AutismKB 2.0

Annotation Detail for MKX


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Basic Information Top
Gene Symbol:MKX ( C10orf48,IFRX,IRXL1,MGC39616 )
Gene Full Name: mohawk homeobox
Band: 10p12.1
Quick LinksEntrez ID:283078; OMIM: 601332; Uniprot ID:MKX_HUMAN; ENSEMBL ID: ENSG00000150051; HGNC ID: 23729
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of MKX mRNAdecreases expression 19933214
D016572 Cyclosporine Cyclosporine results in increased expression of MKX mRNAincreases expression 20106945
D005472 Fluorouracil Fluorouracil results in decreased expression of MKX mRNAdecreases expression 16510598
C051890 irinotecan irinotecan analog results in decreased expression of MKX mRNAdecreases expression 18927307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MKX mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3815322242 14514962 11752688
MESH:D000230 Adenocarcinoma Fluorouracil 2.4917638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D000740 Anemia Fluorouracil 9.8615504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.8611748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Fluorouracil 2.0219217205 16595493 15136595 16557594 18357371 18608205 16110121
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002276 Carcinoid Tumor Fluorouracil 5.2816051944
MESH:D002277 Carcinoma Fluorouracil 9.1617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.1616835633
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 2.1218930000 17045692 16799960 17088986 17971768 16332177
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1518695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5718986760 16280240 17066447 16757204
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2215340226 8697196 12621046 16354765 15668235
MESH:D003110 Colonic Neoplasms Fluorouracil 4.1417016597 15001691 17018589 16510598 17287894 17725105 16340194 18772588 17169374 17172411
MESH:D003110 Colonic Neoplasms irinotecan 4.1417725105 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.7918383874 20501625 17594712 15148649 15289873 17695437 14970324 18802399 17454858 18448328 17094418 16524972 18509181 16282729 18949393 16331619 18288408 16391804 17016601 17401013 17255274 16303861
MESH:D015179 Colorectal Neoplasms irinotecan 2.7917159606 16303861 16391804 15273666 17454858 18509181 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 20055451 15322242
MESH:D007644 Darier Disease Fluorouracil 5.3316733453
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5116714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3710568697 9294722
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5216481741 16337965 17638652 16785472 15173087
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Cyclosporine 3.2319224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Cyclosporine 10.1412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.1420067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D005910 Glioma Fluorouracil 2.9816145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.6115102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4911294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3716120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6615340226 16959395 8697196 18606429 16354765
MESH:D006973 Hypertension Cyclosporine 5.3110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3118670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 2.528314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 8.4212371664
MESH:D007680 Kidney Neoplasms Fluorouracil 8.4216985049
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms Fluorouracil 4.8616603448 17045692 15113037 18383874
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8616984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3112151625
MESH:D008175 Lung Neoplasms Fluorouracil 2.4315246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4311884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.3315086387
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009062 Mouth Neoplasms Fluorouracil 3.9018986760 16757204
MESH:D052016 Mucositis irinotecan 5.5517159606
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D009362 Neoplasm Metastasis irinotecan 3.2818259882
MESH:D009369 Neoplasms Fluorouracil 2.7516928823 18239605 18600527
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D009447 Neuroblastoma irinotecan 3.648761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.278761367
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6616436463
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7616500647 16929163 19003803 15113037
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311222880 11118676 11896295 11399792
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3619082440 18626508
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3416160472 18722050 15538739 18286688
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1816192470
MESH:D013274 Stomach Neoplasms Fluorouracil 2.7816424979 17172411 19015929 15786421 18396642 19084572 17498489 18567086 17522103 16951190
MESH:D013274 Stomach Neoplasms irinotecan 2.7815723263
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.3416280240
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.2316803524
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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