1012619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.1017173139 6705139 1701930 20935162 20007298
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6311237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5412371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.294080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Cyclosporine 8.8319486331
MESH:D002779 Cholestasis estradiol-17 beta-glucuronide 8.8312893835
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1115340226 12621046 16354765 15668235 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0817141729 14669216
MESH:D003327 Coronary Disease fluvastatin 4.8316142594
MESH:D019465 Craniofacial Abnormalities Carbamazepine 2.879014606
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8720055451 10048152 15322242
MESH:D003876 Dermatitis, Atopic fexofenadine 4.7817133778
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.4911748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.4216538176 15057820 20216337 16538175
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 4.1917465707
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.1920420201
MESH:D004362 Drug Toxicity Carbamazepine 8.4720216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.4711462148
MESH:D004421 Dystonia Phenobarbital 4.041851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9615322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.7815138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 9.7817654737
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0510568697 9294722
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.2919915237 16538176 20485159 16415921 18855540
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 11.3217275665
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 11.323659116
MESH:D004828 Epilepsies, Partial Carbamazepine 10.5717116037 15008574 16628512
MESH:D004828 Epilepsies, Partial Phenobarbital 10.573922381 11558140
MESH:D004827 Epilepsy Carbamazepine 7.10821787 19439326 17465707 20417680 9014606 7988514 17178248 19700373 18234410 19620853
MESH:D004827 Epilepsy Phenobarbital 7.1020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.576401628
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 11.837750514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 11.837750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 11.043659116 15276670
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 11.043659116
MESH:D004916 Erythromelalgia Carbamazepine 5.7719549232
MESH:D004942 Esophagitis, Peptic Bile Acids and Salts 6.6211346197
MESH:D005076 Exanthema Carbamazepine 5.5220485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Cyclosporine 2.8819224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis Cyclosporine 8.6212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3410048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly Phenobarbital 8.5816109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.5816120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1116959395 15340226 8697196 18606429 16354765
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.7510459572
MESH:D006965 Hyperplasia Carbamazepine 5.2518773962
MESH:D006967 Hypersensitivity fexofenadine 5.3517910814
MESH:D006973 Hypertension Cyclosporine 4.9810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9818670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8712200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Cyclosporine 2.358314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7612371664
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9121047994
MESH:D008106 Liver Cirrhosis, Experimental oltipraz 2.9216544323
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.9212878042
MESH:D008107 Liver Diseases Phenobarbital 2.1819363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.4815890375 9163691 2125692 18177683
MESH:D008113 Liver Neoplasms Phenobarbital 7.4815975961 19812893 19073162 8742319 19482888 21047994
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4816984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.928603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.9218308698 6150874 17172636 2563599 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9212151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.3014755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3019555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Rifampin 6.1811422169
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 6.1816628512
MESH:D008180 Lupus Erythematosus, Systemic Rifampin 6.1811422169
MESH:D008607 Mental Retardation Carbamazepine 3.739014606
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D009101 Multiple Myeloma fluvastatin 4.5416996129
MESH:D009164 Mycobacterium Infections Rifampin 5.6118474467
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5317484760
MESH:D009224 Myotonia Congenita Carbamazepine 5.5220399394
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3119348381 18481113
MESH:D009421 Nervous System Malformations Carbamazepine 10.0516990009
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.0514600291
MESH:D010018 Osteomalacia Carbamazepine 12.2717016548
MESH:D010018 Osteomalacia Phenobarbital 12.2717016548
MESH:D010146 Pain Carbamazepine 4.0615215642
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5016965848
MESH:D010267 Parapsoriasis Carbamazepine 5.7416538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.9717679678 17145499
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.0512371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.052563599
MESH:D011248 Pregnancy Complications Carbamazepine 5.199014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 10.029014606
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.0211118676 11222880 11896295 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8315572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.5418247401 12479363 15754350 16289102 16644109
MESH:D011537 Pruritus fexofenadine 5.6617133778
MESH:D019310 Pseudolymphoma Carbamazepine 12.799591791 12752131
MESH:D019310 Pseudolymphoma Phenobarbital 12.7912752131
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012640 Seizures Carbamazepine 6.4515946322 9844417 19414003 16876388 16180713 9046859 16938433
MESH:D012640 Seizures Phenobarbital 6.4516876388 3137016 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.876407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0516192470
MESH:D012893 Sleep Disorders Carbamazepine 5.1719414003
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.2516415921 15057820 19915237 16538176 20485159 19694795 18855540
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.071399818
MESH:D014376 Tuberculosis Rifampin 4.7818397238 15236969
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
KEGG:04976 Bile secretion
REACT:22258 Metabolism of lipids and lipoproteins
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35844
    • Releated gene ID Related gene Name
    PA35844SLCO1B3
    Releated disease ID Related disease Name
    PA444511Hyperbilirubinemia
    PA445113Neutropenia
    PA446438Kidney Failure
    PA444773Leukopenia
    PA133888799Organ Transplantation
    PA443340Anemia
    PA445062Neoplasms
    PA445846Thrombocytopenia
    PA443937Drug Toxicity
    PA446975Neurotoxicity Syndromes
    Releated drug ID Related drug Name
    PA143414738atrasentan
    PA449319digoxin
    PA449456enalapril
    PA164778866liothyronine
    PA450428methotrexate
    PA164742950olmesartan
    PA163522138ouabain
    PA142650384pitavastatin
    PA451605telmisartan
    PA151070295thyroxine
    PA451848valsartan
    PA450566mycophenolate mofetil
    PA451365sirolimus
    PA451578tacrolimus
    PA449493erythromycin
    PA449789glycine
    PA449688fluvastatin
    PA134308647rosuvastatin
    PA10500thyroid hormones
    PA450264lopinavir
    PA450761paclitaxel
    PA10034bosentan
    PA451250rifampin
    PA449621fexofenadine
    PA151958355grapefruit juice
    PA10005adefovir dipivoxil
    PA449001cimetidine
    PA449383docetaxel
    PA10816ezetimibe
    PA164748728mycophenolic acid
    PA450085irinotecan
    Drug Bank Top
    No data
    No data
    Drugbank ID Action Drug Name Description
    DB00177 substrate Valsartan Antihypertensive Agents;Angiotensin II Receptor Antagonists
    DB00275 substrate Olmesartan Antihypertensive Agents;Angiotensin II Type 1 Receptor Blockers
    DB00279 substrate Thyrolar Hormone Replacement Agents
    DB00286 substrate Prempro Estrogens
    DB00390 substrate Digoxin Enzyme Inhibitors;Antiarrhythmic Agents;Cardiotonic Agents;Anti-Arrhythmia Agents
    DB00520 substrate Caspofungin Antifungals;Antifungal Agents
    DB00563 substrate Methotrexate Antineoplastic Agents;Antirheumatic Agents;Antimetabolites;Enzyme Inhibitors;Folic Acid Antagonists;Dermatologic Agents;Immunosuppressive Agents;Nucleic Acid Synthesis Inhibitors;Abortifacient Agents, Nonsteroidal;Abortifacient Agents;Antimetabolites, Antineoplastic
    DB01045 inhibitor Rifater Enzyme Inhibitors;Antituberculosis Agents;Nucleic Acid Synthesis Inhibitors;Leprostatic Agents;Antibiotics;Antibiotics, Antitubercular
    DB01092 substrate Ouabain Enzyme Inhibitors;Cardiotonic Agents
    DB01132 inhibitor ActoplusMet Hypoglycemic Agents;Thazolidinediones
    DB01583 substrate Liotrix Hormone Replacement Agents
    DB02659 substrate Cholic Acid
    DB04348 substrate Taurocholic Acid Cholagogues and Choleretics;Detergents
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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